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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY · 2019 ·Vol. 103 ·期 1 ·199-205 · IF 1.65

Different Uptake of Metal Dioxide Nanoparticles (Ceria Nanoparticles, Zirconia Nanoparticles and Silica Nanoparticles) by Wheat

Zhang Wanying,Huang Yingnan,Gong Hua,Dang Fei,Zhou Dongmei

Metal dioxide nanoparticles (NPs) are produced in ever-increasing amounts and widely used in industrial, medical and consumer products. They may pose potential risks to the environment. In this study we quantitatively evaluated the phytoavailability of CeO 2 NPs, ZrO 2 NPs and SiO 2 NPs to wheat ( Triticum aestivum L.). Metal dioxide NPs showed distinct differences in uptake, with uptake rate constants of 90.2 ± 9.9, 12.2 ± 2.5, 0.4 ± 0.02 and 0.9 ± 0.1 L kg −1 h −1 for ZrO 2 NPs, CeO 2 NPs, SiO 2 NPs (13 nm) and SiO 2 NPs (25 nm), respectively. However, such difference cannot be generalized by single factor of NP characteristics and/or root damage. This study provides fundamental information for NP uptake by crop plants.

研究领域: 环境科学 · 植物学

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METABOLIC ENGINEERING · 2021 · IF 9.783

Systems metabolic engineering of Vibrio natriegens for the production of 1,3-propanediol

Ye Zhang,Zihua Li,Yu Liu,Xuecong Cen,Dehua Liu,Zhen Chen

The economic viability of current bio-production systems is often limited by its low productivity due to slow cell growth and low substrate uptake rate. The fastest-growing bacterium Vibrio natriegens is a highly promising next-generation workhorse of the biotechnology industry which can utilize various industrially relevant carbon sources with high substrate uptake rates. Here, we demonstrate the first systematic engineering example of V. natriegens for the heterologous production of 1,3-propanediol (1,3-PDO) from glycerol. Systems metabolic engineering strategies have been applied in this study to develop a superior 1,3-PDO producer, including: (1) heterologous pathway construction and optimization; (2) engineering cellular transcriptional regulators and global transcriptomic analysis; (3) enhancing intracellular reducing power by cofactor engineering; (4) reducing the accumulation of toxic intermediate by pathway engineering; (5) systematic engineering of glycerol oxidation pathway to eliminate byproduct formation. A final engineered strain can efficiently produce 1,3-PDO with a titer of 56.2 g/L, a yield of 0.61 mol/mol, and an average productivity of 2.36 g/L/h. The strategies described in this study would be useful for engineering V. natriegens as a potential chassis for the production of other useful chemicals and biofuels.

CAS / MDL: 107-02-8

研究领域: 生物技术 · 代谢工程 · 微生物生物技术

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Different Uptake of Metal Dioxide Nanoparticles (Ceria Nanoparticles, Zirconia Nanoparticles and Silica Nanoparticles) by Wheat

Systems metabolic engineering of Vibrio natriegens for the production of 1,3-propanediol