SEPARATION AND PURIFICATION TECHNOLOGY
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2023
·
IF 8.6
Wenbei Chen,Huixian Liu,Yuting Chen,Jian Ke,Xin Qiu,Jianqiu Chen,Yibing Ji
Membrane separation technology has infinite potential to produce optically pure drugs. However, there are still challenges regarding chiral membranes, such as the single separation object, poor mechanical properties, and constrained relationship between permeability and enantioselectivity. To improve the membrane properties, heptakis (6-amino-6-deoxy)- β -CD-modified carboxyl-functionalized COF (TpBD-Am7CD) was introduced as a chiral functional material for the preparation of a TpBD-Am7CD stainless steel I-Net cellulose acetate membrane (COF/SSCAM) via interfacial polymerization. Using tryptophan as the template molecule, the membrane preparation and filtration conditions were optimized to achieve maximum enantioselectivity. The optimized COF/SSCAM achieved a better enantiomeric excess percentage (e.e.% = 100.00%) and solute permeation flux (J S = 37 × 10 −6 mol m −2 h −1 ) for racemic tryptophan than the support membrane, which was attributed to the enantioselectivity and hydrophilicity of TpBD-Am7CD. Moreover, COF/SSCAM achieved enantiomeric separation of racemates of propranolol, warfarin, atenolol, and metoprolol, and the e.e.% values were 39.51%, 5.60%, 16.04%, and 3.09%, respectively. In addition, the chiral recognition mechanism was investigated by molecular docking simulation.
研究领域:
材料科学
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生物医学工程
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化学工程
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产品关联
DOI
高影响因子
ACS Agricultural Science & Technology
·
2022
·
IF 0
Bizhu Lv,Ruying Zhong,Yue Wang,Guang Li,Siyun Zhang,Lei Yang,Meng Cai,Jin Zhang,Zhiyan Lu,Haibing Li,Xiao-Bing Zhang
Chiral pesticide enantiomers play an important role in regulating plant growth due to their different physiology, pharmacology, and toxicity. However, efficient separation of chiral pesticides remains a global challenge. Ibuprofen (IBU), a chiral compound that has an important influence on the growth of plants, was chosen as a model molecule of plant growth regulator. Herein, in this work, l-Trp-l-Ala-P6 was chosen as a chiral ligand, and STI-NH2 was chosen as a guest molecule. We designed and fabricated chiral micropore membranes with both high selectivity and high flux effects using the layer-by-layer (LBL) self-assembly method, which achieved the selective separation of R-IBU from the racemic IBU accompanied by high flux and high selectivity. Meanwhile, the effects of separated R-IBU and S-IBU on the growth of wheat seedlings were studied. The results showed that after separation by the LBL-assembled chiral micropore-4, R-IBU exhibited a more effective activity in promoting the growth of wheat seedlings. This LBL-assembled chiral micropore membrane may have potential application in the separation of chiral pesticides in the future.
研究领域:
植物学
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材料科学
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环境科学
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DOI
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Jinfan Li,Chunyan Liu,Xinwen Jia,Mengyun Lu,Ajuan Yu,Benlai Wu
Chiral membranes have limited permeability and selective trade-off, which has been a major problem in chiral membrane separations. To address this issue, the carboxylated cellulose (CC) membranes were prepared with small pore size and low resistance substrate by regulating the amount of polyvinylpyrrolidone (PVP) and casting solution, and the CC@CuLBH composite membrane with chiral separation capability was fabricated by in situ formation of well-dispersed [Cu( L -mal)(Bipy)]·H 2 O (CuLBH) with the carboxyl group on the surface of CC membrane as the metal anchor points. Under the optimal conditions, the CC@CuLBH membrane showed good chiral separation ability with an ee value of 60% for R -1-(1-naphthyl)ethanol ( R -NE). Compared with the CC/CuLBH membrane formed by physical blend, the CC@CuLBH membrane exhibited improved enantioselective permeation for R -NE enantiomer. Both the unique chiral microenvironment of CuLBH and the regular pore structure of CC membrane, in addition to their synergistic effects resulted in the highly permeable and enantioselectivity for the CC@CuLBH composite membrane, which broadened the preparation method of chiral membrane.
研究领域:
材料科学
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化学工程
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分离技术
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产品关联
DOI
高影响因子
Nature Communications
·
2019
·Vol. 10
·期 1
·1-8
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IF 11.878
Wang Yang,Wu Niannian,Wang Yan,Ma Huan,Zhang Junxiang,Xu Lili,Albolkany Mohamed K.,Liu Bo
Precise control of interlayer spacing and functionality is crucial in two-dimensional material based membrane separation technology. Here we show anion intercalation in protonated graphite phase carbon nitride (GCN) that tunes the interlayer spacing and functions of GCN-based membranes for selective permeation in aqueous/organic solutions. Sulfate anion intercalation leads to a crystalline and amphipathic membrane with an accessible interlayer spacing at ~10.8 Å, which allows high solvent permeability and sieves out the solutes with sizes larger than the spacing. We further extend the concept and illustrate the example of GCN-based chiral membrane via incorporating (1R)-(-)-10-camphorsulfonic anion into protonated GCN layers. The membrane exhibits a molecular weight cutoff around 150 among various enantiomers and highly enantioselective permeation towards limonene racemate with an enantiomeric excess value of 89%. This work paves a feasible way to achieve water purification and chiral separation technologies using decorated laminated membranes.
研究领域:
材料科学
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化学工程
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分离技术
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纳米技术
✓ 已验证
DOI
高影响因子
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