POLYMER SCIENCE SERIES A
·
2021
·Vol. 63
·期 2
·143-153
·
IF 1.206
Qiuyue Guo,Chen Yuying,Li Xin,Liu Jun,Gu Qintian,Hu Jian,Jiang Yan,Zhang Hongwen,Liu Hongbo
Abstract In this paper, partly esterified β-cyclodextrin derivative had been synthesized by esterification of β-cyclodextrin and maleic anhydride. Then, it is amidated by diethanolamine. β-Cyclodextrin copolymer had been prepared from amidated β-cyclodextrin derivative, cholic acid and epichlorohydrin in sodium hydroxide aqueous solution. β-Cyclodextrin hydrogel had been prepared through radical polymerization of β-cyclodextrin copolymer, N -isopropylacrylamide and acrylic acid. The structures, compositions and morphology of the hydrogel were characterized by infrared spectroscopy, nuclear magnetic resonance, differential scanning calorimetry and field-emission scanning electron microscope. Its properties were tested and analyzed by ultraviolet spectroscopy, thermogravimetric analysis and swelling experiments. The results show that the β-cyclodextrin hydrogel owns sustained release performance, temperature and pH sensitivities.
研究领域:
材料科学
·
化学工程
·
生物医药
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DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 11
·1544
·
IF 4.7
Shu Wang,Jianyu Pu,Shuquan Xu,Yuanhao Tian,Qian Shu,Rui Zou,Tonghua Zhang
The development of smart protective clothing will help detect injuries from contact sports, traffic collisions, and other accidents. The combination of ecoflex, spacer fabric, and graphene-based aerogel provides a multifunctional composite. It shows a strain sensitivity of 17.71 at the strain range of 40~55%, a pressure sensitivity of 0.125 kPa−1at the pressure range of 0~15 kPa, and a temperature sensitivity of −0.648 °C−1. After 50 impact tests, its protection coefficient only dropped from 60% to 55%. Additionally, it shows thermal insulation properties. The compression and impact process results of finite element numerical simulation analysis are in good agreement with the experimental results. The ecoflex/aerogel/spacer fabric sensor exhibits a simple structure, large pressure strain, high sensitivity, flexibility, and ease of fabrication, making it a candidate for smart protective clothing resistant to impact loads.
研究领域:
材料科学
·
生物医学工程
·
传感器技术
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产品关联
DOI
PubMed
高影响因子
Energetic Materials Frontiers
·
2025
·
IF 3.9
Bo-wei Gao,Yan-ze Liu,Xiao-feng Guo,Xu-ran Xu,Hai-feng Yang,Guang-cheng Yang,Jing Lv,Ling-hua Tan
Based on a simple catechol-amine co-precipitation strategy and biomimetic adhesion characteristics, this study prepared a desensitized CL-20@PCPA core-shell energetic powder using the phenolic and amino compound containing low-cost polycatechol/polyamine (PCPA). The results indicate that the CL-20@PCPA composite powder exhibited an elevated characteristic drop height of impact sensitivity ( H 50 ) of 34.9 cm and a reduced friction explosion probability of 56% compared to pure CL-20. PCPA, containing catechol and amine groups, provided a stable platform for secondary modification to enhance the safety of the powder further. Notably, when the CL-20@PCPA@MXene powder was introduced into a propellant system, the resulting propellants displayed a high H 50 value of 20.3 cm while its heat of detonation remained unchanged. This study provides a simple and low-cost biomimetic interface modification strategy for preparing desensitized energetic materials.
研究领域:
材料科学
·
爆炸物安全
·
界面工程
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产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2020
·
IF 4.089
Mi Yan,Yu Liu,Jinjiang Xu,Liyuan Yang,Lin Zhang,Fude Nie,Shiliang Huang
A crystal engineering strategy has been adopted to prepare a porous high explosive, cyclotrimethylenetrinitramine (RDX). Raw RDX was crystallized with TMS, CAM, and HMPT (TMS = tetramethylene sulfone, CAM = ε-caprolactone monomer, and HMPT = hexamethylphosphoramide), forming three solvates, RDX·TMS, RDX·CAM, and RDX·HMPT, respectively. After desolvation by vacuum pyrolysis and antisolvent extraction, porous RDX containing micro- and nanoscale pores was successfully prepared. The porous RDX exhibits remarkably reduced impact, friction, and electrostatic spark sensitivity in comparison to raw RDX. A mechanism of the reduced sensitivity of porous RDX has also been proposed.
研究领域:
化学工程
·
材料科学
·
爆炸物研究
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产品关联
DOI
高影响因子
PROPELLANTS EXPLOSIVES PYROTECHNICS
·
2023
·Vol. 48
·期 12
·e202300002
·
IF 1.8
Jin Yu,Hanyu Jiang,Siyu Xu,Ergang Yao,Haixia Hao,Heng Li,Yiping Wang,Meng Li,Qing Pei,Yang Zhang,Fengqi Zhao
In order to improve the security of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX) preparation and application process, microfluidic technology was used to improve the crystal quality and surface coating in one step. Using polydopamine (PDA) as coating material, the insensitive HMX@PDA particles were prepared. The morphology, particle size and crystal form of HMX@PDA are regulated by supersaturation. When the concentration of HMX is 0.15 g ⋅ mL −1 , the flow ratio of the two-phase solution is 1 : 1, and the total flow rate is 10 mL ⋅ min −1 , the properties of the samples were optimized to the greatest extent. At this point, the particle size of the sample was about 25 μm, SPAN value is 1.02, which is a stable β -HMX@PDA at room temperature. Through the test, the friction sensitivity and impact sensitivity of HMX@PDA were 36 % and 56 %, which were 52 % and 28 % lower than that of raw HMX, respectively. Meanwhile, the energy of HMX@PDA was not significantly decreased. Thermal analysis showed that PDA inhibited the β → δ crystallization process of HMX at high temperature but did not affect the thermal decomposition process of HMX. This case of preparing HMX@PDA in one-step with microfluidic technology provides a new idea for the desensitization of energetic materials in the future.
研究领域:
材料科学
·
化学工程
·
爆炸物研究
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 91
·88306-88314
·
IF 3.289
Ping Yong,Yuejiao Yang,Zhiyong Wang,Liming Yang,Jie Chen
A thermo- and dual-pH-sensitive ABC triblock copolymer composed of poly(N-isopropylacrylamide)-block-poly(acrylic acid)-block-poly(4-vinyl pyridine) (PNIPAM-b-PAA-b-P4VP, NAV) was synthesized via sequential reversible addition–fragmentation chain transfer (RAFT) polymerization and subsequent hydrolysis. NAV, which had the property of multi-stimuli, containing thermo-sensitive PNIPAM block and opposite pH-sensitive PAA and P4VP blocks, formed diverse nanostructures in an aqueous solution by varying the temperature and pH. Nanostructures including large compound micelles (LCMs), vesicles, spherical micelles and 3D topologies were observed using dynamic light scattering (DLS) and transmission electron microscopy (TEM). More significantly, the solation–gelation behaviour and morphology of the NAV system induced by temperature and pH were investigated by rheology and scanning electron microscopy (SEM), respectively. TEM and SEM revealed that the gelation behaviour of NAV resulted from the bridge effect of the ionized PAA chains between the hydrophobic P4VP cores (V-core) and PNIPAM cores (N-core) over the LCST of PNIPAM. The results obtained from the rheology measurements showed that the gelation temperature was independent of alkaline pH, but slightly tuned by the copolymer concentration or pH (only 6 to 7). Repeated sol–gel transition via temperature changes under alkaline conditions showed the good hydrogel recyclability of NAV.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2024
·
IF 5.9
Jun Gao,Miaomiao Li,Haiying Chen,Ze Xu,Junyao Li,Yong Kong,Xiaoming Zuo
Stimuli-responsive copolymeric hydrogels (CH) are synthesized for controlled drug delivery. Oxidized glycyrrhizic acid is connected to acrylamide through Schiff base reaction, which is then copolymerized with N,N-bis (acryloyl) cystamine and N-isopropylacrylamide by free-radical polymerization for the loading of 5-fluorouracil with a loading efficiency of 96.7 %. The lower critical solution temperature of the CH is 39.14 °C. The N-isopropylacrylamide unit in the CH is sensitive to temperature, endowing the CH with temperature sensitivity. The carboxyl groups of oxidized glycyrrhizic acid can be deprotonated in alkaline solutions, and the electrostatic repulsions between the resultant carboxylate can cause swelling of the CH. The disulfide bond (S–S) of the N,N-bis (acryloyl) cystamine unit can be reduced to sulfhydryl (–SH) by glutathione, and thus the CH is also reduction-sensitive. Therefore, temperature, reduction and pH-controlled delivery of 5-fluorouracil from the CH is achieved. Cytotoxicity assay reveals that the drug-free hydrogels have good biocompatibility while the CH shows high cytotoxicity against human hepatoma SMMC-7721 cells, and the cell viability is only 25 % at the CH concentration of 1 mg mL −1 .
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
高影响因子
Gels
·
2024
·Vol. 10
·期 7
·480
·
IF 5
Jiaqi Wang,Wanying Yang,Yutong Li,Xuerong Ma,Yuxin Xie,Guangyan Zhou,Shouxin Liu
Hydrogels are widely used as excellent drug carriers in the field of biomedicine. However, their application in medicine is limited by their poor mechanical properties and softness. To improve the mechanical properties of hydrogels, a novel triple-network amphiphilic hydrogel with three overlapping crosslinking methods using a one-pot free-radical polymerization was synthesized in this study. Temperature-sensitive and pH-sensitive monomers were incorporated into the hydrogel to confer stimulus responsiveness, making the hydrogel stimuli-responsive. The successful synthesis of the hydrogel was confirmed using techniques, such as proton nuclear magnetic resonance spectroscopy (1H NMR), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). In order to compare and analyze the properties of physically crosslinked hydrogels, physically–chemically double-crosslinked hydrogels, and physically–chemically clicked triple-crosslinked hydrogels, various tests were conducted on the gels’ morphology, swelling behavior, thermal stability, mechanical properties, and drug loading capacity. The results indicate that the triple-crosslinked hydrogel maintains low swelling, high mechanical strength, and good thermal stability while not significantly compromising its drug delivery capability.
研究领域:
生物材料学
·
高分子化学
·
生物医药工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemical Engineering and Processing-Process Intensification
·
2021
·
IF 4.237
Weikun Li,Hongliang Wei,Yuhua Liu,Songmao Li,Gang Wang,Tao Guo,Huayun Han
Hydrogel microspheres (HMs) were prepared from hydroxyethyl starch and carboxymethyl chitosan via in situ reactive spray drying, using epichlorohydrin as the crosslinking agent. SEM characterization showed the HMs were spherical and collapsed structures. The swelling behavior and adsorption performance of the HMs were studied systematically. The experimental results demonstrated that HMs possessed pH and salt sensitiveness and the maximum adsorption capacities of HMs for methylene blue, Eosin Y, Cd 2+ , Cu 2+ , and Ni 2+ were 106.97 mg/g, 143.55 mg/g, 32.51 mg/g, 47.87 mg/g, and 27.18 mg/g, respectively. Further study indicated that the adsorption isotherms and kinetics were respectively fitted with the Langmuir isotherm model and the pseudo-second-order model. In view of the advantages of in situ reactive spray drying for the preparation of novel pH- and salt- responsive HMs, the strategy presented here has a great application potential in wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Yang Xiaoli,Zhang Xiaomin,Zhang Han,Cong Yuhan,Wang Zitan,Ye Erkang
MXene-based hydrogels have become important materials for epidermal applications due to their excellent conductive properties and biocompatibility. Nonetheless, the application of such materials in the epidermal field is limited because of insufficient mechanical properties, unidimensional stimulus response, and complex preparation methods. In this study, an MXene-based hydrogel with outstanding self-healing, temperature sensitivity, and pH sensitivity was prepared by a one-pot method at 60°C for 5 h. The hydrogel is composed of Ti 3 C 2 T x MXene nano-slices, polyacrylamide (PAM), poly( N -isopropylacrylamide) (PNIPA), and polyacrylic acid (PAA), denoted as MXene/PAM/PNIPA/PAA hydrogel (MPANA hydrogel). The MPANA hydrogel exhibits excellent mechanical properties. Its tensile strength, elastic modulus, toughness, and elongation at break are 2.79 MPa, 0.64 MPa, and 51 MJ/m 3 , 412%, respectively, which indicates that the hydrogel possesses good stretchability. Moreover, the MPANA hydrogel demonstrates good self-healing ability, attaining an average strain self-healing efficiency of 94%, achieved in 12 h. Additionally, the MPANA hydrogel shows impressive thermal response sensitivity (−1.3560% °C −1 ) and a rapid pH response time (32–53 s). In conclusion, the MPANA hydrogel has significant potential for applications in epidermal sensors. Graphical
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2016
·
IF 1.733
Kangqi Sun,Juhua Guo,Yufeng He,Pengfei Song,Yubing Xiong,Rong-Min Wang
Using feather keratin (FK) as a biocompatible and inexpensive biopolymer, a kind of dual-sensitive keratin-based polymer hydrogel (FK/PNiPA/PIAc-Gel) with interpenetrating network structure was prepared by two-step polymerization of N-isopropyl acrylamide (NiPA) and itaconic acid (IAc) in presence of crosslinker. After being characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy, its swelling behaviors and environmental sensitivity were investigated. The obtained biopolymer based hydrogel has good swelling and deswelling performance, and it is sensitive to pH value, temperature and salts of environment. Using anticancer drug, doxorubicin hydrochloride (Dox·HCl), and Bovine serum albumin (BSA) as different drug molecules, its release behaviors in different environment were investigated. It was found that the release behaviors of FK/PNiPA/PIAc-Gel were controllable via adjusting pH value or temperature of environment. The cumulative release of the anticancer drug (Dox·HCl) reached 93.3% within 16 h, and the cumulative release rate of macromolecular drug (BSA) got to 75.9% in 24 h. In summary, the keratin-based biopolymer hydrogel with interpenetrating network structure, pH-sensitivity and temperature sensitivity are potentially applied to sustain drug carrier and humid medicinal material in the biomedical field or clinical nursing field.
研究领域:
生物材料学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Jing Liao,Huihua Huang
A smart hydrogel with pH/magnetic dual sensitivity was synthesized by in-situ synthesis of Fe 3 O 4 inside carboxymethyl chitin hydrogel matrix prepared from Hericium erinaceus residue. The structure, pH/magnetic sensitivity, swelling and drug release behavior of the prepared hydrogels were investigated. The results showed that Fe 3 O 4 nanoparticles were successfully synthesized and uniformly distributed within the hydrogels. The prepared hydrogels could be attracted by the magnet and exhibited sustained shrinkage behavior at low pH, with the desirable pH/magnetic sensitivity. The formed Fe 3 O 4 could be developed inside the hydrogels by increasing the concentrations of precursor Fe 2+ /Fe 3+ ions, and the magnetic sensitivity of hydrogels was enhanced, while the pH sensitivity and swelling degree were weakened. The Fe 3 O 4 content-dependent behavior of the prepared hydrogels suggested the adjustable properties of hydrogels. The release of 5-Fu in simulated gastric and intestinal fluids followed the Fick diffusion mechanism and showed different release rates, indicating the pH-controlled drug release behavior.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）