CHEMOSPHERE
·
2021
·
IF 7.086
Mojtaba Mansoorianfar,Khashayar Shahin,Akbar Hojjati–Najafabadi,Renjun Pei
In this study, Ti 3 C 2 MXene nanofragments with a size distribution of about 20 nm were laden on the well-characterized bacteriophages via electrostatic bonding , introducing a new antibacterial agent as a modified virus vector to be used in high-risk bacterial environment. At > MIC of MXene, the MXene-functionalized bacteriophage would be much more active in attacking the bacteria because of the high specificity for host receptors’ recognition and targeting ability of bacteriophage and bacterial surface negative charge when comparing to the phage alone. Also, the induced positive surface moieties drive MXene nanofragments toward the negative surface charge of bacteria. The main mechanisms are the specific targeting capacity of bacteriophages, often by lysing the host and bursting out, and the physical interaction of MXene nanofragments with the bacterial cell membrane, which may rupture the cell wall in microbial death. The results described that the Ti 3 C 2 MXene significantly enhanced the bacteriophage adsorption rate and stability over long-standing cultivation in aquatic environments providing superior antibacterial efficacy against the bacterial cells target. The Ti 3 C 2 MXene-laden bacteriophage demonstrated a fast, efficient attaching to bacterial host cells, high antibacterial potential, and reduced 99.99% of the artificial contamination in water samples. Interestingly, no re-growth of target bacteria was observed in the samples during the experiment period, and the count of bacteria constantly remained below the detection threshold. This research raises attention in proposing a novel antibacterial agent to be synthesized through a simple one-step technique devoid of shortcomings of post-treatments in conventional antibacterial treatments.
研究领域:
微生物学
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Chunquan Li,Yujiao Zhang,Zengjie Zuo,Liqiu He,Fang Yuan,Shuilin Zheng,Zhiming Sun
The migration of free antibacterial agents in the coating will lead to the rapid decline of the antibacterial effect. Consequently, achieving sustained antibacterial efficacy has become a critical focus currently. In this study, through liquid-phase ion exchange and dry modification, Cu 2+ and cetyltrimethylammonium chloride (CTAC) were successively loaded onto stellerite (STI) to synthesize Cu 2+ /STI and Cu 2+ /CTAC/STI composites, then Polyvinyl alcohol (PVA) was used as the matrix to construct Cu 2+ /CTAC/STI/PVA antimicrobial coatings. The results demonstrated that the modified material retained the crystal structure of stellerite while achieving superior antibacterial properties. The incorporation of stellerite not only enhanced the stability of the antibacterial agent but also facilitated its unique delivery function. Specifically, stellerite served as an effective reservoir for antibacterial components, enabling efficient sterilization through the synergistic release of CTAC and Cu 2+ coupled with bacterial adsorption. In addition, Cu 2+ /CTAC/STI/PVA coating exhibited excellent bacterial efficacy and long-lasting antimicrobial performance, indicating the promising application prospects of stellerite-based antibacterial composites in functional coating fields.
研究领域:
材料科学
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微生物学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Jiaxin Wen,Yuxin Guo,Xiangyu Li,Bingyang Wang,Huifang Wang,Xianghua Gao,Baolong Niu,Wenfeng Li
Antimicrobial packaging films are an effective means to avoid food infections. PVA has good film-forming and mechanical properties, but its water resistance and antimicrobial properties are insufficient. In this study, a rod-shaped Ag-MOF with photocatalytic properties was synthesized as an antimicrobial agent by a hydrothermal method using citrate esterified PVA as a film-forming substrate. The MICs of Ag-MOF against Escherichia coli and Staphylococcus aureus were 16 μg/mL and 32 μg/mL, respectively, and it had good biocompatibility. Under blue light irradiation, Ag-MOF induced the production of ROS, which increased the inhibition rate by more than 83.78%. The antimicrobial mechanism experiments showed that it caused irreversible damage to the bacterial cell membrane through the synergistic effect of Ag + and ROS. The best mechanical properties of the films were obtained at 3% citric acid content, with the water vapor transmission rate, water solubility and swelling rate reduced by 0.19 g·mm·m −2 ·h −1 ·kPa −1 , 65.33% and 11.26%, respectively. The antimicrobial rate of the composite film could reach more than 98% by adding only 1 MIC of Ag-MOF. In conclusion, photocatalytic antimicrobial agents have great potential for application in food packaging.
研究领域:
食品科学
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材料科学
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微生物学
✓ 已验证
产品关联
DOI
高影响因子
WATER RESEARCH
·
2024
·
IF 11.4
Hongzhi Liu,Zi Wang,Hesong Wang,Zihan Liu,Jiaxuan Yang,Han Zhang,Heng Liang,Langming Bai
To address the issues of scaling caused by heat and water evaporation in regard to circulating cooling water (CCW), TFC membrane filtration systems have been increasingly considered for terminal treatment processes because of their excellent separation performance. However, membrane biofouling phenomenon significantly hinders the widespread utilization of TFC membranes. In this study, to harness the thermal phenomenon of CCW and establish a stable and durable multifunctional antibiofouling layer, temperature-responsive Pnipam and the spectral antibacterial agent Ag were organically incorporated into commercially available TFC membranes. Biological experimental findings demonstrated that above the lower critical solution temperature (LCST), the contraction of Pnipam molecular chains facilitated the inactivation of bacteria by the antibacterial agent, resulting in an impressive sterilization efficiency of up to 99 %. XDLVO analysis revealed that below the LCST, the establishment of a hydration layer on the functional interface resulted in the creation of elevated energy barriers, effectively impeding bacterial adhesion to the membrane surface. Consequently, a high bacterial release rate of 98.4 % was achieved on the low-temperature surface. The alterations in the functional membrane surface conformation induced by temperature variations further amplified the separation between the pollutants and the membrane, creating an enhanced "elastic interface." This efficient and straightforward cleaning procedure mitigated the formation of irreversible fouling without compromising the integrity of the membrane surface. This study presents a deliberately engineered thermoresponsive antibiofouling membrane interface to address the issue of membrane fouling in membrane-based CCW treatment systems while shedding new light on the mechanisms of "inactivation" and "defense."
研究领域:
环境科学
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材料科学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2023
·Vol. 12
·期 12
·2275
·
IF 5.2
Nur Julizan,Safri Ishmayana,Achmad Zainuddin,Pham Van Hung,Dikdik Kurnia
Food preservation is one of the strategies taken to maintain the level of public health. Oxidation activity and microbial contamination are the primary causes of food spoilage. For health reasons, people prefer natural preservatives over synthetic ones.Syzygnium polyanthumis widely spread throughout Asia and is utilized as a spice by the community.S. polyanthumhas been found to be rich in phenols, hydroquinones, tannins, and flavonoids, which are potential antioxidants and antimicrobial agents. Consequently,S. polyanthumpresents a tremendous opportunity as a natural preservative. This paper reviews recent articles aboutS. polyanthumdating back to the year 2000. This review summarizes the findings of natural compounds presented inS. polyanthumand their functional properties as antioxidants, antimicrobial agents, and natural preservatives in various types of food.Keywords:Syzygnium polyanthum;antioxidant;antimicrobials;natural preservative;food preservation
研究领域:
植物学
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食品科学
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药理学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shiwen Zhao,Danyang Wang,Qiong Zhou,Beibei Wang,Zhao Tong,Honglei Tian,Jianke Li,Yuhuan Zhang
Nanozymes with oxidase or peroxidase-mimicking activity have emerged as a promising alternative for disinfecting resistant pathogens. However, further research and clinical applications of nanozymes are hampered by their low in vivo biosafety and biocompatibility. In this study, inulin-confined gold nanoparticles (IN@AuNP) are synthesized as an antibacterial agent via a straightforward in situ reduction of Au 3+ ions by the hydroxyl groups in inulin. The IN@AuNP exhibits both peroxidase-mimicking and oxidase-mimicking catalytic activities, of which the maximum reaction velocity ( V max ) for H 2 O 2 is 2.66 times higher than that of horseradish peroxidase. IN@AuNP can catalyze the production of reactive oxygen species (ROS), resulting in effective antibacterial behavior against both Gram-negative ( Escherichia coli ) and Gram-positive ( Staphylococcus aureus ) bacteria. Abundant hydroxyl groups retained in inulin endow the nanozyme with high adhesion to bacteria, reducing the distance between the captured bacteria and ROS, achieving an antibacterial ratio of 100 % within 1 h. Importantly, due to the natural biosafety and non-absorption of the dietary fiber inulin, as well as the inability of inulin-trapped AuNP to diffuse, the IN@AuNP exhibits high biosafety and biocompatibility under physiological conditions. This work is expected to open a new avenue for nanozymes with great clinical application value.
研究领域:
生物医学工程
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材料科学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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2011
·
IF 3.044
Huanan Li,Jing Yang,Xiaona Hu,Jie Liang,Yujiang Fan,Xingdong Zhang
To accomplish ideal wound dressing, hydrogels based on a natural polysaccharide, pullulan were synthesized by chemical cross-linking. The tensile strengths of the hydrogel films (1 mm thick) were determined to range from 0.663 to 1.097 MPa in proportion to cross-linking degrees and water contents. The swelling study of the hydrogels in water showed remarkable water absorption property with swelling ratio up to 4000%, which provided the hydrogel with quick hemostatic ability and prevent the wound bed from accumulation of exudates. The water vapor transmission rate and water retention of the hydrogels were found to be in the range of 2213–3498g/m 2 /day and 34.74–45.81% (after 6 days), indicating that the hydrogel can maintain a moist environment over wound bed, which could prevent the dehydration of the wound bed and prevent the scab formation. Biocompatibility test revealed that the hydrogels were not cytotoxic. The hydrogel could load antimicrobial agents and effectively suppress bacterial proliferation to protect the wound from bacterial invasion. These results suggest that the pullulan hydrogels prepared in this study may have high potential as new ideal wound-dressing materials. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
研究领域:
生物材料学
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医学工程
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Lin Yue,Meihong Zheng,Imran Mahmood Khan,Zhouping Wang
The development of antibacterial agents with high bacteria-binding capability and antibacterial efficiency is highly desirable. Herein, cationic polysaccharide chitosan (CS) was combined with photosensitizer Chlorin e6 (Ce6) to construct a novel photodynamic antibacterial agent (CS-Ce6 conjugates) for combating gram-positive bacteria Staphylococcus aureus (S. aureus) and gram-negative bacteria Escherichia coli (E. coli) . CS-Ce6 conjugates with different degrees of substitution (DS) were synthesized and characterized by a spectroscopic method and organic elemental analysis to understand the relationship between structure and antibacterial effect. CS-Ce6 conjugates revealed good reactive oxygen species (ROS) generation ability and photodynamic antibacterial effect. Meanwhile, they both were positively correlated with DS in the range of 4.81% ~ 11.56% resulting in stronger photodynamic antibacterial ability. These findings highlight that CS-Ce6 conjugates have the potential as an effective photodynamic bactericidal agent in the antibacterial field.
研究领域:
微生物学
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药学
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生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
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2020
·
IF 0
Yuhuan Zhao,Xianwen Wang,Feng Gao,Chenya Wang,Zongjin Yang,Hanfei Wu,Chunyan Li,Liang Cheng,Rui Peng
The spread of antibiotic-resistance poses a great threat, making it a growing need to develop other antibacterial strategies and therapeutics. Recently, owing to their excellent physicochemical properties, copper chalcogenides have received extensive attention as photothermal agents. However, most reports are focused on Cu2–xS nanoparticles, whereas very few water-dispersible Cu2–xSe nanomaterials have been reported due to their difficult preparation process. Herein, water-dispersible and biocompatible cuprous selenide nanosheets (Cu2Se NSs) were synthesized by a simple anion exchange method starting from cuprous oxide nanorods (Cu2O NRs), which could also help avoid any environmental pollution caused by the organic solvent used during synthesis. The obtained Cu2Se NSs showed strong absorption in the second near-infrared window (NIR II) with a good photothermal conversion efficiency as high as ∼61.16%, outstanding among the previously reported NIR II photothermal agents. Interestingly, using Staphylococcus aureus and Escherichia coli as model pathogens, these Cu2Se NSs possess an intrinsic bacteriostatic effect and could inhibit the growth of both bacteria species. Furthermore, both the fluorescent-based microscopy and the bacterial morphology analysis using a scanning electron microscope have demonstrated that incubation of both species of bacteria with Cu2Se NSs under laser irradiation (1064 nm) would lead to complete disruption of the bacterial cell wall. Our work presents a facile method to prepare water-dispersible Cu2Se NSs-, which could serve as highly efficient dual-functional antibacterial agents.
研究领域:
材料科学
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生物医学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
CELLULOSE
·
2022
·Vol. 29
·期 4
·2731-2742
·
IF 6.123
Liu Zihan,Luo Yapei,Zhao Xiaomin,Zheng Keying,Wu Minghua,Wang Lili
Natural antibacterial agents have attracted increasing attention due to safety, ecological, and environmental protection concerns. In this study, hinokitiol-grafted-chitosan (HTCS) was prepared via the Mannich reaction and used as an antibacterial agent for the treatment of cotton fabric. The results showed that, compared with chitosan (CS) and hinokitiol (HT) alone, HTCS exhibited a lower value of minimum inhibitory concentration (MIC). Compared with the fabrics treated by CS and HT, the antibacterial rate of the treated fabric against Escherichia coli using HTCS as antibacterial agent increased by approximately 90% and 27%, the bacterial reduction rate against Staphylococcus aureus increased by about 58% and 39%. The HTCS-treated cotton fabric possessed good antibacterial properties even after 25 washing cycles. Moreover, the antibacterial cotton fabric retained original hydrophilicity, handle, and strength. Consequently, HTCS has great potential as a natural antibacterial agent for textiles.
研究领域:
纺织材料学
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生物化学
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应用微生物学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Liming Ge,Zijing Li,Miao Han,Yongjie Wang,Xinying Li,Changdao Mu,Defu Li
Food security is an important global public health issue, which will not only endanger consumers’ life and health, but also cause serious food waste. Herein, antibacterial dialdehyde sodium alginate/ ε -polylysine microspheres (DSA-PL MPs) were developed to effectively prolong the shelf life of fruit. DSA was prepared by periodate oxidation of sodium alginate. Then the PL was conjugated onto DSA backbone via the Schiff’s base reaction to synthesize DSA-PL conjugates, followed by the emulsification and Ca 2+ ions crosslinking to obtain DSA-PL MPs. The results indicate that DSA-PL MPs show smooth spherical particle, relatively narrow size distribution and good dispersity. In vitro degradation rate of DSA-PL MPs is higher in acetate buffer (pH = 5.0) than that in PBS buffer (pH = 7.4), showing acid-sensitive degradation property. Significantly, DSA-PL MPs possess strong broad-spectrum antibacterial activity, which can effectively extend the shelf life of fruit. Overall, DSA-PL MPs possess promising application as antibacterial agents for fruit preservation.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Biointerphases
·
2024
·Vol. 19
·期 3
·
IF 1.6
Huang Yi,Li Ying,Chen Kai-Bo,Zhang Hang
This study aims to explore the essential functional requirements associated with controlling the proliferation of microbes in the domain of textiles used in public health areas. Herein, three antimicrobial agents, specifically iodopropylbutylcarbamate (IPBC), 1-hydroxypyridine-2-thioketone zinc (ZPT), and 2-octyl-3-isothiazolinone (OIT), were chosen for fabric finishing based on their notable effectiveness, minimal toxicity, cost-efficiency, and chemical stability. Utilizing Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) as representative bacterial strains, the Minimum Inhibitory Concentration (MIC 50 ) of individual and combined antimicrobial agents was measured, and their antimicrobial effectiveness was rigorously evaluated. Concurrently, the antimicrobial effectiveness, whiteness, and mechanical durability of the fabric following antimicrobial treatment were thoroughly examined. The results demonstrate that some combinations of the three antimicrobial agents elicit additive effects on both S. aureus and E. coli . Notably, at an equivalent ratio of IPBC, ZPT, and OIT and a total concentration of 0.2 wt. %, the inhibition rates against both bacterial strains surpass 99%. Upon application to nylon fabric, the treated material demonstrates significant antimicrobial properties, with minimal reduction observed in the whiteness and tensile strength of the treated nylon. This study provides practicable strategies relevant to the production of textiles endowed with antimicrobial properties.
研究领域:
公共卫生
·
材料科学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）