Biomaterials Science
·
2025
·
IF 5.7
Shu Sun,Jing Qin,Yifu Zhuang,Pengfei Cai,Xiao Yu,Hongsheng Wang,Xiu-Mei Mo,Jinglei Wu,Mohamed El-Newehy,Meera Moydeen Abdulhameed,Mingyue Fan,Wenhao Qian,Binbin Sun
Clinically, gingival tissue repair is challenging due to the complex oral microbial environment and inflammation. The development of gingival membranes using tissue engineering techniques offers a promising solution to this issue. This study focuses on developing the nanofibrous gingival membrane, combining polylactic acid (PLA), decellularized extracellular matrix (dECM), and magnesium oxide (MgO) nanoparticles. Electrospinning was used to fabricate membranes with varying ratios of PLA, dECM, and MgO, and their mechanical, antibacterial, and cell-proliferation properties were evaluated. NIH-3T3 and rat gingival fibroblasts (RGF) cells were cultured on the membranes to assess biocompatibility. A rat model with gingival defects was used to test in vivo tissue regeneration. It was indicated that the antibacterial nanofibrous membranes with MgO showed enhanced antibacterial effects, reduced inflammation, and promoted gingival tissue repair.
研究领域:
生物材料学
·
组织工程学
·
口腔医学
✓ 已验证
DOI
PubMed
高影响因子
CyTA-Journal of Food
·
2019
·
IF 1.605
Min Pang,Lulu Cao,Lili Cao,Yi She,Hualin Wang
The properties of manufactured nisin-ZrO2/poly (vinyl alcohol)-wheat gluten (ZPWG) films were characterized. The formation of hydrogen bonds among the PVA, WG, and ZrO2 units were detected and caused a decrease in the film crystallinity. Also, the degradation rate was increased with WG content. As expected, the addition of WG and ZrO2 influenced the light transmission, tensile properties, gas permeability and water vapor permeability of the films. Nisin-loaded films presented a low initial burst release of the antimicrobial agent, followed by a gradual release. The initial diffusion of nisin (Mt/M∞<2/3) from the ZPWG film was formulated by the Fickian diffusion equation, showing a linear relationship (R2 > 0.998) between Mt/M∞ and t1/2, and the diffusion coefficient D increased with increasing WG content. Antimicrobial activity testing of nisin-ZPWG films with 40 wt% WG showed excellent inhibitory activity against Staphylococcus aureus, indicating its potential as a new active food packaging material.
研究领域:
食品科学
·
材料科学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Rui Shi,Huan Geng,Min Gong,Jingjing Ye,Chengai Wu,Xiaohua Hu,Liqun Zhang
Trimethoxysilylpropyl octadecyldimethyl ammonium chloride (QAS), which forms facile bonds with hydroxyl groups , acts as a cationic antibacterial agent . In this work, QAS was introduced into a polycaprolactone (PCL)/gelatin hybrid in increasing concentrations to fabricate a long-acting and broad-spectrum antimicrobial micro/nanofiber membrane as a novel wound dressing. The physical interactions and chemical bonding between QAS/PCL and QAS/gelatin were demonstrated by infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS. Measured water contact angle between the PCL-gelatin/QAS (PG-Q) nanofiber membranes suggested a hydrophobic surface , which has been shown to aid in removal of wound dressings. The mechanical strength of the membranes was sufficient to meet the clinical requirements. Furthermore, the 15% QAS (PG-Q15) and 20% QAS (PG-Q20) formulated nanofiber membranes showed a considerable increase in their bacteriostatic activity towards Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria, suggesting a broad-spectrum bactericidal effect by the PG-Q membranes. The PG-Q membranes with various QAS formulations demonstrated little cytotoxicity. Therefore, the long-acting and broad-spectrum antimicrobial electrospun PG-Q micro/nanofibers membrane demonstrate potential efficacy as an antibacterial wound dressing.
研究领域:
生物医学工程
·
材料科学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuye Zhong,Zhenhong Zhang,Zhengjie Chen,Wenshuo Zhang,Xinghai Liu,Pingping Zhao,Tao Zhang,Houbin Li
Gelatin possesses excellent film-forming ability, biodegradability, and biocompatibility, which makes it a promising alternative to petroleum-based plastics. However, its application in food packaging is limited by its brittleness, high water sensitivity, and insufficient microbial protection. In this study, curcumin was introduced as a chain extender into castor oil-based waterborne polyurethane (CWU), which was then blended with gelatin as a functional material to create reactive food composite films (CWGL). The effects of varying CWU concentrations on the microstructure and properties of the films were thoroughly investigated. The incorporation of CWU enhanced the mechanical properties, water solubility, water vapor barrier, oxygen barrier, and UV shielding capabilities of the gelatin-based composite films. Additionally, CWU imparted antioxidant, antibacterial, and pH-responsive properties to the CWGL. Packaging application tests demonstrated that CWGL could extend the shelf life of fresh pork up to 10 days under refrigeration. Furthermore, CWGL exhibited a visible color change (∆E > 5) during pork storage, suggesting its potential use as a freshness-indicating innovative packaging. This study presents a novel strategy to advance the application of gelatin in innovative food packaging.
研究领域:
食品包装
·
材料科学
·
食品科学
·
生物材料
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产品关联
DOI
高影响因子
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2019
·Vol. 56
·期 3
·1095-1103
·
IF 1.85
Zhang Baodong,Huang Chongxing,Zhang Linyun,Wang Jian,Huang Xingqiang,Zhao Yuan,Liu Ying,Li Cuicui
In this study, fresh mangos were packed using a custom-made antimicrobial film coated with sustained-release chlorine dioxide microcapsules. We then compared physical and chemical indexes, such as weight loss rate, firmness, chromatic aberrations, soluble solids, vitamin C, titratable acid, and other nutritional indicators, to examine changes in the mango and film during storage. Our findings revealed that control mango showed loss of edible value and commercial value after 21 days of storage, and the chlorine dioxide microcapsule antibacterial film group still retains food value and commercial value. Cross-sectional scanning electron microscopy images of the used film showed that the polylactic acid film was smooth and flat, whereas cross-sections of the antimicrobial film showed that the film was covered with voids due to deliberate release of chlorine dioxide gas during the packaging process. Thus, the antibacterial film exhibited erosion and degradation. These findings provided important insights into the use of antimicrobial films for the packaging of fruits during storage, which is essential for promoting the application of solid chlorine dioxide antimicrobial film in packaging preservation.
研究领域:
食品科学
·
生物学
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产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Ji Qi,Shanshan Zhao,Jian Chen,Qiwei Guo,Yirong Hong,Fangang Meng
Currently, chemicals or nanoparticles are widely used for modifying membranes to improve their antifouling properties. However, the chemicals released, particularly during long-term water or wastewater filtration, are highly toxic to the environment and humans. Herein, an herb-inspired, green antibacterial membrane with exceptional sustainable antifouling properties was developed using aloin. The resultant membranes exhibited excellent bacterial inactivating efficiency because of the electrostatic interactions between the amine groups on the membrane and the bacterial cells, which contributed to cell deformation. The aloin molecules also significantly increased reactive oxygen species levels, causing oxidative damage to bacterial cells. Moreover, the functional decorative layer, which exhibited remarkable resistance to bacterial adhesion because of the abundant hydroxyl, carbonyl, and amino groups in aloin, endowed the as-prepared membranes with strong polarity, reducing bacterial adhesion and biofilm formation. When applied in a membrane bioreactor, the aloin-modified membranes demonstrated a >27.0% lower fouling rate than commercial microfiltration membranes. Overall, the successful fabrication strategy and material features described offer a green alternative for membrane development and provide new avenues for the design of healthcare materials such as wound dressings.
研究领域:
环境科学
·
生物医学工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Ru-Yu Chang,Wen-Hao Geng,Li-Chao Jing,Jing-Yi Feng,Yue-Xin Wang,Peng-Fei Qian,Ze-Long Bao,Wenyi Wang,Di Zhang,Hong-Zhang Geng
The issue of fouling in the membrane separation processes still remains a huge challenge, due to a series of water pollutions, particularly in biological contamination. In this study, the hollow mesoporous carbon spheres (HMCS) were obtained by the template method, to serve as a slow-release carrier loaded with the broad-spectrum fungicide povidone-iodine (PVP-I). The unique structural properties of the HMCS addressed the issues related to the instability of iodine formulations, rapid iodine loss, and susceptibility to pollutant coverage. Subsequently, a separation membrane was developed by mixing aminated carbon nanotubes (CNT-NH 2 ) and HMCS loaded with PVP-I on the polyether sulfone (PES) substrate. The surface resistance of the composite membrane was reduced from 4.46 MΩ/sq to 12.36 kΩ/sq. The resulting composite conductive membrane exhibited a pure water flux exceeding 300 L·m −2 ·h −1 ·bar −1 and a dye removal efficiency of over 98 %. Additionally, the composite membrane presented antimicrobial properties, with the release of the effective iodine from PVP-I triggered by the conductive network under the applied electric field (ca. 1.99 times more than the self-release). The integration of the antimicrobial slow-release materials facilitated by the electric field presents a promising strategy for mitigating membrane fouling and reducing antimicrobial loss in membrane technology.
研究领域:
环境科学
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Materials Research Express
·
2020
·Vol. 7
·期 5
·055307
·
IF 1.929
Xiaomei Liang,Xin Chen,Jianli Zhu,Lixian Liu,Wei Wang,Xu Wang,Chunsheng Qu
Macromolecules incorporating N-halamines have shown significant antibacterial properties and can be regenerated by chlorination. In this work, a new type of regenerable material made of nano-sized latex particles having N-H groups was prepared via the emulsion polymerization of methacrylamide and dodecafluoroheptyl methacrylate with divinylbenzene as a crosslinker. The N-H moieties in this polymer were subsequently transformed into N-Cl groups by chlorination with an aqueous sodium hypochlorite solution, and films were prepared by casting on substrates previously coated with a self-adhesive silicone rubber. The nanoparticles and the films were characterized by Fourier transform infrared (FTIR) spectroscopy, x-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), contact angle measurements, scanning electron microscopy (SEM) and microbiological tests. The results showed that F and Cl were successfully incorporated in the nanoparticles, that the films were thermally stable and hydrophobic (with a contact angle of 152°), and that these materials exhibited antimicrobial properties. The N-Cl groups killed bacteria by releasing active chlorine as they transitioned to N-H groups, and could be re-chlorinated with a methanol solution of isocyanuric chloride. FTIR and XPS analyses confirmed this regeneration, while SEM image showed that the morphology of the original microspheres was maintained after re-chlorination. The re-chlorinated films also maintained superhydrophobic and bactericidal characteristics.
研究领域:
材料科学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 7
·2956
·
IF 4.6
Jinsong Zeng,Xinyi Xiong,Fugang Hu,Jinpeng Li,Pengfei Li
The demand for antimicrobial materials is gradually increasing due to the threat of infections and diseases caused by microorganisms. Silver nanoparticles (AgNPs) are widely used because of their broad-spectrum antimicrobial properties, but their synthesis methods are often environmentally harmful and AgNPs difficult to isolate, which limits their application in several fields. In this study, an aqueous solution of dialdehyde cellulose (DAC) was prepared and used as a reducing agent to synthesize AgNPs in an efficient and environmentally friendly process. The synthesized AgNPs can be easily separated from the reducing agent to expand their applications. In addition, the AgNPs were immobilized in situ on dialdehyde cellulose to form antibacterial composite films. The results showed that the prepared silver nanoparticles were mainly spherical and uniformly dispersed, with an average size of about 25 nm under optimal conditions. Moreover, the dialdehyde cellulose–nanosilver (DAC@Ag) composite films had excellent mechanical properties, positive transparency, ultraviolet-blocking properties, and effective antibacterial activity againstE. coliandS. aureus. Notably, the composite films exhibited excellent oxygen and water vapor barrier properties, with WVT and ORT of 136.41 g/m2·24 h (30 °C, 75% RH) and <0.02 cm3/m2·24 h·0.1 MPa (30 °C, 75% RH), respectively, better than commercial PE films. Hence, this study not only provides an environmentally friendly method for the preparation of silver nanoparticles, but also offers a simple and novel strategy for the in situ synthesis of silver-loaded antibacterial composite films.Keywords:dialdehyde cellulose solution;silver nanoparticles;in situ synthesis;antibacterial film
研究领域:
材料科学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Lin Liu,Tanghui Liu,Guihong Li,Qingqing Tan,Anjun Tang,TingTing Wen,Ziming Li,Hai Chi,Hongrui Chen,Jie Tang,Xingzhong Zhang
In this work, we provided a facile way to prepare composite antimicrobial films based on polyvinyl alcohol (PVA) incorporated with Zanthoxylum schinifolium essential oil/cinnamaldehyde (ZSEO/CA) Pickering emulsion, and applied them for the preservation of chilled fresh pork. The ZSEO/CA Pickering emulsions stabilized by bacterial cellulose nanofibrils/whey protein isolate (BCNFs/WPI) complexes exhibited uniform droplet size distribution (around 150 nm) and maintained the better stability with an oil phase ratio of 10 wt%, which was selected for subsequent composite film preparation. Compared to pure PVA film, the addition of ZSEO/CA Pickering emulsion in composite films reduced their transmittance, but provided a significant barrier against ultraviolet light. Moreover, the incorporation of emulsion enhanced the hydrophobicity, thermal stability, water vapor permeability (WVP) and antibacterial activity of the composite films. Among them, the composite antimicrobial film with an emulsion proportion of 30 wt% (PVA-PE(30)) showed the optimal performance characteristics, and effectively prolonged the chilled fresh pork storage period. Overall, the incorporation of ZSEO/CA Pickering emulsion into PVA-based films provided a promising strategy to construct composite antimicrobial films for food packaging and preservation.
研究领域:
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaomin Liao,Qin Zhong,Zhou Xu,Hongquan Fu,Jinming Chang,HeJun Gao,Yi Chen,Yunwen Liao
The development of green and highly efficient antimicrobial filter membranes for water disinfection is crucial to public health. Photodynamic therapy (PDT), an emerging bactericidal strategy, has shown significant potential for the preparation of antimicrobial filter membranes. Unfortunately, its antibacterial efficacy is often compromised by self-quenching caused by the aggregation of photosensitizers, as well as the short diffusion length and lifespan of the reactive oxygen species (ROS) generated. Herein, a Fe(Ⅲ)-coordinated cross-linked antibiofouling cellulose composite membrane (Fe/TOCNF-TPZnPc-1.5) with significantly enhanced synergistic photodynamic and Fenton-like bactericidal performance was fabricated via a facile flow-based sequential filtration method for water disinfection. The formation of a Fe(Ⅲ)-coordinated cross-link increases the structural stability of the membrane, prevents the migration and aggregation of tetra(4-carboxyphenoxy)-phthalocyaninatozinc (ii) (TPZnPc), and also provides the Fe(Ⅲ) complexes for the accelerated Fenton-like reaction. Through synergistic photodynamic and Fenton-like reactions, the Fe/TOCNF-TPZnPc-1.5 membrane achieves rapid and effective inactivation for E. coli and B. subtilis with a lethality rate of 100 % under NIR irradiation and H 2 O 2 treatment. The primary active species responsible for bacterial inactivation are singlet oxygen species ( 1 O 2 ) and hydroxyl radicals ( OH). The disinfection performance of the Fe/TOCNF-TPZnPc-1.5 membrane in river water samples demonstrated 100 % disinfection efficiency for waterborne pathogenic bacteria. In addition, the Fe/TOCNF-TPZnPc-1.5 membrane exhibits moderate water permeance (26.6 L m −2 h −1 ), high bacteria rejection (＞96 %), excellent antifouling ability, and 100 % biodegradation within 90 days. These attributes indicate significant potential for the practical application of this composite membrane in water purification.
研究领域:
环境科学
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
De Bai,Jiahong Huang,Yiyang Bo,Mi Wang,Wen Yu,Zhenyuan Wang,Chengyu Wu,Jiaheng Zhang
In this study, we synthesized a supramolecular antibacterial ionic salt, [PHMB][Sal], based on poly(hexamethylene biguanide) hydrochloride (PHMB) and sodium salicylate (SS) to endow plastic membranes with antibacterial function. The antibacterial composites of polyelectrolyte-nonsteroidal ionic salt can be blended with polymer materials, such as polybutylene adipate terephthalate (PBAT), because the melting point of the salt can be coordinated with that of the polymer material. The properties of the prepared membranes containing polyelectrolyte-nonsteroidal ionic salts did not change significantly. The mechanical properties and antimicrobial activities of the prepared hydrophobic membranes were investigated. When 3% of [PHMB][Sal] was added, the antimicrobial activities against Gram-positive Staphylococcus aureus and Escherichia coli were 4.12 and 4.30, respectively, and the antibacterial rate was as high as 99.9%, exhibiting extremely excellent antimicrobial properties. Biodegradable [PHMB][Sal] membrane materials are expected to be used in medical environments as well as on packaging surfaces in logistics, which can effectively prevent bacterial cross-infection.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）