Food Chemistry-X
·
2022
·
IF 6.443
Xinyu Yang,Ru Zhao,Mengxia Wei,Huiyan Gu,Jialei Li,Lei Yang,Tingting Liu
An improved method denoted as salting out-solvent-free microwave rotary distillation (SOSFMRD) was successfully developed for the extraction of essential oils from fresh magnolia ( Oyama sieboldii ) leaves, in which we achieved the rotation of the reaction material by means of a rotating motor to subject the material to uniform microwave irradiation. Magnesium chloride was selected as the salting-out agent through a comparative study on the salting-out effects of different anions and cations of metal salts. The variables of SOSFMRD were systematically optimized. Under the obtained optimization conditions, the essential oil yield was 21.68 ± 1.02 mL/kgDW. Gas chromatography–mass spectrometry analysis showed that the main chemical constituent of O. sieboldii essential oil was dehydrocostuslactone, the content of which reached 30.23 ± 1.27 %. Compared with the other conventional methods, this method has a high yield and low energy consumption, which can effectively reduce impact on the environment.
研究领域:
化学工程
·
植物化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Qiulian Liu,Weihua Li,Xiaolong Qiao,Haiguang Zhao
Colloidal carbon dots (C-dots) have excellent optical properties and they have been widely used for various types of applications. Compared to the C-dots prepared using chemicals, the Biomass-derived C-dots have attracted a great of attention because of their environmental friendliness and biocompatibility. However, currently obtained C-dots using biomass have low quantum yield. In this work, we demonstrated an efficient precursor of Magnolia flower for synthesizing high-quantum yield C-dots via hydrothermal approach. High performance liquid chromatography and Bradford assay were used to analyze the compositions of the Magnolia flower, which determine the quality of the C-dots. The typical emission bands of the as-prepared C-dots cover from 400 to 550 nm at different excitation wavelengths. The C-dots synthesized using violet Magnolia flower have the QY as high as 11.9%, which is higher than that of 10.4% (white Magnolia flower), because the violet color gives the higher content of the N. The as-obtained C-dots have excitation-dependent color and high quantum yield, showing a great potential for the use of the anti-counterfeiting system.
研究领域:
材料科学
·
植物学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Huawang Zhao,Naidan Zhang,Jincheng Zhang,Bekezela Matshazi,Yawen Shi,Minyuan Feng,Weilin Xu,Guangming Cai,Hongjun Yang
Traditional petroleum-based foam dressings offer limitations due to poor biocompatibility, long preparation cycle, and serious environmental pollution. In addition, free small molecules of incomplete polymers and residual toxic cross-linkers pose a threat to the health of patients and hinder the rapid repair of wounds. Recently, natural compounds extracted from plants have gained a lot of interest in the field of wound repair due to their good biocompatibility, biodegradability, and therapeutic effects. In this study, we successfully prepared magnolol-based porous foams by a simple one-pot method using magnolol herbal exhibiting good mechanical properties, hydrophobicity, and biocompatibility, and meets the requirements of wound dressings. The Janus composite dressing was prepared using a magnolol-based porous foam as the inner layer, PVA nonwoven fabric as the middle layer, and polyacrylate as the outer layer. The three-layer structure of magnolol-based porous foam/PVA nonwoven fabric/polyacrylate (MPF/PVA/PAAS) has the capacity to realize unidirectional diversion and rapid water locking of liquid. In vivo experimental data showed that MPF/PVA/PAAS dressing significantly promoted collagen deposition and angiogenesis, and could shorten the wound healing cycle from 14 days to 10 days, significantly accelerating the wound healing process compared to traditional wound dressings. Hence, magnolol-based foam dressings show great application potential in the field of wound treatment.
研究领域:
生物材料学
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药理学
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医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
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2022
·
IF 11.322
Wenwen Guo,Fuwei Liang,Shun Chen,Kejing Yu,Jie Sun,Zengyuan Pang,Bin Fei
In this study, a phosphorus-containing bio-based monomer (MBDPP) was first synthesized from renewable magnolol, and subsequently photo-cured with tri-thiol (TPTMP) or tetra-thiol (PETMP) monomers via thiol–ene polymerization. The synthesized MBDPP/TPTMP and MBDPP/PETMP membranes exhibited high char residues at 700 °C in the TGA tests, which were 19.8 wt% and 24.2 wt% for nitrogen while 16.5 wt% and 20.2 wt% for air, respectively, indicating superior charring capacity of both membranes. DMA results indicated that both the higher stiffness and the T g of the cured MBDPP/PETMP membrane was ascribed to its higher cross-linking density than that of the cured MBDPP/TPTMP owing to the tetra-functional groups of PETMP. In the open flame test, both MBDPP/TPTMP and MBDPP/PETMP membranes self-extinguished immediately when removing the flame source, manifesting excellent intrinsic anti-flammability. The cone calorimeter results further demonstrated that MBDPP/TPTMP and MBDPP/PETMP membranes showed lower PHRR (419 and 388 kW/m 2 , respectively) and THR (41.38 and 38.98 MJ/m 2 , respectively) values than most of the thiol-ene photo-polymerized counterparts previously reported. The excellent anti-flammability of MBDPP/TPTMP and MBDPP/PETMP membranes originated from the formation of expandable char residues that played an efficient role in hampering the transfer of flammable pyrolysis products to flame zone as well as insulating the heat irradiation during combustion. Additionally, both MBDPP/TPTMP and MBDPP/PETMP membranes showed excellent transparency (transmittance >85% in the visible region) and flexibility (breaking elongation around 40%). Taking the intrinsic anti-flammability, exceptional transparency and high flexibility into account, the MBDPP/TPTMP and MBDPP/PETMP systems are suitable as intumescent flame retardant coating materials .
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CARBOHYDRATE CHEMISTRY
·
2019
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IF 0.828
Yemin Xue,Zonghui Zhang,Jingjing Hou,Zhigang Cao,Lingxian Zhang,Fen Lou,Puxu Xu
For preparation of resveratrol and arctigenin from peanut hulls and arctium lappa fruits, respectively, a recombinant β-glucosidase (TmBglA) from hyperthermophile Thermotoga maritima was purified and characterized. The hydrolytic activity was the highest at 90 °C and pH 6.2 for arctiin with Km of 1.61 mM and kcat of 197.4 s−1, and 90 °C and 5.8 for polydatin with Km of 0.38 mM and kcat of 47.6 s−1. The enzyme produced 215.4 mg L−1 resveratrol and 355.7 mg L−1 arctigenin from 400 mg L−1 polydatin and 540 mg L−1 arctiin after 60 min of incubation at 80 °C, with capable of hydrolyzing up to 92.1 and 94.9% of polydatin and arctiin, respectively. The enzymatic hydrolysis of peanut hulls and fructus arctii displayed a conversion yield of 3.8 and 0.33 mg resveratrol and arctigenin per gram of substrate material flour, respectively. Of the reported β-glucosidase, TmBglA exhibited the highest thermostability, kcat, kcat/Km, and conversion productivity for hydrolyzing polydatin and arctiin, and has great potential applications in functional food and medicine production.
研究领域:
生物化学
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酶工程
·
功能性食品
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医药学
✓ 已验证
DOI
高影响因子
JOURNAL OF PHYTOPATHOLOGY
·
2024
·Vol. 172
·期 2
·e13301
·
IF 1.1
Guoyu Wei,Wei Zhao,Huayang Xu,Guangming Wang,Hualei Wang,Anlong Hu
Polygonatum cyrtonema (giant Chinese Solomon's seal) is a perennial herb belonging to the family Liliaceae, with significant medicinal and dietary value. However, a severe rhizome rot has led to a decline in the yield and quality of this species. In this study, a fungus was isolated from symptomatic rhizome samples and identified as Fusarium commune through molecular and morphological analyses. In pathogenicity tests, the identification of F. commune as the causative agent of rhizome rot was confirmed by fulfilling Koch's postulates. Biological characteristics indicated that the optimal growth conditions for F. commune were a temperature of 25°C, pH of 8, carbon source of soluble starch, nitrogen source of peptone and a photoperiod of 24 h light. In order to reduce the use of chemical fungicides and explore natural substances to control the disease, the sensitivity of F. commune to seven phytochemicals was studied. Four phytochemicals (honokiol, 2-allylphenol, magnolol and carvacrol) showed inhibitory activity, with honokiol having a 50% of the maximal effect concentration (EC 50 ) of 9.99 ± 0.14 mg/L. The results of pot experiment showed that the four phytochemicals had significant control efficacy on the rhizome rot of P. cyrtonema , and the highest control efficacy was observed with honokiol. These findings provide a scientific basis for the control of rhizome rot in P. cyrtonema .
研究领域:
植物病理学
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植物化学
·
药用植物
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Jinli Li,Lei Jiao,Weiqing Xu,Hongye Yan,Guojuan Chen,Yu Wu,Liuyong Hu,Wenling Gu
Glutathione (GSH) plays a significant role in various biological functions. The fluctuation of GSH level is closely linked to some serious diseases. Currently, the colorimetric detection of GSH is mainly built on the inhibitory effect on the catalytic activity of the developed nanomaterials . However, tedious synthesis of the nanomaterials is always required to control their morphologies for better catalytic activity. Metal indicators are some specific substances capable of chelating metal ions, during which significant color variation can be triggered, making them promising for colorimetric analysis. More importantly, the recognition of metal ions has nothing to do with the structure of the materials. Herein, CoOOH ultrathin nanosheets were prepared via a facile method, which can be easily reduced to Co 2+ ions by GSH. After being chelated by metal indicator, a rapid and sensitive sensing platform for GSH detection is established with the distinct color change. As a result, the UV–vis absorbances of Co 2+ –xylenol orange disodium salt complexes (a typical metal indicator) at 580 nm exhibit good linearity against GSH concentrations from 33 μM to 1.3 mM with the detection limit of 13.7 μM. The developed sensor is further used in the detection of GSH contained in the human serum and an ideal recovery rate is obtained, demonstrating its excellent applicability for the detection of GSH in practical samples.
研究领域:
分析化学
·
纳米技术
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生物传感器
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Chun-Mei Hu,Wen-Jing Wang,Yuan-Na Ye,Yu Kang,Jing Lin,Pan-Pan Wu,Dong-Li Li,Li-Ping Bai,Xue-Tao Xu,Bao-Qiong Li,Kun Zhang
In this study, twenty novel cinnamic acid magnolol derivatives were synthesized, and screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good to moderate α-glucosidase and α-amylase inhibitory activities with IC 50 values: 5.11 ± 1.46–90.26 ± 1.85 µM and 4.27 ± 1.51–49.28 ± 2.54 µM as compared to the standard acarbose (IC 50 : 255.44 ± 1.89 μM and 80.33 ± 2.95 μM, respectively). Compound 6j showed the strongest inhibitory activity against α-glucosidase (IC 50 = 5.11 ± 1.46 µM) and α-amylase (IC 50 = 4.27 ± 1.51 µM). Kinetic study indicated that compound 6j was reversible and a mixed type inhibitor against α-glucosidase and α-amylase. In silico studies revealed the binding interaction between 6j and two enzymes, respectively. Finally, cells cytotoxicity assay revealed that compound 6j showed low toxicity against 3 T3-L1 cells and HepG2 cells.
研究领域:
药理学
·
药物化学
·
药物发现
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2023
·
IF 5.4
Minzhen Xie,Siqi Gu,Yang Hong,Yan Liu,Xiaohui Rong,Wanying Lu,Heng Liu,Adnan Mohammed Algradi,Anam Naseem,ZunPeng Shu,Qi Wang
Ethnopharmacological relevance Coptis chinensis Franch. (CCF), as an extensively used traditional Chinese medicine , has therapeutic effects on Alzheimer's disease (AD), but its mechanism of action has not yet been elucidated. Aim of the study This study aims to reveal the mechanism of action of CCF via the gut-brain axis, and provide a new strategy for the clinical treatment of AD. Materials and methods APP swe /PS1ΔE9 mice were used as AD models, and were given CCF extract by intragastric administration. Barnes maze was used to test the therapeutic effect of CCF on the treatment of AD. To reveal the mechanism of action of CCF in the treatment of AD, Vanquish Flex UHPLC-orbitrap fusion lumos mass was chosen to detect endogenous differential metabolite; MetaboAnalyst 5.0 was applied to derive relevant metabolic pathways; similarly, to explore the effects of CCF on the gut-brain axis, Vanquish Flex UPLC-Orbitrap fusion lumos mass was utilized to detect the changes in the content of SCFAs in AD mice after CCF administration; the prototype components and metabolites in CCF were identified by UPLC/ESI/qTOF-MS, then their effects on Bifidobacterium breve were explored. Results CCF shortened the latency time of AD mice, improved the target quadrant ratio of AD mice, and made the maze roadmap simpler of AD mice; CCF regulated fifteen potential metabolites of AD mice, interestingly, ILA (indole-3-lactic acid) in SCFAs (short-chain fatty acids) was also included; CCF acted on histidine and phenylalanine metabolic pathways of AD mice; CCF increased the contents of acetic acid and ILA in AD mice; magnoflorine , jatrorrhizine , coptisine , groenlandicine, thalifendine , palmatine , berberine , epiberberine, hydroxylated jatrorrhizine, and 3-methoxydemethyleneberberine in CCF were detected in fecal samples of AD mice; magnoflorine, palmatrubine, 13-methylberberine, berberine, coptisine, and palmatine promoted the growth of Bifidobacterium breve. Conclusions: we have demonstrated that CCF acts on the gut-brain axis by regulating SCFAs to treat AD.
研究领域:
民族药理学
·
神经科学
·
药理学
·
代谢组学
·
中药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）