Using mechanical cues for cancer cells can realize precise control and efficient therapeutic effects. However, the cell cycle-specific response for dynamic mechanical manipulation is barely investigated. Here, RGD-modified iron oxide nanomanipulators were utilized as the intracellular magneto-mechanical transducers to investigate the mechanical impacts on the cell cycle under a dynamic magnetic field for cancer treatment. The G2/M phase was identified to be sensitive to the intracellular magneto-mechanical modulation with a synergistic treatment effect between the pretreatment of cell cycle-specific drugs and the magneto-mechanical destruction, and thus could be an important mechanical-targeted phase for regulation of cancer cell death. Finally, combining the cell cycle-specific drugs with magneto-mechanical manipulation could significantly inhibit glioma and breast cancer growth in vivo . This intracellular mechanical stimulus showed cell cycle-dependent cytotoxicity and could be developed as a spatiotemporal therapeutic modality in combination with chemotherapy drugs for treating deep-seated tumors.
Flexible sensors which are highly stretchable, sensitive, and self-adhesive are critically required for wearable electronics, personalized healthcare monitoring and electronic skins. Conductive hydrogel-based sensors hold great promises for this purpose. However, it remains a critical challenge to integrate all the critical functions ( e.g. , remarkable stretchability, high sensitivity, and self-adhesiveness) into one hydrogel. Here, we propose a bio-inspired hybrid hydrogel framework with a hierarchical configuration that incorporates sodium casein, polydopamine, calcium chloride, and graphene oxide into a polyacrylamide hydrogel. Multiple interpenetrating network architectures and their strong interactions provide superior stretchability of 10,300%, high strain sensitivity with a gauge factor of 13.45 over a broad strain range, robust adhesiveness, fast responsiveness, and excellent reproducibility. This hydrogel-based wearable sensor demonstrates outstanding sensing performance in detecting, quantifying, and remotely monitoring human motions through integration into a cloud platform. A durable glove is further developed using the hybrid hydrogel for wirelessly controlling synchronized motions of a manipulator and accurately recognizing hand gestures. This hybrid hydrogel has shown wide-range applications in fields including wearable electronics, human–machine interfaces, and electronic skins.
危险品化学品经营许可证（带存储）