JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Yang Wang,Lei Zhang
In this paper, we report a new type of 3D ZIF-8@NiAl-LDHs micro-flowers material consisting of sandwich-like structured 2D nanopetals (highly compact ZIF-8 film anchored on both sides of petals). ZIF-8 was successfully incorporated into NiAl-LDHs (ZIF-8@NiAl-LDHs) via seeding strategy directed growth of ZIFs on the surface of LDHs nanopetals. The coating of ZIF-8 significantly increased the adsorption ability to organic pollutants and inorganic cation. 3D ZIF-8@NiAl-LDHs with excellent enrichment and filtration properties has been exploited for the application in water purification, and exhibit superior high adsorption rate and adsorption efficiency of organic (nonsteroidal anti-inflammatory drugs: ketoprofen, flurbiprofen, indometacin and ibuprofe; anionic dyes: congo red, orange g; cationic dyes: methylene blue, rhodamine b) and inorganic cation (Cu 2+ , Pb 2+ ) residues due to their novel hierarchical and submicroscopic structures. Further, 3D ZIF-8@NiAl-LDHs as filter membrane to extraction four kind of trace anti-inflammatory drugs followed by direct quantification detection of targets with HPLC was demonstrated. The validated method was successfully applied for analysis of four anti-inflammatory drugs in environmental water and human urine samples. This work provided a feasible way to design and construct purification materials for wastewater treatment and contaminant detection.
研究领域:
环境科学
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2020
·Vol. 41
·期 14
·2000202
·
IF 4.886
Xuefeng Li,Xueyin Peng,Rongzhe Li,Yikun Zhang,Zuifang Liu,Yiwan Huang,Shijun Long,Haiyan Li
The research on multiple hydrogen bonds (H-bonds) hydrogels have gradually aroused wide interest. In this paper, a multiple H-bonds-reinforced poly(acrylamide- co -2-vinyl-4,6-diamino-2-vinyl-1,3,5-triazine)/tannic acid (P(Am- co -VDT)/TA) hydrogels are prepared. The results suggest that the prepared hydrogel has two types of H-bonds crosslinking regions: A “soft” region of H-bonds between the diaminotriazine (DAT) moieties on the polymer chains and the TA pyrogallol/catechol groups, and a “hard” region of H-bonds forming by DAT moieties with itself. The hard crosslinking region exhibits significantly higher activation energy than the soft region. Such soft and hard dual physically crosslinked networks dramatically enhance the mechanical properties of P(Am- co -VDT)/TA hydrogels in a synergistic manner (tensile strength is 2.34 MPa, elongation at break is 410%). Due to the multiple hydrogen bonds, the hydrogel has good pH sensitivity and rapid response to shape memory within a few minutes. In addition, the hydrogels have the capacity of physical adsorption of the anti-inflammatory drug diclofenac sodium and other molecules with a specific spatially arranged chemical composition. These hydrogels with high mechanical strength, excellent shape memory behavior, and capacity of adsorption of anti-inflammatory drug could be attractive candidates for applications in the fields of biomedicine, tissue engineering, and medical materials.
研究领域:
生物材料
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组织工程
·
生物医药
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Lumin Yang,Haofei Huang,Huajing Zeng,Xiaoduo Zhao,Rui Wang,Zhengfeng Ma,Zengjie Fan,Yong-min Liang,Shuanhong Ma,Feng Zhou
Rheumatoid arthritis (RA) is a chronic inflammatory immune and lubrication dysfunction disease that causes great damage to the joints. Herein, inspired by the unique biochemistry structure and excellent hydration of chondroitin sulfate (CHI) existing in joint system, one kind of novel polysaccharide nanoparticle lubricant, that is chitosan nanoparticles (CS NPs) grafting CHI (CS-CHI), is synthesized by one-step surface chemistry reaction. CHI with negative charges can form hydration layers on the surface of CS NPs, thus improving the lubricity of nanoparticles. Simultaneously, CS-CHI NPs have effective loading and sustained drug release ability for anti-inflammatory drug diclofenac sodium (DS), along with good biocompatibility. Finally, based on a collagen-induced rat RA model, in vitro animals experimental results indicate that the as-synthesized CS-CHI@DS NPs has obvious inhibitory effects on inflammatory factors and can effectively prevent the damaged cartilage from further destruction.
研究领域:
生物医学工程
·
材料科学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL & PHARMACEUTICAL BULLETIN
·
2019
·Vol. 67
·期 9
·1006-1014
·
IF 1.405
Pan Yu,Chao-Jie Xia,Dong-Dong Li,Zhenzhong Wang,Wei Xiao,Lin-Guo Zhao
Chlorogenic acid (CGA) has been considered as one of important active components in a number of medicinal herbs. Recently our group demonstrated that caffeoyl salicylate scaffold derived from CGA can be employed for the development of novel anti-inflammatory agents. The most active compound D104 can be a very promising starting point for the further structural optimization. A series of novel caffeoyl salicylate analogs were designed, synthesized, and evaluated by preliminary biological evaluation. The obtained results showed that the two compounds B12 and B13 can not only inhibit production of nitric oxide (NO) in RAW264.7 cells induced by lipopolysaccharides (LPS) effectively, but also have high safety in in vitro cytotoxic test, which could be comparable with D104. Molecular docking study on the peroxisome proliferator-activated receptor γ (PPARγ) protein revealed that compounds B12 and B13 can follow the same binding mode with D104, and the carboxyl group of caffeoyl salicylate scaffold might play a key role in the interaction with protein target, which implied the carboxyl group should be retained in the further optimization.
研究领域:
药理学
·
药物化学
·
药物研发
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yurong Liu,Shunfen Huang,Shiyi Liang,Peiran Lin,Xiangjie Lai,Xingzi Lan,Han Wang,Yadong Tang,Botao Gao
Wound healing is a systematic and complex process that involves various intrinsic and extrinsic factors affecting different stages of wound repair. Therefore, multifunctional wound dressings that can modulate these factors to promote wound healing are in high demand. In this work, a multifunctional Janus electrospinning nanofiber dressing with antibacterial and anti-inflammatory properties, controlled release of drugs, and unidirectional water transport was prepared by depositing coaxial nanofibers on a hydrophilic poly(ε-caprolactone)@polydopamine-ε-polyl-lysine (PCL@PDA-ε-PL) nanofiber membrane. The coaxial nanofiber was loaded with the phase change material lauric acid (LA) in the shell layer and anti-inflammatory ibuprofen (IBU) in the core layer. Among them, LA with a melting point of 43 °C served as a phase change material to control the release of IBU. The phase transition of LA was induced by near-infrared (NIR) irradiation that triggered the photothermal properties of PDA. Moreover, the Janus nanofiber dressing exhibited synergistic antimicrobial properties for Escherichia coli and Staphylococcus aureus due to the photothermal properties of PDA and antibacterial ε-PL. The prepared Janus nanofiber dressing also exhibited anti-inflammatory activity and biocompatibility. In addition, the Janus nanofiber dressing had asymmetric wettability that enabled directional water transport, thereby draining excessive wound exudate. The water vapor transmission test indicated that the Janus nanofiber dressing had good air permeability. Finally, skin wound healing evaluation in rats confirmed its efficacy in promoting wound healing. Therefore, this strategy of designing and manufacturing a multifunctional Janus nanofiber dressing had great potential in wound healing applications.
研究领域:
生物材料学
·
伤口愈合研究
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2023
·
IF 6.7
Zhang Songbai,Jia Yuanbo,Liu Jingyi,Feng Fan,Wei Zhao,Zhang Min,Xu Feng
Periodontitis can cause irreversible defects in the periodontal ligament (PDL), the regeneration of which is the major obstacle to the clinical treatment of periodontitis. Implanting hydrogel for releasing anti-inflammatory drugs is a promising treatment to promote PDL regeneration. However, existing hydrogel systems fail to mimic the typical viscoelastic feature of native periodontium, which may have been shown as an important role in tissue regeneration. Meanwhile, the synergistic benefits of mechanical cues and biochemical agents for PDL regeneration remain elusive. In this study, we developed a bi-crosslinking viscoelastic hydrogel (Alg-PBA/Spd) by integrating phenylboronic acid-modified alginate with anti-inflammatory agent (spermidine) through borate ester and B–N coordination bonds, where spermidine will be released with the degradation of the hydrogel. Alg-PBA/Spd hydrogel is biocompatible, injectable and can quickly adapt to complex periodontal structures due to the dynamic crosslinking. We demonstrated in rat models that the viscoelastic Alg-PBA/Spd hydrogel significantly promotes the deposition of periodontal collagen and accelerates the repair of periodontal damage. Our results suggest that the viscoelastic Alg-PBA/Spd hydrogel would be a promising mechano-biochemically synergistic treatment for periodontal regeneration.
研究领域:
牙科材料
·
组织工程
·
再生医学
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2020
·
IF 7.097
Chao Teng,Chenshi Lin,Feifei Huang,Xuyang Xing,Shenyu Chen,Ling Ye,Helena S. Azevedo,Chenjie Xu,Zhengfeng Wu,Zhongjian Chen,Wei He
Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein, targeted codelivery of anti-miR 155 and anti-inflammatory baicalein is exploited to polarize macrophages toward M2 phenotype, inhibit inflammation and treat AS. The codelivery system consists of a carrier-free strategy (drug-delivering-drug, DDD), fabricated by loading anti-miR155 on baicalein nanocrystals, named as baicalein nanorods (BNRs), followed by sialic acid coating to target macrophages. The codelivery system, with a diameter of 150 nm, enables efficient intracellular delivery of anti-miR155 and polarizes M1 to M2, while markedly lowers the level of inflammatory factors in vitro and in vivo . In particular, intracellular fate assay reveals that the codelivery system allows for sustained drug release over time after internalization. Moreover, due to prolonged blood circulation and improved accumulation at the AS plaque, the codelivery system significantly alleviates AS in animal model by increasing the artery lumen diameter, reducing blood pressure, promoting M2 polarization, inhibiting secretion of inflammatory factors and decreasing blood lipids. Taken together, the codelivery could potentially be used to treat vascular inflammation.
研究领域:
药理学
·
纳米技术
·
心血管疾病
·
分子生物学
·
炎症
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Xin-jie Cheng,De-zhi Kong,Ya-hui Li,Guang-li Bian,De-qiang Li
Screening and developing dual-target inhibitors of natural 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) as anti-inflammatory drugs with higher efficacy and fewer side effects is becoming increasingly popular. In the current study, an approach by off-line two-dimensional liquid chromatography combined with mass spectrometry (2D-LC-MS) was built and verified, and was used to rapidly screen 5-LOX/COX-2 inhibitors in the extracts of Oroxylum indicum . First, the extracts were incubated with 5-LOX/COX-2 to optimize the incubation conditions. Then, off-line 2D-LC-MS screening was performed on the mixture, and the potential inhibitors were analyzed by comparing the chromatograms of the active group, blank group, and inactivated 5-LOX/COX-2 group. In addition, in vitro enzyme inhibition experiments, LPS-stimulated RAW 264.7 cells experiment and molecular docking technology were employed to confirm the findings. As a result, a total of nine compounds were confirmed as possible 5-LOX/COX-2 inhibitors, and in vitro activity assays showed that oroxin B, baicalein, oroxin A, and chrysin possessed strong inhibitory effects on 5-LOX/COX-2 (IC 50 ≤154.6 μM). Meanwhile, the possible mechanism of interaction between ligands and enzyme active sites was further elucidated by molecular docking technology. The results demonstrated that off-line 2D-LC-MS was a fast, efficient, and accurate method for screening and analyzing bioactive compounds from natural products.
研究领域:
药理学
·
分析化学
·
生物化学
·
天然产物
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2023
·
IF 14
Xinming Wang,Hongpeng Shi,Shixing Huang,Yecen Zhang,Xiaojun He,Qiang Long,Bei Qian,Yiming Zhong,Zhaoxi Qi,Qiang Zhao,Xiaofeng Ye
A challenge in treating cardiac injury is the low heart-specificity of the drugs. Nanostructured lipid carriers (NLCs) are a relatively new format of lipid nanoparticles which have been used to deliver RNA and drugs. However, lipid nanoparticles exhibit higher affinity to the liver than the heart. To improve the delivery efficiency of NLCs into the heart, NLCs can be embedded into a scaffold and be locally released. In this study, a cardiac extracellular matrix (ECM) hydrogel-NLC composite was developed as a platform for cardiac repair . ECM-NLC composite gels at physiological conditions and releases payloads into the heart over weeks. ECM-NLC hydrogel carrying colchicine, an anti-inflammation agent, improved cardiac repair after myocardial infarction in mice. Transcriptome analysis indicated that Egfr downstream effectors participated in ECM-NLC-colchicine induced heart repair. In conclusion, ECM-NLC hydrogel is a potential platform for sustained and localized delivery of biomolecules into the heart, and loading appropriate medicines further increases the therapeutic efficacy of ECM-NLC hydrogel for cardiovascular diseases.
研究领域:
心血管科学
·
药学
·
生物材料
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Guangzhao Tian,Dan Yang,Chunrong Chen,Xiaoge Duan,Dong-Hwan Kim,Hailan Chen
The implantation of neural electrodes usually induces acute and chronic inflammation, which can result in the formation of glial scars encapsulating the implanted electrodes and the loss of neurons near the active electrode sites. Local presentation of anti-inflammatory drugs or neural protective factors has been evidenced as an effective strategy to modulate inflammatory responses and promote electrode–neuron integration. Here, a novel delivery system for the simultaneous presentation of both anti-inflammatory drugs (dexamethasone, Dex) and nerve-growth-promoting factors (nerve growth factor, NGF) from the electrode sites was developed via layer-structured carbon nanotubes and conductive polymers. The modified electrodes exhibited higher charge storage capacitance and lower electrochemical impedance compared to unmodified electrodes and electrodes coated with polypyrrole/Dex. Dex released from the functional coating under controlled electrochemical stimulation was able to inhibit the lipopolysaccharide-induced secretion or mRNA transcription of inflammatory cytokines, including nitric oxide, TNF-α, and IL-6 in RAW264.7 cells, and control the activation of cultured astrocytes. In addition, the functional coatings did not show a toxic effect on PC12 cells and primary neural cells but exhibited promoted activities on the adhesion, growth, and neurite extension of neural cells.
研究领域:
神经科学
·
材料科学
·
生物医学工程
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Hongbo Wang,Jiawei Zuo,Liang Zha,Xia Jiang,Caixia Wu,Yong-An Yang,Wenjian Tang,Tianlu Shi
To develop new anti-inflammatory drugs for the prevention and treatment of acute kidney injury, a series of novel glycyrrhetic ureas were designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. Compounds 5r-5u (2.04, 2.50, 3.25 and 2.48 μM, respectively) with acidic or neutral amino acid showed potent anti-inflammatory activity (IC 50 = 2–3 μM for NO inhibition), amongst them, compound 5r also inhibited tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in a dose-dependent manner. In cisplatin-induced AKI mice model, compound 5r significantly reduced the level of pro-inflammatory factors, ameliorated the pathological damage of kidney tissue, and maintained the normal metabolic capacity.
研究领域:
药理学
·
药物化学
·
炎症研究
·
肾病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2016
·
IF 0
Wei Wei,Xiaoliang Qi,Junjian Li,Gancheng Zuo,Wei Sheng,Jianfa Zhang,Wei Dong
Poly(N,N-diethylacrylamide) is not only a thermosensitive polymer, but also a good hydrogen bond acceptor. Therefore, drugs with carboxyl groups can serve as hydrogen bond donors and form interactions with the tertiary amide groups in N,N-diethylacrylamide. Herein, we report a novel drug delivery system for anionic drugs composed of poly(N,N-diethylacrylamide) and salecan. Salecan was used to improve the hydrophilicity and accelerate the responsive rate of this system. As expected, salecan-enriched hydrogels exhibited higher swelling ratios and were more sensitive to temperature. Moreover, scanning electron microscopy images showed that the hydrogels are superporous structures, with pore-sizes that increase with salecan concentration. The swelling ratios decreased continuously with the increase of temperature in the range 25–37 °C. MTT assay for cell viability and cell adhesion studies confirm the cell compatibility of the system. Delivery tests using diclofenac sodium, an anti-inflammatory drug, indicate that the thermosensitive property of this system is favorable for anionic drug delivery. Interestingly, the release rates of diclofenac sodium from the hydrogels were temperature dependent, with higher temperatures contributing toward faster release rate.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
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