MACROMOLECULAR MATERIALS AND ENGINEERING
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2021
·Vol. 306
·期 10
·2100339
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IF 4.367
Pei Liu,Chang Liu,Jiucun Chen,Bin Wang
Room-temperature phosphorescent (RTP) nitrogen-doped carbon dots (N-CDs) have attracted great interest but their efficiency is usually dependent on a solid matrix. Developing efficient matrix-free RTP CDs is still a great challenge. Here, a simple strategy is reported to synthesize efficient matrix free RTP N-CDs from citric acid (CA) and basic fuchsine (BF) via a single step hydrothermal process. The synthesized N-CDs show strong fluorescence in aqueous solution and the solid state, and the RTP lifetime is long-lived (51.9 ms at 298 K). The phosphorescence of the N-CDs is attributed to the formation of an internal hydrogen bonded network by the organic polymers on the surface of the N-CDs. This reduces the nonradiative transitions of the triplet excitons and mitigates oxygen quenching. The application of N-CDs as security inks is demonstrated.
研究领域:
材料科学
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化学
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产品关联
DOI
高影响因子
Research
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2018
·
IF 0
Jing Yang,Hongjun Zhang,Jia Jia,Xinrong Zhang,Xiaoxiao Ma,Minlin Zhong,Zheng Ouyang
Laser desorption ionization mass spectrometry (LDI-MS) is a primary tool for biological analysis. Its success relies on the use of chemical matrices that facilitate soft desorption and ionization of the biomolecules, which, however, also limits its application for metabolomics study due to the chemical interference by the matrix compounds. The requirement for sample pretreatment is also undesirable for direct sampling analysis or tissue imaging. In this study, antireflection (AR) metal surfaces were investigated as sample substrates for matrix-free LDI-MS. They were prepared through ultrafast laser processing, with high light-to-heat energy conversion efficiency. The morphology and micro/nanostructures on the metal surfaces could be adjusted and optimized by tuning the laser fabrication process. The super-high UV absorption at 97% enabled highly efficient thermal desorption and ionization of analytes. The analytical performance for the matrix-free LDI was explored by analyzing a variety of biological compounds, including carbohydrates, drugs, metabolites, and amino acids. Its applicability for direct analysis of complex biological samples was also demonstrated by direct analysis of metabolites in yeast cells.
研究领域:
分析化学
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生物医学工程
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质谱技术
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DOI
CHINESE JOURNAL OF CHEMISTRY
·
2023
·
IF 5.4
Tao Zhang,Xiaoyan Wu,Lele Liu,Yuxiang Yang,Jialuo Zhuang,Zijian Li,Hong Bi
Comprehensive Summary Carbon dots (CDs) are an emerging class of nanomaterials with intriguing photophysical properties. Recently, achieving room temperature phosphorescence (RTP) for CDs has attracted considerable attention for biomedical and information applications. However, the CDs based RTP materials generally require the use of polymeric and inorganic matrix to provide the rigid environments, which remains a great challenge to obtain matrix-free CDs with RTP. Herein, a novel supramolecular strategy based on strong interparticle interactions has been developed to attain this objective, by covalent decoration of ureido-pyrimidinone (UPy, a multiple hydrogen bonding unit) on the surface of CDs. Structural characterizations validated the core-shell structure of the as-prepared CDs (EDTA-CDs) and demonstrated the successful attachment of UPy via post-modification (UPy-CDs). The presence of UPy recognition units render the strong hydrogen bonding between UPy-CDs, which stabilizes the triplet state via rigidifying effect. As a result, UPy-CDs exhibit matrix-free efficient RTP ( λ em = 534 nm) with high brightness and long lifetime (33.6 ms) in the solid state. Owing to the dual-emission character, we further explored the application potential of UPy-CDs in information encryption and anti-counterfeiting. Overall, this work provides a new and facile strategy for achieving matrix-free phosphorescent CDs with elegant incorporation of supramolecular chemistry.
研究领域:
纳米技术
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材料科学
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光子学
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化学
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产品关联
DOI
高影响因子
Food Science and Human Wellness
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2024
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IF 5.6
Ruijie Xu,Zhijie Yao,Hao Zhang,Haitao Li,Wei Chen
Loss of susceptibility to anoikis signals is a crucial step in metastasis. Anoikis resistance therefore represents a promising adjuvant therapeutic target for cancer management. In this study, we have conducted a rationalized screening to search for novel leading anoikis sensitizer from daily foods. Among 19 tested dietary phytochemicals, the best results were obtained with apigenin, a natural component of celery. Phenotypically, apigenin sensitized breast cancer cells to anoikis, lowered the number of circulating tumor cells, and protected against breast cancer metastasis to lung in mice. Mechanistically, we demonstrated that the thromboxane A 2 (TXA 2 )-TXA 2 receptor (TP) axis has a critical role in acquired anoikis resistance by activating PI3K-Akt signaling pathway. Blockage of TXA 2 signaling up-regulated p53 as well as its target gene p21, caused a G1 phase arrest, and finally led to apoptosis in breast cancer cells. TXA 2 level was positively correlated with breast cancer cell anoikis rate, and apigenin significantly inhibited TXA 2 biosynthesis in vitro and in vivo. Collectively, we identified apigenin as a potent anoikis sensitizer with anti-metastatic properties in a mouse model of breast cancer, and these findings might provide a rationale for introducing apigenin supplementation to breast cancer patients.
研究领域:
肿瘤学
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药理学
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分子生物学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Chuan Huang,Qinbin Zhang,Yichuan Zhang,Mingming Guo
Carbonized polymer dots (CPDs) are proposed as a novel room temperature phosphorescence (RTP) materials that widely used in optoelectronic devices, bioimaging, especially in the field of information encryption and anti-counterfeiting due to their unique optical properties . However, achieving RTP emission under matrix-free conditions requires reasonable structural design to prevent the quenching of triplet excitons , which is very challenging. Herein, we proposed a facile, rapid and effective strategy to prepare matrix-free nitrogen and phosphorus co-doped CPDs (named Arg-CPDs) via microwave assisted heating treatment of arginine (Arg) and phosphoric acid . The Arg-CPDs exhibit bright blue fluorescence in aqueous solution and yellow green RTP emission in solid state, and the RTP emission is visible to the naked eye for about 4 s after switching-off the UV lamp. The phosphorescence lifetime of Arg-CPDs was 149 ms and 667 ms in ambient conditions and low temperature (77 K), respectively, which shown that the typical phosphorescent properties. Moreover, potential applications of the Arg-CPDs in the fields of information protection and encryption are demonstrated. This study provides a facile strategy for the preparation of matrix-free CPDs-based RTP materials toward the information security and their successful application in information security.
研究领域:
材料科学
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光电子学
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纳米技术
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信息安全
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产品关联
DOI
高影响因子
ACS Nano
·
2022
·
IF 18.027
Xingyue Liu,Zhao Chen,Tao Wang,Xinrong Jiang,Xuetong Qu,Wei Duan,Fengna Xi,Zhengfu He,Jianmin Wu
Spatially resolved tissue lipidomics is essential for accurate intraoperative and postoperative cancer diagnosis by revealing molecular information in the tumor microenvironment. Matrix-free laser desorption ionization mass spectrometry imaging (LDI-MSI) is an emerging attractive technology for label-free visualization of metabolites distributions in biological specimens. However, the development of LDI-MSI technology that could conveniently and authentically reveal molecular distribution on tissue samples is still a challenge. Herein, we present a tissue imprinting technology by retaining tissue lipids on 2D nanoflakes-capped silicon nanowires (SiNWs) for further mass spectrometry imaging and cancer diagnosis. The 2D nanoflakes were prepared by liquid exfoliation of molybdenum disulfide (MoS2) with nitrogen-doped graphene quantum dots (NGQDs), which serve as both intercalation agent and dispersant. The obtained NGQD@MoS2 nanoflakes were then decorated on the tip of vertical SiNWs, forming a hybrid NGQD@MoS2/SiNWs nanostructure, which display excellent lipid extraction ability, enhanced LDI efficiency and molecule imaging capability. The peak number and total ion intensity of different lipids species on animal lung tissues obtained by tissue imprinting LDI-MSI on NGQD@MoS2/SiNWs were ∼4–5 times greater than those on SiNWs substrate. As a proof-of-concept demonstration, the NGQD@MoS2/SiNWs nanostructure was further applied to visualize phospholipids on sliced non small cell lung cancer (NSCLC) tissue along with the adjacent normal tissue. On the basis of selected feature lipids and machine learning algorithm, a prediction model was constructed to discriminate NSCLC tissues from the adjacent normal tissues with an accuracy of 100% for the discovery cohort and 91.7% for the independent validation cohort.
研究领域:
生物医学工程
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分析化学
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癌症研究
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纳米技术
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质谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）