CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Qiongfang Zhuo,Jinbao Wang,Junfeng Niu,Bo Yang,Yang Yang
BDD/SnO 2 -F electrode was synthesized by spin-coating and heat treatment, and it was characterized by scanning electron microscope-energy dispersive spectrometer (SEM-EDS), X-ray diffraction (XRD), and linear sweep voltammetry (LSV). Electrochemical oxidation of chlorinated polyfluorinated ether sulfonate (F-53B, ClCF 2 CF 2 CF 2 CF 2 CF 2 CF 2 -O-CF 2 CF 2 -SO 3 K) as PFOS substitute was carried out with the BDD, BDD/SnO 2 , BDD/PbO 2 , and BDD/SnO 2 -F anodes. The effects of F and Sn ratio, current density, initial pH, initial F-53B concentration, the supporting electrolyte, NaCl concentration, and electrode distance on the degradation ratios were investigated. The defluorination and the desulfurization were evaluated by ion chromatography and UV–vis spectra. The intermediate products were analyzed on the liquid chromatography system coupled with a triple-stage quadrupole mass spectrometer (LC-MS/MS). The experimental results showed that BDD/SnO 2 -F had the most outstanding electrochemical oxidation performance. After introduction of F into SnO 2 crystal, the grain size of SnO 2 -F was reduced, the oxygen evolution potential was increased by 0.13 V, and the degradation ratio of F-53B was increased by 15.07%. Under the optimum operating parameters, F-53B removal ratio of 95.6% was obtained, and the defluorination ratio reached 61.39% with NaCl supporting electrolyte concentration of 1 mol/L at current density of 30 mA/cm 2 after electrolysis of 30 min. Finally, the electrochemical degradation pathways and the mechanisms of F-53B were proposed based on the intermediate products and the previous literature reported. This study indicates that the electrochemical performance of BDD anode can be much improved by modification with SnO 2 -F, and BDD/SnO 2 -F anode is kind of effective anode to decompose refractory compounds.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
NUCLEAR ENGINEERING AND DESIGN
·
2024
·
IF 1.9
Chenchen Niu,Aiqing Chen,Kaiwen Hu,Kai Xu
Due to its long half-life, high fission yield, and high mobility in the groundwater, Technetium-99 (Tc-99) is a troublesome nuclide in nuclear waste. Moreover, the primary concern is the high volatility of Tc during nuclear waste vitrification. Previous studies demonstrated that nitrate significantly affected the Tc volatilization during the vitrification of Tc-containing waste. However, identifying how nitrate affects Tc volatilization is challenging due to the complexity of the composition of nuclear waste. This study used a simplified SiO 2 -KNO 3 -KReO 4 feed with rhenium (Re) as a Tc non-radioactive surrogate to study the nitrate effect on the Re volatilization at elevated temperatures. The results showed that KNO 3 could facilitate Re volatilization at temperatures below 800 °C when the molar percentage of KNO 3 in the KNO 3 -KReO 4 binary system exceeded 60 mol%, which was attributed to the eutectic reaction between KReO 4 and KNO 3 at 310 °C. However, the increased KNO 3 content could inhibit the Re volatilization at temperature above 1200 °C since adding KNO 3 could increase the amorphous phase content, where Re was encapsulated and hardly evaporated.
研究领域:
核化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2016
·
IF 3.199
Jiahui Gu,Zhong Xin,Xin Meng,Shuzhen Sun,Qingan Qiao,Hongbo Deng
In this study, the zein extracted from distillers dried grains with solubles (DDGS) is utilized to produce a fat analogue, by employing a simple ”reduced-pressure distillation microparticulation“ method. The optimal conditions for preparing the fat analogue are as follows: a zein concentration of 3 w/v% (based on 60 v/v% ethanol water), an agitator speed of 200 rpm, a xanthan gum amount of 20 wt% (based on zein mass) and a heating temperature of 50 °C. The zein-based fat analogue obtained has a volume-weighted mean diameter (D[4, 3]) of about 16 μm, which is then applied in the formulation of mayonnaise , at fat substitution ratios of 0% (full-fat), 20%, 40%, 60%, 80% and 100%, respectively. Based on the appearance, stability, total calorific value, as well as rheological, microstructure and sensory analyses, it may be concluded that the fat substitution ratio of no more than 40% is acceptable. This paper illustrates another high-value added use of zein.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2014
·
IF 0.697
Chuan-Zhu Gao,Tian-Shuai Wang,Jia Chen,Fan Fei,Ji Chen,Yan Zhang,Bo Yang
A novel and efficient method has been developed for the chiral resolution and separation from cis-cyclohexane-1,2-diamine of (±)-cyclohexane-1,2-diamine, which reacts with xylaric acid, a substitute for tartaric acid. This method provides (1R,2R)-cyclohexane-1,2-diamine, and (1S,2S)-cyclohexane-1,2-diamine and cis-cyclohexane-1,2-diamine in good yield with high optical purity.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Ke Gao,Kai Hua,Xi Chen,Congyi Zheng,Xingtong Li,Qingyan Wu,Lingrui Ji,Linxiao Wang,Wei Wei,Liping Lu
Phthalates (PAEs) constitute the primary components of indoor dust pollutants and significantly impact human reproductive health. However, research on novel alternatives to PAEs and the risk assessment of mixed exposure has remained relatively sparse. In this study, 193 indoor dust samples were collected in 2022 from various campus locations, including classrooms, canteens, dormitories, offices, and laboratories. Forty-four traditional PAEs and their alternatives were identified, with concentrations ranging from 0.44 to 91.5 μg/g. Di(2-ethylhexyl) phthalate (DEHP) and dioctyl terephthalate (DEHTH) were the predominant compounds, with mean concentrations of 86.3 and 59.2 μg/g, respectively. The ingestion pathway was the principal route of exposure, with dormitories identified as the primary exposure sites. The mixed reproductive toxicity equivalent factor (TEFmix) of PAEs and their alternatives was developed using a quantitative structure–activity relationship (QSAR) model in conjunction with machine learning algorithms. The TEFmix was found to be lower than the sum of individual PAEs, potentially due to the antagonistic effects of PAE monomers on reproductive health. Under high-exposure scenarios, the TEFmix of PAEs in canteen dust was determined to be 0.245, surpassing values observed in other environments. Females exhibited a higher risk, with dormitories presenting a greater exposure risk than those in other indoor locations. This study provided essential data to inform regulatory measures aimed at mitigating the impact of PAEs and their alternatives in indoor dust on human reproductive health.
研究领域:
环境科学
·
毒理学
·
公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AQUATIC TOXICOLOGY
·
2024
·
IF 4.1
Huan-Yu Tao,Jianghong Shi,Jiawei Zhang,Hui Ge,Mengtao Zhang,Xiao-Yan Li
Diisobutyl phthalate (DiBP), is widely chemical replacement for Dibutyl phthalate (DBP). Although DBP and DiBP have been detected in surface water worldwide, few studies to date have systematically assessed the risks of DBP and its alternatives to aquatic organisms. The present study compared DBP and DiBP for their individual and joint toxicity as well as thyroid hormone levels in zebrafish embryo. Transcripts of key genes related to the hypothalamic-pituitary-thyroid (HPT) axis were investigated in developing zebrafish larvae by application of real time polymerase chain reaction. The median half-lethal concentrations of DBP and DiBP to zebrafish at 96 h were 0.545 mg L −1 and 1.149 mg L −1 , respectively. The joint toxic effect of DBP–DiBP (0.25–0.53 mg L −1 ) with the same ratio showed a synergistic effect. Thyroid hormones levels increased with exposure to 10 μg L −1 of DBP or 50 μg L −1 of DiBP, and exposure to both compounds significantly increased thyroid gland-specific transcription of thyroglobulin gene ( tg ), hyronine deiodinase ( dio2 ), and transthyretin ( ttr ), indicating an adverse effect associated with the HPT axis. Molecular docking results indicated that DBP (−7.10 kcal/M and −7.53 kcal/M) and DiBP (−6.63 kcal/M and −7.42 kcal/M) had the same docking energy with thyroid hormone receptors. Our data facilities an understand of potential harmful effects of DBP and its alternative (DiBP).
研究领域:
环境科学
·
毒理学
·
发育生物学
✓ 已验证
DOI
PubMed
高影响因子
SYNLETT
·
2025
·
IF 1.4
Yuan-Ding Wan,Zhi Li
Halohydrin esters could be versatile synthetic reagents, but their conventional synthesis commonly involved hazardous ethylene oxide. An economic, mild, safe and scalable one-step halohydrin esters synthesis was achieved from easily accessible NaX, concentrated sulfuric acid, and polyol esters. The halohydrin esters products were applied in hydroxyethylation reactions with various nucleophiles in replacement of EO. Repetition of the protocol allowed unsymmetric difunctionalization of diol esters. The mechanism likely involves acyloxonium intermediate through neighboring group participation.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2020
·
IF 1.701
Bo Zuo,Xiaoxu Ma,Li Wu,Jiang Zhao,Xinlei Gao,Kang Dai
Thirty-one hydrazides were selected as isosteres and other analogs when five phosphates were used as templates by an isosteric exchange from phosphate group (PO4) to hydrazide group (CONHN). Their tribological properties of the lubricant modified with 1% hydrazide or phosphate additives were tested under 98 N load in three base oils, respectively. About 40% of the isosteres showed an acceptable deviation of ±5% relative to the template. The phosphate template molecules and hydrazide isosteres have better tribological properties in triisodecyl trimellitate than trimethylolpropane trioleate or di(2-ethylhexyl) adipate. Especially, most of the other hydrazide analogs have better antiwear property because of the same CONHN group as the isostere. CoMFA and CoMSIA models were used to discuss the dependency of molecular structure. The models show that the higher the structural similarity between the base oil and the additive, the more synergy the molecular force field in a lubricant, which may ameliorate the antiwear or friction-reduction properties. Surface analysis of the worn disc specimen also shows similarity between a template and an isostere by Scanning Electron Microscopy, EDS, and Raman spectra.
研究领域:
材料科学
·
化学工程
·
表面工程
✓ 已验证
DOI
高影响因子
Journal of Zhejiang University-SCIENCE B
·
2019
·
IF 1.879
Bin Zhang,Qian Xue,Han-yi Hu,Meng-fei Yu,Lei Gao,Yi-chen Luo,Yang Li,Jin-tao Li,Liang Ma,Yu-feng Yao,Hua-yong Yang
Background: The shortage of donor corneas is a severe global issue, and hence the development of corneal alternatives is imperative and urgent. Although attempts to produce artificial cornea substitutes by tissue engineering have made some positive progress, many problems remain that hamper their clinical application worldwide. For example, the curvature of tissue-engineered cornea substitutes cannot be designed to fit the bulbus oculi of patients. Objective: To overcome these limitations, in this paper, we present a novel integrated three-dimensional (3D) bioprinting-based cornea substitute fabrication strategy to realize design, customized fabrication, and evaluation of multi-layer hollow structures with complicated surfaces. Methods: The key rationale for this method is to combine digital light processing (DLP) and extrusion bioprinting into an integrated 3D cornea bioprinting system. A designable and personalized corneal substitute was designed based on mathematical modelling and a computer tomography scan of a natural cornea. The printed corneal substitute was evaluated based on biomechanical analysis, weight, structural integrity, and fit. Results: The results revealed that the fabrication of high water content and highly transparent curved films with geometric features designed according to the natural human cornea can be achieved using a rapid, simple, and low-cost manufacturing process with a high repetition rate and quality. Conclusions: This study demonstrated the feasibility of customized design, analysis, and fabrication of a corneal substitute. The programmability of this method opens up the possibility of producing substitutes for other cornea-like shell structures with different scale and geometry features, such as the glomerulus, atrium, and oophoron.
研究领域:
组织工程学
·
再生医学
·
生物制造
✓ 已验证
DOI
PubMed
高影响因子
Micromachines
·
2025
·Vol. 16
·期 5
·552
·
IF 3
Qiqi Dai,Huazhen Liu,Wenbin Sun,Yi Zhang,Weihuang Cai,Chunxiang Lu,Kaidi Luo,Yuanyuan Liu,Yeping Wang
Severe skin damage poses a significant clinical challenge, as limited availability of skin donors, postoperative skin defects, and scarring often impair skin function. Traditional two-dimensional (2D) nanofibers exhibit small pore sizes that hinder cellular infiltration, unable to simulate the three-dimensional (3D) structure of the skin. To address these issues, we developed 3D porous nanofiber scaffolds composed of polycaprolactone–polylactic acid–mussel adhesive protein (PLGA-PCL-MAP) using low-temperature electrospinning combined with nano-spray technology. Meanwhile, this 3D scaffold features high porosity, enhanced water absorption, and improved air permeability. The incorporation of mussel adhesive protein (MAP) further increased the scaffold’s adhesive properties and biocompatibility. In vitro experiments demonstrated that the 3D nanofiber scaffolds significantly promoted the adhesion, proliferation, and migration of epidermal keratinocytes (HaCaTs) and human fibroblasts (HFBs), while providing ample space for inward cellular growth. Successful co-culture of HaCaT and HFBs within the scaffold revealed key functional outcomes: HaCaTs expressed keratinocyte differentiation markers CK10 and CK14, while HFBs actively secreted extracellular matrix components critical for wound healing, including collagen I, collagen III, and fibronectin. This skin substitute with a composite structure of epidermis and dermis based on three-dimensional nanofiber scaffolds can be used as an ideal skin replacement and is expected to be applied in wound repair in the future.
研究领域:
生物医学工程
·
组织工程
·
材料科学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2013
·Vol. 101
·期 8
·1359-1366
·
IF 2.308
Yu-fei Wang,Hong-feng Guo,Da-jun Ying
Dural closure after the neurosurgery can prevent postoperative complications. Although many types of dural substitute have been developed, most of them lack functional and structural characteristics compared with the natural dura mater. In this study, we used electrospinning method to fabricate a multilayer scaffold to promote dural repair. The inner layer of the scaffold that faces the brain tissue is composed of poly-lactic acid (PLA) to reduce tissue adhesion. The middle layer of the scaffold is composed of poly-ɛ-caprolactone and PLA, which provides a watertight seal. The outer layer of the scaffold contains a large amount of collagen to promote cell attachment and proliferation. The results from in vitro study and an animal model have shown that this multilayer fibrous scaffold has sufficient mechanic strength and biochemical properties to enhance dural repair. Therefore, fabrication of scaffold with multiple functional and structural layers may provide a novel approach for tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1359–1366, 2013.
研究领域:
生物材料
·
神经外科
·
组织工程
·
再生医学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2020
·
IF 2.69
Li Yan,Haoyu Wang,Hui Xu,Rui Zheng,Zhengyu Shen
In this study, an ideal nano-scale material, named epidermal stimulating (ES) factors-gelatin/polycaprolactone (GT/PCL) nanofiber, was fabricated using a coaxial electrospinning technique. The ES-GT/PCL nanofibers possessed a highly porous structure with qualified mechanical properties for transplantation. With ES factors stored in the core and GT/PCL in the shell, the ES factors could be protected and released in a sustained manner. After seeding L929 cell line on ES-GT/PCL nanofibers for 7 days in vitro, the proliferation of cells was nearly 1.5 folds compared to the control group. The in vivo study showed that ES-GT/PCL nanofibers can accelerate skin wound healing rate during the healing course, especially on the early stage. The epidermal and dermal thickness, as well as skin appendages and fat tissue, were the most similar to the native skin. These findings provided valuable insights into the addition of multiple bioactive factors to nanometre biomaterials, and optimising the advantages of the compositions as a promising potential dermal substitute construct.
研究领域:
生物材料学
·
再生医学
·
组织工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）