LANGMUIR
·
2019
·
IF 3.683
Zhonglin Cao,Tiansheng Gan,Gaixia Xu,Chunfeng Ma
Inspired by fish skin, biomimetic self-renewal poly[(ethylene oxide)-co-(ethylene carbonate)] (PEOC) brushes with protein resistance had been prepared via surface-initiated ring-opening polymerization (ROP). The results of hydrolytic degradation indicated that the PEOC brushes could degrade in artificial seawater. Ellipsometry, X-ray photoelectron spectrometry, and contact angle results demonstrated that the PEOC brushes degrade uniformly. By using a quartz crystal microbalance with dissipation, we studied the protein adsorption on the surfaces in artificial seawater at different degradation times. After 24, 48, 96, and 168 h of degradation, the PEOC surfaces showed nearly zero Δf and ΔD for bovine serum albumin, lysozyme, and fibrinogen. More importantly, there was a notably lower density of microorganisms adhered to the surface modified with PEOC compared with that of the surface without PEOC in natural seawater. The current study showed that the PEOC brushes exhibit a self-renewal property with persistent protein resistance and prevent the adhesion of microorganisms. Such a biomimetic polymer had a great potential in marine antibiofouling.
研究领域:
材料科学
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生物医学工程
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海洋科学
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DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Li Yang,Lu Xuteng,Cheng Xufeng,Xia Keyu,Hu Junyan,Wang Peiyu,Pang Peiyuan,Gao Bomin,Sun Demeng,Zhang Zhuzhen,Li Dongdong,Deng Zengqin,Tian Changlin,Xie Chang,Yao Jing
Our skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils are widely used for skin maintenance, while the molecular target and mechanism of action remain largely unknown. Here, we report that citronellal, a plant-derived acyclic monoterpene commonly used for personal care, stimulates skin renewal by promoting keratinocyte proliferation through the activation of TRPV3. We further present cryo-EM structures of human TRPV3 in complex with acyclic monoterpenes, including citronellal, citral, linalool and isodihydrolavandulal, determined at resolutions of 3.1-3.6 Å. Our structural and functional analysis unmasks consistent yet subtly different binding modes within the TRPV3 vanilloid site. Our results elucidate that essential oil ligands activate TRPV3 channels by competitively displacing endogenous lipids from the vanilloid site. Together, these findings identify TRPV3 as the molecular target of natural acyclic monoterpenes for skin renewal, and delineate the structural basis of action, thus being instrumental for moving forward skin healthcare.
研究领域:
生物化学
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结构生物学
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皮肤病学
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DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Guilan Fu,Shixin Zhu,Xiuhua Sun,Changlu Gao
Copolymers with quaternized poly(lauryl methacrylate)-b-poly(2-( N , N -dimethylamino) ethyl methacrylate) (PLMA-b-PDMAEMA) as the side chain, polycaprolactone (PCL) and siloxane bridged with hexamethylene diisocyanate (HDI) as the main chain were developed for antifouling marine coatings. With the hydrolysis of the quaternized PLMA-b-PDMAEMA and the degradation of PCL in seawater, the outmost surface of the coating peeled off by water shearing force. By exploring the co-effects of side chains, PCL and siloxane at varying contents, it was found that coatings with higher content of side chains tended to yield better surface hydrophilicity, faster surface self-renewal speed and lower protein adsorption amount. However, coatings with higher content of siloxane demonstrated stronger antibacterial abilities, even though they possessed less hydrophilicity and lower surface renewal speed. In-lab tests showed that the antibacterial rate of the coating can reach 99.7 % against E. coli and 99.6 % against S. aureus . And the lowest adsorption amount of bovine serum albumin was 36 μg/cm 2 . Marine field tests revealed that most of the surface area of the properly designed coatings was clear of marine organisms during ∼330 d of testing.
研究领域:
材料科学
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海洋科学
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生物学
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产品关联
DOI
高影响因子
Toxicology Research
·
2025
·Vol. 14
·期 1
·
IF 2.1
Zhang Yan,Zhou Jin,Zhao Jianxin,Cheng Xiurong,Xing Caihong
In this study, we aimed to investigate the effects of chronic benzene exposure on the self-renewal capacity of C57BL/6 bone marrow HSPCs. Twenty-four male C57BL/6 mice were randomly divided into two groups: the control group and the benzene-exposed group. Mice in the benzene-exposed group inhaled 1,000 mg/m3 (308 ppm; conversion factor: 20 °C, 101 kPa, 1 ppm = 3.25 mg/m3) benzene for 32 weeks and the control group mice inhaled clean air. The peripheral blood hematological alterations were monitored every two weeks. Competitive bone marrow transplantation was performed to assess the self-renewal capacity of bone marrow HSPCs and the donor cell chimerism was quantified through flow cytometry. By the fourth week of benzene exposure, significant reductions in leukocytes, erythrocytes, and hemoglobin levels (P < 0.05) were observed, suggesting the development of benzene poisoning in mice. In the B6.SJL recipient mice, the chimerism ratio of bone marrow cells from C57BL/6 donors exposed to benzene for 20 weeks significantly decreased after transplantation (16 weeks post-transplant: 52.58% ± 17.38% in controls vs. 3.89% ± 1.96% in the benzene group, P < 0.05). Furthermore, the chimerism ratio in recipients of 32-week benzene-exposed donors approached zero by week 84 post-transplant, suggesting a loss of self-renewal capacity in bone marrow HSPCs due to benzene exposure. The study concludes that bone marrow suppression and the diminished self-renewal ability of C57BL/6 bone marrow HSPCs may lead to bone marrow failure in mice, contributing to the potential occurrence of MDS.
研究领域:
毒理学
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血液学
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实验医学
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DOI
PubMed
高影响因子
TOXICOLOGY
·
2025
·
IF 4.6
Jin Zhou,Pinpin Sui,Jianxin Zhao,Xiurong Cheng,Tao Yu,Shiwei Cui,Xiangrong Song,Caihong Xing
Patients with benzene-induced leukemia undergo a continuous transformation from myelosuppression to malignant proliferation. However, the underlying mechanisms in this process remain unknown. Our previous studies have shown that the pathways involved in self-renewal capacity of bone marrow (BM) cells in Mll-Af9 mice exposed to benzene for life are significantly activated after severe blood toxicity. In order to investigate the hematotoxicity effects of benzene on the self-renewal capacity of HSCs, Mll-Af9 chimeric mice were exposed to benzene and hematological parameters were dynamically monitored after benzene exposure. Transcriptomic analysis were used to analyze different time points during benzene exposure and after competitive bone marrow transplantation (BMT). Results showed that despite severe hematotoxicity in mice, but the chimerism rate of Mll-Af9 cells in peripheral blood (PB) cells was significantly increased after 10 weeks benzene exposure ( P < 0.001). After competitive BMT, the chimerism rate of Mll-Af9 cells from 10 weeks benzene-exposed mice was gradually increased and significantly surpassed that of the control at 26 weeks of bone marrow reconstruction (benzene group 86 % VS control group 78 %, P = 0.03). Transcriptome analysis revealed that the expression levels of self-renewal related genes, such as Hox genes ( Hoxb4 , Hoxa7 , Hoxa10 ), Mecom and Ms4a in BM cells of 10 weeks benzene-exposed mice were relatively higher compared to those in the control group, but no significant difference were observed. Interestingly, Hoxa7 , Hoxa10 and Mecom were significantly up-regulated at 26 weeks after bone marrow transplantation. In conclusion, our study suggests that abnormal expression of self-renewal-related genes may be potential early biomarkers for benzene-induced hematotoxicity. This hematotoxicity may contribute to the acquisition of evolutionary advantages by leukemic precursor cells and accelerate malignant transformation.
研究领域:
血液学
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毒理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Yuxiang Shi,Lei Li,Wei-xian Zhang,Shaolin Li
Zero-valent iron (ZVI) is a solid reductant that can react with a wide array of contaminants; however, its effectiveness is significantly reduced by the surface passivation layer formed on its surface. This study introduces mechanochemical depassivation to revitalize passivated ZVI and restore its reactivity. The method is exemplified through mechanical milling to depassivate ZVI with different passivation layers formed in solutions containing Cr(VI), Ni(II), and/or trichloroethylene, as well as in a complex water matrix. The results demonstrate rapid restoration of ZVI reactivity within 10 min of milling, achieving a 7-fold increase in contaminant removal capacity after eight cycles. The method universally outperforms acid pickling and ultrasonication across all of the tested passivation scenarios. Mechanistic analysis attributes its efficacy to the ductile–brittle disparity between the metallic iron and the passivation layers: brittle passivation layers fragment under mechanical stress, while ductile iron resists structural damage. Discrete element method simulations provide further mechanical insights into the milling dynamics and identify the contact frequency as the key factor determining depassivation efficiency. The study provides a versatile, environmentally benign, and effective depassivation method for ZVI reactions that can be integrated into ZVI reuse processes for water treatment applications.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Minglong Yan,Saijun Wu,Yuchen Zhong,Yinghao Wu,Yangmin Wu,Xijian Lan,Wenjie Zhao
Silicone hydrogel coatings, which integrate fouling self-release and fouling resistant properties, represent a groundbreaking advancement in environmentally friendly biofouling mitigation, but are still plagued by static fouling conditions and longevity concerns. In this work, Schiff base chemistry and a sol-gel technique is leverage to develop degradable silicone-hydrogel hybrid antifouling coatings by incorporating amphiphilic silicone-based polymers with terephthalaldehyde (TPE) and cinnamaldehyde (CAL). The synergistic combination of flexible Si─O bonds in the polymer backbone and reversible covalent crosslinking imparts exceptional flexibility (hardness of 0.135), controlled degradability, and dynamic surface self-renewal capabilities, ensuring sustained antifouling performance through surface dynamic stability. During degradation, the amphiphilic polymers will self-enrich at the interface, forming a dual-functional surface that combines fouling release and fouling resists properties. The antibacterial TPE and natural CAL, anchored within the polymer network, exhibit environment-responsive release behavior, effectively suppressing bacterial proliferation and biofilm adhesion. The optimized coating achieves a bactericidal rate of 98.8%, an anti-bacterial adhesion rate of 99.8%, and a predicted anti-fouling longevity of 5.5 years with a thickness of 200 µm. This innovative approach enables a new anti-biofouling coating that involves unique fouling control mode, thereby meeting the diverse application.
研究领域:
材料科学
·
生物医学工程
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海洋科学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 24
·3099-3106
·
IF 0
Chunfeng Ma,Liguo Xu,Wentao Xu,Guangzhao Zhang
Degradable polyurethane (PU) with copolyester oligomer consisting of ε-caprolactone (CL) and glycolide (GA) as the soft segments has been prepared by a combination of ring-opening polymerization and condensation reaction. Enzymatic and hydrolytic degradation experiments demonstrate that the PU can degrade in seawater. Such a polyurethane exhibit a more rapid degradation in comparison with that with poly(ε-caprolactone) (PCL) soft segments because the introduction of GA can reduce the crystallinity, as revealed by differential scanning calorimetry (DSC) and polarizing optical microscope (POM). Marine field tests show that the degradable polyurethane has good antifouling ability due to its self-renewal property. Besides, such polyurethane can serve as a carrier and controlled release system for an antifoulant, and the incorporation of an antifoulant in the polyurethane can significantly improve the antifouling ability and duration.
研究领域:
材料科学
·
海洋生物学
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生物医学工程
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产品关联
DOI
PubMed
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Miao Gao,Lei He,Zhi-Yan Guo,Yan-Ru Yuan,Wen-Wei Li
Nickel hydroxide (Ni(OH)2)-based electrocatalysts are promising for the oxygen evolution reaction (OER) due to their low cost, but their activity and durability still need substantial improvement to meet practical application. Here, we report a sulfate-functionalized Ni(OH)2 nanobelt (S-Ni(OH)2) electrocatalyst, which exhibited self-enhanced OER activity due to its self-renewed surface during anodic oxidation. The S-Ni(OH)2 was in situ grown on the nickel foam (NF) surface in potassium peroxydisulfate solution through one-step hydrothermal treatment. This material outperformed all the existing electrocatalysts in the intensity and duration of the OER activity enhancement. An overpotential drop of 70 mV is shown by the S-Ni(OH)2/NF electrode during 110 h reaction at a current density of 100 mA cm–2, and the overpotential remains as low as 358 mV at a current density of 200 mA cm–2. Such activity enhancement during OER is mainly ascribed to the formation of a highly active NiOOH/Ni(SO4)0.3(OH)1.4 composite on the S-Ni(OH)2 surface as a result of gradual sulfate release. Given the facile and environmentally benign fabrication process (without external addition of a Ni source and surfactant) and good electrochemical properties (high activity and long lifetime), the S-Ni(OH)2 holds great potential for practical OER application. The surface self-renewal strategy developed here might also be expanded to other electrocatalysts and electrochemical processes.
研究领域:
材料科学
·
电化学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Zhongqiang Yu,Yine Ren,Yanke Li,Xuesong Chen,Wen Sun,Lida Wang,Zhengqing Yang,Guichang Liu,Qian Zhang
The release of toxic and persistent substances in conventional antifouling paints has elicited substantial environmental concerns, underscoring an urgent requirement for eco-friendly alternatives. This study presents the successful synthesis of an eco-friendly antifouling coating, denoted as PSBZ-X-Y, through the grafting of a hydrolysable borneol-modified zwitterionic precursor, DEA-IBOA, onto a bio- derived rosin resin. The PSBZ-X-Y coating exhibits a controlled self-renewable rate (50–400 μg/cm 2 ·d) tuned by varying DEA-IBOA modified rosin content, which enhances the coating's durability and regulates the release of borneol. Molecular dynamics (MD) simulations and surface structure analyses, including ATR-FTIR and XPS, reveal that hydrolysis of DEA-IBOA leads to the release of the natural antimicrobial agent borneol and thus facilitates the in-situ generation of zwitterionic surfaces. Amphiphilic surfaces and natural antimicrobial borneol as eco-friendly approaches synergistically enhance the antifouling properties of natural rosin, which in turn promotes the sustainability of amphiphilic surfaces due to its self-renewal capability. Consequently, the coating exhibits remarkable resistance to protein adhesion (FITC-BSA adhesion rate: 0.4 %), bacterial biofilm formation (absorbance of biofilm: 1.3), and diatom attachment (150 cells/mm 2 ), as well as remarkable antifouling properties in real marine environments. More importantly, the hydrolyzed products generated during the coating renewal process demonstrate no adverse effects on the marine ecosystem, thus contributing to eco-friendly antifouling systems based on natural products.
研究领域:
材料科学
·
海洋生物学
·
环境科学
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产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Yue Zhang,Hui Zhao,Qianxi Feng,Rui Guo,Li Zhong,Shengxian Liang
Benzotriazole ultraviolet stabilizers (BUVSs) are pervasive environmental contaminants that pose significant risks to human health. This study evaluated the effects of three typical BUVSs (UV-328, UV-329, and UV-P) on human mesenchymal stem cells (hMSCs), which play crucial roles in tissue maintenance and repair. hMSCs were exposed to BUVSs across a range of concentrations, and their maintenance and differentiation capacities were assessed. At concentrations below 50 μM, no significant cytotoxicity was observed. However, at non-cytotoxic doses, UV-P exhibited stronger effects on the differentiation of hMSCs compared to UV-328 and UV-329, significantly inhibiting adipogenesis and enhancing osteogenesis. Mechanistically, UV-P was found to significantly enrich the PPAR signaling pathway during both differentiation processes. Dual-luciferase reporter assays confirmed UV-P's interaction with PPARγ_LBD at an alternate binding site outside the canonical pocket. These findings raise concerns about the health impacts of BUVSs, particularly UV-P, and underscore the need for further investigation into their toxicological profiles.
研究领域:
细胞生物学
·
毒理学
·
环境健康科学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Zhuan Chen,Wei Sun,Qiang Luo,Hongtao Liu,Yining Wang,Yongping Hou,Yongmei Zheng
Natural organisms have inspired many recent studies in fog collection. Most materials undergo three sequential steps during fog collection: fog capture, coalescence and transportation. Finally, captured droplets intermittently detach from the surface only when they reach substantial volume, solely via gravity, which may result in low capture efficiency and surface refresh rate, hindering fog collection efficiency. Herein, inspired by the Namib desert beetle back, Sarracenia trichome, liquid bridges (LB) in shore birds’ beak and the hierarchical structures of natural liquid transportation systems, we design a LB assisted fog collection system (LBAFCS) using hierarchically grooved surfaces (HGS). The introduction of LB could not only potentially merge the coalescence and transportation steps in conventional fog collection into a combined removal step, presenting a special fog collection mode, but could also allow droplets to be removed without needing to grow to a larger volume, leading to higher surface refresh rate. Increasingly hierarchically arranged grooves on the samples surface could significantly increase the removal frequency of droplets, also resulting in higher surface refresh rate. The results indicate, compared with a 0 mm LB, a 4 mm length LB can facilitate droplet removal via the hydrophilic regions and grooves on the sample, with a respective 16% and 10% increase in droplet penetration velocity and flux. We achieve a 14.7 kg m-2 h-1 fog collection efficiency on our 3rd-groove sample with 4 mm LB, 2.75 times more than on the same sample without a LB (conventional collection mode), and 1.38 times that with 0 mm LB.
研究领域:
材料科学
·
仿生学
·
流体力学
·
表面工程
·
环境技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）