ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Hanpeng Liu,Liguo Jin,Shengli Zhu,Congyang Mao,Shuilin Wu,Chaofeng Wang,Yufeng Zheng,Zhaoyang Li,Hui Jiang,Zhenduo Cui,Xiangmei Liu
Simultaneously endowing carbon nanofibers (CNFs) with flexibility, flame-resistant properties, and high sonoelectric/mechanical-electric energy conversion efficiency is quite challenging, restricting their wide application to smart fabrics. Herein, a carbon-based nanofiber is prepared by electrospinning and subsequent carbonization with the formation of Bi 20 TiO 32 (BT), followed by in situ growth of hydrothermally produced Bi 2 S 3 (B) and MoS 2 (M) successively. Compared with pure CNF, the synthesized carbon/Bi 20 TiO 32 /MoS 2 /Bi 2 S 3 (CBT/M/B) fiber exhibited not only enhanced flexibility and antiflaming performance but also sensitive conversion ability of the mechanical power into electricity. Its enhanced flexibility is due to its electrospinning micro/nanostructure and interactions between grain boundaries. Importantly, the CBT/M/B fiber achieved the realization of relying on unique human motion to provide energy and convert it in a piezoelectric manner, thus exhibiting satisfactory antibacterial effects. This research provides valuable insights into smart wearable antibacterial fibers characterized by flexible, antiflaming, and mechanosensitive functions.
研究领域:
材料科学
·
智能纺织品
·
生物医学工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Qifen Li,Leixiang Wang,Yuxin Li,Shukai Nan,Ziqing Tan,Qian Yang,Chengbo Li,Xianrui Xie,Huanhuan Yan,Guige Hou,Shun Duan,Yu-Qing Zhao
We report highly efficient, antioxidant, anti-inflammatory, pH-responsive antibacterial coatings developed via direct assembly of a nature compound tannic acid (TA) with the cationic antibiotic quaternized polyethyleneimine (QPEI). The surface of polypropylene was modified with these coatings. Under acidic conditions, the coatings significantly enhanced the antibacterial performance against Staphylococcus aureus and Escherichia coli, and the antibacterial rate reached more than 90 %. The free radical scavenging rate could exceed 91 %. Thus, the excess reactive oxygen species (ROS) could be cleared, and the oxidative stress production could be significantly reduced. In vitro anti-inflammatory experiments revealed that the coatings significantly reduced the expression of TNF-α and IL-6 and promoted the release of IL-10. These results indicated the excellent anti-inflammatory effects of the coatings. In vivo experiments revealed that the coatings could rapidly achieve bactericidal effects and subsequently prevent inflammatory reactions, thereby inhibiting the generation of fibrosis. Through molecular docking simulation experiments, the mechanism of LBL self-assembly between QPEI and TA components has been clarified for the first time. By designing the surface coating of a material and combining it with bioactive components, multiple functions could be achieved to meet the clinical needs of stoma patches and promote the development of medical materials.
研究领域:
生物材料学
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医学工程
·
微生物学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Research
·
2025
·
IF 9.6
Yuan Zhou,Lan Li,Fangsheng Chen,Tingting Huang,Maoen Pan,Heguang Huang
Postoperative pancreatic fistula remains a challenging complication after pancreaticoduodenectomy. Addressing this issue requires effective strategies to promote anastomotic healing. In this study, we developed a novel hydrogel designed to close pancreaticoenteric anastomosis after pancreaticoduodenectomy. The hydrogel—composed of polyvinyl alcohol, chitosan, and dopamine-modified oxidized hyaluronic acid—exhibited excellent antibacterial, anti-inflammatory, and wound healing properties. It was designed to conform well to the anastomotic site for clinical application. The hydrogel demonstrated good biocompatibility, appropriate mechanical strength, low swelling, and strong adhesive properties, meeting specific requirements for pancreaticoenteric anastomosis environments. Moreover, by activating the cell cycle, it promoted cell proliferation and migration, thereby accelerating anastomotic closure. Addition of the potent broad-spectrum antibiotic meropenem further enhanced its antibacterial efficacy, targeting common microbial species involved in delayed healing and fistula formation after pancreatic surgery. In a rat model of pancreatic fistula, the hydrogel effectively sealed the anastomosis, filled potential suture gaps, and exerted antibacterial, anti-inflammatory, and tissue regeneration–promoting effects around the anastomotic site. Therefore, this hydrogel, with its ideal degradation properties, shows promising application prospects in closing pancreaticoenteric anastomosis following pancreaticoduodenectomy, thereby offering an effective solution to reduce complications such as pancreatic fistula after pancreatic surgery.
研究领域:
医学
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生物材料学
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外科手术
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 9
·3918-3925
·
IF 5.251
Hailin Cong,Liping Zhou,Qingye Meng,Yixin Zhang,Bing Yu,Youqing Shen,Hao Hu
Polymer gels can be classified as chemical and physical gels, depending on the type of cross-link. Physical gels usually form by physical cross-linking, such as hydrogen bonding, van der Waals and/or p–p interactions, which can avoid the use of additional cross-linking agents. Polyamidoamine (PAMAM) dendrimers possess abundant active groups on their surfaces. Modified dendrimers have been used as versatile linkers in some projects. In this work, polymer gels composed of PAMAM dendrimers without any covalent bonding cross-linking agents were prepared. The number of amino groups and ester groups on the surface of the dendrimers was precisely regulated to help form hydrogen bonds between adjacent dendrimers. The prepared dendrimer-based polymer gels retain the properties of PAMAM dendrimers such as antibacterial properties, and the unique structures make the gels exhibit high compressive strengths but relatively low tensile strengths. Interestingly, the prepared gels show good anti-inflammatory properties in acute inflammation models of mice with ear edema. The inflammatory inhibition rate and hematoxylin–eosin (H&E) staining method were used to confirm the anti-inflammatory effect. This present study demonstrates that the dendrimer-based polymer gels achieved through hydrogen bonding could be a versatile platform for tissue engineering.
研究领域:
材料科学
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生物医学工程
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药理学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yongyi Yang,Rong Liu,Li Xie,Yang Li,Mengqi Chen,Huang Zhu,Qingqing Pan
Injectable hydrogels can be suitable for any irregular wounds to play an important role in wound healing, which have attracted much attention from researchers. Here, a chitosan-based double alternating injectable hydrogel had been proposed, which aligned with characteristics of wound healing. First of all, carboxymethyl chitosan (CMCS) and oxidized gellant (OGG) were used to fabricate above double-alternating injectable hydrogel skeleton (COG) through Schiff base bond. Then, dipotassium glycyrrhizinate (DPG) and bioactive glass (BG) were loaded respectively into COG, forming COG2-D10 and COG2-B0.5 hydrogel. Various properties of above hydrogels such as rheological behaviors, injectable capability, cytocompatibility, antibacterial and anti-inflammatory activity were systematically investigated. The results indicated that above hydrogel not only had a stable network structure, good toughness, injectability, and excellent adhesive properties, but also exhibited efficient antibacterial, anti-inflammatory, hemostatic, and biocompatible properties. The investigation of in vivo full-thickness skin wound healing showed that compared with COG2-D10 or COG2-B0.5 hydrogel alone, the double-alternating COG2-D10/COG2-B0.5 hydrogel could better enhance the efficacy of drugs, promote cell migration and proliferation, accelerate collagen fiber deposition and neovascularization, and significantly improve wound healing ( p < 0.01). Therefore, the double-alternating therapy strategy of hydrogel will provide a new approach for the clinical treatment of skin wound healing.
研究领域:
生物材料学
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医学工程
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组织工程学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2020
·
IF 10.652
Chao Zhou,Chengju Sheng,Lingling Gao,Jia Guo,Peng Li,Bo Liu
The development of treatment of wound healing cannot meet clinical requirements owing to the complex bacteria-infection and inflammatory reaction. It is necessary to develop wound dressings that are fast antibacterial property, anti-inflammation and promoting cell migration and proliferation for shortening wound healing period. In this work, we first synthesized two poly(ionic liquids) (PILs): poly(1-ethyl-3-vinylimidazolium furan-2-carboxylate) (PEIF) and poly(1-butyl-3-vinylimidazolium furan-2-carboxylate) (PBIF). The PILs were then mixed with 5 wt% montmorillonite (MMT) clay and 2-furfurylamine-modified hyaluronic acid (HAF), and chemically crosslinked with four-arm maleimide-polyethylene glycol (Mal 4 PEG) to form degradable semi-inter penetrate network (semi-IPN) hydrogels. In vitro assays demonstrated that the synthesized semi-IPN hydrogels exhibited high antibacterial activities against Escherichia coli and Staphylococcus aureus due to the high antibacterial activity of PILs. Furthermore, the semi-IPN hydrogel could be quickly degraded, and the PILs exhibited high anti-inflammatory activities when they were released from degraded hydrogels. The degradation solutions of hydrogels contained glycosaminoglycan, which was beneficial to cell proliferation and migration. The in vivo anti-infection results further demonstrated that the semi-IPN hydrogels could kill S. aureus and accelerate the healing of infected wounds.
研究领域:
生物材料学
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医学工程
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药剂学
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产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
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2022
·
IF 11.467
Mingyan Deng,Ye Wu,Yan Ren,Haoyang Song,Li Zheng,Guangzhi Lin,Xin Wen,Yiran Tao,Qingquan Kong,Yu Wang
In this study, an adipic acid dihydrazide (ADH)/ tannic acid (TA)-grafted hyaluronic acid (HA)-based multifunctional hydrogel was synthesized through a spontaneous amino-yne click reaction and used to promote the improved healing of infected diabetic wounds. This hydrogel exhibited a range of beneficial properties such as tunable gelation time, adjustable mechanical properties , pH-sensitive response characteristics, excellent injectability, the ability to readily adhere to tissue, and ultra-intimate contact capabilities. Following the encapsulation of ultrasmall Ag nanoclusters (AgNCs) and deferoxamine loaded polydopamine/ hollow mesoporous manganese dioxide (PHMD, PDA/H-mMnO 2 @DFO) nanoparticles , the prepared hydrogel presented with robust antibacterial, anti-inflammatory, and pro-angiogenic properties and a desirable smart drug release profile. In this fabricated platform, PHMD was able to effectively alleviate localized oxidative stress and prolonged oxygen deprivation via the decomposition of endogenous H 2 O 2 to produce O 2 . Further in vivo assays revealed that this hydrogel was capable of facilitating the healing of infected wounds through the sequential engagement of antibacterial, anti-inflammatory, and pro-angiogenic activities. Together, this synthesized clickable environmentally-responsive hydrogel offers great promise as a tool that can be applied to aid in the healing of chronically infected diabetic wounds and other inflammatory conditions.
研究领域:
生物医学工程
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材料科学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Heliyon
·
2024
·
IF 3.4
Fanzhuo Zeng,Anqi Chen,Wei Chen,Shuai Cheng,Sen Lin,Rongcheng Mei,Xifan Mei
Background Spinal cord injury (SCI) is a serious and difficult to treat traumatic disease of the central nervous system. Spinal cord injury causes a variety of detrimental effects, including neuroinflammation and ferroptosis, leading to chronic functional impairment and death. Recent studies have shown that microglia/macrophages (M/Ms) at the injury site remain primarily in the pro-inflammatory state, which is detrimental to recovery. However, information on the factors behind pro-inflammatory polarization skew in the injured spinal cord remains unclear. In this study, we found that Tumor Necrosis Factor-α(TNF-α) ablation protected after SCI by suppressing neuroinflammation and ferroptosis. Though using TNF-α knock out mice (TNF−/−), we induced downregulation of TNF-α in M/Ms and further investigated its effect on SCI outcome. In TNF−/− mice, significant behavioral improvements were observed as early as 7 days after injury. We showed that TNF-α inhibition promote injury-mediated M/Ms polarization from pro-inflammatory to anti-inflammatory phenotype in vivo. Furthermore, accumulated iron in M/Ms after SCI increased the expression of TNF-α and the population of M/Ms to pro-inflammatory phenotype. Moreover, zinc supplement reduced the secondary damage caused by iron overload. In conclusion, we found that knock out of TNF-α promotes recovery of motor function after spinal cord injury in mice by inhibiting ferroptosis and promoting the shift of macrophages to an anti-inflammatory phenotype, indicating that there is great potential for this therapy to SCI.
研究领域:
神经科学
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免疫学
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药理学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Zhuangzhuang Niu,Pengqi Zhu,Gang Li,Caifang Gao,Yuqin Liu,Xiaoli Liu,Jinghua Sun,Ruiping Zhang
Excessive ultraviolet (UV) radiation can cause human skin erythema, tanning, inflammation and other adverse reactions. Human skin can spontaneously synthesize endogenous melanin under UV radiation to defend the damage of UV, but the skin problems such as light damage and light aging cannot be avoided due to its low UV shielding efficiency. Therefore, we design a natural and biocompatible PGDA (PDA-L doped sunscreen hydrogel) sunscreen hydrogel by crosslinking melanin-like L-lysine doped polydopamine (PDA-L) and amino acid biopolymer poly-γ-glutamic acid, which displays good biosafety, efficient UVA shielding performance and excellent anti-inflammatory performance in the application of the skin protection of sun and repair after sunburn. The introduction of PDA-L to the hydrogel can improve the absorption intensity in the UV region and antioxidative performance of the hydrogel. Meanwhile, the usage of biocompatible PGDA sunscreen hydrogel can avoid the skin oxidative damage and penetrative toxicity of the conventional sunscreen.
研究领域:
材料科学
·
生物医学工程
·
皮肤病学
·
药学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Hao Yuan,Wan Li,Chengwu Song,Rongzeng Huang
The inherent weak mechanical strength of chitosan physical cross-linking hydrogels (CS hydrogels) limits their applications in biomaterials. Hence, puerarin (PUE) as a self-assembly active small molecule in herbal was introduced in CS hydrogels to fabricate CS/PUE 18 composite hydrogels with interpenetrating network structure. The result of rheological measurement showed that storage modulus and loss modulus of CS/PUE 18 composite hydrogels were improved by three orders of magnitude, indicating that the introduction of PUE significantly reinforced CS hydrogels. The results of SEM and BET measurement demonstrated that macromolecular chains of CS intertwined with nanofibers of PUE, which caused the network structure of CS/PUE 18 composite hydrogels to become denser. XRD patterns and FT-IR spectra verified that the amino groups in CS formed hydrogen bonding with the hydroxyl groups in PUE. Degradation and swelling experiments showed that CS/PUE 18 composite hydrogels have pH sensitivity. Moreover, CS/PUE 18 composite hydrogels exhibited multi-functionality including injectability, thixotropy, cytocompatibility, antibacterial and anti-inflammatory properties. The release behavior of berberine chloride hydrate (BCH) and PUE from the resultant CS/PUE 18 composite hydrogels have pH dependence. These results revealed that injectable CS/PUE 18 composite hydrogels with dual antibacterial and anti-inflammatory properties could be potential delivery vehicles for sustained and controlled release.
研究领域:
生物材料
·
药剂学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2022
·
IF 4.865
Yue Zhu,Yiding Shen,Yun Xiang,Kai Fang,Keyuan Xu,Pingping Ma,Chunyuan Cai,Jianfeng Ma,Xinkun Shen
Titanium (Ti) oral implants, as foreign bodies, can easily trigger an inflammatory response, and the metal ions/nanoparticles released by friction/corrosion in the body can also damage soft and hard tissues, leading to implant failure. To make up for deficiencies, a multifunctional composite coating composed of silica (SiO 2 ) particles and zirconium hydrogen phosphate (ZrP) on the surface of Ti was prepared by combining micro-arc oxidation (MAO) and sol-gel technology. The characterization results of the surface physicochemical properties confirmed that a series of SiO 2 /ZrP-modified MAO coatings were successfully constructed. Compared with the control group, the doping of SiO 2 particles effectively improved the friction resistance of the surface MAO coating, but worsened its corrosion resistance . After the surface was further covered with ZrP coating, the corrosion resistance defect caused by SiO 2 particles was eliminated. With the increase of the ZrP thickness, the friction resistance of the target sample increased gradually. In addition, the specimens coated by ZrP coatings also presented better anti-inflammatory and osteogenic capabilities than the samples subjected to pure/SiO 2 -doped MAO treatment. Based on these advantageous properties, this novel composite coating may project good application prospects in promoting early osseointegration.
研究领域:
材料科学
·
生物医学工程
·
牙科材料
·
表面工程
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产品关联
DOI
高影响因子
Gels
·
2024
·Vol. 10
·期 4
·278
·
IF 5
Chao Zhou,Mengdi Sun,Danni Wang,Mingmei Yang,Jia Ling Celestine Loh,Yawen Xu,Ruzhi Zhang
Repairing damaged tissue caused by bacterial infection poses a significant challenge. Traditional antibacterial hydrogels typically incorporate various components such as metal antimicrobials, inorganic antimicrobials, organic antimicrobials, and more. However, drawbacks such as the emergence of multi-drug resistance to antibiotics, the low antibacterial efficacy of natural agents, and the potential cytotoxicity associated with metal antibacterial nanoparticles in hydrogels hindered their broader clinical application. In this study, we successfully developed imidazolium poly(ionic liquids) (PILs) polymer microspheres (APMs) through emulsion polymerization. These APMs exhibited notable antibacterial effectiveness and demonstrated minimal cell toxicity. Subsequently, we integrated the APMs into a gelatin methacryloyl (GelMA)—polyethylene glycol (PEG) hydrogel. This composite hydrogel not only showcased strong antibacterial and anti-inflammatory properties but also facilitated the migration of human skin fibroblasts (HSF) and human umbilical vein endothelial cells (HUVECs) and promoted osteogenic differentiation in vitro.
研究领域:
组织工程
·
生物医用材料
·
抗菌研究
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）