Viruses-Basel
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2022
·Vol. 14
·期 12
·2692
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IF 5.818
Qinyan Wang,Qikai Yin,Shihong Fu,Jingxia Cheng,Xiuyan Xu,Jing Wang,Bin Wu,Xiaodong Tian,Yan Li,Jing Lu,Ying He,Fan Li,Kai Nie,Songtao Xu,Xiaoqing Lu,Huanyu Wang,Bin Wang,Guodong Liang
In Yangquan County, the sandfly-transmitted virus (Wuxiang virus) was first isolated from sandflies in 2018. However, relationships between the abundance and seasonal fluctuations of local sandflies and sandfly-transmitted viruses are unknown. Herein, we report that sandfly specimens were collected in three villages in Yangquan County, from June to August, 2019. A total of 8363 sandflies were collected (June, 7927; July, 428; August, 8). Eighteen virus strains (June, 18; July, 0; August, 0) were isolated in pools of Phlebotomus chinensis. The genome sequence of the newly isolated virus strain was highly similar to that of the Wuxiang virus (WUXV), isolated from sandflies in Yangquan County in 2018. Our results suggested that the sandfly-transmitted viruses, and the local sandfly population, are stable in Yangquan County, and that June is the peak period for the virus carried by sandflies in this area.Keywords:sandfly;Wuxiang virus;Phlebovirus;spatial and temporal distribution
研究领域:
病毒学
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昆虫学
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流行病学
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DOI
PubMed
高影响因子
Journal of Orthopaedic Translation
·
2025
·
IF 7.8
Jiaxin Zhang,Haotian Bai,He Liu,Xiaonan Wang,Mingwei Xu,Guokun Zhang,Zexin Di,Xin Zhao,Jincheng Wang,Luquan Ren
Rationale Imbalances in the osteogenic–osteoclastic microenvironment hinder effective osseointegration between the prosthesis and host bone, which is a key factor contributing to the high incidence of prosthesis loosening and periprosthetic fractures in osteoporosis patients. Developing an implant interface that can reverse the dysregulated osteogenic microenvironment is an effective strategy to address this challenge. Methods A novel bioinspired interface with a spatial gradient structure was engineered by 3D-printed porous titanium alloy implants and hollow mesoporous silica nanoparticles coating. Apart from the bioinspired bone microstructure, the amine-functionalized nanocoating of the bioactive interface could also load and temporally sustain the zoledronic acid (ZOL) release. A series of in vitro experiments were carried out to characterize the bioactive interface and to clarify the regulation of osteogenic–osteoclastic balance by ZOL temporal release from the nanocoatings. Afterward, an osteoporotic model was utilized to validate the in vivo bioactive interface osseointegration effect. Results Based on the structural features and chemical properties of the bioactive interface, efficient ZOL loading was achieved. Additionally, the temporal release mechanism of ZOL through free diffusion and ionic bond ionization enabled long-term sustained release. Meanwhile, the early high-concentration local release of ZOL effectively inhibited osteoclast formation and activation in the microenvironment. As the ZOL release decreased over time, the focus shifted to promoting the process of bone formation, thereby reversing the dysregulated osteogenic microenvironment. According to this, we identified the optimal gradient concentration (10 -5 M) of the ZOL temporal release system that efficiently exerts bidirectional regulatory effects. Most notably, the spatial gradient structured interface loaded with this optimal concentration of ZOL (10 -5 M) significantly augmented osseointegration under in vivo osteoporotic conditions. Conclusion Overall, our study provides a novel nanocoating capable of temporally releasing ZOL to reverse the dysregulated osteogenic microenvironment, aiming to maintain the long-term stability of artificial prostheses for osteoporosis patients. The translational potential of this article This study validates the structure–performance-effect relationship of ZOL-releasing nanocoatings with a temporal release mechanism, providing a novel approach to addressing the high incidence of postoperative complications in osteoporotic patients undergoing prosthetic replacement.
研究领域:
生物医学工程
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骨科
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Sciences
·
2024
·
IF 5.9
Yafei Xia,Ting Gao,Yuhui Liu,Meng Qi,Jian-Ming Zhu,Hui Tong,Yiwen Lv,Chengshuai Liu
Coal power plants annually generate quantities of byproducts that release environmentally hazardous heavy metals like Cd and Pb. Understanding the behavior and spatiotemporal impacts on soils of these releases is crucial for pollution control. This study investigated the concentrations and isotope ratios of Cd/Pb in combustion byproducts, depositions and soils collected from a coal-fired power plant or its surrounding area. The pulverized fuel ash (PFA) and desulfurized gypsum (DG) exhibited heavier Cd isotopes with Δ 114 Cd values of 0.304‰ and 0.269‰, respectively, while bottom ash (BA) showed lighter Cd isotopes (Δ 114 Cd BA-coal = –0.078‰), compared to feed coal. We proposed a two-stage condensation process that governs the distribution of Cd/Pb, including accumulation on PFA and DG within electrostatic precipitators and desulfurization unit, as well as condensation onto fine particles upon release from the stack. Emissions from combustion and large-scale transport make a significant contribution to deposition, while the dispersion of Cd/Pb in deposition is primarily influenced by the prevailing wind patterns. However, the distribution of Cd/Pb in soils not only exhibit predominant wind control but is also potentially influenced by the resuspension of long-term storage byproducts. The power plant significantly contributes to soil in the NW–N–NE directions, even at a considerable distance (66%–79%), demonstrating its pervasive impact on remote regions along these orientations. Additionally, based on the vertical behavior in the profile, we have identified that Cd tends to migrate downward through leaching, while variations in Pb respond to the historical progression of dust removal.
研究领域:
环境科学
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地球化学
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产品关联
DOI
PubMed
高影响因子
Aggregate
·
2024
·
IF 13.9
Li Wang,Lu Fan,Anne M. Filppula,Yu Wang,Luoran Shang,Hongbo Zhang
The development of tumor drug microcarriers has attracted considerable interest due to their distinctive therapeutic performances. Current attempts tend to elaborate on the micro/nano-structure design of the microcarriers to achieve multiple drug delivery and spatiotemporal responsive features. Here, the desired hydrogel microspheres are presented with spatiotemporal responsiveness for the treatment of gastric cancer. The microspheres are generated based on inverse opals, their skeleton is fabricated by biofriendly hyaluronic acid methacrylate (HAMA) and gelatin methacrylate (GelMA), and is then filled with a phase-changing hydrogel composed of fish gelatin and agarose. Besides, the incorporated black phosphorus quantum dots (BPQDs) within the filling hydrogel endow the microspheres with outstanding photothermal responsiveness. Two antitumor drugs, sorafenib (SOR) and doxorubicin (DOX), are loaded in the skeleton and filling hydrogel, respectively. It is found that the drugs show different release profiles upon near-infrared (NIR) irradiation, which exerts distinct performances in a controlled manner. Through both in vitro and in vivo experiments, it is demonstrated that such microspheres can significantly reduce tumor cell viability and enhance the efficiency in treating gastric cancer, indicating a promising stratagem in the field of drug delivery and tumor therapy.
研究领域:
生物材料学
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肿瘤治疗学
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药剂学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Longchao Guo,Ting Wang,Qingyuan Wang,Wei Feng,Ziyang Li,Shaoqing Wang,Ping Xia,Feng Zhao,Xue Yu
Fluorescent materials have been employed in the field of anti-counterfeiting thanks to their feasible and flexible design approach, visualization feature, and handy identification. However, versatile fluorescent materials are still eager to be developed for advanced information security. Here, an efficient temporal and spatial anti-counterfeiting strategy is proposed with the multi-response behaviors from the as-explored transition metal and lanthanide ions doped BaZnOS phosphors under distinct stimulus. Diverse optical performance of the corresponding phosphor with the irradiation of X-ray, ultraviolet (UV), and near-infrared laser as well as the stimulation of stress and temperature endows a spatial anti-counterfeiting strategy. Moreover, with the cooperation of the photo-stimulated and up-conversion behaviors, a temporal anti-counterfeiting could be achieved elaborately. Herein, this work not only gives an insight to understand the multi-dimensional response of the corresponding tailored phosphor under distinct exterior stimulations, but also provides a feasible and facilitated way to address the counterfeit issues accordingly.
研究领域:
材料科学
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光学工程
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2018
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IF 4.427
Binfeng Zhao,Ximing Wang,Hangbiao Jin,Huiqiang Feng,Guang Shen,Yiming Cao,Chang Yu,Zhengbiao Lu,Quan Zhang
The residues and risks of heavy metals in the environment and organisms have attracted great concern for many years. However, the information on their long-term spatiotemporal trends and potential health and ecological risks are scarce. In this study, a total of 1815 seawater samples, 451 sediment samples, and 54 seafood samples were collected in Xiangshan Bay, China, between 2011 and 2016. The residue, distribution, seasonal variation, and potential health risks of seven heavy metals in seawater, sediment, and seafood were evaluated. Dissolved Zn (mean = 16.8 μg L −1 ) and Cu (mean = 3.4 μg L −1 ) concentrations were high in seawater. Sediments were mainly contaminated by Zn (mean = 120.8 mg kg −1 ) and Cr (mean = 81.7 mg kg −1 ). The highest levels of Cu and Zn were observed in Ostreidae with the concentrations of 84.3 and 99.0 mg kg −1 , respectively. The Kendall test indicated that only As, Cu, Cd, and Hg showed decreasing trends in seawater with time and no significant temporal trends were identified for heavy metals in sediment between 2011 and 2016. Only As may pose non-carcinogenic risks to both adults and children in some seafood. These data provide a reliable reference for government to use in developing reasonable and scientific regulations on the ecological and food safety of this area.
研究领域:
环境科学
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海洋生物学
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公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Plant Science
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2021
·
IF 5.754
Yang Mei,Zhao Yujiao,Qin Yuejian,Xu Rui,Yang Zhengyang,Peng Huasheng
Poria cocos (Schw.) Wolf is a saprophytic fungus that grows around the roots of old, dead pine trees. Fushen, derived from the sclerotium of P. cocos but also containing a young host pine root, has been widely used as a medicine and food in China, Japan, Korea, Southeast Asian countries, and some European countries. However, the compound variations at the different growth periods and in the different parts of Fushen have not previously been investigated. In this study, an untargeted metabolomics approach based on ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and targeted quantitative analysis was utilized to characterize the temporal and spatial variations in the accumulation of specialized metabolites in Fushen. There were 119 specialized metabolites tentatively identified using the UPLC-Q/TOF-MS. The nine growth periods of Fushen were divided into four groups using partial least squares discrimination analysis (PLS-DA). Four different parts of the Fushen [fulingpi (FP), the outside of baifuling (BO), the inside of baifuling (BI), and fushenmu (FM)] were clearly discriminated using a PLS-DA and orthogonal partial least squares discrimination analysis (OPLS-DA). Markers for the different growth periods and parts of Fushen were also screened. In addition, the quantitative method was successfully applied to simultaneously determine 13 major triterpenoid acids in the nine growth periods and four parts. The quantitative results indicated that the samples in January, March, and April, i.e., the late growth period, had the highest content levels for the 13 triterpenoid acids. The pachymic acid, dehydropachymic acid, and dehydrotumulosic acid contents in the FM were higher than those in other three parts in March, whereas the poricoic acid B, poricoic acid A, polyporenic acid C, dehydrotratrametenolic acid, dehydroeburicoic acid, and eburicoic acid in FP were higher beginning in October. These findings reveal characteristics in temporal and spatial distribution of specialized metabolites in Fushen and provide guidance for the identification of harvesting times and for further quality evaluations.
研究领域:
中药学
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代谢组学
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植物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ISPRS International Journal of Geo-Information
·
2021
·Vol. 11
·期 1
·6
·
IF 2.899
Lijun Chen,Shangjing Jiang
Cycling rhythm performance is the result of a complex interplay between active travel demand and cycling network supply. Most studies focused on bicycle flow, but little attention has been paid to cycling rhythm changes for public bicycles. Full sample data of origin–destination enables an efficient description of network-wide cycling mobility efficiency in urban public bicycle systems. In this paper, we show how the spatiotemporal characteristics of cycling speed reveal the performance of cycling rhythms. The inference method of riding speed estimation is proposed with an unknown cycling path. The significant inconsistency of docking stations in cycling rhythm was unraveled by the source–sink relationship comparison. The asymmetry of the cycling rhythm on the path is manifested as the rhythm difference among paths and bidirectional inconsistency. We found that cycling rhythm has a temporal multilayer and spatial mismatch, which shows the inflection points of the cycling rhythm where the travel behavioral preference changes and the exact road segments with different rhythms. This finding suggests that a well-designed cycling environment and occupation-residential function should be considered in active transport demand management and urban planning to help induce active travel behavior decisions.
研究领域:
城市交通规划
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出行行为分析
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智能交通系统
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数据驱动决策
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可持续城市发展
✓ 已验证
DOI
高影响因子
ADVANCED MATERIALS
·
2024
·
IF 27.4
Jiacheng Huang,Lintao Qiu,Chujun Ni,Guancong Chen,Qian Zhao
Shape memory polymers (SMPs) show attractive prospects in emerging fields such as soft robots and biomedical devices. Although their typical trigger-responsive character offers the essential shape-changing controllability, having to access external stimulation is a major bottleneck toward many applications. Recently emerged autonomous SMPs exhibit unique stimuli-free shape-shifting behavior with its controllability achieved via a delayed and programmable recovery onset. Achieving multi-shape morphing in an arbitrary fashion, however, is infeasible. In this work, a molecular design that allows to spatio-temporally define the recovery onset of an autonomous shape memory hydrogel (SMH) is reported. By introducing nitrocinnamate groups onto an SMH, its crosslinking density can be adjusted by light. This affects greatly the phase separation kinetics, which is the basis for the autonomous shape memory behavior. Consequently, the recovery onset can be regulated between 0 to 85 min. With masked light, multiple recovery onsets in an arbitrarily defined pattern which correspondingly enable multi-shape morphing can be realized. This ability to achieve highly sophisticated morphing without relying on any external stimulation greatly extends the versatility of SMPs.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Chenguang Ouyang,Tian Tu,Haojie Yu,Li Wang,Zhipeng Ni,Jian Yang,Yanzhao Dong,Xiaodi Zou,Weijie Zhou,Jinyi Liu,Dingning Chen,Yu Wang,Xudong Wu,Hong Yi,Xunchun Yuan,Zhenfeng Liu,Hui Lu
Janus hydrogels have promising applications in tendon healing and anti-peritendinous adhesions. However, their complicated preparation methods, weak mechanical properties, and unstable adhesion interfaces have severely limited their application in suture-free and high-quality tendon healing. In this work, by controlling the interfacial distribution of free -COOH groups and cationic-π structures on both sides of the hydrogels, a series of PZBA-EGCG-ALC Janus hydrogels with varying degrees of asymmetric properties are successfully prepared using a simple and efficient one-step synthesis method. The tensile strength and elongation at the break of the Janus hydrogel are as high as 0.51 ± 0.04 MPa and 922.89 ± 28.59%. In addition, the Janus hydrogel can achieve a high difference in adhesion strength (nearly 20-fold) while maintaining a strong adhesion strength on their bottom sides (up to 524.8 ± 33.1 J m −2 ). In the spatial dimension, its excellent mechanical compliance and one-sided adhesion behavior can provide effective mechanical support and physical barriers for the injured Achilles tendons. More importantly, the Janus hydrogel can also minimize early inflammation generation in the time dimension via its ROS-responsive PZBA-EGCG prodrug macromolecules. This study provided a more effective and convenient suture-free strategy for constructing Janus hydrogels to promote high-quality tendon healing.
研究领域:
生物材料学
·
再生医学
·
创伤修复
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Physics Reviews
·
2024
·Vol. 11
·期 2
·
IF 11.9
Mao Qian,Zhu Rong
Since tactile sensing provides rich and delicate sensations, touch-based object recognition has attracted public attention and has been extensively developed for robots. However, robotic grasping recognition in real-life scenarios is highly challenging due to the complexity of real-life objects in shapes, sizes, and other details, as well as the uncertainty of real grabs in orientations and locations. Here, we propose a novel robotic tactile sensing method, utilizing the spatiotemporal sensing of multimodal tactile sensors acquired during hand grasping to simultaneously perceive multi-attributes of the grasped object, including thermal conductivity, thermal diffusivity, surface roughness, contact pressure, and temperature. Multimodal perception of thermal attributes (thermal conductivity, diffusivity, and temperature) and mechanical attributes (roughness and contact pressure) greatly enhance the robotic ability to recognize objects. To further overcome the complexity and uncertainty in real-life grasping recognition, inspired by human logical reasoning “from easy to hard” in solving puzzles, we propose a novel cascade classifier using multilayered long short-term memory neural networks to hierarchically identify objects according to their features. With the enhanced multimodal perception ability of tactile sensors and the novel cascade classifier, the robotic grasping recognition achieves a high recognition accuracy of 98.85% in discriminating diverse garbage objects, showing excellent generalizability. The proposed spatiotemporal tactile sensing with logical reasoning strategy overcomes the difficulty of robotic object recognition in complex real-life scenes and facilitates its practical applications in our daily lives.
研究领域:
机器人技术
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人工智能
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传感器技术
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2024
·
IF 27.4
Wenjie Yang,Chenglin Zheng,Li Sun,Zhiying Bie,Yuchen Yue,Xiuhong Li,Wentao Sun,Tomiki Ikeda,Jingxia Wang,Lei Jiang
Blue phase liquid crystals (BPLCs) have exhibited promising applications in 3D flexible displays due to their molecular-level self-assembled chiral structures, fast response, and tunable polarized colors. However, there remain challenges for spatiotemporal programming of 3D chiral color units for BPLC dynamic patterning. Herein, the programmable temporal evolution of micrometer-scale color units and spatial configuration switch of chiral modes are achieved by spontaneous ink diffusion-driven asymmetric lattice deformation in dual-chiral polymer-templated blue phases. Custom-printed colorful patterns are designed by machine learning-assisted parameter optimization, which displays programmable multidimensional encrypted information that incorporates temporal evolving colors (wavelength), spatial distribution (depth), chiral modes (L/R). The quantitative relationship between ink diffusion kinetics and blue-phase dynamic 3D structural optics is established by in situ characterization, finite element analysis, and mathematical geometry modeling. This work provides insights into the microgeometric manipulation of 3D chiral color of BPLCs in the application of information security and self-adaptive indicators.
研究领域:
材料科学
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光学
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信息加密
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自适应显示
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）