SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Xinxin Zhou,Shucheng Liu,Manlei Zhang,Chen Shi,Mengyi Chen,Chenzhi Hou,Bin Di
Diabetes mellitus, a metabolic disease characterized by hyperglycemia, has been witnessed as a rapidly escalating worldwide health crisis. China currently had 140.9 million diabetic population in 2021, which was the largest globally. DM has witnessed a significant surge in the past few decades, leading to an alarming rise in the overall burden caused by this disease. To monitor the near real-time DM prevalence and the consumption of first-line anti-diabetic drugs, a wastewater-based epidemiology (WBE) approach based on the back-calculation of metformin concentration was implemented in 237 cities in China. The quantitative analysis of metformin in wastewater was conducted by LC-MS/MS with satisfactory results of method validation. The average concentration of metformin in wastewater was 14.07 ± 13.16 μg/L, and the per capita consumption was 5.16 ± 2.08 mg/day/inh, ranging from 0.90 to 10.36 ± 4.63 mg/day/inh. The calculated metformin prevalence was found to be 0.52 % ± 0.28 %, and the final estimated DM prevalence was 11.33 % ± 4.99 %, which was nearly consistent with the result of the International Diabetes Federation survey of 9.98 %. The results suggested that metformin might be one of the suitable WBE biomarkers in DM monitoring and WBE strategy could potentially enable the estimation of DM prevalence in most of Chinese cities after reasonable correction of associated parameters.
研究领域:
公共卫生
·
流行病学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Xinxin Zhou,Kexin Liu,Chen Shi,Manlei Zhang,Shucheng Liu,Chenzhi Hou,Bin Di
Gout is a metabolic arthritis caused by hyperuricemia. In recent years, the prevalence of gout has been increased significantly in China due to the improvement of the living standards, and gout has become another common metabolic disease following diabetes mellitus. Gout severely affects the health status and life quality of human. In order to monitor the near real-time prevalence of gout, a wastewater-based epidemiology (WBE) approach was carried out in 257 Chinese cities using febuxostat as the biomarker. Febuxostat in wastewater was measured by a LC-MS/MS method with satisfactory results of method validation. The average concentration of febuxostat in wastewater was 53.05 ± 31.76 ng/L, with the estimated per capita consumption of 124.40 ± 73.37 mg/day/1000 inhabitant. The calculated prevalence of febuxostat was 0.41 % ± 0.24 %, and the prevalence of gout was finally estimated to be 1.30 % ± 0.77 % (0.60 % to 2.11 %), which was nearly consistent with value of 1.10 % obtained from the Guideline for the diagnosis and management of hyperuricemia and gout in China (2019). The results indicated that the febuxostat-based WBE approach might be reasonable to assess the near real-time gout prevalence in China.
研究领域:
流行病学
·
环境科学
·
公共卫生
·
代谢
✓ 已验证
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Moying Yang,Yan Yao,Haotian Shen,Fei Teng,Yunuo Liu,Yuyang Ma,Bin Di,Mengxiang Su
Depression has gradually become a serious public health problem. Traditionally, data on depression are mainly derived from questionnaires or antidepressant prescriptions, and these methods may suffer from update delays and survey bias, resulting in a low actual prevalence of depression. To monitor the prevalence of depression in near real-time, this study developed an analytical method of UPLC-MS/MS by wastewater-based epidemiology to detect 10 typical antidepressants and metabolites in four provinces of China. The method has high sensitivity in that the lower limit of quantification was 2 ng/L. And the method provides recoveries and matrix effects ranging from 85.12 % to 102.98 % and 84.95 % to 112.75 %, respectively. The results showed that among the four provinces, the highest average detected concentration of antidepressants was in Jiangsu (91.82 ± 150.46 ng/L), followed by Guangxi (76.06 ± 130.44 ng/L), Anhui (61.53 ± 94.09 ng/L), and Hainan (27.87 ± 28.33 ng/L). Most wastewater treatment facilities had antidepressants such as venlafaxine, fluvoxamine, and agomelatine. The average back-calculated consumption of venlafaxine and fluvoxamine was 815.88 ± 2015.96 mg/day/1000 inh and 497.02 ± 405.21 mg/day/1000 inh, respectively. Based on this study, the estimated prevalence in the population over 15 in Jiangsu, Anhui, and Hainan was finally determined to be 4.90 %, 5.36 %, and 2.93 %, indicating regional diversity. This study offered a workable way to track the prevalence of depression using wastewater-based epidemiology, which aided public health agencies in comprehending the state of depression prevalence.
研究领域:
环境科学
·
分析化学
·
流行病学
·
公共卫生
·
药物监测
✓ 已验证
产品关联
DOI
高影响因子
Journal of Clinical Medicine
·
2022
·Vol. 11
·期 9
·2573
·
IF 4.964
Rocío Redondo-Rodriguez,Natalia Mena-Vázquez,Alba María Cabezas-Lucena,Sara Manrique-Arija,Arkaitz Mucientes,Antonio Fernández-Nebro
Objective: In this study, we aimed to evaluate the worldwide incidence and prevalence of ANCA-associated vasculitis (AAV). Methods: A systematic search of Medline and Embase was conducted until June 2020 for studies that analyzed the incidence and prevalence of patients aged >16 years diagnosed with AAV in different geographical areas. A meta-analysis was undertaken to estimate the pooled incidence per million person-years and prevalence per million persons in AAV overall and for each subtype of AAV: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). The 95% confidence interval (CI) and I2for heterogeneity were calculated. Results: The meta-analysis included 25 studies that met the inclusion criteria and covered a total of 4547 patients with AAV. Frequency increased over time. The global pooled incidence (95% CI) was 17.2 per million person-years (13.3–21.6) and the global pooled prevalence (95% CI) was 198.0 per million persons (187.0–210.0). The pooled incidence per million person-years for each AAV subtype varied from highest to lowest, as follows: GPA, 9.0; MPA, 5.9; and EGPA, 1.7. The individual pooled prevalence per million persons was, as follows: GPA, 96.8; MPA, 39.2; and EGPA, 15.6. AAV was more predominant in the northern hemisphere. By continent, a higher incidence in America and pooled prevalence of AAV was observed in America and Europe. Conclusion: The pooled incidence and prevalence of AAV seem to be increasing over time and are higher in the case of GPA. AAV was generally more frequent (incidence and prevalence) in the northern hemisphere.
研究领域:
风湿病学
·
免疫学
·
流行病学
·
血管炎
·
自身免疫性疾病
·
临床流行病学
·
转化医学
✓ 已验证
DOI
高影响因子
ACS ES&T Water
·
2023
·
IF 5.3
Xue-Ting Shao,Yue-Tong Zhao,Bing Jiang,Yan-Ying Li,Jian-Guo Lin,De-Gao Wang
Wastewater-based epidemiology has some advantages in assessing chronic diseases with high prevalence, but selecting appropriate biomarkers is difficult. The aim of this study was to screen biomarkers in wastewater to accurately assess the prevalence of hypertension (ten drugs), diabetes (eight drugs), and gout (four drugs). The concentrations of biomarkers in the influent from 37 wastewater treatment plants in 34 Chinese cities were assessed using LC/MS–MS combined with solid-phase extraction. Biomarkers with excretion rates above 5% and high stability (>80%) and detection frequency (>80%) were selected to evaluate the prevalence. Sartans, hydrochlorothiazide, sotalol, and nornifedipine have been identified as biomarkers for hypertension; metformin and glibenclamide for diabetes; and oxypurinol and febuxostat for gout. The prevalence rates of hypertension, diabetes, and gout in China assessed using these biomarkers were 26% (95CI %: 18.8–36.5), 9.58% (95CI %: 6.62–14.2), and 5.95% (95CI %: 4.22–6.74), respectively, which were consistent with government survey data. We found a co-occurrence of hypertension, diabetes, and gout prevalence, and they were associated with unhealthy lifestyle, economics, and medical level. The results suggested that wastewater-based epidemiology is an effective approach to accurately assess disease prevalence by selecting multiple biomarkers, providing valuable information for public health.
研究领域:
流行病学
·
公共卫生
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）