JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2023
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IF 3.4
Huanhuan Yang,Cong Liu,Chuanhong Zhu,Yan Zheng,Juan Li,Qianyun Zhu,Hao Wang,Xiangming Fang,Quan Liu,Man Liang,Zilong Liu
Determination of antipsychotics from biological samples is meaningful in the field of clinical and forensic medicine. Compared to blood, keratinized matrices such as hair and nails have attracted increasing attention in drug analysis for wider detection window. Nevertheless, the distribution and stability of antipsychotics in keratinized matrices are not clarified yet. Therefore, we developed a LC-MS/MS based method for simultaneous determination of 10 antipsychotics from blood, hair and nails, with high recovery (78.1–107.4%, 71.3–93.5% and 75.2–90.5%), low LOD (5–10 pg/mL, 5–10 pg/mg and 5 pg/mg) and high accuracy (96.0%−101.6%, 97.5%−102.5% and 97.6–101.7%). The method was applied to sets of blood, hair, and nail samples of 54 patients who received long-term therapy, and significant correlations between drug concentrations in blood and hair was found, while the correlation between nails and other matrices varied depending on the drug. Except for olanzapine , the concentrations of antipsychotics in segmental hair samples were consistent with drug exposure. Besides, the hair and nail samples of suspects in two forensic cases were analyzed and provided supporting evidence for the suspects’ psychiatric state. Our research offered a deeper understanding of keratinized matrix as stable and retrospective bio-samples for antipsychotics detection in forensic practice.
研究领域:
临床医学
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法医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Coatings Technology and Research
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2020
·Vol. 17
·期 5
·1377-1387
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IF 1.815
Peng Xiaoxiao,Liu Yan,Xin Binjie,Guo Hengyi,Yu Yunge
Intended for preparing silane-modified waterborne polyurethane dispersions and then applying them to the development of environmentally friendly nail enamels, the synthesis mechanism was investigated in this paper to determine the optimal technological parameters. Aimed at the synthesis of waterborne polyurethane dispersions, a one-step method was conducted on the prepolymers and the main raw materials, isophorone diisocyanate (IPDI), polycaprolactone diol (PCL), 1,4-butanediol (BDO), 2,2-dimethylol butyric acid (DMBA), (3-aminopropyl) triethoxysilane (APTES), triethylamine (TEA) and solvent water, were adopted. Subsequently, the water-based nail enamel together with its dry film was prepared by pigments and functional additives. Morphological characteristics and chemical composition of dry film of nail enamel were characterized by using atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR). The crystallinity of film was analyzed by an X-ray diffractometer (XRD). Benefiting from a thermogravimetric analyzer (TG) and differential thermal analyzer (DSC), the thermal properties of the prepared film were characterized. The hardness, adhesion, glossiness, water absorption, drying time and some other indicators of the water-based nail enamel were tested using a loading pencil hardness tester and other equipment. The experimental results showed the waterborne polyurethane modified by silane coupling agent exhibited favorable film-forming property, glossiness, flexibility, hardness, and adhesion and can be used for developing the environmentally friendly water-based nail enamel with a concentration of silane coupling agent of 1.5%, showing a broad market prospect in the cosmetics field.
研究领域:
材料科学
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化妆品化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2022
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IF 9.224
Mengqin Zhou,Zhenlong Liu,Tongliao Liu,Yan Zhu,Ning Lin
As a renewable and highly crystalline nano-object, chitin nanocrystals (ChNC) are the mechanical building blocks in the cell walls of fungi and the exoskeletons of shellfish, insects, and other crustaceans and have attracted intense interest in the production of functional materials. The structural feature of ChNC is composed of acetylglucosamine units with two hydroxyl groups and one acetyl group, and the latter can be transformed into more active amino groups by deacetylation. One issue is that obtaining more accessible amino groups by increasing the degree of deacetylation of ChNC under the preservation of the original crystalline property and rodlike morphology determines its subsequent modification and potential application. We analyze the influence of acid hydrolysis on the formed amino groups in the preparation process of ChNC and further investigate the tradeoff between gradiented deacetylation and varied crystalline index of this natural nanocrystal. The deacetylated ChNC obtained surface amino groups and retained its crystallinity, followed by surface fluorescence modification in an electrophilic addition reaction based on electrophilic addition reaction between the amino groups on its surface and the thiocyano groups of a fluorescent molecule. Finally, the fluorescent-modified ChNC is introduced into a water-borne polyurethane-based nail polish coating, providing a bright fluorescence performance, superior mechanical enhancement, and a rigid nanocomponent as a multifunctional additive.
研究领域:
材料科学
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
FIBERS AND POLYMERS
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2015
·Vol. 16
·期 6
·1303-1311
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IF 0.881
Alebeid Omer Kamal,Zhao Tao,Seedahmed Ahmed Ibrahim
A new approach for dyeing and functional finishing for cotton fabric using Henna extract and TiO 2 nano-sol was investigated. In this study, 3-chloro-2-hydroxy propyl trimethylammonium chloride was used to substitute metallic mordants (heavy-metal salts) in pre-treating cotton fabric. This eventually will prevent heavy metal pollution as well as obtain dyeing without addition of salt. TiO 2 nano-sol was prepared by sol-gel method using different amounts of tetraisopropyl orthotitanate (TTIP) and applied on cationized cotton fabrics using the same finishing formulation and treatment sequence. Treated fabrics were then dyed with Henna extract at different dyeing temperatures (60 ℃, 80 ℃, and 90 ℃). TiO 2 nanoparticles were characterized by transmission electron microscopy (TEM). The chemical and morphological structures of the dyed fabrics were characterized by attenuated total reflection-Fourier transform infrared (ATR-FTIR), scanning electron microscopy (SEM), and X-ray diffractometry (XRD). Color strength, fastness properties (washing, rubbing, and light), UV-blocking, antibacterial activity, and tensile strength were investigated. Samples treated with TiO 2 and dyed with Henna extract exhibited outstanding enhancement in both the UV protection and antibacterial efficacy with minimal impact on color depth and tensile strength. Enhancement or decrement in the UV protection, antibacterial activity and dyeing properties are governed by the amount of TTIP and the dyeing temperature.
研究领域:
纺织科学
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材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
CLINICA CHIMICA ACTA
·
2023
·
IF 5
Jing Li,Xin Zhou,Morotomi Takashi,Kenichiro Todoroki,Toshimasa Toyo'oka,Qing Shi,Toufeng Jin,Jun Zhe Min
Background Recent research has been reported that N -acetyl-leucine content is significantly reduced in the saliva of diabetic patients, but no reports of detection in human nails have been found. This study aims to develop a novel method for the chiral separation of N -acetyl-DL-leucine (Ac-DL-Leu) in human fingernails to investigate the differences between healthy volunteers (HVs), prediabetes (PDs) and diabetic patients (DPs), and to verify its effectiveness in early warning of diabetes. Method Chiral resolution was performed using DBD-Apy pre-column derivatization on a C18 column (2.1 × 150 mm, 1.9 μm) at 40 °C, and detected by UPLC-ESI-MS/MS. Results The resolution and the limit of detection (LOD) of Ac-DL-Leu were 1.75 and 1.50 fmol, respectively. The linear range of Ac-DL-Leu was 10–2000 fmol and the determination coefficient (R 2 ) was above 0.9997. The recovery of Ac-DL-Leu in human nails was 96.92–105.69 %. The contents of Ac-D-Leu and Ac-L-Leu were analyzed in 18 HVs, 13 PDs and 16 DPs fingernails. The results showed that their contents were significantly lower in DPs than in PDs and HVs ( p < 0.0001). Conclusions A method for evaluating the effectiveness of Ac-DL-Leu enantiomers in human fingernails as a biomarker for diabetes was firstly developed.
研究领域:
分析化学
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医学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）