ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2014
·Vol. 22
·期 5
·3856-3864
·
IF 2.757
Yang Xingjian,Lu Guining,Wang Rui,Guo Chuling,Zhang Hongliang,Dang Zhi
This paper is focused on the selection of cosolvents in the remediation of contaminated soils. The aim of this study was to investigate the combined effects of Triton X-100 (TX-100) and different cosolvents on the solubilization behavior of 4,4′-dibromodiphenyl ether (BDE-15) and the washing of BDE-15 from a contaminated soil. 1 H NMR spectroscopies were used to elucidate the interactions among TX-100, cosolvents, and BDE-15 in aqueous micellar solution. Results showed that the solubility of BDE-15 was enhanced by the observed synergism among TX-100, BDE-15, and cosolvents, and the TX-100/dimethyl sulfoxide (DMSO) system exhibited the best performance in the solubilization of BDE-15. Similar synergism was further evidenced in the washing of BDE-15 from a contaminated soil. With 10 % ( v / v ) DMSO and 6.4 mM TX-100 solution added, considerable synergistic effect was achieved in TX-100/DMSO system, leading to the highest removal efficiency (92.9 %) of BDE-15 from the soil, relative to that of 67.3 % with TX-100 alone at the same concentration.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Processes
·
2022
·Vol. 10
·期 9
·1815
·
IF 3.352
Yao Ma,Haoliang Li,Chunsheng Xie,Xiaodong Du,Xueqin Tao,Guining Lu
Soil-washing is a potential technology for the disposal of soil contaminated by e-waste; however, the produced soil-washing effluent will contain polybrominated diphenyl ethers (PBDEs) and a large number of surfactants, which are harmful to the environment, so the treatment of PBDEs and the recycling of surfactants are the key to the application of soil-washing technology. In this study, coconut shell granular-activated carbon (GAC) was applied to remove PBDEs from Triton X-100 (TX-100) surfactant which simulates soil-washing effluent. The adsorption results show that, GAC can simultaneously achieve effective removal of 4,4′-dibromodiphenyl ether (BDE-15) and efficient recovery of TX-100. Under optimal conditions, the maximum adsorption capacity of BDE-15 could reach 623.19 μmol/g, and the recovery rate of TX-100 was always higher than 83%. The adsorption process of 4,4′-dibromodiphenyl ether (BDE-15) by GAC could best be described using the pseudo-second-order kinetic model and Freundlich isothermal adsorption model. The coexistence ions had almost no effect on the removal of BDE-15 and the recovery rate of TX-100, and the solution pH had little effect on the recovery rate of TX-100; BDE-15 had the best removal effect under the condition of weak acid to weak base, indicating that GAC has good environmental adaptability. After adsorption, GAC could be regenerated with methanol and the adsorption effect of BDE-15 could still reach more than 81%. Density functional theory (DFT) calculation and characterization results showed that, Van der Waals interaction and π–π interaction are dominant between BDE-15 and GAC, and hydrogen bond interactions also exist. The existence of oxygen-containing functional groups is conducive to the adsorption of BDE-15, and the carboxyl group (-COOH) has the strongest promoting effect. The study proved the feasibility of GAC to effectively remove PBDEs and recover surfactants from the soil-washing effluent, and revealed the interaction mechanism between PBDEs and GAC, which can provide reference for the application of soil-washing technology.Keywords:granular-activated carbon;polybrominated diphenyl ethers;Triton X-100;soil-washing effluent;adsorption;density functional theory calculation
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Dental Sciences
·
2024
·
IF 3.4
Yi Luo,Mengting Duan,Runze Liu,Pei Liu,Wei Fan,Bing Fan
Background/purpose Root canal irrigants are difficult to diffuse deep into the dentinal tubules for root canal disinfection. The purpose of this study was to assess the ability of different diffusing enhancers to deliver chlorhexidine (CHX) into dentinal tubules. Materials and methods The diffusing property of five diffusing enhancers (acetone, DMSO, Triton X-100, JFC-E and azone) into dentinal tubules was firstly assessed using the Rhodamine B. The ability of the diffusing enhancers to deliver CHX into dentinal tubules was then evaluated both qualitatively and quantitatively. A deep dentinal tubule Enterococcus faecalis infection model was further established to test the bactericidal effect of CHX delivered by different diffusing enhancers. Finally, the in vitro cytotoxicity of these diffusing enhancers was tested using the CCK-8 method. Results Azone, Triton X-100 and JFC-E exhibited the largest maximum diffusing depths at all root canal parts ( P < 0.05). Azone group also showed the highest percentage of diffusing depths for all root canal parts, followed by Triton X-100 ( P < 0.05). The percentage of dead bacteria in dentinal tubules close to cementum layer was significantly higher in the CHX + azone group than in the other groups ( P < 0.05), followed by CHX + Triton X-100 and CHX + JFC-E groups. The concentration of CHX diffusing onto the exterior surface of root was significantly higher in CHX + azone group than in the other groups ( P < 0.05). All the diffusing enhancers showed relatively low cytotoxicity. Conclusion Azone showed the highest diffusing ability with low cytotoxicity and might be employed as a carrier agent for either intracanal irrigants or medications to achieve more thorough root canal disinfection.
研究领域:
牙科学
·
药学
·
微生物学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2019
·
IF 2.923
Yao Wang,Baohuan Jia,Min You,Haoran Fan,Siyu Cao,Hui Li,Wenkai Zhang,Gang Ma
Amyloid fibrillation by hen egg white lysozyme (HEWL) under the influences of two common surfactants, sodium dodecyl sulfate (SDS) and Triton X-100 (TX-100), was investigated with atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy. Detailed AFM investigations indicated that both SDS and TX-100 were able to induce some significant morphological changes of HEWL amyloid fibrils. Both SDS and TX-100 could induce a morphological change which was characterized with alternating fibril regions with increased thicknesses along the fibril axis. In addition, TX-100 was also able to induce a morphological change which was characterized with fibril branching. In contrast, the positively charged cetyltrimethylammonium bromide displayed no such effect as compared with the negatively charged SDS and the nonionic TX-100. These intriguing modulation effects of SDS and TX-100 on amyloid fibrillation were hypothesized to be due to surfactant-induced surface-catalyzed secondary nucleation owing to the noncovalent interaction between the surfactants and HEWL. The proposed hypothesis was further supported by FTIR spectroscopic investigation, which demonstrated the formation of a SDS–amyloid fibril complex and TX-100–amyloid fibril complex. Detailed FTIR analysis suggested that the tail group of SDS associated with amyloid fibrils is more disordered similar to that of SDS in aqueous solution, while the headgroup of SDS appears to interact with amyloid fibrils strongly similar to that of SDS in the solid state, and the ether groups of TX-100 associated with amyloid fibrils experienced a different microenvironment as compared with that of neat TX-100. Additional control experiments with FTIR spectroscopy revealed that the interactions of SDS/TX-100 with HEWL amyloid fibrils were different from those of SDS/TX-100 with HEWL amorphous aggregates. In addition, the β-sheet structures of the HEWL amyloid fibrils were found to be increased due to the influences of SDS and TX-100. Our work provides new insight into the modulation effects of surfactants on amyloid fibrillation.
研究领域:
生物化学
·
分子生物学
·
蛋白质科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
XENOBIOTICA
·
2020
·
IF 1.902
Ruicong Ma,Gentao Li,Xue Wang,Yajuan Bi,Youcai Zhang
To date, relatively little is known about the interactions of pharmaceutical excipients with hepatic and renal drug uptake transporters. The present study was designed to systematically evaluate the effects of 16 commonly consumed excipients on human organic cation transporter 1 and 2 (hOCT1 and hOCT2), human organic anion transporter 1 and 3 (hOAT1 and hOAT3) and human organic anion transporting polypeptide 1B1 and 1B3 (hOATP1B1 and hOATP1B3).The inhibitory effects and mechanisms of excipients on transporters were investigated using in vitro uptake studies, cell viability assays, concentration-dependent studies, and the Lineweaver–Burk plot method.Triton X-100 is a non-competitive inhibitor for all six transporters. Tween 20 inhibits hOCT2, hOAT1, hOAT3, and hOATP1B3 in a mixed way, whereas it competitively inhibits hOATP1B1. The inhibition of Tween 80 is competitive for hOCT2, non-competitive for hOATP1B1 and hOATP1B3, and mixed for hOAT1 and hOAT3. Concentration-dependent studies identify Triton X-100 as a strong inhibitor of hOCT1 and hOCT2 with IC50 values of 20.1 and 4.54 μg/mL, respectively. Additionally, Triton X-100, Tween 20, and Tween 80 strongly inhibit hOAT3 with IC50 values ≤31.0 μg/mL.The present study is significant in understanding the excipient–drug interactions and provides valuable information for excipient selection in drug development.
研究领域:
药理学
·
药物开发
·
制药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2024
·Vol. 14
·期 10
·505
·
IF 4.9
Zhenzhen Li,Lei Wang,Mengjie Tang,Yulong Sun,Li Zhang,Zhongxiu Chen
Triton X-100 (TX-100) is a commonly used surfactant in the manufacture of biosensors. The factors limiting the use of TX-100 in biosensors are environmental concerns. In this study, the binary system of sodium dodecyl benzene sulfonate (SDBS) and fatty alcohol-polyoxyethlene ether (AEO) was investigated from the physicochemical principle of surfactant interaction and its application in biosensors. The results demonstrated that a mixture of SDBS and AEO at an appropriate molar ratio had a comparable activity to TX-100 in terms of surface activity, micelle formation, dynamic adsorption, foaming, emulsifying, and cell permeability. Theory and experimentation support the idea that SDBS-AEO might take the place of TX-100 in the manufacturing of biosensors. This study contributes to the development of alternatives to TX-100 and provides a new perspective for an in-depth study of the interaction mechanism of additives in biosensor design.
研究领域:
材料科学
·
化学工程
·
生物技术
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Li Hou,Juanjuan Huang,Shendong Liu,Tianran Lin,Shulin Zhao
The three-dimensional liposome networks are fabricated and act as signal amplification modules for the fabrication of a magneto-controlled fluorescent immunosensor, in which antibody-conjugated magnetic bead (MB-Ab), streptavidin-biotin recognition and liposome amplification as the triple signal amplification pathway. The Aptamer-Liposome-AuNCs (Apt-Lip-AuNCs) is employed as a fluorescence signal probe, which can release abundant of AuNCs by Triton-X 100 to produce fluorescence emission signal upon being excited at 369 nm. In the presence of target CEA, the labeled anti-CEA on the MB and the immobilized aptamer on the Apt-Lip-AuNCs sandwich the target CEA. Upon addition of streptavidin and Biotin-Lip-AuNCs, three-dimensional liposome networks are formed by a streptavidin-biotin reaction due to the capture of streptavidin for Biotin-Lip-AuNCs and the residual biotin site of liposome on the Apt-Lip-AuNCs, thereby increasing the loading capacity of AuNCs. CEA can be linearly assayed in the range from 0.05 ng mL −1 to 40 ng mL −1 with a detection limit of 13.2 pg mL −1 (3 σ/K ). It provided a concise sensing platform for CEA determination and showed a great potential application for on-site testing in early clinical diagnosis.
研究领域:
生物化学
·
分析化学
·
生物技术
·
纳米技术
·
临床诊断
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）