APPLIED CATALYSIS B-ENVIRONMENTAL
·
2016
·
IF 8.328
Min Jiang,Yilin Gao,Zhaoyu Wang,Zhengxin Ding
Spinel CuCo 2 O 4 nanoplates were synthesized through a solvothermal method coupled with a calcination treatment in air. The prepared CuCo 2 O 4 samples were fully characterized by diverse physical and chemical techniques including powder X-ray diffraction (XRD), field emission scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS) and N 2 sorption measurement. The CuCo 2 O 4 material was developed as an efficient, low-cost and stable cocatalyst to boost photochemical CO 2 conversion with Ru(bpy) 3 2+ as a homogeneous photosensetizer. The catalytic performance of the CuCo 2 O 4 samples was evaluated toward visible-light-driven deoxygenative reduction of CO 2 to CO under mild conditions. Various parameters of the reaction system and the synthesis conditions of CuCo 2 O 4 were investigated and optimized to maximize the catalytic performance of CO 2 reduction system. The stability and the reusability of the CuCo 2 O 4 cocatalyst were examined. Moreover, the CuCo 2 O 4 cocatalyst was further proved to be highly active to promote CO 2 photoreduction catalysed by CdS semiconductor as a heterogeneous light harvester, and markedly reinforced photocatalytic CO 2 reduction performance was achieved.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xingguo Zhou,Hanghang Liu,Yanhui Zheng,Yaobao Han,Tingting Wang,Hao Zhang,Qiao Sun,Zhen Li
Radiotherapy has been extensively used to treat cancer patients because it can effectively damage most solid tumors without penetration limits. A hypoxic microenvironment in solid tumors leads to severe radioresistance and expression of hypoxic inducible factor-1 (HIF-1), which results in poor efficacy of radiotherapy alone. Herein, we report the excellent efficacy of radiotherapy achieved using a new type of yolk–shell Cu2–xSe@PtSe (CSP) nanosensitizer functionalized with the HIF-1α inhibitor acriflavine (ACF). We prepare the CSP nanosensitizer through the interfacial redox reactions between chloroplatinic acid and Cu2–xSe nanoparticles (CS) and then functionalize the nanosensitizer with ACF through their electrostatic interactions. We show that the synthesized CSP nanosensitizer can arrest the cell cycle (i.e., at the gap 2/mitosis (G2/M) phases) of tumor cells to enhance their sensitivity to X-rays and decompose endogenous H2O2 into O2 to reduce hypoxia and increase the production of reactive oxygen species, which leads to severe damage to DNA double strands and apoptosis of tumor cells. We also show that the ACF on the surface of CSP nanoparticles can effectively reduce the expression of HIF-1α. All these effects lead to a low vascular endothelial growth factor, low density of microvessels in tumor, decreased cell proliferation, and increased cell apoptosis, which synergistically and drastically enhance the efficacy of radiotherapy. This work provides insights and guidance for developing novel nanosensitizers to enhance the efficacy of radiotherapy.
研究领域:
肿瘤学
·
纳米医学
·
放射生物学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Biomedical Nanotechnology
·
2022
·Vol. 18
·期 2
·369-380
·
IF 3.641
Li Shimei,Zhang Wei,Lan Xudong,Tan Longfei,Chen Xudong,Lv Kong-Peng,Huang Zhongbing,Gou Li,Wan Jing,Meng Xianwei
Microwave (MW) hyperthermia has been widely studied in tumor therapy, while the lack of specificity, and the potential toxicity induced by instability or difficulty in degradation of existed MW thermal sensitizers still limits the application. Herein, a new biocompatible Poly(lactic-co-glycolic
acid) (PLGA)-based nanosensitizer of Dtxl-Gd@PLGA-PEG-TPP (DGPPT) with capacities of magnetic resonance (MR) imaging and mitochondrial targeting for MW hyperthermia combined with chemotherapy was constructed via a double emulsion solvent evaporation method. The modified TPP significantly enhanced
the specificity of sensitizer for targeting mitochondria, a heat-sensitive energy supply plant in cells. Thus the MW thermal damage induced by the loaded Gd in PLGA nanospheres was also strengthened. Together, the system could also achieve MR imaging due to the existence of Gd. In addition,
the encapsulated Dtxl performed the chemotherapy of inhibiting mitochondrial function for assisting with MW hyperthermia. In vivo experiments demonstrated that PLGA had high biocompatibility that no obvious damage occurred even the dose was up to 200 mg/kg. Meanwhile, DGPPT+MW representing
the combination of mitochondrial targeting and MW hyperthermia-chemotherapy has also been proved to shrink tumor size effectively. This study provides a new direction for building biosafe and multifunctional MW sensitizer with active targeting ability to impede tumor growth.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Huajing Yang,Rui Li,Shiyang Jin,Yuhang Tian,Chunyue Wang,Yucao Sun,Zhifei Dai,Wen Cheng
Hepatocellular carcinoma (HCC) is the most common primary malignant disease of the liver. Although immunotherapy offers new opportunities for treating advanced HCC, its therapeutic effect is still limited by the immunosuppressive tumor microenvironment (TME). Herein, a nanosensitizer RGD@Ce6@MSA-2@Liposome (RCM-Lip) is synthesized to specifically initiate the HCC tumor immune microenvironment through sonodynamic therapy (SDT)-triggered immunogenic cell death (ICD) and MSA-2-activated cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. RCM-Lip consists of a sonosensitizer (Chlorin e6, Ce6) with a STING agonist (MSA-2) and a tumor targeting peptide RGD inserted on the outer liposome surface. Under ultrasound irradiation, RCM-Lip generates reactive oxygen species that induce cytotoxicity and apoptosis of tumor cells. Meanwhile, tumor antigens released by apoptosis are taken up by dendritic cells (DCs), while STING is activated in the DCs by MSA-2. Moreover, DC maturation is stimulated, further enhancing the systematic anti-tumor immune responses. Sono-immunotherapy mediated by RCM-Lip promotes DCs maturation and tumor infiltration of CD8 + T cells, increasing inflammatory cytokine secretion. Consequently, the immunologically “cold” TME of HCC is successfully turned into a “hot” one, leading to a significant tumor suppression effect with good bio-safety. These results suggest a promising method for precise tumor targeting and synergistic cancer sono-immunotherapy. Statement of Significance Our study addressed the therapeutic dilemma of hepatocellular carcinoma (HCC) as an immunological “cold” tumor by the synergistic application of sonodynamic therapy (SDT) and STING agonist. The cGAS-STING signaling pathway plays a pivotal role in innate immunity against cancer, but the clinical application of STING agonists were hampered by inflammatory responses due to off-target activation. Our innovative solution introduces RGD-targeted peptide to encapsulate sonosensitizer and STING agonist, strengthening therapeutic effects and reducing systemic toxicity. The targeted sono-immunotherapy promoted DCs maturation and tumor infiltration of CD8 + T cells, producing intense tumor-killing effect on mice model with good bio-safety. As a result, the immunological “cold” tumor microenvironment of HCC is successfully turned into a “hot” one.
研究领域:
肿瘤学
·
免疫学
·
医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science Bulletin
·
2025
·
IF 21.1
Qiang Wang,Yingfei Wen,Bo Bi,Kuan Li,Yuanqi Liu,Binbin Li,Shangbo Zhou,Zihang Li,Jiaqi Xu,Miaojuan Qiu,You Li,Meiying Wu,Yu Chen,Wei Wu,Jing Zhao
Peritoneal metastasis (PM) is typically intractable by immunotherapy due to an immunosuppressive microenvironment and the peritoneal-plasma barrier. Sonodynamic therapy (SDT) presents unique advantages of noninvasive in situ treatment and the potential for antitumor immune activation. Building upon SDT technology, the study reports on a novel biodegradable sonosensitizer, CaS 2 O 8 , characterized by a narrow bandgap, abundant oxygen vacancies and a rapid ultrasound (US) response for abdominal SDT. Such sonosensitizer only produces lethal reactive oxygen species (ROS) after US irradiation, which is nontoxic in a physiological environment. After US irradiation, CaS 2 O 8 yields a large amount of sulfate radical (•SO 4 - ), as well as sonodynamic related ROS (•OH, and 1 O 2 ), which exerts a synergistic effect with Ca 2+ overload to induce Z-conformation nucleic acid by augmenting oxidative damage. As a result, the PANoptosis is initiated through the ZBP1/RIPK3 pathway in tumor cells. This inflammatory cell death leads to a multi-faceted release of tumor cell contents which serve as an in situ tumor antigen to induce a robust antitumor immune response. Notably, the precision sono-immunotherapy enhances the infiltration of T cells into tumors by transforming an immunosuppressive phenotype into an immunostimulatory one. Therefore, targeting PANoptosis by CaS 2 O 8 -induced SDT can provide an alternative or additional clinical treatment and prolonged survival outcome for patients with PM.
研究领域:
肿瘤学
·
生物医学工程
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Rui Lin,Hui Zhou,Xuee Xu,Xinhua Ouyang
Solid additives have been demonstrated as a simple and effective approach to improve the performance of organic solar cells (OSCs). The exploitation of excellent solid additive is an important aspect to obtain efficient OSC. This research designs and synthesizes a novel solid additive IDT(BDT-IC) 2 as the sensitizer for OSCs. The IDT(BDT-IC) 2 is an A-π- d -π-A type molecule, which possesses a highly planar π-conjugated structure. This molecule exhibits a complementary light absorption with suitable energy levels, which meets the requirement of a qualified sensitizer. It helps to enhance the external quantum efficiency spectrum of the device. Thus, an increased photocurrent is achieved. The addition of IDT(BDT-IC) 2 promotes the formation of a cascade energy level alignment and tunes the miscibility of the active layer. Both the exciton dissociation and electron transportation are improved, which enhances the fill factor. As a result, the average power conversion efficiency (PCE) of the PM6:Y6 OSC is increased from 15.75 % of the control device to 16.34 % by incorporating merely 0.25 wt% of IDT(BDT-IC) 2 . And the highest PCE with a value of 16.70 % is obtained. This research offers a facile and effective strategy for highly efficient OSCs by applying solid additive as the sensitizer.
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 3
·期 7
·3777-3784
·
IF 0
Guojian Tian,Shengyun Cai,Xin Li,Hans Ågren,Qiaochun Wang,Jinhai Huang,Jianhua Su
Two new D–A–π–A configuration metal-free organic sensitizers (T1–T2) based on 5,7-dihexyl-6,12-diphenyl-5,7-dihydroindolo[2,3-b]carbazole and a DPP unit with a bulky branched alkyl chain have been synthesized for dye-sensitized solar cells. Due to a bulky branched alkyl chain being attached to the donor and DPP unit, both compounds obtain high Voc values. Under standard global AM 1.5 solar light conditions, the T1 based-device gives a high conversion efficiency of 8.24% with a Jsc of 15.72 mA cm−2, a Voc of 0.74 V and a FF of 0.71. These excellent performances make the donor dihydroindolo[2,3-b] carbazole and DPP unit promising candidates for further application in DSCs.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
RSC Advances
·
2020
·Vol. 10
·期 71
·43290-43298
·
IF 3.119
Xinxin Wang,Xiuhua Hang,Altan Bolag,Wu Yun,Tana Bao,Jun Ning,Hexig Alata,Tegus Ojiyed
Aiming to explore the relationship between the molecular structure and photovoltaic performance, three pyran isomer dyes DO, DM and DP were synthesized and applied as a co-sensitizer with N719 dye in dye-sensitized solar cells (DSCs). These sensitizers were investigated by theoretical calculation, UV-vis absorption spectroscopy and cyclic voltammetry measurement to understand their structure, optical and electrochemical properties. The DSC devices based on N719 and the co-sensitizers were characterized using I–V tests, incident photon-to-current conversion efficiency and electrochemical impedance spectroscopy measurements. As compared to the standard N719-based DSCs, the co-sensitization system of N719 and DM with the most sterical structure exhibited an enhancement of the power conversion efficiency (PCE) by 18% from 7.60% to 8.96%. Both the short-circuit photocurrent density (Jsc) and open-circuit voltage (Voc) of the co-sensitized systems were increased resulting from the better maintained N719 dye loading amount on TiO2 as well as the prevention of dye aggregation. Co-sensitization of the DO molecule with less steric hindrance reduced the desorbed N719 dye amount by half leading to a decline of the photo-harvesting ability and photocurrent generation in DSCs.
研究领域:
材料科学
·
物理化学
✓ 已验证
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2020
·
IF 6.513
Yihui Wang,Yue Sun,Shupei Liu,Lijuan Zhi,Xiaobing Wang
Titanium dioxide (TiO 2 ) nanoparticle has good photo-/sono-catalytic features, the reunion of this particle in solution-phase generally limits the extensive biomedical application. In the present study, the aggregation of TiO 2 nanoparticles was alleviated by facile fabrication under different pH conditions. A novel TiO 2 nanocomposite was further synthesized by properly conjugation with trace amount of DVDMS sensitizer (named DFT). The characterization, sonoactivity, as well as the antibacterial efficiency were specially evaluated. The results showed that the sonochemical activity of DFT was greatly improved as compared with the simple surface modification of TiO 2 (F-TiO 2 ) and free DVDMS, regarding to the hydroxyl radicals and singlet oxygen yields using the same ultrasound exposure. Moreover, ultrasonic stimulation of DFT exhibited excellent bacterial eradication, with up to 92.41% of killing efficiency in S. aureus . The flow cytometry analysis indicated an increased intracellular ROS and membrane disturbance by combination of DFT and ultrasound. The findings suggest that the proper fabrication and DVDMS incorporation greatly improved the sonocatalytic process of TiO 2 , and the ultrasound based biomedical applications of DFT deserve future deep investigation.
研究领域:
材料科学
·
生物医学工程
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2016
·
IF 4.055
Hao-Liang Cheng,Zu-Sheng Huang,Lingyun Wang,Herbert Meier,Derong Cao
Two novel zinc porphyrin dyes containing either benzotriazole or 2 H -[1,2,3]triazolo[4,5- c ]pyridine as auxiliary acceptors, respectively, were synthesized for dye-sensitized solar cells. These two auxiliary acceptors were firstly applied into porphyrin based dyes. The photophysical and electrochemical properties of the dyes were investigated. These two dyes show the whole visible light absorption when they are adsorbed on the TiO 2 film, which means that they are promising sensitizers for dye-sensitized solar cells. The absorption intensity of the triazolopyridine containing dye is higher than that of the benzotriazole containing dye, resulting in a better light harvesting. Thus, the dye-sensitized solar cell based on the former dye achieved higher conversion efficiency of 6.65% than the cell based on the latter dye (6.17%) with chenodeoxycholic acid as the coadsorbant.
研究领域:
材料科学
·
光化学
·
能源科学
✓ 已验证
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2024
·
IF 3.7
Wen-Yuan Zhang,Yu-Xia Li,Wen-Le Zhang,Bo Wang,Xue-Qin Sun,Yu-Kui Hu,Jia-Cheng Liu
Dye-sensitized solar cells (DSSCs) are considered a promising solution to current energy challenges. In this study, three porphyrin sensitizers ZnP1–ZnP3 with donor-π-acceptor (D-π-A) configurations were synthesized. The donors included 9,9-dimethylfluorene, 4-biphenyl, and 1,1′:3′,1″-terphenyl groups, whereas alkynylbenzoic acid was used as the acceptor. The modification of the side alkyl chain addressed the poor solubility of the porphyrin sensitizer. The synthesized porphyrin sensitizers were structurally characterized by nuclear magnetic resonance, high-resolution mass spectrometry, and ultraviolet absorption spectroscopy. The introduction of electron donor groups into 1,1′:3′,1″-terphenyl and alkynylbenzoic acid into the acceptor group improved the light-harvesting ability of the sensitizer, increased the short-circuit photocurrent density, and enhanced cell efficiency ( η = 3.6%). Finally, density functional theory was used to verify the experimental results.
研究领域:
材料科学
·
化学
·
可再生能源
✓ 已验证
DOI
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Yu Zhang,Man Shu,Xiao Chu,Jielong Zhou,Qiao Zhou,Guoqing Zhong,Renshan Li,Yue He,Guiquan Zhang,Ziyang Xu,Teliang Lu,Mei Li,Xiongfa Ji,Anjun Qin,Jin Ke,Zhidan Tan
Osteosarcoma (OS) is an aggressive malignant tumor with high recurrence and metastatic potential, primarily affecting adolescents. Despite the standard clinical "sandwich" treatment regimen, patient survival rates have remained stagnant. Microwave ablation (MWA), known for its rapid heating and strong tissue penetration, has emerged as a viable therapeutic strategy for bone tumors. However, MWA poses challenges, particularly the potential for iatrogenic damage to adjacent healthy tissues and the concern that inappropriate energy delivery parameters may paradoxically stimulate neoplastic progression. In this study, microwave-triggered organic nanoparticles, termed ATT, were synthesized via a spontaneous [2+2] cycloaddition-cycloreversion (CA-CR) reaction. Findings from cell-based assays and animal studies indicated that ATT effectively generated reactive oxygen species (ROS) and produced heat under microwave (MW) irradiation, achieving a remarkable tumor inhibition rate of 95%. Owing to its unique donor-acceptor (D-A) structure and twisted molecular configuration, ATT facilitates efficient charge transfer under MW irradiation. The process generates electron-hole pairs, enhancing ROS production and enabling effective microwave dynamic therapy (MDT) effect. Moreover, ATT acts as a polar molecule that efficiently absorbs MW and generates heat through resonance, thereby potentiating the therapeutic performance of microwave thermal therapy (MTT). This study presents a novel microwave-triggered organic nanomaterial that integrates MTT and MDT, offering a prospective therapeutic intervention for OS.
研究领域:
肿瘤学
·
纳米医学
·
生物有机化学
·
治疗放射学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）