JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
·
2018
·
IF 1.091
Bei-Dou Zhou,Li-Lan Zeng,Yu-Gui Tong,Jia-Ying Fang,Zhi-Peng Ruan,Xiao-Yun Zeng,Yuan-Yuan Fang,Gui-Fen Xu,Dong-Bao Hu
Ten substituted 1,3-dihydroxyxanthones were synthesized in one step. The yields ranged from 40 to 76%. Compounds 8–10 were first reported. Next, the compounds’ in vitro anti-proliferative activities against nine human cancer cell lines, antityrosinase, and antioxidant activities were evaluated. Compounds 1, 4, 6–7, and 9–10 exhibited enhanced cytotoxicity against certain cancer cells. Compounds 2, 8, 9, and 10 inhibited tyrosinase activity to a certain extent. In addition, compound 4 exhibited the best antioxidant activity, which was consistent with theoretical calculations. These results demonstrated that compounds 1–2, 4, and 6–10 were promising leads for further investigation.
研究领域:
药理学
·
有机化学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Song Shiqing,Wu Yuying,Wang Huatian,Xie Kun,Liu Hao,Sun Min,Shao Li,Yue Heng,Feng Tao,Yao Lingyun
The Torreya grandis meal (TGM) is a protein-rich by-product during the seed oil manufacturing process. In this study, the T. grandis meal protein (TGMP) was extracted from the defatted TGM by alkali extraction and isoelectric point precipitation, and the effect of in vitro digestion on peptide release of the TGMP was evaluated using static digestion model. The TGMP was composed of 17 amino acids with the molecular weight was major located at 35 kDa by SDS-PAGE. Under simulated digestion, the variation in peptide content, amino acid composition, and molecular weight distribution of the hydrolyzed TGMP were determined. The degree of hydrolysis (DH) of TGMP was revealed to be 16.52% after 120 min of gastric digestion and 18.85% after 270 min of gastrointestinal digestion, indicating that the simulated digestion is insufficient to hydrolyze the TGMP thoroughly. Meanwhile, the bioactivity assessment suggested that the antioxidant and anti-tyrosinase activity of the TGMP was significantly enhanced after simulated digestion. The obtained results would provide valuable information on the digestive characteristics of TGMP in the gastrointestinal tract, and would also help to develop functional peptides from the T. grandis meal.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Shi-Huan Guo,Zimeng Zhang,Xi Zuo,Sitong Jiao,Jingyao Sun,Yahao Yang,Yahong Yuan,Tianli Yue
In order to develop novel anti-browning agents with both antioxidant and anti-tyrosinase properties, a series of N -caffeoyl amino acid methyl esters were designed and synthesized. Most of the synthesized compounds exhibited superior scavenging activities against DPPH radicals and ABTS cation radicals compared with caffeic acid and L-ascorbic acid. The kinetics analysis of radical scavenging for both DPPH and ABTS radicals by N -caffeoyl phenylalanine methyl ester ( 3a) suggested that the scavenging processes may follow second-order reaction kinetics. Additionally, among the compounds prepared, N -caffeoyl cysteine methyl ester ( 3o) exhibited stronger inhibitory effect on tyrosinase than kojic acid and the inhibition type was mixed. Molecular docking studies further elucidated that compound 3o binds to tyrosinase with histidine residues in the active pocket. Anti-browning experiments confirmed that the browning rates of apple slices and apple juice treated with compound 3o were significantly reduced, showing a stronger anti-browning effect than kojic acid. In conclusion, compound 3o has potential applications as an anti-browning agent.
研究领域:
食品科学
·
有机化学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Arabian Journal of Chemistry
·
2023
·
IF 6
Kaiquan Yu,Jian Li,Yuqi Chen,Min Zhang,Jiaxin Li,Shani Li,Qing Li,Ling Liu,Lilan Yi,Qingjiao He
Although Abelia macrotera has long been used as the raw material for the special snack “immortal tofu” by Chinese population, the composition and activity of its leaf and stem are rarely studied. Ultrahigh-performance liquid chromatography-quadrupole (UHPLC-Q)-Exactive Orbitrap mass spectrometry and various experiments were used for in vitro study of its chemical composition and antioxidant, antityrosinase, and anti-inflammatory activities . A fast, accurate, and sensitive UHPLC-Q-Exactive Orbitrap mass spectrometry method has been established and effectively used for the determination of the chemical composition of the leaf and stem of A. macrotera . The biological activities of the leaf and stem extracts of the A. macrotera were determined in vitro by antioxidant and anti-inflammatory methods. A total of 142 chemical constituents including 48 flavonoids, 65 organic acids, 12 phenylpropanoids, and 19 others were identified by UHPLC-Q-Exactive Orbitrap mass spectrometry. The results show that the leaf and stem extracts have wide and significant antioxidant capacities, including scavenging effects of DPPH, ABTS and hydroxyl radicals, and the ability to reduce both iron and copper metal ions. Additionally, they showed a strong inhibition of NO production, with a dose-dependent inhibition. To the best of our knowledge, this is the first study to report the identification and content determination of the chemical components of the A. macrotera leaf and stem. These results will be beneficial to further understand its medicinal value.
研究领域:
药用植物学
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分析化学
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 20
·15444
·
IF 5.6
Monika Michalak
Natural ingredients have been used for centuries for skin treatment and care. Interest in the health effects of plants has recently increased due to their safety and applicability in the formulation of pharmaceuticals and cosmetics. Long-known plant materials as well as newly discovered ones are increasingly being used in natural products of plant origin. This review highlights the beneficial effects of plants and plant constituents on the skin, including moisturizing (e.g.,Cannabis sativa,Hydrangea serrata,Pradosia mutisiiandCarthamus tinctorius), anti-aging (e.g.,Aegopodium podagraria,Euphorbia characias,Premna odorataandWarburgia salutaris), antimicrobial (e.g.,Betula pendulaandEpilobium angustifolium), antioxidant (e.g.,Kadsura coccinea,Rosmarinus officinalis,Rubus idaeusandSpatholobus suberectus), anti-inflammatory (e.g.,Antidesma thwaitesianum,Helianthus annuus,Oenanthe javanica,Penthorum chinense,Ranunculus bulumeiandZanthoxylum bungeanum), regenerative (e.g.,Aloe vera,Angelica polymorpha,Digitaria ciliaris,Glycyrrihza glabraandMarantodes pumilum), wound healing (e.g.,Agrimonia eupatoria,Astragalus floccosus,Bursera morelensis,Jatropha neopaucifloraandSapindus mukorossi), photoprotective (e.g.,Astragalus gombiformis,Calea fruticose,Euphorbia characiasandPosoqueria latifolia) and anti-tyrosinase activity (e.g.,Aerva lanata,Bruguiera gymnorhiza,Dodonaea viscosa,Lonicera japonicaandSchisandra chinensis), as well as their role as excipients in cosmetics (coloring (e.g.,Beta vulgaris,Centaurea cyanus,Hibiscus sabdariffaandRubia tinctiorum), protective and aromatic agents (e.g.,Hyssopus officinalis,Melaleuca alternifolia,Pelargonium graveolensandVerbena officinalis)).Keywords:plants;skin;photoprotection;wound healing;anti-aging;anti-tyrosinase;essential oils;colorants;cosmetics;pharmaceutics
研究领域:
植物学
·
药理学
·
化妆品科学
·
皮肤病学
✓ 已验证
DOI
PubMed
高影响因子
PROCESS BIOCHEMISTRY
·
2019
·
IF 2.883
Yu-Xia Wang,Wei-Chao Su,Qin Wang,Yu-Feng Lin,Yuan Zhou,Long-Fang Lin,Su Ren,Yan-Ting Li,Qing-Xi Chen,Yan Shi
In this study, the antityrosinase and antioxidant activities of four guanidine compounds (GCs), including guanylthiourea (GT), guanidine thiocyanate (GTC), phenylguanidine (PG), and phenethyldiguanide (PTDG), were investigated. The results showed that the GCs reduced the monophenolase and diphenolase activities of tyrosinase. The IC 50 values of GT, GTC, PG, and PTDG were 0.27, 3.53, 6.68, and 5.18 mM for monophenolase and 0.23, 3.24, 3.97 and 2.50 mM for diphenolase, respectively. The inhibition of diphenolase activity was reversible for the four GCs. The inhibition types of GT and PTDG were competitive, while those of GTC and PG were mixed. FRAP, ABTS, DPPH, and DNA damage protection assays revealed that only GT possessed significant antioxidant activity. Furthermore, GT was found to decrease the melanin content and expression of TYR, MITF and DCT in both B16F10 cells and zebrafish. Overall, our results indicated that GT can inhibit tyrosinase activity in vitro , which suggests that these GCs are potential candidates for novel small-molecule tyrosinase inhibitors and that GT could have broader application prospects.
研究领域:
药理学
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生物化学
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）