JOURNAL OF CHEMICAL THERMODYNAMICS
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2022
·
IF 3.269
Tao Li,Liukai Zhu,Jiaheng Li,Zidan Cao,Jiao Sha,Yu Li,Baozeng Ren
The solubility properties of tinidazole (TNZ) in investigated fourteen mono-solvents were further studied at several temperature points (278.15 K ∼ 323.15 K) under 101.2 kPa using the laser monitoring technique. The selected solvents were acetone, methanol, ethanol, 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, 2-butoxyethanol, methyl acetate, ethyl acetate, n-propyl acetate, n-butyl acetate, NMP, DMF, DMAC, respectively. The order of solubility of tinidazole in fourteen mono-solvents at 298.15 K is: NMP > DMAC > DMF > acetone > 2-methoxyethanol > methylacetate > 2-ethoxyethanol > ethyl acetate > 2-propoxyethanol > n-propyl acetate > 2-butoxyethanol > n-butyl acetate > methanol > ethanol. As shown by the solubility data of TNZ in chosen fourteen mono-solvents in this work, TNZ is more soluble in higher temperature. The KAT-LSER model and molecular dynamics simulation were adopted to probe the influence of solvent effects and solute–solvent interaction on TNZ solubility. The obtained solubility data of TNZ was fitted by (λh equation, NRTL model, NRTL-SAC model, two-Suffix Margules model, and UNIQUAC model). The results indicate that five models can fit the experimental values well, in which the NRTL-SAC model gives the best regression effect. Moreover, the apparent thermodynamic properties (△ sol G °, △ sol H ° and △ sol S °) of TNZ in various solvents were calculated by Van’t Hoff equation. In accordance with the analysis and calculation of dissolution, the dissolution process is is entropy-motivated and endothermal.
研究领域:
药学
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物理化学
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高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2019
·
IF 4.213
Yan Yang,Haichao Li,Yingying Xu,Yichen Dong,Weiguang Shan,Jie Shen
In view of the high incidence and long-term treatment of dental caries, personalized dental fillers with long therapeutic action have broad application prospects in the dental clinic. The objective of this study was to fabricate and evaluate novel dental fillers using state-of-the-art 3D printing technology. Tinidazole (TNZ), a commonly used antibacterial drug in the dental clinic, was chosen as the model compound. Models of molars with carious cavities were obtained via 3D scanning. TNZ dental fillers were indirectly produced by thermal pressing using customized 3D printed molds. In addition, bio-relevant in vitro dissolution and mechanical testing methods were developed using customized 3D printed release and compression molds, respectively. It was observed that the formability, mechanical properties, and release behavior of the TNZ dental fillers were affected by mold materials, plasticizers, and release modifiers. The developed dental fillers were capable of sustained releasing TNZ over one week. The TNZ release characteristics can be tailored based on clinical requirements by varying hydroxypropyl methylcellulose E5 (HPMC-E5) concentrations and filler dimensions. Moreover, computational simulation based on the finite element method showed that the biomechanical behavior of the TNZ dental fillers met the daily use requirement. The present study demonstrated that the state-of-the-art 3D printing technology can be used to design and fabricate personalized dental fillers with high mechanical strength and “on-demand” drug release characteristics.
研究领域:
牙科学
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材料科学
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药学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2025
·Vol. 26
·期 17
·8366
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IF 4.9
Jingfei Luan,Boyang Liu,Liang Hao,Wenchen Han,Anan Liu
A high-performance Z-scheme heterojunction photocatalytic compound, ZnBiGdO4/SnS2(ZS), was prepared for the first time using a microwave-assisted solvothermal method. ZS significantly improved the separation efficiency of photoinduced carriers and effectively broadened the response range to visible light through the unique mechanism of the Z-type heterojunction. Therefore, ZS exhibited an excellent photocatalytic performance during the degradation process of tinidazole (TNZ). Specifically, the removal rate of TNZ by ZS reached 99.63%, and the removal rate of total organic carbon (TOC) reached 98.37% with ZS as catalyst under visible light irradiation (VLIN). Compared to other photocatalysts, the photocatalytic performance of ZS was significantly better than that of ZnBiGdO4, SnS2, or N-doped TiO2(N-T). The removal rate of TNZ by ZS was 1.12 times, 1.26 times, or 2.41 times higher than that by ZnBiGdO4, SnS2, or N-T, respectively. The mineralization efficiency of TNZ for TOC with ZS as a catalyst was 1.15 times, 1.28 times, or 2.57 times higher than that with ZnBiGdO4, SnS2, or N-T as a catalyst, respectively. Free radical scavenging experiments and the electron paramagnetic resonance experiments confirmed that ZS could generate multiple reactive species such as hydroxyl radicals (•OH), superoxide anions (•O2−), and photoinduced holes (h+) during the photocatalytic degradation process of TNZ. The photocatalytic degradation performance of ZS on TNZ under VLIN was evaluated, concurrently, the reliability, reproducibility, and stability of ZS were verified by five cycle experiments. This study explored the degradation mechanism and degradation pathway of TNZ with ZS as a catalyst under VLIN. This study not only provides new ideas for the design and preparation of Z-type heterojunction photocatalysts but also lays an important foundation for the development of efficient environmental remediation technologies for TNZ pollution.
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高影响因子
WATER SCIENCE AND TECHNOLOGY
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2022
·Vol. 85
·期 12
·3357-3369
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IF 2.43
Xu Anlin,Liu Wanqun,Chu Leping,Zhang Yunhai,He Yide,Zhang Yongjun
The cathode is the key component in the electro-peroxone process (E-Peroxone), which is popularly constructed with carbon materials. This study developed an innovative method to fabricate a cathode with waste-tire carbon (WTC) whose performance was evaluated for the degradation of tinidazole (TNZ), an antibiotic frequently detected in water. It was found that the addition of WTC in the cathode can significantly promote the yield of H 2 O 2 and the current efficiency: around 2.7 times that of commercial carbon black at the same loading. The critical influencing factors were studied, including the current density, ozone concentration, initial pH value, chlorine ions and initial TNZ concentration. The scavenger tests demonstrated the possible involvement of •OH and . Some transformation products of TNZ were identified with UPLC-MS and the degradation pathway was proposed accordingly. These results demonstrated the potential of WTC for developing E-Peroxone cathodes. The cathode with WTC generated more H 2 O 2 than a commercial carbon black cathode. Reaction conditions including current density, O 3 dose, pH values, initial TNZ concentration and electrolyte were studied. The main reactive oxygen species were probably •OH and . Transformation products were identified and a degradation pathway was proposed.
研究领域:
环境工程
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电化学
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水处理
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材料科学
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药物污染
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ADVANCED MATERIALS
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2024
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IF 27.4
Shuoyuan Li,Yan Yue,Wenqi Wang,Mingyue Han,Xufeng Wan,Qiaochu Li,Xiaoting Chen,Jian Cao,Yangming Zhang,Jiyao Li,Jianshu Li,Lei Cheng,Jiaojiao Yang,Duan Wang,Zongke Zhou
Implant-associated infections (IAIs) are the main cause of prosthetic implant failure. Bacterial biofilms prevent antibiotic penetration, and the unique metabolic conditions in hypoxic biofilm microenvironment may limit the efficacy of conventional antibiotic treatment. Escaping survival bacteria may not be continually eradicated, resulting in the recurrence of IAIs. Herein, a sonosensitive metal-organic framework of Cu-TCPP (tetrakis(4-carboxyphenyl) porphyrin) nanosheets and tinidazole doped probiotic-derived membrane vesicles (OMVs) with high-penetration sonodynamic therapy (SDT), bacterial metabolic state interference, and bacterial cuproptosis-like death to eradicate IAIs is proposed. The Cu-TCPP can convert O 2 to toxic 1 O 2 through SDT in the normoxic conditions, enhancing the hypoxic microenvironment and activating the antibacterial activity of tinidazole. The released Cu(II) under ultrasound can be converted to Cu(I) by exogenous poly(tannic acid) (pTA) and endogenous glutathione. The disruption of the bacterial membrane by SDT can enhance the Cu(I) transporter activity. Transcriptomics indicate that the SDT-enhanced Cu(I) overload and hypoxia-activated therapy hinder the tricarboxylic acid cycle (TCA), leading to bacterial cuproptosis-like death. Moreover, the OMVs-activated therapy can polarize macrophages to a M2-like phenotype and facilitate bone repair. The sonodynamic biofilm microenvironment modulation strategy, whereby the hypoxia-enhanced microenvironment is potentiated to synergize SDT with OMVs-activated therapy, provides an effective strategy for antibacterial and osteogenesis performance.
研究领域:
生物材料
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纳米技术
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生物医学工程
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传染病学
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免疫学
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骨科学
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
·
IF 4.098
Xueqing Guo,Yang Liu,Wenjuan Dong,Qin Hu,Yong Li,Shaomin Shuang,Chuan Dong,Lishuai Cai,Xiaojuan Gong
Azithromycin (AZM) 1 is one of the most widely used antibiotics. AZM abuse is easy to cause great harm to human body, so developing a rapid and sensitive method to detect AZM is of great importance. Herein, 3-aminothiophenol as only reaction precursor, nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs) 2 were fabricated by one-step hydrothermal carbonization method. All characteristics demonstrate that N,S-CQDs possess good water solubility, high fluorescence stability and low cytotoxicity. Without being disturbed by amino acids and drugs, the most interesting finding is that AZM can efficiently quench the fluorescence of N,S-CQDs by a synergistic effect of electrostatic interaction and static quenching. A fluorescent probe for the detection of AZM was constructed with high selectivity and good sensitivity, achieving two linear ranges of 2.5–32.3 μM and 37.2–110 μM and a limit of detection of 0.76 µM. The proposed fluorescent method was used for the detection of AZM in cells with fulfilling results. More importantly, the fluorescent probe was successfully used to the detection of AZM in tablets and human urine with recovery rate and relative standard deviations of 98.2–104.8% and 0.04–3.46%, respectively, which was confirmed by the standard method of HPLC-UV. This finding illustrates the usefulness and feasibility of N,S-CQDs as an effective fluorescent probe for the detection of AZM in tablets and human urine, which is helpful for supervising and guiding pharmacy.
研究领域:
药物分析
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荧光材料
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生物医学工程
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PubMed
高影响因子
International Journal of Nanomedicine
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2020
·
IF 5.115
Gaofeng Liang,Hao Shi,Yijun Qi,Jinghua Li,Aihua Jing,Qiwei Liu,Wenpo Feng,Guangda Li,Shegan Gao
Introduction Biofilms protect bacteria from antibiotics and this can produce drug-resistant strains, especially the main pathogen of periodontitis, Porphyromonas gingivalis. Carbon quantum dots with various biomedical properties are considered to have great application potential in antibacterial and anti-biofilm treatment.Methods Tinidazole carbon quantum dots (TCDs) and metronidazole carbon quantum dots (MCDs) were prepared by a hydrothermal method with the clinical antibacterial drugs tinidazole and metronidazole, respectively. Then, TCDs and MCDs were characterized by transmission electron microscopy, UV–visible spectroscopy, infrared spectroscopy and energy-dispersive spectrometry. The antibacterial effects were also investigated under different conditions.Results The TCDs and MCDs had uniform sizes. The results of UV–visible and energy-dispersive spectrometry confirmed their important carbon polymerization structures and the activity of the nitro group, which had an evident inhibitory effect on P. gingivalis, but almost no effect on other bacteria, including Escherichia coli, Staphylococcus aureus and Prevotella nigrescens. Importantly, the TCDs could penetrate the biofilms to further effectively inhibit the growth of P. gingivalis under the biofilms. Furthermore, it was found that the antibacterial effect of TCDs lies in its ability to impair toxicity by inhibiting the major virulence factors and related genes involved in the biofilm formation of P. gingivalis, thus affecting the self-assembly of biofilm-related proteins.Conclusion The findings demonstrate a promising new method for improving the efficiency of periodontitis treatment by penetrating the P. gingivalis biofilm with preparations of nano-level antibacterial drugs.
研究领域:
口腔医学
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纳米生物学
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
·
IF 3.232
Guodong Ren,Xiaoyu Hou,Yu Kang,Rong Zhang,Min Zhang,Wen Liu,Lihong Li,Shuangyan Wei,Haojiang Wang,Bin Wang,Haipeng Diao
Herein, nitrogen-doped carbon dots (N-CDs) emitting blue fluorescence were prepared using L-tartaric acid and triethylenetetramine through a simple and quick microwave-assisted method. The synthesized N-CDs displayed excitation-dependent fluorescence behavior, and their maximum excitation and emission wavelengths were 350 and 425 nm, respectively. The obtained N-CDs, which featured excellent fluorescence properties with a high fluorescence quantum yield of 31%, were applied to detect metronidazole (MNZ), which can effectively quench the fluorescence intensity of N-CDs due to the inner filter effect. This phenomenon was used as basis to develop a label-free fluorescent method for rapid MNZ determination, with the limit of detection of 0.22 μM and corresponding linear range of 0.5–22 μM. Hence, we had established a fluorescence method for MNZ detection and applied it to detect MNZ in real samples with satisfactory results. Finally, N-CDs with superior biocompatibility were applied for cell imaging and MNZ detection by the changes in fluorescence intensity.
研究领域:
材料科学
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分析化学
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生物医学工程
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Qianqian Wang,Weihua Liu,Lin Hao,Chun Wang,Qiuhua Wu,Zhi Wang
A magnetic porous organic framework (M-POF) was rationally designed and served as a sorbent for magnetic solid-phase extraction of six nitroimidazoles from chicken meat prior to their assay by high-performance liquid chromatography with diode array detection. The M-POF exhibited good magnetic responsiveness and outstanding affinity to nitroimidazoles with large adsorption capacity up to 36 mg g −1 . Under optimal conditions, the developed method offered good linearity ( r greater than 0.992) in the range of 1.5–100.0 ng g −1 , low limits of detection (S/N = 3) of 0.5–0.8 ng g −1 , low limits of quantification of 1.5–2.5 ng g −1 and high enrichment factors of 80–175 for the nitroimidazoles. The method was successfully applied to analyze nitroimidazoles in chicken meat. The recoveries were 80.2–118% with relative standard deviations lower than 12%. The adsorption mechanism was further explored and the results showed that the M-POF exhibited adsorption potential for compounds with strong polar interactions.
研究领域:
分析化学
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食品科学
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材料科学
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PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2016
·
IF 4.712
Na Xu,Hong-Wei Li,Yuqing Wu
A novel one-step hydrothermal synthesis of highly fluorescent platinum nanoclusters protected by polyethylenimine (Pt-NCs@PEI) is described. The products are characterized well by UV–vis absorption, fluorescence spectra , X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM) imaging. The Pt-NCs@PEI possess high quantum yield at 28%, which is the relatively high one among the reported Pt-NCs; especially, the synthesis is in one-step and the reaction time is much shorter (<1 h) than the related methods. In addition, the Pt-NCs@PEI have large Stocks-shift (∼150 nm), high tolerability to the extreme pH and high ionic strengths , and excellent photo-stability under UV–vis irradiation, lay the foundation for the practical bio-applications. Finally, the obtained Pt-NCs@PEI are used to determine trace amount of metronidazole (MTZ) in buffer solution in showing a linear response over a concentration range of 0.25–300 μM and a low detection limit of 0.1 μM. Furthermore, the related investigation on response mechanism will be helpful to design and synthesize new metal nanoclusters as fluorescent probe to detect the trace amount of harmful medicine residuum as nitroimidazoles in human body.
研究领域:
分析化学
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纳米材料科学
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生物医学工程
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PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Yu Wang,Juanjuan Wang,Ming Guan,Parashuram Kallem,Hongdeng Qiu,Jia Chen
In this work, Fe/Ni bimetallic nitrogen-doped porous graphene (Fe/Ni-NPG) nanomaterials with rich pores, strong magnetism and good reusability were successfully prepared by one-step combustion and can be used as magnetic solid phase extraction (MSPE) adsorbents for the determination of 5-nitroimidazoles (5-NDZs) in environmental water samples. The dispersion and active sites of the materials were increased by the introduction of nitrogen. The adsorption behavior of Fe/Ni-NPG for 5-NDZs was investigated, which corresponds to the quasi-second-order kinetics and Langmuir adsorption model. The π-π electron donor-acceptor interaction (π-π EDA), hydrogen bond and electrostatic interaction between Fe/Ni-NPG and 5-NDZs are the main factors that help to obtain excellent adsorption properties. Several important conditions of MSPE are systematically optimized. Under the optimal MSPE conditions, the linear range of DMZ was 0.6–500 μg/L, the linear range of TNZ and ONZ was 0.7–500 μg/L, and the correlation coefficient R 2 ≥ 0.9991. The limit of detection was 0.18–0.2 μg/L, the limit of quantification was 0.6–0.7 μg/L, and the RSDs of intraday and interday precision were 1.58%–4.66% and 3.77–9.69%, respectively. In the three spiked actual environmental water samples, the recovery was 78.05%–107.05% (RSDs<7.82%). The results show that this method based on Fe/Ni-NPG provides an accurate and reliable way to detect 5-NDZs in environmental water.
研究领域:
分析化学
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环境科学
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材料科学
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PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Yang Wang,Hongwei Yuan,Ye Wan,Lei Zhang
Herein, a magnetic three-dimensional acanthosphere-like hierarchical Co@graphitic carbon (3D Co@GC) is introduced as an efficient adsorbent for extraction of three nitroimidazoles (NMZs: metronidazole (MNZ), ornidazole (ONZ) and tinidazole (TNZ)) from environmental water and food samples. The proposed 3D Co@GC was synthesized by a simple template-free method, which consisted of plentiful freely arranged one-dimensional nanowires. The adsorption properties of 3D Co@GC for three NMZs were investigated systematically by adsorption kinetic and isotherm studies. 3D Co@GC exhibits good adsorption capacity and fast adsorption kinetics toward three NMZs by virtue of its unique hierarchical structure. In addition, it was also found that a bit of methanol can effectively elute the adsorbed NMZs, eliminating the need for other dangerous strong acid or base solutions. Thus, 3D Co@GC as adsorbent to extraction three trace NMZs followed by direct quantification detection of targets with high-performance liquid chromatography with ultraviolet–visible detector (HPLC-UV) was developed. The parameters of dispersed magnetic solid-phase extraction (d-MSPE) were optimized by univariate and multivariate methods (Box-Behnken design). This established method revealed wide linear range and low limits of detection. Furthermore, the satisfactory recoveries of NMZs (86.7–106.7%) were acquired in spiked river water, honey, milk, and muscle samples. This study might provide a potential strategy for the efficient extraction and sensitive analysis of trace NMZs in river water, honey, milk, and muscle samples.
研究领域:
环境科学
·
分析化学
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PubMed
高影响因子
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