Crystals
·
2025
·Vol. 15
·期 6
·512
·
IF 2.4
Shixin Fan,Wenling Zheng,Shizhao Ren,Wangchuan Xiao,Fenghua Chen,Rongrong Xue
Amorphous solid dispersion (ASD) technology is popularly used for enhancing the solubility of poorly water-soluble drugs. Drug molecules in ASDs can be dispersed in the form of either amorphous (AASD) or molecular (MASD) forms. The boundary between AASDs and MASDs (A–M boundary) is defined as the drug concentration at which the existence of MASDs obviously influences the physicochemical properties of ASDs. In this work, fluorescence spectroscopy based on the aggregation-caused quenching (ACQ) phenomenon was used to determine the A–M boundary of curcumin (CUR) ASDs prepared via neat ball milling. The relationship between the fluorescence intensity and the loading of CUR in the sample is consistent with the Stern–Volmer equation. For the CUR ASDs with PVP, the samples with CUR loading below 10% show significantly increased fluorescence and have a higher solubility (~178 μg·mL−1), suggesting the A–M boundary is around 10%. Similar A–M boundaries around 10% were also observed for CUR ASDs with PVPVA, Soluplus, HPMC, and HPMCAS. It is of great significance to define the A–M boundary of ASDs for guiding pharmaceutical ASD formulas by balancing drug loading, stability, and solubility.
研究领域:
药剂学
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Yingli Wang,Xiangfei Han,Jing Wang,Yongjun Wang
Unlike conventional ‘top-down’ and ‘bottom-up’ techniques, a novel low-cost CO 2 -assisted in situ nanoamorphization (ISN) method has been developed to prepare amorphous drug nanosuspensions. In order to improve the dissolution rate and oral bioavailability of tacrolimus (FK506), herein FK506 nanosuspensions with different particle size were successfully prepared using ISN method through adjusting the amount of acid-base pair and the stabilizer, the mean particle sizes of obtained FK506 nanosuspensions were 167.3 ± 2.8 nm (FK506-NA), 302.8 ± 2.0 nm (FK506-NB) and 513.5 ± 15.1 nm (FK506-NC), respectively. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) confirmed the amorphous state of FK506 in all nanosuspensions that would be beneficial to the improvement of drug bioavailability because the amorphous drug form is more soluble and has a higher dissolution rate than the crystalline state. In vitro dissolution studies showed that the dissolution rate order of different formulation is as follows: FK506-NB > FK506-NA > FK506-NC > FK506-D (without acid-base pair included) > Prograf ® (commercial hard capsule). In vivo pharmacokinetic studies showed that all FK506 nanosuspensions clearly increased the oral bioavailability of FK506 in comparison with Prograf ® , especially for FK506-NB. The C max and AUC 0–12 h of FK506-NB were about 2.05-fold ( p < 0.01) and 1.5-fold ( p < 0.05) higher than that of Prograf ® . These findings suggest that this simple and versatile ISN technique has great potential for use in the preparation of nanosuspensions to increase drug oral bioavailability.
研究领域:
药剂学
·
药物传递系统
·
生物药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Xin Chen,Duanxiu Li,Yanwen Duan,Yong Huang
Drug co-amorphization is an emerging technology to improve the pharmacokinetic properties of drugs and overcome their side effects. Herein co-amorphization of sinomenine (SIN), an anti-rheumatoid arthritis alkaloid, and an antihistamine drug tranilast (TRA) was investigated for the sustained release of SIN and alleviating its histamine-release adverse reactions. The full co-amorphization of SIN-TRA was determined by powder X-ray diffraction and modulated temperature differential scanning calorimetry , while their CO 2 − and N + –H stretching vibrations in FTIR and protonated nitrogen signals in N 1s X-ray photoelectron spectra suggest the proton transfer between SIN and TRA. These intermolecular interactions could also be observed in their 1D and 2D NMR spectra. All co-amorphous samples exhibited sustained SIN release and excellent physical stability. Therefore, our study not only characterized the strong intermolecular interactions between SIN and TRA, but also discovered a promising drug combination strategy for the sustained release of SIN and reduction of its side effects.
研究领域:
药剂学
·
药物化学
✓ 已验证
产品关联
DOI
高影响因子
COMBUSTION EXPLOSION AND SHOCK WAVES
·
2014
·Vol. 50
·期 6
·664-669
·
IF 0.486
Ao W.,Zhou J. H.,Yang W. J.,Liu J. Z.,Wang Y.,Cen K. F.
Ignition, combustion, and oxidation characteristics of mixtures of amorphous and crystalline boron powders are studied by using a laser ignition system and a thermogravimetric analyzer. Yellow, green, and white-glow flames are observed. When the weight ratio of the amorphous boron powder ( K ) is lower than 0.33, burning of the mixtures is found to be at the ignition stage, while the combustion stage gradually appears with increasing K . The emission spectrum intensity is weakened by 3/4 as K decreases from 1 to 0.75. No obvious emission spectrum is detected at K < 0.33. The ignition delay time is found to decrease significantly with increasing K , but it does not change much at K < 0.8. Mixtures with larger values of K have a lower peak temperature of differential thermal gravity and a greater weight gain and maximum reaction rate. The Satava-Sestak method is applied to study the kinetics of the oxidation reaction of the mixtures. The calculated apparent activation energy decreases from 297 to 191 kJ/mol as K increases from 0 to 1. For mixtures with K ranging from 0.23 to 0.75, the apparent activation energy mainly stays constant at a value of 280 kJ/mol.
研究领域:
材料科学
·
燃烧与热能工程
✓ 已验证
DOI
高影响因子
NANOTECHNOLOGY
·
2024
·Vol. 35
·期 46
·465601
·
IF 2.9
Wei Yang,Site Luo,Yang He,Han Wang,Haihu Yu
Amorphous arrays assembled from colloidal microspheres are a way that obtains angle-independent structural colors. In order to obtain additional properties, colloidal microspheres, which are constituent units, can be modified with other materials. Here, we utilized the silane-functionalized carbon quantum dots (SiCDs) by incorporating them into the Stöber reaction to fabricate Fe3O4@SiO2/SiCDs nanospheres with a core–shell structure. Amorphous colloidal arrays (ACAs) were constructed on commercial printing paper using Fe3O4@SiO2/SiCDs nanoparticles as structural units by a simple permeation assembly. Macroscopically, the prepared ACAs exhibit the magnetic properties of Fe3O4, while under sunlight, they display bright, angle-independent structural colors. Under ultraviolet light, the array shows significant fluorescence. This enables the presentation of multidimensional information under varying magnetic and lighting conditions. By adjusting the thickness of the outer SiO2/SiCDs composite layer, the optical properties and magnetism can be controlled easily. Moreover, due to the strong light absorption capability and high refractive index of Fe3O4, the digital patterns constructed with Fe3O4@SiO2/SiCDs nanospheres demonstrate excellent multi-level anti-counterfeiting characteristics, even under water exposure. The magnetic properties of Fe3O4@SiO2/SiCDs nanospheres, along with their distinct display characteristics under different optical environments, suggest their wide applicability in the fields of multifunctional anti-counterfeiting pigments, bioimaging, and sensing displays.
研究领域:
材料科学
·
光学
·
纳米技术
·
防伪技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Han Zhang,Sijia Sun,Hao Ding,Ying Chen
Using amorphous SiO 2 (A-SiO 2 ) and tetrabutyl titanate (TBOT) as raw material, a composite photocatalyst with surface loaded quantum dot size TiO 2 (A-SiO 2 /TiO 2 , AST) was prepared. The degradation of tetracycline hydrochloride as well as mechanism of performance improvement by A-SiO 2 were investigated. The TiO 2 on the composite was anatase with a content of 9.96 wt% and a size of 7–8 nm (quantum dot level). TiO 2 was uniformly distributed and was closely bonded at the interface by chemical bonds. The degradation rate of AST was 95% after 60 min UV exposure, which was comparable to pure nano-TiO 2 . The particle size of TiO 2 in AST was reduced from 20–50 nm to 7–8 nm comparing with pure nano-TiO 2 and changed from a highly agglomerated to a well-dispersed state due to abundant hydroxyl groups on A-SiO 2 surface. TiO 2 bandgap width increased from 3.25 eV to 3.39 eV. These led to the exposing of active sites on TiO 2 and significantly increased photogenerated carrier separation efficiency. This study provides a feasible and simple method to improve TiO 2 nanoparticles’ photocatalytic activity, reduce the usage and achieve recycling to cut the application cost by surface coated.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2020
·
IF 3.465
Zhenxuan Li,Mengxiao Guo,Xiaowen Sun,Lucheng Li,Xiaolan Guo,Lidong Huang,Jiangtian Xiao,Defu Xu,Dagang Liu
The excess phosphate and tetracycline (TC) in natural environments potentially threatens ecosystem. Few studies were conducted on efficient and cost-effective method for dealing with these pollutants together. we attempted to reutilize this abandoned calcite for the removal of other pollutant in wastewater, such as tetracycline. Firstly, removal of high concentration phosphate by calcite was studied in batch experiments. Thereafter, removal of TC by this used calcite (P-loaded calcite) was investigated under different conditions: pH, phosphate concentration, dried state and humid state. Using calcite for high concentration phosphate removal, the results showed that (1) concentrations of phosphate higher than 30 mg.L −1 , resulted in a significant phosphate precipitation on calcite surface at both pH7.7 and pH 8.3 within 24 h. The corresponding pH and calcium results confirmed this precipitation occurrence; (2) the precipitated phase was supposed to be amorphous calcium phosphate through the results of IR, XPS, XRD and BET analysis. Compared to that by pure calcite, the TC removal rate by P-loaded calcite increased significantly with the initial phosphate concentration in both cases of Humid Experiment and Dried Experiment . This may be attributed to the adsorption of TC on the precipitated amorphous calcium phosphate, which has a larger specific surface and increasingly generates > Ca + sites. From the similarity of TC removal rate by P-loaded calcite between pH7.7 and pH 8.3, it is hypothesized that TC removal is due to TCH 2 ° and TCH- adsorption on > Ca + sites. The minor difference of TC removal rate by P-loaded calcites between Humid Experiment and Dried Experiment is mainly due to slight dissolution of precipitated amorphous calcium phosphate. Our research will serve as reference knowledge for the reutilization of abandoned calcite in phosphate removal, which provides a new way to reduce the wasted materials and environmental risks induced by tetracycline.
研究领域:
环境科学
·
污染控制
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Han Yu,Ying Cheng,Yaokun Fu,Lu Zhang,Sanyang Guo,Yuan Li,Wei Zhang,Shumin Han
Carbon-based materials have been proposed as an ideal medium to reduce the reaction energy barriers and improve the (de)hydrogenation kinetics of magnesium-based hydrogen storage material (MgH 2 ) in term of their excellent dispersion. However, tedious preparation process and uneven distribution of carbon restrict the application. Therefore, in this paper, we cover MgH 2 by in-situ formed amorphous carbon via a facile approach of co-sintering Mg with fluorene followed by hydriding combustion and ball milling processes, named as MgH 2 -carbonization product of fluorene (MgH 2 -CPF). As a result, the MgH 2 -CPF composite prepared at 823 K initially dehydrogenates at 557 K, 94 K lower than the as-milled MgH 2 (651 K). Meanwhile, the composite can release 5.67 wt% H 2 within 1000 s at 623 K. Even at a lower temperature of 423 K, the MgH 2 -CPF composite still reabsorbs 5.62 wt% H 2 within 3600 s, while the as-milled Mg can hardly absorb hydrogen under a same condition. Furthermore, by addition of CPF, the apparent activation energy of the system is decreased from 161.2 kJ/mol to 87.2 kJ/mol. Our finding suggests that the carbon layer can keep the MgH 2 from aggregation, promote hydrogen transport and improve the efficiency of hydrogen absorption and desorption.
研究领域:
材料科学
·
氢储存
·
能源材料
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2019
·
IF 3.197
Xiangjun Shi,Shengjie Song,Zejie Ding,Baibai Fan,Wan Huang,Tiantian Xu
At present, coamorphous systems have attracted increasing interest in the pharmaceutical field owing to their enhanced stabilities, increased solubilities, and improved bioavailabilities compared with those of their pure amorphous and crystalline counterparts. In this study, a novel coamorphous solid form of ibrutinib (IBT) and saccharin (SAC) (1:1 molar ratio) was prepared through rotary vacuum evaporation and then characterized. Differential scanning calorimetry and X-ray powder diffraction indicated the formation of the coamorphous IBT-SAC after rotary vacuum evaporation. Compared with amorphous IBT, coamorphous IBT-SAC exhibited enhanced stability owing to the intermolecular interaction between IBT and SAC. Moreover, the solubility and dissolution of the coamorphous IBT-SAC were increased up to 4.0-7.7 times and 4.3 times, respectively, compared with those of its crystalline Form A. In addition to the superior behaviors of coamorphous IBT-SAC in vitro , the in vivo bioavailability study revealed notable increases in the C max and area under the curve 0-t of the coamorphous form compared with those of its crystalline Form A. The current study demonstrates that the coamorphization of IBT and SAC presents a promising technology to overcome the limitations of solubility and stability that arise from IBT and can therefore contribute to a major improvement in the bioavailability of IBT.
研究领域:
药剂学
·
药物化学
✓ 已验证
DOI
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Ming Yan,Zhengkang Shao,Haipeng Dong,Ningzhong Bao,Lizun Guo,Dongguang Wang,Baikang Zhu,Hengcong Tao
As a petrochemical derivative, polypropylene finds widespread application in microelectronics and wireless communication. Developing polypropylene-based composites with enhanced dielectric performance and minimal loss is of great interest for capacitor dielectric applications. In this work, we propose a novel filler to optimize the dielectric properties of polypropylene. A thin amorphous carbon layer was coated onto boron nitride (BN) via glucose hydrothermal crosslinking, yielding BN@aC. Composites were then fabricated by melt blending polypropylene with varying concentrations of BN@aC. The influence of filler type (pristine BN vs. BN@aC) and loading on dielectric behavior was thoroughly examined. Notably, BN@aC outperformed pristine BN in enhancing dielectric performance. At 1 kHz and a low filler content of 1.5 wt%, the composite achieved a dielectric constant of 2.85 while maintaining an exceptionally low loss tangent of 3.04 × 10 −3 . Furthermore, given the thermal challenges associated with miniaturized electronic devices, the thermal stability of the composites was preliminarily assessed. This innovative BN@aC design provides a viable pathway for engineering dielectric materials with superior performance. Highlights Preparation using glucose as a carbon source BN@aC core-shell structural materials. Improved the interface interaction between boron nitride and PP. BN@aC promotes an increase in the dielectric constant and a decrease in the dielectric loss of PP. Composites have good thermal properties.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 15
·10656-10669
·
IF 3.442
Tong Mingxing,Yang Jiaxing,Jin Qiuyang,Zhang Xuan,Gao Jing,Li Guohua
In this work, a simple strategy to fabricate amorphous carbon-coated tungsten oxide with oxygen vacancies (WO 3− x /C, 0 < x < 1) via pyrolysis of hybrid-polyoxometalates (hybrid-POMs) in nitrogen atmosphere is reported. TGA, XRD, Raman, FTIR, SEM, TEM, EDS, XPS and BET have been used to characterize the as-prepared products. The results showed that their compositions, microstructures and concentrations of oxygen vacancies were closely related with the species of organic amines in the hybrid-POMs. When the WO 3− x /C composites were used as catalysts for degradation of dyes such as methylene blue, methyl orange and Rhodamine B under visible light irradiation, they showed much enhanced photocatalytic abilities compared to that of WO 3 and P25, which could be ascribed to the coating of WO 3 by amorphous carbon and the construction of defects (oxygen vacancy) in WO 3 . The synthetic strategy presented in our work is simple and shows a great potential in fabricating efficient transition metal-based composites for photocatalysis applications and so on.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Jingwei Li,Zhengyi Huang,Cong Wang,Lei Tian,Xiaoqing Yang,Rongfu Zhou,Mohamed Nawfal Ghazzal,Zhao-Qing Liu
Refining carrier transfer in bandgap-broken heterojunctions, which consist of two semiconductors with broken bandgaps, is crucial yet highly challenging for photocatalysis. Herein, we incorporated amorphous carbons (AC) into the bandgap-broken V 2 O 5 /GdCrO 3 heterojunctions, inducing a linkage effect to facilitate photoexcited carrier transfer. The created V-O-C and Cr-O-C bonds in V 2 O 5 -AC-GdCrO 3 interfaces show almost identical orbital energies to overcome the broken-gap energy barriers at interfaces. The holes at GdCrO 3 ’s valence band and electrons at V 2 O 5 ’s conduction band tent to migrating toward the carbon ring of amorphous carbon via Cr-O-C and V-O-C bonds, thereby enhancing carrier separation of bandgap-broken V 2 O 5 /AC/GdCrO 3 heterojunction. By controlling the relative amount of metal-O-C bonds in the interface, the modulation of charge transfer kinetics was also achieved on V 2 O 5 /AC/GdCrO 3 , resulting in ∼7 times higher of H 2 generation than V 2 O 5 /GdCrO 3 . The concept could be expanded to the other carbon allotropes, including graphene, carbon nanotube, and graphdiyne conjugated structures, demonstrating a universal strategy in reaching optimal charge transfer of broken-bandgap heterojunctions for photocatalytic H 2 production.
研究领域:
材料科学
·
能源科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）