Yunfei Zuo,Pei Li,Wen-Jin Wang,Changhuo Xu,Shuting Xu,Herman H. Y. Sung,Jianwei Sun,Guorui Jin,Weiping Wang,Ryan T. K. Kwok,Jacky W. Y. Lam,Ben Zhong Tang
Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor-specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ-H 2 is designed that can realize robust theranostic effects both in vitro and in vivo. In vitro, TQ-H 2 specifically targets the lysosome and reacts with hydroxyl radical (·OH) to generate TQ-HA, which lights up the cells. TQ-HA generates reactive oxygen species (ROS) under light irradiation, enabling the simultaneous induction and monitoring of apoptosis and ferroptosis in tumor cells. Remarkably, TQ-HA also acts as a self-amplifier, autocatalytically activating TQ-H 2 by generating ·OH under light exposure. This self-amplification aligns with the tumor microenvironment, where TQ-H 2 undergoes chemical transformation, distinguishing tumors from healthy tissue via near-infrared (NIR) fluorescence imaging. Furthermore, ROS generated by TQ-HA effectively kills tumor cells and inhibits tumor growth without harming normal cells. This study offers a promising strategy for targeted tumor theranostics using self-amplifying microenvironment-responsive fluorescent probes.
Yan Liang,Lingxia Xu,Fusheng Qu,Ke Tang,Hua Wang,William W. Yu
In this work, fluoranthene-modified polysiloxane (FMPS) was synthesized via the Diels–Alder reaction. This fluorescent polymer showed better thermal stability, stronger fluorescence emission, and higher sensitivity for picric acid (PA) detection with a super-amplification effect (LoD = 69.5 nM) compared with the monomer fluoranthene. Furthermore, FMPS exhibited much higher detection efficiency toward PA in the nanoparticle state (79 times) than in the solution state. We found that the excellent detection ability of FMPS could be attributed to its unique porous nanostructure. The results were confirmed by transmission electron microscopy, scanning electron microscopy, and theoretical calculations. This work provides guidance for the design of linear fluorescent polymers with rapid responses and high sensitivity toward nitroaromatic compound detection.
Electronic tattoos have great potential in health and movement sensing applications on the skin. However, existing electronic tattoos cannot be conformal, sticky, and multilayered at the same time. Here, we have achieved multilayered integration of the electronic tattoo that is highly stretchable (800%), conformal, and sticky. This electronic tattoo can enable the crease amplification effect, which can amplify the output signal of integrated strain sensors by three times. The tattoo can be transferred to different surfaces and form a firm attachment, where no solvent or heat is needed. The tattoo fabrication is straightforward and scalable; a layer-by-layer strategy and two materials (metal-polymer conductors and the elastomeric block copolymer) are used to fabricate the circuit module with desirable numbers of layers within the tattoo. A three-layered tattoo integrating 1 heater and 15 strain sensors is developed for temperature adjustment, movement monitoring, and remote control of robots.
危险品化学品经营许可证（带存储）