Coatings
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2023
·Vol. 13
·期 10
·1711
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IF 3.4
Zhimin Cao,Qian Guo
Long-term immersion in seawater easily causes surface fouling and affects the marine aquaculture industry. The commonly used method is to apply copper-based coatings on surfaces, however, the release of copper ions will harm marine organisms. Antimicrobial peptides (AMPs) are a substance extracted from organisms that possess environmental friendliness. This study extracted AMPs from traditional Chinese medicine, analyzed their amino acid sequences, and bound them to the surfaces of cage materials based on the strong adhesion of dopamine in weakly alkaline environments. The Fourier transform infrared spectrometer (FTIR) spectrum results showed that the antibacterial peptide was successfully bound to the substrate surface, and the contact angle results demonstrated a significant change in the wettability of the substrate surface. Antibacterial tests were conducted on the surface of the sample usingStaphylococcus aureus(S. aureus). The results illustrated that 304 stainless steel (SS) and nylon (PA) surfaces modified by the antibacterial peptide exhibited significant biofilm resistance, with antibacterial adhesion properties reaching 88.68% and 82.61%, respectively, exhibiting the robustness of the antimicrobial efficiency. This study can provide theoretical support for the antifouling performance of the surfaces of marine aquaculture cages.Keywords:marine cage;peptide-modified surface;antimicrobial surface;antibacterial robustness
研究领域:
生物学
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海洋科学
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材料科学
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产品关联
DOI
高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Fang Shanfang,Dang Yuan-Ye,Li Haizhou,Li Hongxia,Liu Jiayong,Zhong Rongcui,Chen Yongzhi,Liu Shouping,Lin Shuimu
Bacteria have developed increasing resistance to currently used antimicrobial agents. New classes of antimicrobial drugs are urgently required to fight drug-resistant pathogens. Here, we designed and synthesized a series of calix[4]arene derivatives as antibacterial agents by biomimicking the structural properties and biological functions of antibacterial peptides. After introducing cationic hydrophilic moieties and preliminary structural optimization, we obtained a lead compound (16) that exhibited excellent antibacterial activity against Gram-positive bacteria, low toxicity toward mammalian cells and poor hemolytic activity. The antibacterial mechanism studies showed that compound 16 can destroy bacterial cell membrane directly, leading to bacterial death and a low tendency to develop bacterial resistance.
研究领域:
微生物学
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药物化学
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合成化学
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产品关联
DOI
PubMed
高影响因子
Journal of Coatings Technology and Research
·
2018
·Vol. 15
·期 6
·1239-1250
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IF 1.619
Peng Kaimei,Dai Xuexin,Mao Haili,Zou Hongtao,Yang Zaibo,Tu Weiping,Hu Jianqing
A robust, efficient, and orthogonal click chemistry (copper (I)-catalyzed alkyne-azide cycloaddition) was used to prepare an antimicrobial polymer and precisely control the conjugation ratio of antibiotic molecules to polymer. Antimicrobial polyurethanes with pendant benzisothiazolinone (PU-BIT) were synthesized using click chemistry to connect azide functional polyurethane (PU-N 3 ) and alkyne functional benzisothiazolinone (BIT-Al). The direct contact-killing and non-leaching antimicrobial properties of PU-BIT were verified by both antimicrobial drop and disk diffusion. This approach provides a new methodology and platform for the development of contact-killing and non-leaching antimicrobial materials for a variety of practical applications. This research is the first to demonstrate that the broad-spectrum BIT antibiotic is a selective antibiotic for Gram-positive bacteria when covalently linked to a polymer. PU-BIT film containing 0.8 wt% BIT exhibited a selective antimicrobial performance with bactericidal efficacy of 91.6% and 30% against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli , respectively. The mechanism of the selective antimicrobial activity of PU-BIT is also discussed.
研究领域:
材料科学
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生物学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2020
·
IF 6.155
Jiangqi Xu,Zixu Xie,Fanglin Du,Xing Wang
In this work, the one-step stereochemical antimicrobial finishing of cotton textiles (CT) was achieved by the oxidative copolymerization of a dopamine-menthol derivative (DAM) and dopamine (DA). The obtained DAM-modified CT (P(DAM- co -DA)-CT) exhibited broad-spectrum microbial anti-adhesion properties against bacteria ( E. coli and P. aeruginosa ), including superbugs (MRSA and VREF), and fungi ( A. niger , A. flavus , M. racemosus and P. chrysogenum ). Because of its unique stereochemical antimicrobial mechanism, the obtained P(DAM- co -DA)-CT is a non-releasing antimicrobial material that causes no skin sensitization and exhibits good biocompatibility. The coating was also found to enhance the UV-resistant and mechanical properties of the CT. Furthermore, it displayed durable washing fastness and antimicrobial properties after the endurance of 30 laundering cycles. The observed achievements provide a broader understanding of stereochemical antimicrobial surfaces and endow this method with wider applications.
研究领域:
材料科学
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微生物学
·
纺织工程
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DOI
高影响因子
BIOMACROMOLECULES
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2025
·
IF 5.4
Yujia Lu,Guanyi Li,Yanwen Zhang,Yuxuan Ge,Bin Hao,Yu Yin,Yaxue Zhao,Yin Wang
Antimicrobial peptides (AMPs) are a class of peptides consisting of cationic amino acid residues and a hydrophobic segment, which have been used as an alternative to antibiotics in treating multidrug-resistant bacteria. However, the relationship among the molecular design, assembled structures, and resultant efficacy remains elusive. Herein, we report a class of constitutionally isomeric AMPs assembled into filaments with similar dimensions. Spectroscopic characterizations demonstrated that subtle changes in the position of amino acids led to dramatic variations in molecular packing and surface charges, which were verified by molecular dynamics simulations. In vitro antibacterial assays showed that all AMPs exerted antibacterial activity against Gram-positive methicillin-resistant Staphylococcus aureus (MRSA), but the efficacy was dependent on the molecular design. Given the good biocompatibility to eukaryotic cells, these AMPs could be potentially used as antibacterial agents. We believe that this finding provides an avenue to tune the bioactivity of AMPs by rational molecular design.
研究领域:
生物化学
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微生物学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2025
·
IF 7.3
Chunquan Li,Yujiao Zhang,Zengjie Zuo,Liqiu He,Fang Yuan,Shuilin Zheng,Zhiming Sun
The migration of free antibacterial agents in the coating will lead to the rapid decline of the antibacterial effect. Consequently, achieving sustained antibacterial efficacy has become a critical focus currently. In this study, through liquid-phase ion exchange and dry modification, Cu 2+ and cetyltrimethylammonium chloride (CTAC) were successively loaded onto stellerite (STI) to synthesize Cu 2+ /STI and Cu 2+ /CTAC/STI composites, then Polyvinyl alcohol (PVA) was used as the matrix to construct Cu 2+ /CTAC/STI/PVA antimicrobial coatings. The results demonstrated that the modified material retained the crystal structure of stellerite while achieving superior antibacterial properties. The incorporation of stellerite not only enhanced the stability of the antibacterial agent but also facilitated its unique delivery function. Specifically, stellerite served as an effective reservoir for antibacterial components, enabling efficient sterilization through the synergistic release of CTAC and Cu 2+ coupled with bacterial adsorption. In addition, Cu 2+ /CTAC/STI/PVA coating exhibited excellent bacterial efficacy and long-lasting antimicrobial performance, indicating the promising application prospects of stellerite-based antibacterial composites in functional coating fields.
研究领域:
材料科学
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微生物学
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生物医学工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
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2018
·Vol. 6
·期 39
·6311-6321
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IF 4.776
Yuanxiu Hong,Yuejing Xi,Junxue Zhang,Dongdong Wang,Hailong Zhang,Ning Yan,Shisheng He,Jianzhong Du
We present an antibacterial polymersome–hydrogel composite that combines the advantages of both antimicrobial peptides and antibiotics. The polymersomes are self-assembled from poly(ε-caprolactone)-block-poly(lysine-stat-phenylalanine) [PCL-b-P(Lys-stat-Phe)], exhibiting long-acting intrinsic antibacterial capabilities against both Gram-positive and Gram-negative bacteria. In addition, penicillin is encapsulated into the polymersomes, showing quick and enhanced antibacterial activities. Furthermore, a dynamic hydrogel network is prepared based on the Schiff base linkages between the aldehyde groups of dibenzaldehyde-functionalized PEG (DF-PEG) and the amino groups of chitosan. During this process, the penicillin-loaded polymersomes are grafted into the hydrogel networks by Schiff base linkages to afford polymersome–hydrogel composites, which exhibit two-stage antibacterial behavior: (1) penicillin can be released from the hydrogel networks for quick antibacterial function; (2) the polymersomes and the remaining penicillin can be further released for long-term antibacterial effects. Overall, this polymersome–hydrogel composite represents a new type of injectable antibacterial biomaterial for quick and long-acting antibacterial applications.
研究领域:
生物材料
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微生物学
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药剂学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2014
·Vol. 49
·期 9
·3391-3399
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IF 2.305
Jie Zhiqiang,Zhang Bing,Zhao Lianhong,Yan Xiufang,Liang Jie
A novel regenerable antimicrobial silica gel was prepared by a dehydration between silanols of silica gel and hydrolyzed 3-chloropropyltrimethoxysilane, a quaternization between grafted hydrolyzed 3-chloropropyltrimethoxysilane and (5,5-dimethylhydantoinyl-3-ylethyl)-dimethylamine (DHEDA), and a chlorination of amide groups of DHEDA. The as-prepared antimicrobial silica gel was characterized by FT-IR and X-ray photoelectron spectroscopy. Antimicrobial tests showed that the as-prepared antimicrobial silica gel was capable of about a 6-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 10 min of contact. Interestingly, more than 2 × 10 4 CFU/mL of Escherichia coli O157:H7 could be almost inactivated under flowing water condition. Furthermore, the as-prepared antimicrobial silica gel exhibits good regenerability and storage stability.
研究领域:
材料科学
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微生物学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
·
IF 4.539
Xuemei Li,Jianxin Gan,Peng Cao,Wenling Guo,Rongmin Wang,Pengfei Song,Yufeng He
The antibacterial materials are rapidly emerging as a primary component in mitigation of bacterial pathogens, and functional polymers play a vital role for the preparation of antibacterial coatings. In this study, using one-pot soap-free emulsion polymerization, we synthesized blackberry-shape cationic copolymer particles (BsCCP) with broad-spectrum antibacterial activity, and the BsCCP emulsion was added to the coating of the interior walls, which afforded BsCCP-based coating (BsCCP-C). The effects of surfactants, initiators, temperature, and monomer ratio on the synthesis of BsCCP were investigated. Besides, BsCCP was characterized by Fourier Transform infrared spectra (FT-IR), scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). The antibacterial activities of BsCCP and BsCCP-C against Escherichia coli and Staphylococcus aureus were evaluated. BsCCP showed positive charge, high specific surface area and rough surface, which presented strong bactericidal activity. Its antibacterial mechanism was also discussed and demonstrated. To sum up, the BsCCP and BsCCP-C with high antibacterial activity showed great potential and was expected to be a candidate of antibacterial coating materials, which are able to use for rapidly and effectively resisting to the bacterial propagation.
研究领域:
材料科学
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生物学
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医学
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产品关联
DOI
高影响因子
CELLULOSE
·
2024
·Vol. 31
·期 10
·6551-6564
·
IF 4.9
Ding Qi,Liu Jiang-long,Liu Yan-Yan,He Wen-Zhan,Zhang Lin,Xu Ying-Jun
For addressing the issue of limited durable antibacterial cotton fabric, this study developed and synthesized quaternary ammonium salt antimicrobial agents. The chemical structure was analyzed by FTIR and 1 H NMR. The cotton fabric was subjected to surface modification techniques, such as pad-dry-cure, following the careful selection of appropriate quaternary ammonium salt. The chemical state and surface morphology were evaluated through XPS and SEM. Furthermore, the cotton fabric underwent comprehensive assessments, which included antibacterial testing, laundering cycle testing, evaluation of mechanical properties, and analysis of comfort performance. The results demonstrated that the treated cotton fabric achieved a high bacteriostatic and fungistatic rate of 99.99%, 87.5%, and 99.99% against S. aureus , E. coli , and C. albicans respectively even after 50 laundering cycles, while maintaining exceptional antibacterial effectiveness and laundering durability due to the formation of covalent bonds with the cotton fabric. The treated cotton fabric met AAA grade standards for antibacterial rate without causing any significant decline in mechanical properties. Furthermore, enhancements in hydrophilicity, softness, and wrinkle resistance were observed.
研究领域:
纺织科学
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材料科学
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微生物学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Shuhua Deng,Yuan Ma,Anfu Chen,Changmin Cai,Qixiang Zhan,Junhao He,Jiajun Luo,Junxia Zheng,Caihong Lei
Wound infections are a major challenge in wound healing. Since the overuse of antibiotics, drug-resistant bacteria have emerged thus caused drug-resistant infections. Compared with overused antibiotics, hydrogel hold potential to be applied in wound healing since their high-water content and mechanical similar with extracellular matrix. A series of polyacrylamide (PAAm) hydrogel with various elastic moduli were developed, and the skin-mimic mechanical properties of Ag 3 PO 4 /PAAm composite hydrogel were investigated. The tunable elasticity PAAm hydrogel mixed with Ag 3 PO 4 and carbon dots (Ag 3 PO 4 @CDs) for anti-bacterial functions were fabricated. The presence of carbon dots has effectively reduced the photodegradation of Ag 3 PO 4 , improved the photocatalytic efficiency of Ag 3 PO 4 , and enhanced the antibacterial functions of the composite hydrogel. These hydrogels exhibit good antibacterial properties and featured with elastic modulus similarity to skin. This study provides a strategy for designing antibacterial composite hydrogel to promote wound healing.
研究领域:
生物材料学
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医学工程
·
抗菌研究
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Juanjuan Xu,Yuanpei Li,Haojie Wang,Mengxi Zhu,Wenpo Feng,Gaofeng Liang
Background The biofilms could protect bacteria from antibiotics and promote the production of drug-resistant strains, making the bacteria more difficult to be eradicated. Thus, we developed an AMP@PDA@AgNPs nanocomposite, which is formed by modifying silver nanoparticles (AgNPs) with antimicrobial peptides (AMP) modified nanocomposite to destroy biofilm in this study.Methods The AMP@PDA@AgNPs nanocomposite was prepared with polymerization method and characterized by using ultraviolet-visible (UV-vis) spectroscopy, dynamic light scattering (DLS), Fourier transform-infrared spectroscopy (FT-IR), and transmission electron microscope (TEM). The antibacterial effects of the nanocomposite were investigated by using agar diffusion method and minimum inhibitory concentration (MIC) test. The quantitative analysis of the biofilm formation by the nanocomposite was conducted using crystal violet staining and confocal laser scanning microscope (CLSM).Results The DLS and TEM analysis showed it was a spherical nanocomposite with 200 nm size and well dispersed . The results of UV-vis and FT-IR confirmed the presence of AMP and AgNPs. The nanocomposite had an excellent biocompatibility at 100 μg/mL. And the AMP@PDA@AgNPs nanocomposite showed superior antimicrobial activity against both Gram-negative (E. coli, P. aeruginosa) and Gram-positive (S. aureus) bacteria than AgNPs or AMP. Importantly, the mRNA expression of biofilm-related genes were decreased under the action of the nanocomposites.Conclusion An AMP@PDA@AgNPs nanocomposite with good biocompatibility was successfully prepared. The nanocomposite could destruct bacterial biofilms by inhibiting the expression of biofilm-related genes. The synergistic strategy of AMPs and AgNPs could provide a new perspective for the treatment of bacterial infection.
研究领域:
纳米技术
·
微生物学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）