NANOTECHNOLOGY
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2020
·Vol. 32
·期 8
·085102
·
IF 3.551
Yujie Cai,Luyao Wang,Haolu Hu,Wei Bing,Limei Tian,Jie Zhao
Herein, we successfully developed a new multifunctional antibacterial system, which combined mechano-bactericidal (Au-nanostars) and photothermal (MoS2) mechanism. Meanwhile, the targeting molecule of vancomycin was modified on the surface of MoS2–Au nanocomposites (Van-MoS2–Au), that generally yield high efficiency in antibacterial performance due to their effective working radii. Van-MoS2–Au nanocomposites were capable of completely destroying both gram-negative (E. coli) and gram-positive (B. subtilis) bacteria under 808 NIR laser irradiation for 20 min, and nearly no bacterial growth was detected after 12 h incubation. Moreover, these nanocomposites could destruct the refractory biofilm as well, which was a much more difficult medical challenge. The new antibacterial nanomaterials might offer many biomedical applications because of the biocompatibility and strong antibacterial ability.
研究领域:
生物医学工程
·
材料科学
·
抗菌研究
✓ 已验证
DOI
高影响因子
Small
·
2025
·
IF 12.1
Shuaidong Qi,Jing Wang,Decui Cheng,Tingting Pan,Ruoming Tan,Hongping Qu,Li-Min Zhu
Microbial fouling poses significant challenges in healthcare and maritime industries and impacts more significantly on human health with the spread of drug-resistant bacteria. Mechanical biocidal strategies using nano-scale structures have emerged as a promising antimicrobial approach over the past decade. However, the durability and structural requirements for optimal biocidal performance remain unexplored. Herein, a rationally designed mechano-photocatalytic antimicrobial strategy is reported by systematically optimizing inorganic nanowire (NW) architectures. It is demonstrated that close-packed NWs with diameters less than 100 nm achieve high mechanical biocidal efficiency. The synergistic mechano-photocatalytic approach eliminates >99% of bacteria within 30 mins and inhibits >94% of marine algal fouling. The fabricated NWs exhibit robust durability, retaining 80% bactericidal efficacy through repeated fouling cycles. Even without photocatalytic activation, mechanical disruption alone inactivates >90% of bacteria and prevents >70% of algal attachment. Intriguingly, ultraviolet photostimulation unexpectedly stimulates marine algal growth without the photoactive NWs, contrasting sharply with its inhibitory effect on pathogenic bacteria. These findings advance the rational design of durable mechano-photocatalytic nano-architectures, emphasizing their dual-action antimicrobial potential. The work underscores the viability of inorganic nanostructures in combating microbial fouling across diverse environments, from medical settings to marine infrastructure, while addressing critical gaps in durability for real-world applications.
研究领域:
材料科学
·
微生物学
·
生物医学工程
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Rujian Jiang,Yaozhen Yi,Lingwan Hao,Yuxiang Chen,Limei Tian,Haixu Dou,Jie Zhao,Weihua Ming,Luquan Ren
Overuse of antibiotics can increase the risk of notorious antibiotic resistance in bacteria, which has become a growing public health concern worldwide. Featured with the merit of mechanical rupture of bacterial cells, the bioinspired nanopillars are promising alternatives to antibiotics for combating bacterial infections while avoiding antibacterial resistance. However, the resident dead bacterial cells on nanopillars may greatly impair their bactericidal capability and ultimately impede their translational potential toward long-term applications. Here, we show that the functions of bactericidal nanopillars can be significantly broadened by developing a hybrid thermoresponsive polymer@nanopillar-structured surface, which retains all of the attributes of pristine nanopillars and adds one more: releasing dead bacteria. We fabricate this surface through coaxially decorating mechano-bactericidal ZnO nanopillars with thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) brushes. Combining the benefits of ZnO nanopillars and PNIPAAm chains, the antibacterial performances can be controllably regulated between ultrarobust mechano-bactericidal action (∼99%) and remarkable bacteria-releasing efficiency (∼98%). Notably, both the mechanical sterilization against the live bacteria and the controllable release for the pinned dead bacteria solely stem from physical actions, stimulating the exploration of intelligent structure-based bactericidal surfaces with persistent antibacterial properties without the risk of triggering drug resistance.
研究领域:
生物材料学
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微生物学
·
纳米医学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Yaozhen Yi,Rujian Jiang,Ziting Liu,Haixu Dou,Lingjie Song,Limei Tian,Weihua Ming,Luquan Ren,Jie Zhao
Constructing safe and effective antibacterial surfaces has continuously received great attention, especially in healthcare-related fields. Bioinspired mechano-bactericidal nanostructure surfaces could serve as a promising strategy to reduce surface bacterial contamination while avoiding the development of antibiotic resistance. Although effective, these nanostructure surfaces are prone to be contaminated by the accumulation of dead bacteria, inevitably compromising their long-term antibacterial activity. Herein, a bioinspired nanopillar surface with both mechano-bactericidal and releasing actions is developed, via grafting zwitterionic polymer (poly(sulfobetaine methacrylate) (PSBMA)) on ZnO nanopillars. Under dry conditions, this nanopillar surface displays remarkable mechano-bactericidal activity, because the collapsed zwitterionic polymer layer makes no essential influence on nanopillar structure. Once being incubated with aqueous solution, the surface could readily detach the killed bacteria and debris, owing to the swelling of the zwitterionic layer. Consequentially, the surface antibacterial performances can be rapidly and controllably switched between mechano-bactericidal action and bacteria-releasing activity, guaranteeing a long-lasting antibacterial performance. Notably, these collaborative antibacterial behaviors are solely based on physical actions, avoiding the risk of triggering bacteria resistance. The resultant nanopillar surface also enjoys the advantages of substrate-independency and good biocompatibility, offering potential antibacterial applications for biomedical devices and hospital surfaces.
研究领域:
材料科学
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生物医学工程
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纳米技术
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表面科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）