INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yingying Yang,Jingyu Xu,Jinghui Zhou,Xing Wang
Lignin is a renewable raw material with excellent adsorption, biodegradability , and non-toxicity. As a new, green nanomaterial, lignin nanoparticles (LNPs) have been explored as high-value renewable materials for applications in many fields. Herein, we provide a simple, rapid approach for the fabrication of size-controlled LNPs using a titrimetric nanoprecipitation method. The prepared LNPs were formed through a layer-by-layer self-assembly approach from inside to outside based on π-π interactions and had spherical shapes with porous surfaces and particle sizes from 272.0 to 915.4 nm. The average particle size of LNPs varied with stirring speed and decreased as the volume of deionized water increased. Compared with those of the original lignin, the chemical structural characteristics of LNPs did not change significantly. The proposed scheme for the preparation of LNPs is simple, inexpensive, and possesses the properties of both lignin and nanomaterials. The sizes of LNPs were controlled. Therefore, this is a good scheme for high-value applications of lignin.
研究领域:
材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2020
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IF 8.758
Manman Xie,Ziyang Wang,Qian Lu,Shuming Nie,Christopher J. Butch,Yiqing Wang,Bo Dai
Herein, we present a new magnetic iron oxide nanoparticle (MION) with a succinylated heparin monolayer coating, which exhibits the highest T1 relaxivity at 7 T and the lowest r2/r1 reported for any MION at these high-field conditions. While the recent proliferation of 7 T MRI instruments in hospitals worldwide has enabled widespread access to higher quality, more finely detailed, diagnostic imaging, clinically available contrast agents have not kept pace due to the general phenomenon of reduced efficacy of T1 relaxation as magnetic field strength is increased. Development of new MION agents is one strategy to address this need, and to this end, we demonstrate the in vitro magnetic properties of the MIONs reported here to extend to in vivo applications, providing greatly increased contrast in tumor imaging in a murine xenograft subject at 7 T. While MION-based contrast agents can have side effects in clinical application, these are generally thought to be less than those of gadolinium-based agents and here are further reduced by the small size allowing direct glomerular filtration from the blood followed by renal-excretion. Finally, we show the succinylated heparin monolayer coating to provide class leading magnetic properties over a homologous series of particles with core size ranging from 2 to 18 nm and show the properties to be strongly related to the surface area. We suggest the increased porosity and hydrophilicity of the coating to increase water accessibility to the surface resulting in the increased magnetic properties.
研究领域:
医学影像学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
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2015
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IF 4.762
De-Yun Ma,Zhi Li,Jun-Xia Xiao,Rong Deng,Pei-Feng Lin,Rui-Qun Chen,Yun-Qiu Liang,Hai-Fu Guo,Bei Liu,Jian-Qiang Liu
By using a strategy of introducing hydrophobic groups to the linkers, a hydrostable MOF was constructed based on 5-nitroisophthalate and 2,2′-dimethyl-4,4′-bipyridine coligands, revealing a 3D dia topology structure with a 1D channel parallel to the c axis. TGA, PXRD, and water vapor sorption results show high thermal and water stability for the framework. The framework is very porous and possesses not only high busulfan payloads with an encapsulation efficiency up to 21.5% (17.2 wt %) but also very high CO2 selective capture compared with that of other small gases (i.e., CH4, N2, O2, CO, and H2) at 298 K based on molecular simulations due to the pore surface being populated by methyl and nitryl groups. Furthermore, in vitro MTT assays were conducted on four different cells lines with increasing concentrations of the framework, and the results showed that the framework was nontoxic (cell viability >80%) in spite of the concentrations up to 500 μg/mL.
研究领域:
材料科学
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生物学
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环境科学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
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2021
·Vol. 9
·期 21
·7065-7075
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IF 6.843
Xin Wang,Bingqing Deng,Meng Yu,Tao Zeng,Yuyu Chen,Jianqiang Hu,Qianqing Wu,Aiqing Li
Drug delivery nanoplatforms have been applied in bioimaging, medical diagnosis, drug delivery and medical therapy. However, insolubility, toxicity, instability, nonspecific targeting and short retention of many hydrophobic drugs limit their extensive applications. Herein, we have constructed a passive targeting and long retention therapeutic nanoplatform of core–shell gefitinib/poly (ethylene glycol)-polytyrosine nanocomplexes (Gef-PY NCs). The Gef-PY NCs have good water-solubility, non-toxicity (correspond to 1/10 dosage of effective gefitinib (hydrochloride) (Gef·HCl) (normal drug administration and slow-release) and high stability (120 days, 80% drug retention at 4 or 25 °C). The core–shell Gef-PY NCs present unexpected kidney targeting and drug slow-release capacity (ca. 72 h). The good water-solubility, non-toxicity and high stability of Gef-PY NCs effectively solve the bottleneck question that Gef-based therapy could be used only in intraperitoneal injection due to its insolubility and severe toxicity. Such excellent properties (e.g., water-solubility, non-toxicity, high stability, kidney targeting and long retention) of Gef-PY NCs create their prominent anti-fibrosis capabilities, such as decreasing approximately 40% tubulointerstitial fibrosis area and 68% expression of collagen I within 7 days. This therapeutic efficacy is well-matched with that of 10 times the dosage of toxic Gef·HCl. It is very hopeful that Gef-PY NCs could realize clinical applications and such a strategy offers an effective route to design high-efficiency treatments for kidney- and tumor-related diseases.
研究领域:
药学
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纳米技术
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治疗学
✓ 已验证
DOI
PubMed
高影响因子
NANO
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2023
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IF 1.2
Chen Wang,Lu Gan,Yuxuan Li,Shan Wang,Li Lu,Siyao Zhang,Wenrui Wang,Yan Chen
Graphite carbon nitride (g-C 3 N 4 ) polymer with two-dimensional planar structure is a new star in nanodrug delivery systems in recent years because it shows characteristics of low cost, nontoxicity, biocompatibility and easy functionalization. However, conventional g-C 3 N 4 shows bulk, macro size, small specific surface area and poor water solubility. To improve this, most works are always confined to physical ultrasound, oxidative peeling or template-strategy, which have the disadvantages of redundant steps, environment-unfriendliness and high cost. In this paper, a modified supramolecular self-assembled strategy was carried out to construct a novel graphitic carbon nitride nanoplatform (named by CA-MA X ) using melamine and cyanuric as precursors. The chemical structure characterization, drug loading experiment and cell tests in vitro of the CA-MA X nanoplatform were carried out and discussed in detail. Results indicated that the obtained samples show enhanced specific surface area, more exposed groups and good biocompatibility. Compared to the traditional carbon nitride (named by MA-CN), the newly prepared CA-MA X carrier shows improved drug loading efficiency and good pH-responsive loading, as well as releasing. Cell uptake experiment demonstrates that CA-MA 2 -DOX can be swallowed by cancer cells and during treatment of the cancer cell process, the CA-MA 2 -DOX complex experiences phagocytizing by the cancer cell, controlled-release DOX and kills the cancer cell after DOX was passively diffused into the nucleus. CA-MA 2 -DOX exhibited significant in vitro antitumor activity. To our knowledge, this is the first time the supramolecular self-assembled method was used in carbon nitride nanocarrier construction for cancer treatment.
研究领域:
纳米技术
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材料科学
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药学
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生物医学工程
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肿瘤学
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化学合成
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
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2024
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IF 2.7
Yu-Hui Jiang,Kai-Ruo Zhu,Xin-Yu Xiao,Shang-Ru Zhai
The advanced treatment and resource utilization of oily wastewater are of great significance to solve water shortages and realize carbon peaking and carbon neutrality goals. The construction of biomass-based superwetting surfaces with recyclability, non-toxicity, and degradability is considered to be a promising strategy to overcome the unavoidable bottlenecks of “secondary pollution” and high costs in the current design of superhydrophobic structures. In this work, a strategy for preparing multifunctional sodium alginate (SA) superhydrophobic surfaces was proposed. By virtue of the synergistic mechanism of SA, SiO2 nanoparticles, pseudo-polyrotaxane and methyltrimethoxysilane, a superhydrophobic sponge with a green biomass-based carrier was prepared, which was constructed using a superhydrophobic elastomer with a three-dimensional network. The modified SA aerogel has a contact angle of 155.2° and even exhibits strong corrosion resistance in harsh environments with a water contact angle greater than 155°. Notably, the increase of green biomass-based materials provides a promising and sustainable development path for the preparation of hydrophobic substrates.
研究领域:
环境科学
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材料科学
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化学工程
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可持续发展
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
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2022
·Vol. 10
·期 19
·3723-3733
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IF 7.571
Qing Hao,Jinghong Wang,Jie Shen,Rong Gu,Yu Rao,Jian Feng,Huanhuan Wang,John L. Brash,Hong Chen
In analogy with adsorbed protein films, we have fabricated a family of 2D nanofilms composed of poly(N-vinyl caprolactam-co-vinylimidazole) (PNVCL) nanogels. NVCL was copolymerized with 1-vinylimidazole (VIM), and then cross-linked with α,ω-dibromoalkanes with 2 to 8 carbons via quaternization to form the nanogels. The swelling ratio of the gels was precisely controlled by regulating the inter-chain spacing of the polymers at the level of the carbon atom chain length of the cross-linker. The short-chain alkanes used are relatively rigid and their dimensions provide an accurate estimate of the chain spacing in the nanogels. It was shown that small differences in the carbon atom number of the cross-linking agent led to significant differences in the mechanical properties of the nanogels, in particular in the softness, deformability, and contact area (in film form), all of which increased with increasing carbon number. Films of the softer gels not only showed good adhesion to a number of substrates, but were also mechanically robust. In addition, the films showed excellent light transmission and nontoxicity to L929 cells. Nanogels of intermediate softness were shown to inhibit the adhesion of bacteria and human umbilical vein smooth muscle cells (HUVSMCs), and to be resistant to the adsorption of the plasma protein fibrinogen, indicating strong anti-biofouling properties. Gels that were either too stiff or too soft showed somewhat weaker anti-fouling activity in terms both of HUVSMCs adhesion and protein adsorption.
研究领域:
材料科学
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生物医学工程
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纳米技术
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生物材料
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Yao Xiao,Hai-Qin Lu,Chang-Rong Shi,Fu-Hou Lei,Darryn Rackemann,Kai Li,Wen Li,William O.S. Doherty
The decolorization of remelt syrup is the most critical step in the sugar refining process as it directly affects the quality of refined sugar. Adsorption is a useful method that can be applied to decolorize the syrup. A quaternary ammonium-functionalized chitosan/graphene oxide composite aerogel (GO-QACSA) was developed as an effective adsorbent for the removal of high-molecular-weight reducing sugar alkaline degradation products (HRSADPs), the main class of colorants in remelt syrup. The advantages of GO-QACSA to remove HRSADPs can be attributed to its well-connected 3-D network-like porous structure, nontoxicity, high hydrophilicity, and the richness of quaternary ammonium groups. The equilibrium adsorption capacity of GO-QACSA for HRSADPs reached 364.09 mg/g and the removal rate was > 90%. GO-QACSA exhibited an ultra-fast adsorption rate. Recycling experiments indicated that GO-QACSA exhibited good renewability and reusability. The interaction mechanism for the adsorption of HRSADP on GO-QACSA was studied, and the results revealed that two layers of HRSADPs adhered to the surface of GO-QACSA via electrovalent bonds formed between the quaternary ammonium and carboxylate groups. On average, 2–3 carboxylate ions in one HRSADP molecule bonded with the quaternary ammonium cations of GO-QACSA. Four phenomenological mathematical models, namely, External mass transfer resistance (EMTR), Internal mass transfer resistance (IMTR), combined EMTR–IMTR, and Adsorption on active sites (AAS), were presented based on the best-fit equilibrium isotherms. These models could be used to provide new insights into the adsorption mass transfer behaviors of the system.
研究领域:
材料科学
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化学工程
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环境科学
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食品科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）