ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 415
·期 3
·493-507
·
IF 4.478
Li Zhuoya,Huang Xinyi,Wang Xuan,Ren Jianwei,Xu Buyi,Luo Chunying,Wang Yanjun,Wang Lian,Harada Kouji H.,Zou Xiaoli
A rapid and sensitive high-performance liquid chromatography–high-resolution orbitrap mass spectrometry method was developed for the simultaneous screening of 354 organic poisons and metabolites in blood and urine, including drugs, medications, pesticides, rodenticides, veterinary drugs, alkaloids, and mycotoxins with a multi-toxicant chromatography-mass spectrometry information library. The method and library showed good prospects in clinical poisoning screening and forensic toxicological identification. Blood and urine samples were extracted successively with ethyl acetate in acidic and alkaline conditions; then, the extract was blown to nearly dry by nitrogen gas and redissolved with methanol-aqueous solution (v:v, 50:50), and the dissolved solution was analyzed by LC-MS/MS after filtering. Precursor ions’ m / z was set for identification, retention time, fragment ions, and isotopic pattern which were used for confirmation. No interference peaks were found in the blank samples, showing good specificity. The LODs of toxicants in urine and blood were 1.00×10 −3 –50.0 ng/mL and 2.07×10 −3 –50.0 ng/mL, respectively, while the LOQs were 3.30×10 −3 –1.67×10 2 ng/mL and 6.91×10 −3 –1.67×10 2 ng/mL. The intra-day precision and inter-day precision of urine samples were 2.31–9.13% and 4.75–12.3%, respectively, which were 1.92–10.8% and 2.01–12.1% in blood samples. The established method was applied to analyze 9 cases of clinical poisoning patients, and bromadiolone, carbofuran, and amanitins were detected, respectively. A total of 382 biospecimens from drug abusers were analyzed with the proposed method, which indicated that some drugs were detected in 62 cases, mainly including methamphetamine, heroin, and MDMA. The results were consistent with the information from traditional liquid chromatography-triple quadrupole mass spectrometry. Graphical abstract
研究领域:
临床医学
·
法医学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Pengkun Zhang,Haoyu Wang,Yujie Lai,Yunzhuo Xu,Longyan Chen,Qinhan Wu,Dong-Hau Kuo,Dongfang Lu,Mengistu Tadesse Mosisa,Jiqing Li,Jinguo Lin,Xiaoyun Chen
The rising accumulation of pollutants, including heavy metals and toxic organics, necessitates effective environmental remediation to protect health and biological systems. In this study, a cubic cerianite CeO 2 -like Co/S co-doped CeO 2 sulfur-oxide catalyst (labeled as CeCoOS) with super catalytic reduction performance of pollutants with NaBH 4 as a reducing agent under dark was prepared via a green and facile preparation method. Transition metal Co 2+ -cation and S 2− -anion co-doped CeO 2 adjusted the energy bandgap and introduced oxygen vacancy (Vo), which converted Ce 4+ around Vo into Ce 3+ to maintain electric neutrality. The heterovalent Ce 4+ /Ce 3+ states in Co/S-CeO 2 enhance the electron lifetime and facilitate fast electron transfer . The valence transition between Ce 4+ /Ce 3+ and Vo make the Co/S co-doped in CeO 2 catalyst increase its electrochemically active surface sites and accelerate the pollutants reduction reaction. The CeCoOS-3 with Co/S dopants has an excellent catalytic reduction activity to completely reduce 20 ppm toxic 4-NP in 10 min, 50 ppm organic dyes of MB, RhB, and MO in 6 min, and 50 ppm heavy metal Cr 6+ in 10 min. The CeCoOS-3 sulfur-oxide catalyst also exhibited excellent stability in the reusability test. Therefore, CeCoOS sulfur-oxide catalysts are expected to be used for dye decolorization, detoxification of organic toxins, and reduction of electroplating wastewater.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2015
·
IF 1.56
Zonghe Zhang,Ping Zheng,Wei Li,Ru Wang,Abbas Ghulam
Denitrification plays a key role in the biological nitrogen removal from the wastewater using granular sludge as the integral part of a high-rate denitrification technology. It is helpful to evaluate the effect of typical organic toxicants on the activity of denitrifying granular sludge for the application of denitrification technology. In this study, four typical organic toxicants, namely, penicillin, chloramphenicol, 2,4-dinitrophenol and polymyxin B sulphate were used to assess the effect of organic toxicants on the activity of denitrifying granular sludge. The results of individual toxicity indicated that penicillin, chloramphenicol and 2,4-dinitrophenol had significant inhibition, whose half-inhibitory concentrations were 0.534, 0.162 and 0.474 g/L with respective inhibitory magnitudes of 90.79%/(g/L), 282.5%/(g/L) and 138.83%/(g/L). Polymyxin B sulphate showed no significant inhibition. The results of combined toxicity indicated that the binary mixture of penicillin and chloramphenicol had an antagonistic effect, both the binary mixture of penicillin and 2,4-dinitrophenol and the binary mixture of chloramphenicol and 2,4-dinitrophenol had additive effects. The ternary mixture of penicillin, chloramphenicol and 2,4-dinitrophenol had a partial additive effect.
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）