JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2024
·Vol. 107
·期 7
·4631-4640
·
IF 3.5
Xu Wang,Hexin Zhang,Xiao Yu,Xiumei Mo,Jie Gao,Yunfeng Hu,Jie Min,Qi Ding,Yuchi Fan,Wan Jiang
The dicalcium phosphate anhydrous (DCPA, CaHPO 4 ) bioceramic has long been difficult to prepare by conventional sintering techniques due to its weak thermal stability. Here, the DCPA ceramic is prepared at 250°C by cold sintering process (CSP) using the dicalcium phosphate dihydrate (DCPD, CaHPO 4 ·2H 2 O) as the starting powder. It is found that the dehydration temperature of DCPD powder is greatly reduced during CSP, which facilitates the densification even without additive water. However, the ceramic only reaches a relatively low density of around 90% without additive water, which can be ascribed to the lack of particle rearrangement and the readily loss of dehydration water during sintering. In comparison, a high relative density of 95% can be obtained when the DCPD hydrate is densified with additive water, in which both hydration water and additive water play important roles. The obtained DCPA ceramic with high density exhibits a flexural strength of 46.17 MPa and Young's modulus closer to human bones compared with hydroxyapatite. Combined with the low cytotoxicity, the DCPA bioceramic has great potential to be applied for bone tissue engineering.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2013
·
IF 2.206
Chongjun Liu,Leping Dang,Wenshuai Bai,Hongyuan Wei
The water activity aT[H2O] that corresponds to the transformation between hydrate and anhydrate forms of a drug is important to pharmaceutical process development; however, the traditional method for measuring aT[H2O] can be time-consuming. A thermodynamic model derived from the thermodynamic equilibrium in this study provides an easy way to predict the value of aT[H2O] at different temperatures through the solubility ratio of hydrate to anhydrate. The model also provides a new way to determine the solubility of the metastable form with accessible accuracy and offers a tool to study the activity coefficient of the solute. Experimental validation of the model was performed using the compounds theophylline and carbamazepine. The results illustrate that this new method is acceptably accurate and reproducible.
研究领域:
药学
·
物理化学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 12
·9348-9358
·
IF 4.6
Xu Ma,Hong Su,Yongming Liu,Fenghua Chen,Rongrong Xue
Quercetin (QUE) is a functional flavonoid molecule with low water solubility. The study of its amorphous solid dispersions (ASDs) is still insufficient. This work reveals that the solubility of the physical mixtures of anhydrous QUE and polymers (PVP or soluplus) is better than that of the ASDs of QUE and the corresponding polymers. Gel-like phase separation occurring during the QUE ASDs dissolution process (weak in ASDs with PVP and strong in ASDs with soluplus) reduces the driving force for QUE release, which makes research on the QUE ASDs insufficient, and can be avoided in the QUE physical mixtures with polymers. Combination of metastable polymorph and polymer is a feasible strategy for improving the solubility of poorly water-soluble molecules whose ASDs encounter the gel-like phase separation.
研究领域:
药剂学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Shuai Yu,Zihao Wang,Yuanchang Ma,Fumin Xue
Natural polymer additives including ethyecellulose (EC), hydroxy propyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), and sodium lignin sulfonate (SLS) were selected to modify the crystal form and morphology of clozapine crystals. The effects of cooling crystallization, anti-solvent crystallization and additives on clozapine crystal morphology were studied. The type of additive has an obvious effect on the morphology of crystal, while the dosage of additive has a great effect on the average particle size of crystal. Medicinal crystal form of clozapine anhydrate can be obtained after enhanced drying of clozapine monohydrate. Clozapine crystal particles with controllable crystal form, morphology and particle size can be prepared by anti-solvent crystallization method with additive. To further explore the mechanism of natural polymer additives on morphology regulation, molecular simulation was used to analyze the interaction between the main crystal surface, solvent and additives.
研究领域:
药学
·
材料科学
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2015
·
IF 2.587
Xia Zhang,Qiuxiang Yin,Wei Du,Junbo Gong,Ying Bao,Meijing Zhang,Baohong Hou,Hongxun Hao
The crystal structures of monohydrate and anhydrous substance were determined from the single crystals for the first time. The phase transformation between anhydrate and monohydrate of sodium dehydroacetate was in situ investigated by using Raman spectroscopy. The mechanism of the phase transformation was proposed. The results showed that the monohydrate crystalline phase of sodium dehydroacetate can transform to anhydrous phase through solid–solid transformation upon heating or solution-mediated phase transformation. From powder X-ray diffraction (PXRD) patterns and thermal gravimetric analysis (TGA) data, it was found that the anhydrous crystals obtained by these two methods are the same in structure. However, the scanning electron microscopy (SEM) results revealed that the surface of the anhydrous sodium dehydroacetate crystals obtained by high-temperature dehydration was much rougher than that obtained by solution-mediated phase transformation. Furthermore, the dynamic vapor sorption (DVS) results showed that the anhydrous crystals with rough surface had faster hydration rate than the anhydrous crystals with smooth surface when increasing humidity. The reasons behind these phenomena were discussed.
研究领域:
药物化学
·
晶体学
·
药剂学
·
材料科学
·
物理化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）