ACS Applied Materials & Interfaces
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2017
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IF 7.504
Jiulin Shen,Fu Li,Zhonghuan Cao,David Barat,Guoli Tu
Here we demonstrate a simple and effective method of fabricating polymeric scattering substrate for flexible organic light-emitting diodes (OLEDs) that require no costly patterning, etching, or molding processes, aspects that are desirable for the commercialization of large-scale lighting panels. Systematic study of the influences of relative index of refraction, particle size, and doping concentration on transmittance and haze of transparent colorless polyimide (cPI) films was carried out. It was found that the reduction of transmittance and haze of the doped films decreases along with the decrease of the difference of refractive index between the particles and polymer matrix, and it could be compensated by the increase of particle size or doping concentration.
研究领域:
材料科学
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光学工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2021
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IF 9.229
Wei Zhu,Xiaoqiang Feng,Zhiduo Liu,Menghan Zhao,Peng He,Siwei Yang,Shiwei Tang,Da Chen,Qinglei Guo,Gang Wang,Guqiao Ding
Surface-enhanced Raman scattering (SERS) substrates based on graphene and its derivatives have recently attracted attention among those interested in the detection of trace molecules; however, these substrates generally show poor uniformity, an unsatisfactory enhancement factor, and require a complex fabrication process. Herein, we design and fabricate three-dimensional (3D) graphene/silicon (3D-Gr/Si) heterojunction SERS substrates to detect various types of molecules. Notably, the detection limit of 3D-Gr/Si can reach 10–10 M for rhodamine 6G (R6G) and rhodamine B (RB), 10–7 M for crystal violet (CRV), copper(II) phthalocyanine (CuPc), and methylene blue (MB), 10–8 M for dopamine (DA), 10–6 M for bovine serum albumin (BSA), and 10–5 M for melamine (Mel), which is superior to most reported graphene-based SERS substrates. Besides, the proposed 3D-Gr/Si heterojunction SERS substrates can achieve a high uniformity with relative standard deviations (RSDs) of less than 5%. Moreover, the 3D-Gr/Si SERS substrates are reusable after washing with ethyl alcohol to remove the adsorbed molecules. These excellent SERS performances are attributed to the novel 3D structure and abundantly exposed atomically thin edges, which facilitate charge transfer between 3D-Gr and probe molecules. We believe that the 3D-Gr/Si heterojunction SERS substrates offer potential for practical applications in biochemical molecule detection and provide insight into the design of high-performance SERS substrates.
研究领域:
材料科学
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纳米技术
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分析化学
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生物传感
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Ting Zhou,Dechan Lu,Qiutian She,Cairou Chen,Jingbo Chen,Zufang Huang,Shangyuan Feng,Ruiyun You,Yudong Lu
We successfully prepared a two-dimensional surface enhanced Raman spectroscopy(SERS) substrate for the trace detection of Interleukin-6(IL-6) in plasma. Glycoproteins in serum were captured by a two-dimensional silver plate modified with 4-mercaptobenzoic acid (4-MPBA). And then, the [email protected] core-shell nanoprobes modified with IL-6 antibody accurately recognized IL-6 glycoprotein. The [email protected] NPs were embedded with Prussian Blue (PB) molecule, which only peaked at 2172 cm −1 in the biological silence zone. The calibration model of 4-MPBA and PB double signal molecules can avoid the interference of other glycoprotein macromolecules in the environment, thus realizing the quantitative detection of IL-6. The results showed that the higher the IL-6 content, the stronger the Raman signal. And the detection limit of IL-6 in serum can reach 5 pg/mL, the applicable range is 0.5–50000 pg/mL (R 2 = 0.9928). Therefore, this method can be used as a multifunctional SERS activity technology, which can be used to detect IL-6 ultra-sensitively and quantitatively.
研究领域:
生物传感
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分析化学
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分子诊断
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2019
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IF 8.456
Fengrui Xu,Fengguo Ma,Zhaozhao Ding,Liying Xiao,Xiaoyi Zhang,Qiang Lu,Guozhong Lu,David L. Kaplan
The formation of hot spots is an effective approach to improve the performance of surface-enhanced Raman scattering (SERS). Silk nanoribbons (SNRs), with a height of about 1–2 nm, and Au nanoparticles (AuNPs) were assembled by electrostatic interactions to introduce sandwich hot spot structures. These sandwich structures were optimized by tuning the ratio of SNRs and AuNPs, resulting in strong SERS signals with a sensitivity of 10–13 M and enhancement factor (EF) of 5.8 × 106. Improved SERS spectrum uniformity with relative standard deviation (RSD) about 11.2% was also achieved due to the homogeneous distribution of these hot spot structures. The inherent biocompatibility of SNRs and facile fabrication processes utilized endowed the SERS substrates significant benefits toward biomedical applications, confirmed by cytocompatibility and improved SERS bioimaging capacity in vitro. The results of this study suggest the feasibility of forming high performance bioimaging systems through the use of naturally derived materials with special nanostructures.
研究领域:
材料科学
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纳米技术
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生物医学工程
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分析化学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
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2024
·Vol. 14
·期 20
·14041-14050
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IF 3.9
Dongbo Xi,Ruipeng Chen,Shuyue Ren,Zhenhong Jia,Zhixian Gao
In the present study, we address the limitations of conventional surface-enhanced Raman scattering (SERS) techniques for sensitive and stable detection of melamine in food products, especially dairy. To overcome these challenges, we developed a novel SERS-active substrate by incorporating gold nanoparticles (AuNPs) onto carboxyl-functionalized two-dimensional (2D) MXene material doped with nitrides, specifically Au–Ti2N–COOH. Our strategy leverages the unique physicochemical properties of MXene, a class of atomically thin, 2D transition metal carbides/nitrides, with tunable surface functionalities. By modifying the MXene surface with AuNPs and introducing carboxyl groups (–COOH), we successfully enhanced the interaction between the substrate and melamine molecules. The carboxyl groups form hydrogen bonds with the amino groups on the melamine's triazine ring, facilitating the adsorption of melamine molecules within the ‘hotspot’ regions responsible for SERS signal amplification. A series of characterization methods were used to confirm the successful synthesis of Au–Ti2N–COOH composites.Using Au–Ti2N–COOH as the SERS substrate, we detected melamine in spiked dairy product samples with significantly enhanced sensitivity and stability compared to nitride-doped MXene alone. The detection limit in liquid milk stands at 3.7008 μg kg−1, with spike recovery rates ranging from 99.84% to 107.55% and an approximate RSD of 5%. This work demonstrates the effectiveness of our approach in designing a label-free, rapid, and robust SERS platform for the accurate quantitation of melamine contamination in food, thereby mitigating health risks associated with melamine adulteration.
研究领域:
材料科学
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分析化学
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食品安全
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产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
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2024
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IF 7
Shijie Liu,Lijun Zhao,Miaoyun Li,Jong-Hoon Lee,Yaodi Zhu,Yanxia Liu,Lingxia Sun,Yangyang Ma,Qiancheng Tu,Gaiming Zhao,Dong Liang
There is an urgent need for quick, sensitive, thorough, and low-cost preliminary screening and rapid identification method for probiotic resource development. Here, we constructed a culture-free, accurate and sensitive “separation-enrichment-detection” rapid evaluation and identification method of probiotics in fermented food based on Ramanomes technology, and established a Ramanome reference of lactic acid bacteria and yeasts by AgNPs nanostructure array (AgNPs NSA) chips with uniform “hot spots” and high signal enhancement ability as SERS substrates. Systematic cluster analysis could clearly distinguish among different genera of lactic acid bacteria and yeast, and could indicate the affinity and difference between lactic acid bacteria of the same genus and yeast of the same genus. The recognition accuracy of convolutive neural networks was 100 %, and the recognition sensitivity was less than 10 CFU/mL. We constructed a probiotic isolation and enrichment method by velocity gradient centrifugation and density gradient differential centrifugation, and the average recoveries of lactobacilli and yeasts were greater than 98 % in the practical application, and the accuracy of the verified classification was 100 %. In conclusion, this study has established a preliminary screening strategy of “screening before cultivating” for lactic acid bacteria and yeasts, which breaks through the principle limitation of the current traditional paradigm of “cultivating before screening”. It can greatly improve the preliminary screening rate of probiotics in fermented foods, and provide a good technical support for the mining of probiotic resources from environmental or complex matrix samples.
研究领域:
食品科学
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微生物学
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生物技术
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分析化学
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产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
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2022
·Vol. 13
·期 1
·7
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IF 5.743
Huiping Fu,Ning Ding,Dan Ma,Qing Xu,Bingyong Lin,Bin Qiu,Zhenyu Lin,Longhua Guo
In this work, a simple, low-cost, green, and mild method for the preparation of three-dimensional nanocomposite materials of gold nanorods (Au NRs)@TiO2is reported. The surface of Au NRs was coated with TiO2in situ reduction at room temperature without a complicated operation. The synthetic Au NRs@TiO2nanocomposites were used as surface-enhanced Raman spectroscopy (SERS) active substrates for the reusable and sensitive detection of environmental pollutants. The results showed that the pollutants on Au NRs@TiO2nanocomposites have higher SERS activity and reproducibility than those on the Au NR substrate without the presence of TiO2. Moreover, the SERS substrate can be readily recycled by UV-assisted self-cleaning to remove residual analyte molecules. Malachite green (MG) and crystal violet (CV) were used as examples to demonstrate the feasibility of the proposed sensor for the sensitive detection of environmental pollutants. The results showed that the limit of detections (LODs) were 0.75 μg/L and 0.50 μg/L for MG and CV, respectively, with the recoveries ranging from 86.67% to 91.20% and 83.70% to 89.00%. Meanwhile, the SERS substrate can be easily regenerated by UV light irradiation. Our investigation revealed that within three cycles, the Au NRs@TiO2substrates still maintained the high SERS enhancement effect that they showed when first used for SERS detection. These results indicated that the method can be used to detect MG and CV in really complex samples. Due to the high sensitivity, reusability, and portability and the rapid detection property of the proposed sensor, it can have potential applications in the on-site detection of environmental pollutants in a complex sample matrix.Keywords:surface-enhanced Raman spectroscopy (SERS);self-cleaning;photocatalytic activity;recyclable;environmental pollutants
研究领域:
材料科学
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环境科学
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分析化学
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纳米技术
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DOI
PubMed
高影响因子
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