The role of wood sterol in alopecia induced by high fat diet through lipid metabolism
Prolonged consumption of high fat diet (HFD) contributes to skin inflammation, leading to receding hairline and thinning hair, impacting appearance and psychological well-being. This study aimed to investigate ameliorative effect of wood sterol (WS) on mice with weakened hair follicles due to HFD and to unravel underlying mechanism. The WS (96.38%) was obtained through solvent crystallization using methanol aqueous solution and 2-butanone mixed solvent, with 20 h of crystallization time, 25°C of crystallization temperature, 1:3.5 of solid-liquid ratio, 50% of concentration of methanol-water and 50% of proportion of 2-butanone. The high-fat-induced alopecia model was established by feeding mice on a HFD for three months. The mice were treated with different doses of WS, with 10 mg/d and 5 mg/d, respectively. After intervention, mice regained hair growth, with the hair follicle number reaching 26.75 and terminal hair/vellus hair ratio recovering to 4.89. With inter-sex differences, male mice showed more significant decrease in testosterone levels and more significant improvement in estradiol levels with high-dose WS, but in female mice it was low-dose WS. In summary, wood sterol facilitated the recovery of weakened hair follicles and promoted hair growth. The potential mechanisms involved regulating hair follicle growth by reducing synthetic precursor cholesterol and acting as 5α-reductase inhibitor, contributing to a balance between androgen and estrogen. It provides a potential preventive improvement option for alopecia problems caused by high-fat diet.
危险品化学品经营许可证（带存储）