ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Huawang Zhao,Naidan Zhang,Jincheng Zhang,Bekezela Matshazi,Yawen Shi,Minyuan Feng,Weilin Xu,Guangming Cai,Hongjun Yang
Traditional petroleum-based foam dressings offer limitations due to poor biocompatibility, long preparation cycle, and serious environmental pollution. In addition, free small molecules of incomplete polymers and residual toxic cross-linkers pose a threat to the health of patients and hinder the rapid repair of wounds. Recently, natural compounds extracted from plants have gained a lot of interest in the field of wound repair due to their good biocompatibility, biodegradability, and therapeutic effects. In this study, we successfully prepared magnolol-based porous foams by a simple one-pot method using magnolol herbal exhibiting good mechanical properties, hydrophobicity, and biocompatibility, and meets the requirements of wound dressings. The Janus composite dressing was prepared using a magnolol-based porous foam as the inner layer, PVA nonwoven fabric as the middle layer, and polyacrylate as the outer layer. The three-layer structure of magnolol-based porous foam/PVA nonwoven fabric/polyacrylate (MPF/PVA/PAAS) has the capacity to realize unidirectional diversion and rapid water locking of liquid. In vivo experimental data showed that MPF/PVA/PAAS dressing significantly promoted collagen deposition and angiogenesis, and could shorten the wound healing cycle from 14 days to 10 days, significantly accelerating the wound healing process compared to traditional wound dressings. Hence, magnolol-based foam dressings show great application potential in the field of wound treatment.
研究领域:
生物材料学
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药理学
·
医学
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产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Wenwen Guo,Fuwei Liang,Shun Chen,Kejing Yu,Jie Sun,Zengyuan Pang,Bin Fei
In this study, a phosphorus-containing bio-based monomer (MBDPP) was first synthesized from renewable magnolol, and subsequently photo-cured with tri-thiol (TPTMP) or tetra-thiol (PETMP) monomers via thiol–ene polymerization. The synthesized MBDPP/TPTMP and MBDPP/PETMP membranes exhibited high char residues at 700 °C in the TGA tests, which were 19.8 wt% and 24.2 wt% for nitrogen while 16.5 wt% and 20.2 wt% for air, respectively, indicating superior charring capacity of both membranes. DMA results indicated that both the higher stiffness and the T g of the cured MBDPP/PETMP membrane was ascribed to its higher cross-linking density than that of the cured MBDPP/TPTMP owing to the tetra-functional groups of PETMP. In the open flame test, both MBDPP/TPTMP and MBDPP/PETMP membranes self-extinguished immediately when removing the flame source, manifesting excellent intrinsic anti-flammability. The cone calorimeter results further demonstrated that MBDPP/TPTMP and MBDPP/PETMP membranes showed lower PHRR (419 and 388 kW/m 2 , respectively) and THR (41.38 and 38.98 MJ/m 2 , respectively) values than most of the thiol-ene photo-polymerized counterparts previously reported. The excellent anti-flammability of MBDPP/TPTMP and MBDPP/PETMP membranes originated from the formation of expandable char residues that played an efficient role in hampering the transfer of flammable pyrolysis products to flame zone as well as insulating the heat irradiation during combustion. Additionally, both MBDPP/TPTMP and MBDPP/PETMP membranes showed excellent transparency (transmittance >85% in the visible region) and flexibility (breaking elongation around 40%). Taking the intrinsic anti-flammability, exceptional transparency and high flexibility into account, the MBDPP/TPTMP and MBDPP/PETMP systems are suitable as intumescent flame retardant coating materials .
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF PHYTOPATHOLOGY
·
2024
·Vol. 172
·期 2
·e13301
·
IF 1.1
Guoyu Wei,Wei Zhao,Huayang Xu,Guangming Wang,Hualei Wang,Anlong Hu
Polygonatum cyrtonema (giant Chinese Solomon's seal) is a perennial herb belonging to the family Liliaceae, with significant medicinal and dietary value. However, a severe rhizome rot has led to a decline in the yield and quality of this species. In this study, a fungus was isolated from symptomatic rhizome samples and identified as Fusarium commune through molecular and morphological analyses. In pathogenicity tests, the identification of F. commune as the causative agent of rhizome rot was confirmed by fulfilling Koch's postulates. Biological characteristics indicated that the optimal growth conditions for F. commune were a temperature of 25°C, pH of 8, carbon source of soluble starch, nitrogen source of peptone and a photoperiod of 24 h light. In order to reduce the use of chemical fungicides and explore natural substances to control the disease, the sensitivity of F. commune to seven phytochemicals was studied. Four phytochemicals (honokiol, 2-allylphenol, magnolol and carvacrol) showed inhibitory activity, with honokiol having a 50% of the maximal effect concentration (EC 50 ) of 9.99 ± 0.14 mg/L. The results of pot experiment showed that the four phytochemicals had significant control efficacy on the rhizome rot of P. cyrtonema , and the highest control efficacy was observed with honokiol. These findings provide a scientific basis for the control of rhizome rot in P. cyrtonema .
研究领域:
植物病理学
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植物化学
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药用植物
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产品关联
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Chun-Mei Hu,Wen-Jing Wang,Yuan-Na Ye,Yu Kang,Jing Lin,Pan-Pan Wu,Dong-Li Li,Li-Ping Bai,Xue-Tao Xu,Bao-Qiong Li,Kun Zhang
In this study, twenty novel cinnamic acid magnolol derivatives were synthesized, and screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good to moderate α-glucosidase and α-amylase inhibitory activities with IC 50 values: 5.11 ± 1.46–90.26 ± 1.85 µM and 4.27 ± 1.51–49.28 ± 2.54 µM as compared to the standard acarbose (IC 50 : 255.44 ± 1.89 μM and 80.33 ± 2.95 μM, respectively). Compound 6j showed the strongest inhibitory activity against α-glucosidase (IC 50 = 5.11 ± 1.46 µM) and α-amylase (IC 50 = 4.27 ± 1.51 µM). Kinetic study indicated that compound 6j was reversible and a mixed type inhibitor against α-glucosidase and α-amylase. In silico studies revealed the binding interaction between 6j and two enzymes, respectively. Finally, cells cytotoxicity assay revealed that compound 6j showed low toxicity against 3 T3-L1 cells and HepG2 cells.
研究领域:
药理学
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药物化学
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药物发现
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）