JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2017
·
IF 1.9
Wanlu Zhang,Guangji Li,Yinlei Lin,Liying Wang,Shuqing Wu
We aimed to introduce hydrophilic sulfobetaine-type zwitterionic groups to macromolecular chains of copolymers to construct novel copolymer hydrogels with anti-protein-fouling performance that could be used as soft contact lens (SCL) materials. Using hydroxyethyl methacrylate (HEMA), N-vinyl pyrrolidinone (NVP) and sulfobetaine methacrylate (SBMA) as comonomers, several copolymer hydrogels with different SBMA contents, poly(HEMA-NVP-SBMA), are synthesized via radical copolymerization in an aqueous phase. Surface chemistry, structural morphologies, water contact angle (WCA), equilibrium water content (EWC), visible light transmittance and tensile mechanical properties are investigated. The prepared hydrogels exhibit a closed-type porous structure. With increasing SBMA content in the comonomer mixture, the prepared copolymer hydrogel pore size gradually increases up to the micron level, WCA tends to decrease, EWC tends to increase, and visible light transmittance slightly increases, but their tensile mechanical properties decline. The amounts of protein Lyz and BSA adsorbed on the copolymer hydrogels and on commercially available EASY DAY® SCLs as a control are also determined by protein adsorption tests. The amount of protein adsorbed on the copolymer hydrogel decreases with increasing SBMA content. For the hydrogel prepared using the comonomer mixture with 5.0 wt % SBMA, the amount of adsorbed Lyz is 0.91 μg/cm2, which corresponds to only 56.8% of the amount adsorbed on EASY DAY® SCLs. Thus, novel SCL materials with high water content and excellent anti-protein-fouling performance were efficiently constructed by introducing sulfobetaine-type zwitterionic groups into a traditional polymer hydrogel system.
研究领域:
材料科学
·
生物医学工程
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DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2023
·
IF 11.1
Guangling He,Yuhua Liu,Wenyan Liu,Lei Dong,Liangmin Yu,Li Wang
Antifouling hydrogels have received extensive attention in the field of marine antifouling due to their excellent hydrophilicity and environmental friendliness. However, the antifouling applications of traditional hydrogels are limited by their poor antibacterial properties , and capsaicin derivatives, as nontoxic and environmentally friendly antifoulants, can be used to improve the antibacterial properties of hydrogels. From the perspective of practical application, hydrogels were obtained by crosslinking the copolymer of the capsaicin derivative N,N'-((4,5,6-trihydroxy-1,3-phenylene) bis (methylene)) diacrylamide (TPA), lipophilic monomers and hydrophilic monomers. This hydrogel exhibited anti-protein performance due to its hydrophilicity, and the capsaicin derivative caused the hydrogel coating to exhibit excellent algae inhibition performance (the minimum adhesion density of diatoms on the surface of the hydrogel coating was less than 440 cells/mm 2 ), better algae anti-adhesion abilities than hydrogel reported in the other paper, and antibacterial effects (the antibacterial rate was more than 95%). After 73 d of panel testing in a real marine environment, there was still a good antifouling effect in the hydrogel coating. Hence, the antifouling performance was improved significantly by capsaicin derivative (TPA)-functionalized hydrogel coating. A new strategy is provided in this study for the preparation of hydrogels with superior marine antifouling properties.
研究领域:
材料科学
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海洋生物学
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环境科学
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DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2020
·Vol. 31
·期 11
·2816-2826
·
IF 2.578
Xiao Wang,Birong Zeng,Ting Chen,Xinyu Liu,Tong Wu,Hong Shen,Weiang Luo,Conghui Yuan,Yiting Xu,Guorong Chen,Lizong Dai
To endow polyethersulfone (PES) membranes with enhanced hydrophilicity and anti-protein adsorption performance, amphiphilic dithiolane-containing copolymers poly[poly(ethyleneglycol)methylethermethacrylate-co-2-(methacryloyloxy)ethyl 5-(1,2-dithiolan-3-yl)pentanoate-co-(4-formylphenyl)-2-methylprop-2-enoate]{abbr. Poly(MAPEG-co-MALA-co-MAHA)} with different polymerization degree were successfully synthesized, and then blended with PES to prepare microfiltration membranes by immersion precipitation phase inversion process. The chemical structure and molecular weight of poly(MAPEG-co-MALA-co-MAHA) were characterized by NMR, FTIR and GPC. The morphology and surface property of the as-prepared blending membranes were also characterized by SEM, AFM and contact angle testing etc. Compared with pure PES membrane, the contact angle of PES/poly(MAPEG-co-MALA-co-MAHA) membranes decreased from 74.2° to 53.7°, and the bovine serum albumin (BSA) adsorption declined from 121.4 to 58.8 μg cm −2 . Meantime, the water flux of PES/poly(MAPEG-co-MALA-co-MAHA) membranes increased from 38.6 to 89.1 L m −2 h −1 , the flux recovery ratio increased from 68.3% to 93.3% and the irreversible flux decline ratio decreased from 31.7% to 6.7%. Furthermore, the mechanical property of PES/poly(MAPEG-co-MALA-co-MAHA) membrane was better than that of pure PES membrane. In addition, the rejection of BSA and Au nanoparticle reached 77.3% and 66.2% respectively. The results showed that the addition of poly(MAPEG 18 -co-MALA 18 -co-MAHA 18 ) with tiny amount could not only improve the hydrophilicity and antifouling of the membrane, but also endow the microfiltration membrane with the rejection of nanoparticles.
研究领域:
材料科学
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环境工程
·
生物医学工程
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2014
·
IF 2.538
Hong Meng,Qiang Cheng,Chunxi Li
The adhesion of proteins to the surface and pores of ultrafiltration membrane is one of the most important causes of membrane fouling, consequently lead to deterioration of membrane performance. In the present study, a polyacrylonitrile (PAN)-based zwitterionic ultrafiltration membrane was developed to improve its anti-protein-fouling capacity. 3-Dimethylaminopropylamine was first grafted onto the hydrolyzed PAN membrane by activation. Subsequently, carboxylic zwitterions were produced on the membrane surface by quaternization with 3-bromopropionic acid. The zwitterionic membranes were rigorously characterized in terms of chemical composition, morphology, and surface properties indicating that the zwitterion could successfully be bonded onto the PAN membrane without having significant effects on the membrane morphology. The anti-protein-fouling properties of the membrane were tested using static protein adsorption and dynamic-filtration experiments. The experimental results show that, although the hydrophilicity of the zwitterionic membrane decreased, the flux recovery rate of the zwitterion-grafted membrane was much higher than that of the hydrolyzed PAN membrane. Therefore, the formation of zwitterionic hydration layer may effectively prevent the adsorption interaction between protein and membrane surface, which is beneficial for the improvement of the anti-protein-fouling capacity.
研究领域:
材料科学
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膜科学与技术
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生物医学工程
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表面化学
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分离科学
✓ 已验证
DOI
高影响因子
Coatings
·
2025
·Vol. 15
·期 5
·588
·
IF 2.8
Songbo Xie,Xiufen Liao,Yanye Fan,Jiacheng Li,Qiumei Jiang,Yihua Zheng,Zhimin Huang,Shella Li
Traditional marine antifouling coatings function through releasing toxic antifouling agents, causing serious harm to marine ecosystems. To address this challenge, an eco-friendly fluoro-silicon-modified polythiourethane (FSi-PTU) coating has been prepared via a polymerization reaction with dihydroxy propyl silicone oil (HO-PDMS-OH), 1H,1H,2H,2H-perfluorohexanol (FTOH), hexamethylene diisocyanate (HDI), and pentaerythritol tetrakis (3-mercaptopropionate) (PETMP). The FSi-PTU polymer incorporates siloxane segments and fluorinated side chains, which are inhomogeneously distributed on the coating surface and construct a hydrophobic surface. The FSi-PTU coating exhibits good hydrophobicity, strong adhesion (≥2.14 MPa), and improved mechanical properties. The antifouling properties of the FSi-PTU coating have been researched. The results of laboratory tests demonstrate that the FSi-PTU coating exhibits excellent anti-protein adsorption and anti-algal attachment performance. The FSi-PTU-2 coating shows certain antifouling properties in the actual seawater test for three months. The results provide a certain reference value for developing eco-friendly marine antifouling coatings.
研究领域:
材料科学
·
海洋生物学
✓ 已验证
产品关联
DOI
高影响因子
MARINE POLLUTION BULLETIN
·
2024
·
IF 5.3
Wenjian Dong,Chunhua Ni,Xia Li,Liangmin Yu,Xuefeng Yan
Tin-free self-polishing antifouling coatings have the highest market share since organotin self-polishing antifouling coatings have been banned. However, its high dependence on cuprous oxide was found to have caused potential harm to the environment, making it necessary to improve the functionality of the resin. In this paper, a zinc acrylate resin with side chain hanging indole derivative structure was prepared by using N-(1H-5-bromoindole-3-methylene) (BIAM) with good biological activity as functional monomer. The functional resin with good antifouling performance was selected by antibacterial and algae inhibition experiments. The results showed that when the BIAM content was 9 %, the inhibition rates of the resin on E. coli and Prymnesium parvum reached 98 % and 90 %, respectively. Tin-free self-polishing antifouling coatings were prepared using the above resins as film-forming materials. The anti-protein adsorption performance and antifouling performance of the coating were tested by anti-protein adsorption experiment and real sea hanging plate experiment. The results showed that the coating containing indole derivative structure had good anti-protein adsorption performance and antifouling performance, and the higher the BIAM content, the better the anti-protein adsorption performance and marine antifouling performance.
研究领域:
材料科学
·
生物学
·
海洋科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Guozhen He,Tao Dong,Zhaochu Yang,Bjo̷rn Torger Stokke,Zhuangde Jiang
Biofouling deteriorates the performance of sensors operated in biofluids. Protein adsorption is believed to be the first step of biofouling, which also reduces biocompatibility by further inducing cell adhesion, platelet activation, and even inflammation. Current studies of antifouling coatings are focused on polymers and hydrogels, which have succeeded in remaining resistant to protein adsorption, but their application on sensor electrodes is limited due to low conductivity and biocompatibility. Here, we report a spontaneous antibiofouling strategy for sensor electrodes by controlling oxygen vacancies in WO3 nanosheets. Irreversible adsorption of proteins was reduced by 76% in unprocessed human plasma when electrodes were coated with WO3 rich in surface oxygen vacancy. These electrodes maintained 91% of the initial current density after 1 month of incubation in human plasma.
研究领域:
材料科学
·
纳米技术
·
生物传感器
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Teng Wang,Tianqi Xu,Hao Yuan,Lang Xu,Ying Cai,Tian Zuo,Wenjing Liu,Jiawen Zhang,Lingmin Yi
Non-specific protein adsorption on material surfaces is a critical challenge in the fields of biomedicine applications, often compromising device functionality and causing potential health risks. To address this challenge, a series of amphiphilic mixed brush coatings composed of hydrophilic poly(carboxybetaine methacrylate) (PCBMA) and hydrophobic poly[methyl(3,3,3-trifluoropropyl)siloxane] (PMTFPS) were designed and prepared. The surface restructuring behaviors of these mixed brushes affect their synergistic antifouling effects, resulting in distinctly different protein-resistant properties. When the PCBMA chains are shorter than the PMTFPS chains and the grafting density of PCBMA is moderately higher than that of PMTFPS, the mixed brushes exhibit excellent protein adsorption resistance after both dry and wet treatments. The presence of a suitable number of PMTFPS chains on the surface not only provides the fouling-release property but also minimizes the disturbance on hydration from protein contact, thereby maximizing synergistic antifouling effects. This work can provide unique insight for designing brush coatings with excellent protein-resistant performance in the future.
研究领域:
生物医学工程
·
材料科学
·
表面工程
·
高分子科学
·
生物污损防护
✓ 已验证
产品关联
DOI
高影响因子
Biomedical Materials
·
2024
·
IF 3.9
Xiaolu Chen,Dawei Yan,Hao Deng,Hulin Yang,Suping Peng,Wei Zhang,Shijie Cai,Qiyi Zhang,Haohao Ren,Yonggang Yan
Stopping postoperative soft tissue adhesions is one of the most challenging clinical problems that needs to be addressed urgently to avoid secondary injury and pain to patients. Currently, membrane materials with anti-protein adsorption and antibacterial activity are recognized as an effective and promising anti-adhesion barrier to prevent postoperative adhesion and the recurrent adhesion after adhesiolysis. Herein, poly(amino acid) (PAA), which is structurally similar to collagen, is selected as the membrane base material to successfully synthesize PAA-5 membranes with excellent mechanical and degradation properties by in-situ melt polymerization and hot-melt film-forming technology. Subsequently, CuSO4/H2O2 induced co-deposition of the polydopamine/polysulfobetaine methacrylate (PDA/PSBMA) coatings brought excellent biological properties to the PAA-5 membranes. In vitro studies indicated that the introduction of copper ions and quaternary ammonium salts resulted in superior hemocompatibility, anti-protein activity and cytocompatibility of PDC-5S and PDC-10S. Additionally, PDC-5S and PDC-10S demonstrated significant antibacterial activity against E. coli and S. aureus, with an inhibition rate of more than 90%. As a result, this study sheds light on newly discovered PAA membranes with anti-protein adsorption and antibacterial activity can sever as one of the promising candidates for the prevention of postoperative peritoneum adhesions.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DENTISTRY
·
2021
·
IF 4.379
Kang Li,Zhongni Zhang,Yuhong Sun,Hongye Yang,James Kit Hon Tsoi,Cui Huang,Cynthia Kar Yung Yiu
Objectives To evaluate the anti-proteolytic and cross-linking effect of N -(3,4-dihydroxyphenethyl)methacrylamide (DMA) on the demineralized dentin matrix in vitro . Methods Four experimental solutions were selected: 50% ethanol/water solution (Control); 1, 5, and 10 mmol/L DMA dissolved in 50% ethanol/water solution. Sound human molars were sectioned to produce dentin beams with dimension of 1×1×6 mm. The dentin beams were demineralized with 10% phosphoric acid for 8 h to remove the apatite . The demineralized specimens were randomly separated into four groups and immersed in the four experimental solutions for 1 h. After the treatment , the ultimate tensile strength (UTS), loss of dry mass and the release of hydroxyproline by storing the treated specimens in 0.1 mg/mL collagenase solution for 24 h were assessed. The swelling ratio of another ten specimens from each group were evaluated. The interaction between DMA with dentin matrix was observed under Field Emission Scanning Electron Microscopy (FESEM). UTS data was analyzed by two-way ANOVA followed by Tukey test, and the other data was analyzed by one-way ANOVA followed by Tukey test (α = 0.05). Results The two-way ANOVA factors, different solutions ( p < 0.001), collagenase degradation ( p < 0.001) and their interactions ( p < 0.001) all significantly affected the UTS. The 10 mM DMA treatment significantly decreased the percentage of loss of dry mass, release of hydroxyproline and swelling ratio of demineralized dentin matrix compared to other treatment groups ( p < 0.05). The FESEM observation depicted that with increasing concentration of DMA, the structure of dentin matrix was protected and the porosity within dentin collagen network was decreased. Conclusions The treatment by 10 mM DMA/ethanol solution for 1 hour is capable of enhancing the mechanical properties of demineralized dentin matrix against collagenase degradation and may be clinically useful to improve the durability of hybrid layer. Clinical Significance The 10 mM DMA/ethanol primer may offer an alternative choice for dentists to strengthen the mechanical properties of demineralized dentin matrix and resist its degradation by collagenase.
研究领域:
牙科学
·
材料科学
·
生物材料
✓ 已验证
DOI
PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Ying-Zi Wu,Yu-Zhuang Gao,Cong-Lei Zhao,Meng-Ying Wu,Yi-Xian Wu
A series of amphiphilic polyisobutylene- b -poly(2-ethyl-2-oxazoline) (PIB- b -PEOX) diblock copolymer/Ag nanoparticle composites were successfully in-situ synthesized via cationic ring-opening polymerization of 2-ethyl-2-oxazoline (EOX) with high initiation efficiency by using allyl bromide end functionalized polyisobutylene (PIB-allylBr) as a macroinitiator and AgClO 4 as a coinitiator. The microphase separation formed in the resulting PIB- b -PEOX diblock copolymers due to the thermodynamic imcompability of hydrophilic PEOX segments and hydrophobic PIB segments. The micromorphology of phase separation is dependent on the copolymer composition, in which sea-island micromorphology formed for PIB 118 - b -PEOX 80 and bicontinuous phase micromorphology formed for PIB 118 - b -PEOX 97 . The micelles with nano-scale size in the range of 15 - 80 nm and having high drug loading rate of ca. 48.9% can be formed by self-assembly of the amphiphilic diblock copolymers in n-hexane. The drug cumulative release rate can be increased with an increase in the proportion of PEOX segments, due to the strong interaction between ibuprofen and the PEOX segments. The hydrophilicity of the PIB- b -PEOX diblock copolymer surfaces can be improved after ethanol vapor induction. The PIB- b -PEOX diblock copolymers behave biocompatibility and good anti-protein adsorption property. The amphiphilic PIB- b -PEOX) diblock copolymer /Ag nanoparticle composites exhibit high antibacterial efficiency for Gram-negative bacterium ( E. coli) and Gram-positive bacterium (S. aureus) . To the best of our knowledge, this is the first example of PIB- b -PEOX diblock copolymer/Ag nanoparticle (6.4 ±2.6 nm) composites synthesized in-situ with good biocompatibility, anti-protein adsorption, and antibacterial properties, which would have potential applications for drug delivery and anti-protein coating in biomedical areas
研究领域:
高分子化学
·
纳米技术
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Yan Dai,Jiali Zhang,Shimeng Zhang,Linhua Li,Chao Qu,Jiang Chen,Lei Lu
Bacterial keratitis is a major cause of blindness, hindered by the rising threat of antibiotic resistance. Although corneal bandage lenses (CBLs) are widely utilized in ophthalmic treatment, their effectiveness in treating bacterial keratitis remains limited due to risks of secondary infections, patient discomfort, and complications. In this study, we developed a novel biomimetic coating on CBLs by grafting Ag/Cu bimetallic nanoparticles (Ag/Cu-NPs) and thiol-functionalized heparin (Hep-SH) using a rapid polydopamine (PDA) deposition technique, effectively mimicking the ocular surface glycocalyx structure. The resulting Ag/Cu-NPs/Hep-SH coated CBLs (PNH-CBLs) exhibited significant antibacterial activity, with over 80 % reduction in Staphylococcus aureus ( S. aureus ) and 70 % in Escherichia coli ( E. coli ) due to the sustained release of Ag + and Cu 2+ , along with displaying favorable in vitro biocompatibility. Animal experiments conducted on New Zealand white rabbits with bacterial keratitis demonstrated successful treatment therapeutic outcomes, with PNH-CBLs leading to a significant decrease in clinical score. These biomimetic lenses also exhibited selective anti-protein adsorption properties, minimizing inflammation and promoting surface lubrication. Overall, this innovative approach addresses critical challenges in antibiotic resistance and offers a promising therapeutic strategy for managing ophthalmic infectious diseases.
研究领域:
眼科学
·
纳米技术
·
生物材料
·
抗菌治疗
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）