DYES AND PIGMENTS
·
2023
·
IF 4.5
Xin Hu,Meiying Liu,Xiaoqing Yi,Wei Long,Jianwen Tian,Lihua Chen,Weifeng Zhu,Xiancai Li,Xiaoyong Zhang,Yen Wei
Dopamine is the most abundant catecholamine neurotransmitter in the brain and has extensive applications in biomedicine and materials science. Here, novel metal-free fluorescent organic particles (FOPs) with excellent biocompatibility and high photostability, namely DA-PEG-PEI, were successfully synthesized through combination of ring-opening reaction and crosslinking reaction between polyethyleneimine (PEI) and dopamine-containing copolymers (DA-PEGDGE). Because of the crosslink-enhanced emission (CEE) effect of PEI and a quantity of functional groups such as catechol and amines on the surface of the particles, DA-PEG-PEI FOPs possessed high water dispersibility and superior optical properties , making them highly potential for biological imaging applications. Moreover, owing to the existence of functional components/groups, such as amines, catechol groups, the resultant DA-PEG-PEI FOPs can be potentially applied for loading or carrying different bioactive molecules , such as anticancer agent bortezomib, siRNA and CPG oligodeoxynucleotide through formation of dynamic bonds or electrostatic interaction . Furthermore, this reaction can occur under ambient environment, room temperature, in the present of oxygen and without catalysts. Therefore, we believe that this work could not only provide a simple and elegant route for preparation of FOPs, but also have great potential for construction of multifunctional theranostic platforms.
研究领域:
材料科学
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生物医学工程
·
化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaodi Ye,Ting Sai,Bingtao Wang,Juan Li,Chengfeng Zhang,Zhenghong Guo,Siqi Huo
Despite great advances in overcoming the inherent flammability of polycarbonate (PC), it remains highly challenging to achieve a property portfolio of flame retardancy, mechanical properties and transparency. To ameliorate this issue, a sulfonate organic rigid particle (sSANNa) was synthesized by incorporating sodium sulfonate into the acrylonitrile-styrene copolymer (SAN) molecular chain. Only 0.5 wt% sSANNa endowed the resultant PC/0.5sSANNa composite with desired flame-retardancy, including limiting oxygen index (LOI) of 34.0 % and vertical burning (UL-94) V-0 rating, and well-preserved optical properties. The peak heat release rate (PHRR) and total smoke release (TSR) of PC/0.5sSANNa were respectively decreased by 23 % and 15 % compared to pure PC, attributing to the organic sulfonates promoting the formation of a denser char layer during combustion. Meanwhile, PC/0.5sSANNa showed an enhanced notch impact strength reaching 76.9 kJ·m −2 due to the craze induction mechanism of sSANNa and improved interfacial interaction between PC matrix and sSANNa. This work establishes a promising design strategy for creating transparent, flame-resistant yet tough PC composites by integrating sulfonate and organic rigid particles, expecting to broaden the high-tech applications of PC (e.g. transparent fireproofing board, covers for unmanned vehicles and architectural lighting equipment).
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Oceanology and Limnology
·
2021
·Vol. 39
·期 5
·1622-1633
·
IF 1.265
Qu Yang,Xu Kuidong,Li Tao,Wang Maoyu,Zhong Huan,Chen Tianyu
The ocean is an important inventory of anthropogenic mercury (Hg), yet the history of anthropogenic Hg accumulation in the ocean remains largely unexplored. Deep-sea corals are an emerging archive of past ocean chemistry, which take in sinking or suspended particulate organic matter as their food sources. Such organic matter would exchange Hg with the local seawater before being consumed by the deep, sea corals. As such, the organics preserved in the coral skeleton may record the Hg evolution of the ambient seawater during the time of coral growth. Here, we report the first data on Hg concentrations variability of a deep-sea proteinaceous coral in the oligotrophic North Pacific at the water depth of 1 249 m, in attempt to understand the transfer of anthropogenic Hg into the deep Pacific ocean over the last seven centuries. We find that the Hg concentrations of different coral growth layers have remained relatively constant albeit with considerable short-term variability through time. The overall stable Hg concentration of the last seven centuries recorded in our sample suggests that anthropogenic pollution is not yet a clearly resolvable component in the deep oligotrophic North Pacific waters, in agreement with recent estimation from modelling works and observational studies of modern seawater profiles. As there is hardly an unambiguous way to separate anthropogenic Hg from the natural background based on recent seawater profiles, our historical data provide valuable information helping to understand the oceanic cycle of Hg through time.
研究领域:
海洋地球化学
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环境科学
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古气候学
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生物地球化学循环
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深海生态学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 23
·9152-9161
·
IF 3.069
Rong Wang,Ju Ding,Yanrong Zhang
Fluorescent organic particles are important in a number of areas, including medical imaging; hence, the development of organic materials that exhibit aggregation-induced emissions is an important objective. To that end, we report the synthesis of naphthalimide- and benzimide-based 2-(2-hydroxyphenyl)benzothiazole (HBT) derivatives (HNIBT and HPIBT, respectively) that exhibit aggregation-induced emission enhancement (AIEE), in contrast to most naphthalimide- or benzimide-based derivatives that are prone to aggregation-induced quenching. Experimental studies like single-crystal X-ray diffraction analysis and theoretical calculations demonstrate that the ability to undergo excited-state intramolecular proton transfer is pivotal for AIEE. Further studies revealed that a terminal alkynyl chain at the N-imide site of HPIBT has little impact on the emission behavior of the resultant compound (HPIBT-yl). HPIBT-Pe, an amphiphilic molecule obtained through the click reaction of HPIBT-yl and a tetraethylene-glycol-derived azide, self-assembled to form highly photostable particles that have long-term fluorescence imaging potential in cellular environments.
研究领域:
材料化学
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生物医学工程
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Wu Shichao,Hu Shuo,Yang Xiangrui
The strategy for dual drug-loaded nanomedicine with targeting properties was always complex. Herein, a novel strategy for the preparation of metal-organic particle-based nanomedicine has been developed, and combretastatin A4 (CA4) and mitoxantrone (MIT) loaded MOPs (CMMOPs) have been obtained. In this system, using merely Cu(II) as a bridge to connect and coordinate with the dual drugs has resulted in the CMMOPs possessing a fairly high drug load of almost 90%. Moreover, the coordination between Cu(II) and the drugs was stable at physiological pH but easily cleavable in the tumor acidic microenvironment, which would provide a good targeting property for CMMOPs. The in vivo experiments indicated that CMMOPs possessed a significantly enhanced antitumor efficiency with negligible side effects. The results suggest that CMMOPs could be a potential anticancer formulation for tumor-targeted drug delivery.
研究领域:
药学
·
纳米技术
·
肿瘤学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Hui Liu,Mengqi Liu,Kuiyuan Chen,Mei Shan,Yongye Li
Penthiopyrad is a widely used chiral fungicide for controlling rust and Rhizoctonia diseases. Development of optically pure monomers is an important strategy to realize amount reduction and increment effects of penthiopyrad, wherein, fertilizers as the co-exiting nutrient supplement may alter the enantioselective residues of penthiopyrad in soil. In our study, influences of urea, phosphate, potash, NPK compound, organic granular, vermicompost and soya bean cake fertilizers on enantioselective persistence of penthiopyrad were fully evaluated. This study demonstrated that R -(−)-penthiopyrad dissipated faster than S -(+)-penthiopyrad during 120 days. High pH, available nitrogen, invertase activities and reduced available phosphorus, dehydrogenase , urease, catalase activities were situated to benefit removing the concentrations of penthiopyrad and weakening enantioselectivity in soil. With respect to the impact of different fertilizers on soil ecological indicators, vermicompost contributed to enhanced pH. Urea and compound fertilizer played an absolute advantage in promoting available nitrogen. All fertilizers didn't go against available phosphorus. Dehydrogenase responded negatively to phosphate, potash and organic fertilizers . Urea increased invertase, besides, it and compound fertilizer both diminished urease activity. The catalase activity was not activated by organic fertilizer. Based on all the findings, soil application of urea and phosphate fertilizers was recommended and considered as a better option to exhibit high efficiency for the dissipation of penthiopyrad. The combined environmental safety estimation can effectively guide the treatment of fertilization soils in line with the nutrition requirements and pollution regulation from penthiopyrad.
研究领域:
农业化学
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土壤学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2017
·Vol. 6
·期 2
·280-289
·
IF 5.256
Jian Cui,Guangfa Zhang,Lanxia Xin,Peng Yun,Yehai Yan,Feng Su
With nanoparticles (NPs) getting more and more crucial to various key technologies, it is essential to sustainedly develop new NPs with desirable functionalities. In this regard, nanoscale metal–organic particles (NMOPs) offer a competitive choice due to their highly tunable nature, whereas seeking new organic ligands (e.g. polymeric ones) represents a preferable research direction on NMOPs. With these points in mind, a water- and ethanol-soluble vinylimidazole-based polymer, poly[1-vinylimidazole-co-(poly(ethylene glycol) methacrylate)] (VI-co-PEGMA), was designed, synthesized, and demonstrated to be exactly such a new ligand. The formation of NPs through coordination-driven self-assembly of VI-co-PEGMA and dysprosium ions (Dy3+) was studied as functions of the molecular structure of VI-co-PEGMA, Dy3+ addition rate, mixing rate and duration, and Dy3+/VI-co-PEGMA feed ratio. The as-synthesized NPs exhibit bimodal dysprosium fluorescence and magnetism with a strong dependence on the coordinated Dy3+ contents. Moreover, these NPs may also possess guest loading capacity, as indicated by their amorphous nature and the high coordination number of Dy3+. By coating the NPs with silica shells, the resultant NP@silica materials further develop an anti-disassembling ability in aqueous media, which is absent from most of the NMOPs based on water-soluble ligands. An application demonstration performed using mouse L-929 cells shows that silica-coated NPs can act as bimodal magneto-fluorescent probes for cellular bioimaging. This work thus represents a meaningful attempt for the development of new functional NPs based on the existing NMOP strategy by using an elaborately designed polymer as the organic linker and Dy3+ as the metal center.
研究领域:
材料科学
·
纳米技术
·
化学
·
生物材料
·
生物医学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）