ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Fan Gao,Lingyun Zhu,Fan Zhang,Meng Li,Hairong Lian,Sen Feng,Xinfeng Cheng,Xianling Xiang
Metformin (MET) and its metabolite guanylurea (GUA) are prevalent in aquatic environments, raising concerns about their potential risks to aquatic organisms. However, the toxicity of these compounds through different exposure routes has not been reported. This study evaluated the effects of MET and GUA on the growth of the green algae Tetradesmus obliquus and on life table parameters of the freshwater rotifer Brachionus calyciflorus through various exposure routes, including waterborne, foodborne, and combined waterborne + foodborne. Our results indicated that both MET and GUA, at concentrations of 1 mg/L and 100 mg/L, inhibited algae growth, with GUA causing greater stress than MET. Additionally, compared to waterborne exposure, foodborne and combined waterborne + foodborne exposures of MET and GUA at these concentrations significantly decreased the net reproductive rate (R 0 ), intrinsic rate of population increase (r m ), and life expectancy (e 0 ) of B. calyciflorus . Notably, the impact of exposure routes on the life table parameters of B. calyciflorus was generally greater than the impact of exposure concentrations. Therefore, previous studies focusing solely on waterborne exposure may have underestimated the toxicity of MET and GUA.
研究领域:
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Xi Mu,Zhanxiang Wang,Lichun Liu,Xiaohong Guo,Chen Gu,Hua Xu,Liuyuan Zhao,Wanyanhan Jiang,Hongmei Cao,Xiaoxuan Mao,Tao Huang,Hong Gao,Jianmin Ma
In this study, we collected 308 serum samples from 17 to 20 year old first-year university students who were recruited from Lanzhou University in China a few days after their enrollment to measure the serum Pb, Cd, Hg, and As levels, and specific questionnaires for age, sex, settlement and dietary structure were designed. A 3-D atmospheric transport model was used to simulate the atmospheric concentration and dry deposition across China based on gridded Pb emission inventory to examine the association between the spatial distribution of serum concentrations and environmental fates of Pb. The mean serum Pb, Cd, Hg, and As concentrations averaged over all participating young students were 21.38, 1.46, 3.86, and 4.69 μg/L, respectively. The Pb, Cd, and Hg levels in 3%, 7%, and 20% serum samples exceeded the standards. The minimum serum As and Hg concentrations and the maximum serum Pb and Cd concentrations occurred in urban areas. Seafood diet habits ( P < 0.05), sex ( P < 0.05), and relocation ( P < 0.01) caused significant differences in serum As, Pb, and Cd concentrations. A cluster analysis was carried out to classify the exposure pathways for target contaminants. The results indicated that 4 heavy metals in the serum of volunteers from northern China could be grouped into the same category, in which significant positive correlations were found between the serum heavy metal levels and background concentrations of surface soil. However, in other provinces and metropolises, the atmospheric pollution level played a critical role involving in the inhalation exposure pathway. We demonstrated that serum Pb levels in freshman students were related to the atmospheric transport and dry deposition of Pb.
研究领域:
环境科学
·
公共卫生
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Environmental Research and Public Health
·
2022
·Vol. 19
·期 15
·9382
·
IF 4.614
Wenxin Liu,Hong Zhang,Jiaqi Ding,Wanyu He,Lin Zhu,Jianfeng Feng
Organophosphate esters (OPEs) are widely used as an additive in flame retardants, plasticizers, lubricants, consumer chemicals, and foaming agents. They can accumulate in aquatic organisms from water (waterborne exposure) and food (dietary exposure). However, the bioaccumulation characteristics and relative importance of different exposure routes to the bioaccumulation of OPEs are relatively poorly understood. In this study,Daphnia magnawere exposed to fo typical OPEs (tris(2-chloroethyl) phosphate (TCEP), tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), tris(2-butoxyethyl) phosphate (TBOEP), and triphenyl phosphate (TPHP)), and their toxicokinetics under waterborne and dietary exposure routes were analyzed. For the waterborne exposure route, the bioconcentration factors (BCFs) increased in the order of TBOEP, TCEP, TDCPP, and TPHP, which were consistent with their uptake rate constants. TPHP might have the most substantial accumulation potential while TBOEP may have the smallest potential. In dietary exposure, the depuration rate constants of four OPEs were different from those in the waterborne experiment, which may indicate other depuration mechanisms in two exposure routes. The biomagnification factors (BMFs) of fur OPEs were all below 1, suggesting trophic dilution in the transfer of four OPEs fromScenedesmus obliquustoD. magna. Except for TBOEP, the contributions of dietary exposure were generally lower than waterborne exposure inD. magnaunder two exposure concentrations. This study provides information on the bioaccumulation and contribution of OPEs inD. magnavia different exposure routes and highlights the importance of considering different exposure routes in assessing the risk of OPEs.
研究领域:
环境科学
·
生态毒理学
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Huicheng Zhu,Na Zheng,Changcheng Chen,Ning Li,Qirui An,Wenhui Zhang,Qiuyan Lin,Zhifei Xiu,Siyu Sun,Xiaoqian Li,Yunyang Li,Sujing Wang
The endocrine disruptor phthalates (PAEs) are widely used as important chemical additives in a variety of areas around the globe. PAEs are toxic to reproduction and development and may adversely affect the health of adolescents. Risk assessments of exposure to PAEs from different sources are more reflective of actual exposure than single-source assessments. We used personal exposure parameters to estimate the dose of PAEs to 107 university students from six media (including dormitory dust, dormitory air, clothing, food, disposable food containers, and personal care products (PCPs)) and three exposure routes (including ingestion, inhalation, and dermal absorption). Individual factors and lifestyles may affect PAE exposure to varying degrees. Based on a positive matrix factorization (PMF) model, the results indicated that the main sources of PAEs in dust were indoor building materials and plastics, while PCPs and adhesives were the major sources of airborne PAEs. The relative contribution of each source to PAE exposure showed that food and air were the primary sources of dimethyl phthalate (DMP) and dibutyl phthalate (DBP). Air source contributed the most to diethyl phthalate (DEP) exposure, followed by PCPs. Food was the most significant source of diisobutyl phthalate (DiBP), benzyl butyl phthalate (BBP), and bis(2-ethylhexyl) phthalate (DEHP) exposure. Additionally, the exposure of DEHP to dust was not negligible. The ingestion pathway was the most dominant among the three exposure pathways, followed by dermal absorption. The non-carcinogenic risk of PAEs from the six sources was within acceptable limits. DEHP exhibits a low carcinogenic risk. We suggest university students maintain good hygienic and living habits to minimize exposure to PAEs.
研究领域:
环境科学
·
公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Junjie Ao,Tao Yuan,Jiayuan Gu,Yuning Ma,Zhemin Shen,Ying Tian,Rong Shi,Wei Zhou,Jun Zhang
Organic ultraviolet (UV) filters are emerging contaminants that may pose health risks to humans. We measured the concentrations of four commonly used organic UV filters (2-hydroxy-4-methoxybenzophenone (BP-3), 4-methylbenzylidene camphor (4-MBC), homosalate (HMS), and octocrylene (OC)) in 203 indoor dust samples and 98 human urine samples from households in eastern China. The total concentrations of the four organic UV filters ranged from 66.6–56,123.0 ng g −1 in indoor dust and 1.17–52.15 μg g −1 (creatinine-adjusted concentration (Cr)) in urine. BP-3 was the most abundant organic UV filter in the urine samples (median concentration: 1.89 μg g −1 Cr), while OC was the most abundant in the indoor dust samples (median concentration: 325.7 ng g −1 ). No significant correlations were found between organic UV filter concentrations in paired urine and dust samples, but the concentrations of UV filters in the indoor dust samples were positively correlated with family income and sunscreen use. The sources of the organic UV filters in the indoor dust samples differed based on the geographical location of the tested household. The fraction of human exposure to organic UV filters that resulted from ingestion or dermal absorption of indoor dust was close to 8%.
研究领域:
环境科学
·
公共卫生
·
毒理学
✓ 已验证
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Jiaqi Ding,Wanyu He,Wanxiao Sha,Guoqiang Shan,Lingyan Zhu,Lin Zhu,Jianfeng Feng
Exposure routes are important for health risk assessment of chemical risks. The application of physiologically based toxicokinetic (PBTK) models to predict concentrations in vivo can determine the effects of harmful substances and tissue accumulation on the premise of saving experimental costs. In this study, Tri(2-chloroethyl) phosphate (TCEP), an organophosphate ester (OPE), was used as an example to study the PBTK model of mice exposed to different exposure doses by multiple routes. Different routes of exposure (gavage and intradermal injection) can cause differences in the concentration of chemicals in the organs. TCEP that enters the body through the mouth is mainly concentrated in the gastrointestinal tract and liver. However, the concentrations of chemicals that enter the skin into the mice are higher in skin, rest of body, and blood. In addition, TCEP was absorbed and accumulated very rapidly in mice, within half an hour after a single exposure. We have successfully established a mouse PBTK model of the TCEP accounting for multiple exposure Routes and obtained a series of kinetic parameters. The model includes blood, liver, kidney, stomach, intestine, skin, and rest of body compartments. Oral and dermal exposure route was considered for PBTK model. The PBTK model established in this study has a good predictive ability. More than 70% of the predicted values deviated from the measured values by less than 5-fold. In addition, we extrapolated the model to humans. A human PBTK model is built. We performed a health risk assessment for world populations based on human PBTK model. The risk of TCEP in dust is greater through mouth than through skin. The risk of TCEP in food of Chinese population is greater than dust.
研究领域:
毒理学
·
环境健康科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）