Laser & Photonics Reviews
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2025
·
IF 10
Jun Gou,Xiutao Yang,Hang Yu,He Yu,Yuchao Wei,Ziyi Fu,Laijiang Wei,Zexu Wang,Jiayue Han,Zhiming Wu,Yadong Jiang,Jun Wang
Conventional nm-scale Bi 2 O 2 Se-based near-infrared (NIR) photodetectors (PDs) exhibit commendable performance in terms of responsivity and response speed. Currently, the growing complexity of application scenarios requires NIR PDs to possess not only these fundamental functionalities but also the capability for NIR polarization detection and operation well under dim light conditions. Here, this study proposes the 2D ReS 2 /3D Bi 2 O 2 Se homo-heterojunction PD, which exhibits high photo-response speed, polarization-sensitive detection capabilities, and enhanced sensitivity in the NIR spectrum. In detail, a device constructed from µm-thick Bi 2 O 2 Se demonstrates polarization-sensitive photodetection at a wavelength of 850 nm, exhibiting a polarization ratio of 1.4 achieved by applied voltage modulation. Based on photogating effect and strong intrinsic absorption, the homo-heterojunction PD also can detect light power level of nW at 1310 nm, with a response speed of ≈10 µs and responsivity of 34.8 A W −1 at this wavelength. Additionally, this configuration exhibits an outstanding specific detectivity exceeding 10 10 Jones within the wavelength range of 700 to 1310 nm. Even at a cut-off wavelength of 1550 nm, the device achieves a specific detectivity of ≈10 9 Jones. The ReS 2 /Bi 2 O 2 Se heterojunction NIR PD shows promise for advanced optoelectronic applications due to its high sensitivity and polarization-sensitive photodetection in NIR band.
研究领域:
材料科学
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光电子学
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
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IF 6.451
Yanan Xu,Hui Wu,Chusen Huang,Caiqin Hao,Beina Wu,Chongchong Miao,Shen Chen,Nengqin Jia
Vicinal-dithiol-containing Proteins (VDPs) are overexpressed in cancer cells and become a potential biomarker for aggressive tumors, the synthesized 2-p-aminophenyl-1, 3, 2-dithiarsenolane (VTA2) is proved to be a highly selective ligand for vicinal dithiols of VDPs in cells. In this report, we developed a new cytosensor based on three-dimensional (3D)-like VTA2-conjugated multiwalled carbon nanotubes (VTA2@MWCNTs) array modified indium tin oxide (ITO) electrode for sensitive and selective detection of VDPs-overexpression tumor cells. The layer-by-layer assembling and cellular detection performances of the 3 D -VTA2@MWCNTs-based cytosensor were investigated by atomic force microscopy (AFM) and electrochemical methods including cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). Attributed to signal amplification and targeting recognition of the 3 D -structured MWCNTs@VTA2, the fabricated cytosensor showed high specificity and sensitivity to the detection of VDPs-overexpression HL-60 cells ranging from 2.7×10 2 to 2.7×10 7 cells mL −1 with a low detection limit of ca. 90 cells mL −1 . Furthermore, the captured cancer cells on the cytosensor also could be directly visualized by optical microscopy technology. This proposed 3 D -MWCNTs array-based cytosensing strategy provides a simple, sensitive approach for non-invasive cell detection, presenting potential applications in cancer diagnosis.
研究领域:
生物传感器技术
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癌症诊断
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纳米材料应用
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Ru Wu,Sha Yu,Siyu Chen,Yuan Dang,Shao-Hua Wen,Jieli Tang,Yuanzhen Zhou,Jun-Jie Zhu
Enzyme-based electrochemical sensor possesses a significant advantage in the highly efficient detection of small molecules , however, the poor electron transport efficiency limits their wide application. In this study, taking advantage of the distinct biocatalytic activity of laccase and the excellent electroconductibility of carbon dots , a carbon dots-enhanced laccase-based electrochemical sensor for the detection of dopamine (DA) is established. Thereinto, laccase can specifically recognize DA and promote its electrocatalytic oxidation on the electrode, while, the carbon dots can be used as the immobilization substrate of laccase and enhance its electron transfer efficiency, thus achieving the highly sensitive detection of dopamine. The electrochemical performance of the modified electrode interface is studied by electrochemical impedance spectroscopy and differential pulse voltammetry . As demonstrated, the electrocatalytic activity of the proposed electrochemical sensor for DA is significantly improved and exhibits a low detection limit (0.08 μM) and a wide linear range (0.25 μM–76.81 μM). The excellent selectivity allows the sensor has the capacity for specific discrimination the DA from other interferents. Furthermore, by analyzing the DA in human serum verifies the practicability of this assay in real sample analysis.
研究领域:
生物化学
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医学检测
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DOI
PubMed
高影响因子
Materials Today Sustainability
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2022
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IF 7.244
T. Luo,Y. Chen,Y. Wang
Melanoma poses a great threat to human health. However, the typical methods of early diagnosis and real-time detection are still challenged due to low sensitivity and complicated operations. Tyrosinase (TYR) is a key biomarker in melanoma development. Currently, few methods based on rapid real-time detection of TYR are available. Rapid detection methods using carbon dots (CDs) as fluorescent probes are emerging. Here, we developed an optimal synthetic route for the preparation of DA-CDs that showed a good response to TYR in water, cell lysates, and mice serum samples. The generation of our DA-CDs did not require crosslinker and other adjuvants. It only required appropriate proportions of citric acid (CA) and dopamine (DA), and 330 s of microwave-assisted heating. Our design greatly shortened the synthetic time of DA-CDs and applies it to the rapid and sensitive detection of TYR for the first time. The linearity response for TYR was within the concentration range from 0.2 U/mL to 5 U/mL. In addition, the synthetic DA-CDs exhibited good biosafety in vitro and in vivo. Therefore, our DA-CDs have the potential to be mass-produced for TYR detection.
研究领域:
生物医学
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材料科学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Liyan Zhang,Xiaoting Liu,Nan Zhang,Xianqiang Liu,Wei Jiang
Sensitive and accurate detection of flap endonuclease 1 (FEN1) is essential to understand its roles in DNA replication and repair and explore its functions in tumor diagnosis and prognosis. Here, we designed a magnetic separation-assisted cascade hybridization chain reaction (HCR) amplification strategy for enzyme-free and sensitive detection of FEN1. Firstly, the forked dsDNAs contained the recognition site (5′ overhanging DNA flap) of FEN1 were modified on magbeads surface to form magnetic recognition probes. By the recognition and catalytic cleavage of FEN1, the 5′ flaps were removed into solution and then purified by magnetic separation. Then, the obtained flaps served as triggers to activate the linear-assembly of hairpin probes H1 and H2 (primary HCR), forming nicked double helices with split fragments. Finally, the fragments acted as new triggers to activate the branched-assembly of hairpin probes H3 and H4 (secondary HCR), causing fluorophore/quencher labeled on H3 far away and fluorescence recovery. Benefiting from the purification of triggers by magnetic separation and the signal amplification effect of cascade HCR, this strategy achieved a low detection limit of 3.6 × 10 −5 U μL −1 for FEN1, and enabled the assay of it in actual samples. The results demonstrate that our strategy will provide a potent approach for sensitive detection of FEN1 in early tumor diagnosis and prognosis.
研究领域:
分子生物学
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肿瘤诊断
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生物化学
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产品关联
DOI
高影响因子
CHEMICAL PAPERS
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2022
·Vol. 76
·期 10
·6323-6333
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IF 2.146
Li Yan,Wu Tingxia,Song Lingyu,Zhu Yongbao,Chen Yizhe,Huang Yufu,Tang Junping,Cheng Kai,Lin Donghai,Chen Guosong
Natural graphite has a large electrical conductivity in plane direction, hundreds times of that in vertical direction. Regulating graphite flakes perpendicular to the plane will improve the performance of the sensor. As a non-connected method, magnetic field-assisted orientation can be no-additives. However, some studies believe that diamagnetic materials are non-magnetic, and must be doped by ferromagnetic materials before oriented by a magnetic field. Here, original graphite flakes were vertically oriented by a low magnetic field during the electrode preparation to increase effective surface area. The performance of electrode was enhanced in both potassium ferricyanide/potassium ferrocyanide probe system and detection of hydroquinone (HQ) and catechol (CC). For HQ and CC detection, the sensitivities of vertically oriented graphite flakes electrode are 5.05 times and 6.35 times higher than that of graphite flakes without magnetic field, respectively. This magnetic alignment technology could construct other electrode materials for electrochemical sensors.
研究领域:
材料科学
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电化学传感器
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DOI
高影响因子
NANOTECHNOLOGY
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2022
·Vol. 33
·期 21
·215502
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IF 3.953
Fang-hui Wu,Guo-qiang Wen,Xiang-rui Luo,Xu-dong Xu,Zi Liu,Wen-bin Sun,Yan-shang Kang,Zhengquan Yan
To improve the sensitivity for electro-chemiluminescent (ECL) detection of chloramphenicol (CAP), a common broad-spectrum antibiotic, boron nitride quantum dots (BNQDs) were prepared with excellent photoelectric property and low toxicity. After its structure and electrochemical property were investigated in detail, it was noted that the ECL signal of Ru(Phen)32+ could be strengthened by the proposed BNQDs, which was further activated by ten's times in the presence of CAP. Under the optimized conditions, there was an excellent linear relationship between ΔECL and lgcCAP in a wide linear range from 1.0 × 10−10 to 1.0 × 10−6 mol l−1 CAP. The detection limit was super-low to be 3.3 × 10−11 mol l−1 (S/N = 3). When applied for CAP detection in real pharmaceutical and food samples, the recoveries were between 97.8% and 105.7% with R.S.D. less than 3.3%. A possible CAP-activated ECL mechanism of BNQDs-Ru(phen)32+ was also proposed. This work will offer a great potential for efficient monitoring of CAP pollution and clinical diagnosing of CAP-related diseases in future.
研究领域:
分析化学
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环境科学
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药学
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2019
·
IF 4.916
Chengqian Duan,Yuhua Dong,Qinglin Sheng,Jianbin Zheng
A non-enzymatic electrochemical sensor-NiCo 2 S 4 /GCE was constructed for sensitive and selective detection of hydrazine (N 2 H 4 ), which was designed based on porous nanostructure and synthesized through a facile hydrothermal method . The nanocomposite has been characterized using a series of characterizations such as X-ray powder diffraction (XRD), scanning electron microscopic (SEM), transmission electron microscopy (TEM), showing the porous NiCo 2 S 4 sphere was made of interconnected nanoparticles with porous structure. Electrochemical measurements revealed that the porous NiCo 2 S 4 sphere based sensor exhibited an excellent voltammetric response towards the N 2 H 4 oxidation with a wide linear range of 1.7 μM to 7.8 mM, a low detection limit of 0.6 μM (S/N = 3), a sensitivity of 179.1 μA mM −1 cm −2 . Moreover, determinations of N 2 H 4 in tap water samples were carried out by standard addition. Acceptable results with relative standard deviation of 2.1–3.0% and recovery of 95.20–103.6% were obtained for five parallel measurements. Therefore, NiCo 2 S 4 /GCE promised to be a new platform for electrochemical detection of N 2 H 4 .
研究领域:
材料科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Zhifeng Cai,Yi Zhang,Meiling Jin,Meiling Hao,Huijuan Yang,Yang Peng,Jingwen Lu,Yaofang Zhang,Jiaxu Dong,Jiali Ren,Ran Zhang,Ya Wang
One-pot means was performed for the rapid preparation of copper nanoclusters (Cu NCs), which were employed as a fluorescence system for the sensitive apigenin measurement in pharmaceutical samples. Herein, CuCl 2 aqueous solution was reduced to Cu NCs through ascorbic acid and the Cu NCs were protected through trypsin under 65 ℃ for 4 h. The entire preparation process was rapid, facile and environmentally friendly. The trypsin-capped Cu NCs were demonstrated through ultraviolet–visible spectroscopy, fluorescence spectroscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and fluorescence lifetime, respectively. The Cu NCs revealed blue fluorescence with emission wavelength around 465 nm under the excitation wavelength of 380 nm. The fluorescence weakening feature of Cu NCs with apigenin was observed. On this basis, a facile and sensitive turn-off fluorescent nanoprobe for the sensing of apigenin in real samples was developed. The logarithm of relative fluorescence intensity revealed a good linear relationship with apigenin contents from 0.5 μM to 300 μM with the detection limit of 0.079 μM. The Cu NCs-based fluorescent nanosensor have been employed to measure the apigenin amounts in real samples such as medical saline, bovine and human serum. The results revealed excellent potential of this Cu NCs-based fluorescent nanoprobe for the convention computation of apigenin amounts in real samples.
研究领域:
分析化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Shaozhen Jing,Xiaolei Wu,Xueliang Wang,Daniel Shiu-Hin Chan,Tsun-Yin Li,Chun-Yuen Wong,Chung-Hang Leung,Wanhe Wang,Jing Wang
Background Boron-containing drugs are widely used in anti-inflammatory, anti-bacterial, anti-tumor and other applications, thus it is important to develop methods for their detection. However, the sensitive detection of delanzomib through its boronic group remains challenging because of steric hindrance and interference from its own fluorescence. Results We report an iridium(III) complex containing the 1,2-dione group for the detection of delanzomib for the first time. The complex shows significantly decreased luminescence at 580 nm upon addition of delanzomib in aqueous solution. Complex 1 has good selectivity and sensitivity for delanzomib with a linear relationship in the range of 1 – 30 μM and a limit of detection (LOD) of 0.628 μM and a limit of quantification (LOQ) of 1 μM. Furthermore, complex 1 is successfully applied for the monitoring of delanzomib in health-related samples. Significance This study provides a solid basis for the advancement of analytical tools for the monitoring of boron-containing drugs.
研究领域:
分析化学
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药学
·
生物医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
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IF 7.504
Xuejiao Wang,Xupeng Zhu,Yiqin Chen,Mengjie Zheng,Quan Xiang,Zhixiang Tang,Guanhua Zhang,Huigao Duan
Highly sensitive and low-cost surface-enhanced Raman scattering (SERS) substrates are essential for practical applications of SERS. In this work, we report an extremely simple but effective approach to achieve sensitive SERS detection of molecules (down to 10–10 M) by using a particle/molecule/film sandwich configuration. Compared to conventional SERS substrates which are preprepared to absorb analyte molecules for detection, the proposed sandwich configuration is achieved by postassembling a flexible transparent gel tape embedded with plasmonic nanoparticles onto an Au film decorated with to-be-detected analyte molecules. In such a configuration, the individual plasmonic gel tape and Au film have low or no SERS activity but the final assembled sandwich structure shows strong SERS signal due to the formation of numerous hot spots at the particle–film interface, where the analyte molecules themselves serve as both spacer and signal probes. Because of its simple configuration, we demonstrate that the proposed SERS substrate can be obtained over a large area with extremely low cost. Particularly, because of the on-demand nature and the flexibility, such a postassembly strategy provides an ideal solution to detect the pesticide residue on fruit surfaces with significantly enhanced sensitivity.
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Xu-Qin Ran,Hai-Long Qian,Xiu-Ping Yan
Sensitive and precise determination of chloramphenicol (CAP) is of great significance for human health due to its high risk in trace amounts. Solid-state artificial nanochannels are expected to be highly promising sensing devices owing to single-molecule sensitivity, target-specific selectivity, and portability. Herein, we report an aptamer self-assembly-functionalized artificial nanochannel-based sensor for highly sensitive and precise determination of CAP. Aptamer self-assembly (AAs) served as the specific recognition component and were in situ grown on the surface of stable anodic aluminum oxide (AAO) nanochannels to develop an AAs@AAO nanochannel-based sensor. Selective interaction with CAP led to the disassembly of AAs and sensitive current change of AAs@AAO nanochannels, allowing sensitive and precise sensing of CAP in complex food samples. The developed AAs@AAO nanochannel-based sensor showed a wide linear range from 0.32 to 1600 pg. mL–1, low limit of detection (LOD) of 0.1 pg. mL–1, high precision with relative standard deviation of 2.9%, and quantitative recoveries of 93.4–102.2% for CAP in milk, milk powder, and honey samples. This work proposes a versatile nanochannel-based platform for facile, sensitive, and precise sensing of hazardous residues in food samples.
研究领域:
生物传感
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食品安全检测
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）