JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2020
·
IF 6.155
Mi Wu,Wen Liu,Jinrong Yao,Zhengzhong Shao,Xin Chen
The controlled release of antibiotic drugs to injured sites has great advantages over the conventional intravenous administration of antibiotics, which is associated with systemic toxicity, for wound care. Electrospun nanofibrous/microfibrous mats, with a similar structure to the native extracellular matrix, is a promising wound dressing. Herein, drug-loaded halloysite nanotubes (HNTs) incorporated into regenerated silk fibroin (RSF) microfibrous mats were prepared by electrospinning to achieve sustained drug release and long-lasting antimicrobial protection. A broad-spectrum antibiotic, tetracycline hydrochloride (TCH), was selected as the model drug. Transmission electron microscopic images revealed that the TCH-loaded HNTs were homogeneously embedded in the RSF electrospun microfibers without significant changes in morphology. The drug release profiles showed that the RSF microfibrous mats with TCH-loaded HNTs exhibited a significantly reduced burst phase and a long release time over two weeks compared to the pure TCH-loaded HNTs and the TCH-loaded RSF microfibrous mats without HNTs. These results were attributed to the two-step release of TCH first from the HNTs and then RSF matrix in the electrospun mats. Finally, the antimicrobial properties of the RSF microfibrous mats with TCH-loaded HNTs were evaluated using both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. The results demonstrated long-lasting antimicrobial activity for at least one week, showing the great potential of TCH-loaded RSF microfibrous mat as a wound dressing material. Therefore, these TCH-loaded RSF microfibrous mats with excellent biocompatibility and sustained antimicrobial protection are extremely attractive systems for clinical applications.
研究领域:
生物材料学
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医学
·
药剂学
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DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Shuangshuang Wang,Jixuan Song,Yuchao Li,Xingchuan Zhao,Lin Chen,Guang Li,Liping Wang,Zhengfeng Jia,Xiangcai Ge
An environmentally benign and convenient approach to impart titanium (Ti) surfaces with antibacterial functionalities was described in this work. Polydopamine (PDA) was first deposited onto an alkali activated Ti substrates. Then 2-bromoisobutyryl bromide (BIBB) was immobilized on the surface of PDA coated Ti. Finally, the BIBB functionalized Ti initiated the polymerization of N, N -diethylaminoethyl methacrylate (DEAEMA) and N, N -dimethylaminoethyl methacrylate (DMAEMA) to obtain Ti@PDA-g-polymer brushes by activators regenerated by electron transfer atom transfer radical polymerization (ARGET-ATRP). The prepared PDEAEMA and PDMAEMA brushes on Ti surfaces would be subsequently quaternized by using 1-bromooctane, which would impart the obtained products with quaternary ammonium groups. The surface compositions of the functionalized Ti were characterized by X-ray photoelectron spectroscopy (XPS). The hydrophilic/hydrophobic properties of the functionalized Ti surfaces were determined by static water contact angle measurements, and morphologies were characterized by scanning electron microscope (SEM). Antibacterial abilities of quaternized PDEAEMA and PDMAEMA coated Ti were evaluated by the contact killing test, in which live/dead cell staining method was employed. The results showed that the quaternized polymer decorated Ti exhibited good bactericidal effects against Escherichi coli ( E. coli ), and its inhibition rate of E. coli were observed to be nearly 90%.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xu Zhang,Mingzhe Wang,Lin Liu,Huan Yu,Yang Liu,Xiaozheng Duan,Lei Wang,Hengchong Shi,Shifang Luan
Interventional cardiovascular catheters (ICCs) are prone to complications such as venous thrombosis and occlusion during clinical applications, primarily due to the gradual adhesion and accumulation of cells, proteins, and microorganisms on their surfaces. Heparin sodium (HS) represents a typical clinically antithrombotic agent, whereas its hydrophilicity usually limits stable binding to hydrophobic catheter surfaces. Herein, we propose an easy-operating one-step strategy for fabricating hydrophobic-modified heparin based on electrostatic assembly between ethyl lauroyl arginate (ELA), a cationic antimicrobial compound, and anionic HS. The resulting ELA-HS complex shows water-insoluble and alcohol-soluble features, which can form a uniform and robust coating driven by electrostatic and hydrophobic interactions upon a series of catheters with diverse shapes and multi-cavity structures via solvent immersion. Molecular dynamics (MD) simulation elucidated the formation mechanism of hydrophobic-modified heparin, as well as the assembly mechanism between the coating and substrates. Importantly, this obtained ELA-HS coating with adaptive dissociation effectively resists the adsorption of fibrinogen and significantly reduces the adhesion of blood cells, including platelets, lymphocytes, and monocytes. Leveraging ELA’s inherent bactericidal properties, the coating also demonstrates substantial antibacterial efficacy, reducing bacterial colonization by over 99% whether gram-negative Escherichia coli ( E.coli. ) and gram-positive Staphylococcus aureus ( Sa. ). In vivo validation further confirms the coating’s dual functionality in preventing thrombosis and microbial infection, even in stringent acute models of canine jugular vein implantation. This ELA-HS modification strategy offers a practical solution to enhance the hemocompatibility and infection resistance of interventional catheters, addressing critical clinical challenges associated with thrombosis and bacterial adhesion.
研究领域:
生物医学工程
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材料科学
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心血管医学
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产品关联
DOI
高影响因子
Materials
·
2024
·Vol. 17
·期 15
·3734
·
IF 3.1
Yuyang Zhou,Peng Deng,Wei Chen
There is a significant trend towards the integration of natural substances with bio-polymers for fully bio-based functional composites. Polylactic acid is regarded as a promising biodegradable polymer for replacing synthetic polymers. Differing from the case of natural fiber, the incompatibility of polylactic acid with bio-based molecules prevents it from being used to fabricate high-quality sustainable composites. This work presents a simultaneous ultraviolet shielding and antibacterial finishing process of polylactic acid combined with bioactive baicalin and an eco-friendly ester, which is highlighted for (a) the lack of synthetic chemicals involved in such process, (b) adsorption enhancement achieved at a mild temperature, and (c) marginal color change on treated polylactic acid. A response surface methodology was adopted to analyze the impacts of various factors on the baicalin quantity in polylactic acid, and to optimize the treatment condition. The uptake ratio of baicalin in polylactic acid was drastically promoted from 8.5 mg/g to 21.1 mg/g using methyl cinnamate. The response surface methodology based on a central composite design experiment indicated that the usage of baicalin was the most significant factor followed by methyl cinnamate and temperature. After optimization, a very faint color depth of 1.2 was apparent, but UPF 50+ and 92% bacterial reduction could be achieved. In all, the success in strengthening of the functionalities of polylactic acid extends the applications of polylactic acid products.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Suriguga Meng,Qinggele Borjihan,Douxin Xiao,Yutian Wang,Mei Chen,Chunzu Cheng,Alideertu Dong
In bacterial cellulose (BC)-based living materials, the effective and permanent incorporation of bactericidal agents into BC remains a persistent challenge. In this study, midazole quaternary ammonium salt was grafted onto a dispersion of bacterial cellulose, which was subsequently directly added to the fermentation medium of BC-producing bacteria to obtain BC-based hydrogel materials (BC/BC-[PQVI]Br) with inherent antibacterial properties. The BC/BC-[PQVI]Br hydrogel prepared in this study exhibits favorable tensile properties, with a maximum tensile stress of 970 KPa and water retention for up to 6 h. Moreover, it demonstrates acceptable antibacterial activity against S. aureus (93 %) and E. coli (71 %), respectively. Additionally, the hydrogel displays a high cell survival rate of 98 % after contact with NIH 3T3 cells, indicating its non-cytotoxic nature. Furthermore, the mouse wound experiment confirms the excellent wound healing effect of the hydrogel. This research presents an innovative approach towards developing environmentally friendly active wound dressings with microbial-derived antibacterial functionality.
研究领域:
生物材料学
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医学
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微生物学
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产品关联
DOI
PubMed
高影响因子
IONICS
·
2021
·Vol. 27
·期 6
·2707-2715
·
IF 2.817
Zhang Ziqi,Zhang Yan,Liu Yang,Zhang Siqi,Yao Kaida,Sun Yueqiu,Wang Xiangzhi,Huang Weimin,Liu Xiaobo
Metal-organic frameworks are well-aligned nanoporous crystals which can be applied to biomedical field, thanks to the large superficial area, ordered pores array, and biocompatible metallic ion composition. In this work, we fabricated a novel Nd 3+ ion-doped ZIF-8 since there are some reports showing that Nd 3+ has anti-carcinogenic properties and can be used for therapeutic application in aberrant angiogenesis recently. Therefore, we attempted to use electrochemical anodic oxidation and electrochemical in situ deposition techniques to produce coating which contains Nd 3+ on Ti implant. And then we detected the biotoxicity, antibacterial function, and corrosion resistance of this new coating so as to facilitate further research on Nd 3+ ion implantation in vivo. SEM and TEM were applied to observe the surface morphology. N 2 adsorption–desorption was used to investigate the specific surface area and pore structure. The XRD and XPS were carried out to investigate the compound surface including the chemical composition and element-bonding configurations. The corrosion resistance properties of the samples were tested by electrochemical method. ICP was conducted to investigate the release behavior.
研究领域:
生物医学工程
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材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
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IF 3.909
QingBo Xu,XiaTing Ke,LiWen Shen,NaiQin Ge,YanYan Zhang,FeiYa Fu,XiangDong Liu
To obtain durably antimicrobial cotton fabric, carboxymethyl chitosan (CMC) was covalently linked to cotton fibers via an esterification with the cellulose hydroxyl groups, and the silver nanoparticles (Ag NPs) were adhered to the fiber surface by the coordination bonds with the amino groups of CMC. The finished cotton fabrics have an excellent antibacterial function and outstanding laundering durability. Even after 50 consecutive laundering tests, the modified cotton fabrics still show satisfactory bacterial reduction rates (BR) against both S. aureus and E. coli , which are all higher than 94%. These findings allow for broader applications of antimicrobial cotton textiles with a decreased safety risk and lower environmental impact arise from the Ag NPs.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yan Zhang,Qun Tang,Kangqi Huang,Zongshu Xu,Shaoxiong Feng,Heping Li,Zhiming Zou
There is a growing demand for the development of intelligent active packaging films to maintain and monitor the freshness of meat food . Herein, nano Co-based MOF (ZIF67) with ammonia-sensitive and antimicrobial functions was successfully synthesized and then integrated into cellulose acetate (CA) matrix to prepare intelligent active films. The impacts of ZIF67 incorporation on the structure, physical and functional characteristics of CA film were fully investigated. The results demonstrated that the ZIF67 nanofillers were evenly dispersed in CA matrix, resulting in remarkable improvement on tensile strength , toughness, thermal stability , UV barrier, hydrophobicity and water vapor barrier ability of CA film. Furthermore, the prepared CA/ZIF67 films exhibited superb antimicrobial and ammonia-sensitive functions. The CA/ZIF67 intelligent films turned their color from blue at beginning to brown during progressive spoilage of shrimp . These results revealed that the CA/ZIF67 films with excellent antimicrobial and ammonia-sensitive functions could be applied in intelligent active food packaging.
研究领域:
食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Yafang Liu,Ming Yi,Yan Wang
Membrane fabricated with a method of ingenious simplicity to be equipped with antibacterial function is the key to address the biofouling issue in separation applications. Herein, we proposed an innovative approach to armor abundant antibiotics on the membrane with minimal loss of the active functional groups of the antibiotics. Boronate ester-based membrane was first fabricated with non-solvent induced phase separation (NIPS) method. A loose nanofiltration (LNF) membrane with unique trinity structure was then constructed through the cross-linking between boronate ester complexes and trimesoyl chloride (TMC) on the top layer. Due to the pH responsive and dynamic nature of boronate ester complexes, boronic acid groups can be released under acidic conditions, acting as binding sites for diol-bearing antibiotics. This not only allows the sufficient anchoring of antibiotics (here kanamycin (KM) was chosen as model antibiotics), but also minimizes the consumption of active groups of KM molecules. The resultant membrane delivers excellent biocidal effect against both Gram-negative and positive bacteria, while also exhibiting superior water permeance of 134.86 ± 5.62 L m −2 h −1 bar −1 . This work reveals the great potential of boronate esters complexes for the development of high-flux antibacterial membranes.
研究领域:
材料科学
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环境工程
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微生物学
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Weihan Tao,Xianglu Zhao,Yinchun Fang,Xianfeng Wang
Biomimetic construction of structural colors on materials as an environmentally friendly coloring method has received more and more attention. If the structural color of the materials has special functions, it will broaden the application field. However, functional structural colors are usually prepared through the coassembly of building units with functional agents or functional modification of structural colors. In this study, poly(2,2,3,4,4,4-hexafluorobutyl acrylate/methyl methacrylate/[3-(methyl acrylamide) propyl] trimethylammonium chloride) (PAMM) microspheres containing hydrophobic and antibacterial functional groups were prepared, which were used to construct multifunctional structural colors on black polyester fabrics through the atomization deposition method. PAMM microspheres with different particle sizes (332.1, 318.3, 302, 289.9, 257.2 nm) were successfully prepared by adjusting the amounts of monomers in the synthesis reaction, which can form different structural colors of pink, green, cyan, blue, and purple on the polyester fabrics. The fabrics with structural color can significantly inhibit the growth of E. coli and S. aureus, and the antibacterial rates of both are greater than 94%. The fabrics with structural color showed outstanding hydrophobicity with a static water contact angle greater than 140°. This research provides an idea for the preparation of multifunctional fabrics with structural colors through the synthesis of building units of polymer microspheres with multifunctional groups.
研究领域:
材料科学
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纺织工程
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生物医学
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Wenjing Yang,Xuan Chen,Xun Yuan,Jia Yao,Weiliang Cai,Shuping Peng,Cijun Shuai
A novel design of antibacterial and magnetic halloysite nanotubes loaded with Ag and Fe 3 O 4 was reported. In detail, magnetic nanoparticles (Fe 3 O 4 ) were immobilized on the surface of halloysite nanotubes (HNTs) via electrostatic adsorption (termed as HNTs/Fe 3 O 4 ). The magnetic HNTs/Fe 3 O 4 was then modified by polydopamine to in-situ grow Ag nanoparticles by a redox reaction , forming a composite nanostructure of HNTs/Fe 3 O 4 @Ag. The HNTs/Fe 3 O 4 @Ag was incorporated into poly- l -lactic acid (PLLA) scaffold fabricated via selective laser sintering , with the intent to endow the scaffold with robust antibacterial function and favorable cell activity. The results showed that the released Ag + from the scaffold significantly against E. coli activity, with bacterial inhibition rate above 99%. Moreover, ion release behavior showed a scaffold enable to sustain release Ag + over 28 days. Furthermore, Fe 3 O 4 nanoparticles constructed magnetic microenvironment greatly enhanced cell activity and promoted cell proliferation . In addition, tensile strength of the scaffold increased by 52.9% compared with PLLA scaffold. These positive results suggested that the HNTs/Fe 3 O 4 @Ag nanostructure possessed potential in facilitating bone repair.
研究领域:
生物材料学
·
纳米医学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wentao Zhu,Fang-Yi Huo,Lei-Ming Cao,Zi-Zhan Li,Qian Zhu,Rongxiang He,Bolei Chen,Yong Liang,Bo Cai,Hong He,Lin-Lin Bu,Ligang Hu
Mimicking natural bio-surfaces with specific microstructures that possess inherent antibacterial ability provides a promising bacteriostatic strategy. However, current methods for biomimetic surface antisepsis can only be implemented on planar substrates made of limited materials. Herein, we developed a 3D printing-based strategy to facilely customize biomimetic microstructures on specified surfaces to successfully enable bacteriostatic function. Two-photon polymerization was employed to fabricate elaborate bacteriostatic microstructures on either flat or curved surfaces regardless of their material (daily-used glass or plastics). Streptococcus mutans were cultured on microstructured surfaces as model bacteria to validate surface bacteriostatic performance. As an example, the strategy was adopted to endow clear aligner substrate surface with bacteriostatic ability, which would enhance the applicability and convenience of these orthodontic devices for maintaining personal oral hygiene. Our strategy will inspire daily or industrial applications aiming at surface sterilization in a customized, convenient, and safe manner.
研究领域:
生物医学工程
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）