ADVANCED FUNCTIONAL MATERIALS
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2024
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IF 18.5
Jinhui Huang,Hao Liu,Qiuyu Chen,Hui Xie,Shaobing Zhou
Bedridden patients are at high-pressure injuries risk, and timely turning or moving a bedridden patient is crucial to release localized pressure and reduce pressure injury risk. Pressure-sensing electronics can collect real-time pressure signals reflecting the movement of a patient and help carers evaluate pressure injury risk early and intervene timely. However, most pressure-sensing electronics cannot be seamlessly mounted on the curved surface of the skin, resulting in signal instability and inaccuracy. Besides, detecting small pressures over a wide range is challenging. Herein, a lamellar shape-memory conductive (LSMC) aerogel is developed to assemble 3D wireless point-of-care electronics for assisting pressure injury prevention. The lamellar structure makes the LSMC aerogel highly compressible, endowing the assembled electronics with high sensitivity and low detection limit. Moreover, the excellent shape-memory effect allows the fabrication of 3D electronics on certain curved surfaces for adaptive wearing and provides sensitive and stable signals. Furthermore, a point-of-care monitoring system that integrates the LSMC aerogel-based 3D electronics with wireless technology is developed. The system records real-time pressure signals at certain locations (e.g., foot), which facilitates carers to analyze an individual's bedridden time and body movements, assess pressure injury risk, and intervene timely; this greatly benefits pressure injury prevention.
研究领域:
生物医学工程
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材料科学
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电子工程
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产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Jing Hong,Zhanchi Zhu,Zhaojun Wang,Jiawei Li,Zhongqing Liu,Rui Tan,Ying Hao,Guosheng Cheng
Electrical stimulation (ES) has a remarkable capacity to regulate neuronal differentiation and neurogenesis in the treatment of various neurological diseases. However, wired devices connected to the stimulating electrode and the mechanical mismatch between conventional rigid electrodes and soft tissues restrict their motion and cause possible infections, thereby limiting their clinical utility. An approach integrating the advantages of wireless techniques and soft hydrogels provides new insights into ES-induced nerve regeneration. Herein, a flexible and implantable wireless ES-responsive electrode based on an annular gelatin methacrylate-polyaniline (Gel/Pani) hydrogel is fabricated and used as a secondary coil to achieve wireless ES via electromagnetic induction in the presence of a primary coil. The Gel/Pani hydrogels exhibit favorable biocompatibility, biodegradability, conductivity, and compression resistance. The annular electrode of the Gel/Pani conductive hydrogel (AECH) supports neural stem cell growth, while the applied wireless ES facilitates neuronal differentiation and the formation of functional neural networks in vitro. Furthermore, AECH is implanted in vivo in rats with ischemic stroke and the results reveal that AECH-mediated wireless ES significantly ameliorates brain impairment and neurological function by activating endogenous neurogenesis. This novel flexible hydrogel system addresses wireless stimulation and implantable technical challenges, holding great potential for the treatment of neurodegenerative diseases.
研究领域:
神经科学
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生物医学工程
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组织工程
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材料科学
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再生医学
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DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2022
·Vol. 7
·期 10
·2200066
·
IF 8.856
Li Tang,Shaoji Wu,Yue Xu,Youwei Li,Bailin Dai,Caixia Yang,Aifeng Liu,Jianxin Tang,Liang Gong
Electronic skin (e-skin) is widely studied for its ability to detect physiological information and provide feedback through electrical signals. Biocompatible stimulus-responsive DNA-based hydrogels exhibit high sensitivity, which makes them outstanding candidates for biomedical applications. However, several disadvantages, such as weak mechanical properties, expensive manufacturing costs, cumbersome double chain design, and difficulty obtaining bulk size, seriously limit their practical application. Based on the double network (DN) strategy, a universal, low-cost, and high-toughness deoxyribonucleic acid/poly( N -hydroxyethyl acrylamide) (DNA/pHEAA) DN hydrogel is designed. The transparent hydrogel shows tensile stress/strain of 0.96 ± 0.043 MPa/2537.55 ± 23.24%, rapid self-recovery ability (peak stress/energy dissipation recovery rate of 99.72%/95.38% after 30 s resting), excellent fatigue resistance (peak stress/energy dissipation retention rate of 91.08%/81.05% after 100 loading-unloading cycles with strain of 50%), reversible adhesive ability (≈45 KPa), and good biocompatibility. Thus, the DNA/pHEAA DN hydrogel can be used as an e-skin. Sensing signals are displayed on a smartphone as images sent through wireless technology; the images change with the collected signals, achieving motion detection. The universal and low-cost design of stimulus-responsive DNA-based hydrogels with high toughness, excellent self-recovery, and anti-fatigue performance is expected to promote their application in the biomedical field.
研究领域:
材料科学
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生物医学工程
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纳米技术
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电子学
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生物材料
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）