ACS Applied Bio Materials
·
2020
·
IF 0
Zhiguo Ye,Guixin Li,Jing Lei,Mei Liu,Yan Jin,Baoxin Li
Discovering efficient antibacterial materials is crucial in the area of increasing drug resistance. Herein, we synthesized carbon dots (C-dots) with superior antibacterial activity through a simple one-step hydrothermal method. In this method, p-phenylenediamine serves as not only the carbon source but also the origin for the functional group anchored on the obtained C-dots. The antibacterial activity of the obtained C-dots was tested against Staphylococcus aureus and Escherichia coli. The minimum bactericidal concentrations of the synthesized C-dots against S. aureus and E. coli were 2 and 30 μg/mL, respectively, which are lower than that of previously reported C-dots. The antibacterial mechanism was investigated, and the results indicated that a large number of −NH3+ groups on the C-dots’ surface enhanced their antibacterial activity. Besides, the C-dots exhibited negligible cytotoxicity.
研究领域:
材料科学
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微生物学
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药物化学
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DOI
PubMed
Green Processing and Synthesis
·
2022
·Vol. 11
·期 1
·445-457
·
IF 3.97
Ziqian Wu,Zhihuan Fu,Yunbo Tian,Murtaza Hasan,Liting Huang,Yuanting Yang,Cuijing Li,Ayesha Zafar,Xugang Shu
The emergence of drug-resistant bacteria and the lack of effective antimicrobial agents have posed a threat to public safety, so a new efficient strategy is needed to deal with the increasing severity of bacteria. Herein, a substitute antibacterial agent with high stability and biocompatibility was synthesized by incorporating lysine hydrochloride and copper sulfate pentahydrate following the liquid-phase synthesis method. The composition and structure of the Cu( ii ) complex (Lys–Cu) were characterized by performing ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, X-ray diffractometry (XRD), thermogravimetric analysis-differential scanning calorimetry, and single-crystal XRD. The crystal structure of Lys–Cu belongs to a monoclinic system, space group P 2 1 , with cell parameters of a = 5.14350(10), b = 16.8308(2), c = 11.4915(2) Å, Z = 2, and D = 1.548 g·cm −3 . Bacteriostatic tests were carried out on Escherichia coli and Staphylococcus aureus . The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of Lys–Cu against S. aureus were 0.3125 and 0.9250 mg·mL −1 , respectively. The MIC and MBC values of Lys–Cu against bacterial strain E. coli were 0.4685 and 0.9250 mg·mL −1 , respectively.
研究领域:
化学
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微生物学
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材料科学
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DOI
高影响因子
JOURNAL OF FOOD SCIENCE
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2013
·Vol. 78
·期 1
·M90
·
IF 1.775
Xiaodong Geng,Ronghua Yang,Jianying Huang,Xiao Zhang,Xiangyang Wang
Total of 3 water-soluble quaternary-based chitin/chitosan derivatives, which have an identical molecular weight and anion, were synthesized and characterized. Their antibacterial activities against Salmonella cholerae-suis and Bacillus subtilis were evaluated in vitro . The polysaccharides exhibited the antibacterial efficiency. Their minimum inhibitory concentration (MIC) values vary from 0.02 to 20.48 mg/mL, and their minimum bactericidal concentration (MBC) values vary from 0.08 to 40.96 mg/mL against S. cholerae-suis and B. subtilis , respectively. Futhermore, the extent of Bacillus subtilis cells damage was examined via transmission electron microscopy (TEM) to show how N,N,N -trimethylchitosan (TMC) gradually destroyed and killed B. subtilis cells when they were treated with TMC. One of those quaternary polymers, O -([2-hydroxy-3-trimethylammonium])propyl chitin (OHT-chitin), which can be directly and easily synthesized from chitin in bulk quantities, also was demonstrated its antibacterial activity. These water soluble quaternary-based chitin/chitosan derivatives that have antibacterial effect should be potentially used as antimicrobial agents in many fields. Practical Application: The main practical application behind the investigation and evaluation antibacterial activity of 3 water-soluble quaternary-based chitin/chitosan derivatives could be potentially used as antimicrobial agents in many fields. These polysaccharides represent a renewable source of natural biodegradable polymers and meet with the emergence of more and more food safe problems.
研究领域:
微生物学
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材料科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
ADVANCED POWDER TECHNOLOGY
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2018
·
IF 2.943
Qiong Liu,Ju Li,Xin Zhong,Zan Dai,Zhong Lu,Hao Yang,Rong Chen
In this work, sphere-like Ag/Bi 2 O 3 nanocomposites with the average size of ca. 170 nm were successfully synthesized by simple deposition-precipitation method. The antibacterial activities of as-prepared Ag/Bi 2 O 3 nanocomposites were evaluated by minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC) and colony counting methods. It was found that Ag/Bi 2 O 3 nanocomposites displayed greatly improved antibacterial ability against common pathogenic Gram-positive and Gram-negative bacteria in comparison with single-component Bi 2 O 3 nanospheres. More importantly, Ag/Bi 2 O 3 nanocomposites exhibited remarkably outstanding antibacterial activities against clinical drug-resistant bacteria. The antibacterial activity of Ag/Bi 2 O 3 nanocomposite increased with the increase of Ag content and 15 wt% Ag/Bi 2 O 3 nanocomposites showed the highest antibacterial activity. Furthermore, a plausible antibacterial mechanism of Ag/Bi 2 O 3 nanocomposite was proposed. It was believed that the enhanced generation of H 2 O 2 could lead to the membrane leakage of cytosol and the inactivation of respiratory chain dehydrogenaes, which was possibly responsible for the enhanced antibacterial activities of nanocomposites.
研究领域:
材料科学
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微生物学
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医学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2019
·Vol. 137
·期 8
·48405
·
IF 2.188
Qing Wen,Lijuan Xu,Xiansen Xiao,Zhenghui Wang
Cationic nanopolystyrenes (CNPSs) were prepared by the polymerization of styrene with a cationic polymerizable emulsifier, N-(2-(methacryloyloxy)ethyl)-N,N-dimethyltetradecane-1-ammonium bromide (MDTB), in the presence of 2,2′-azobis(2-methylpropionamidine) dihydrochloride (APPH). The polymerization kinetics was investigated through monomer conversion versus polymerization time. 1 H NMR spectra and FTIR spectra were used to confirm the structures of MDTB and nanopolymers. The particle size, ζ-potential, molecular weight, and thermal stability were also investigated by Zetasizer, gel permeation chromatography, and thermogravimetric analysis, respectively. The antibacterial activities of the obtained products were evaluated by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Staphylococcus aureus ATCC 29913 ( S. aureus , a Gram-positive bacterium) and Escherichia coli ATCC 25922 ( E. coli , a Gram-negative bacterium). The results indicated that the polymerization has the characteristics of microemulsion polymerization, all nanopolystyrenes are cationic and can be stored in the form of a microemulsion in aqueous phase, CNPSs present stable chemical structure at 190 °C, and their MIC and MBC reach 0.0625 and 0.125 mg mL −1 for E. coli , 0.0325 and 0.0625 mg mL −1 for S. aureus , respectively. Therefore, CNPSs are a promising new type of polymer antimicrobial agent, which can be used in the development of antimicrobial polymer materials and their products. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48405.
研究领域:
高分子化学
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材料科学
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微生物学
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DOI
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Lingling Zhao,Yue Ma,Zhaomeng Sun,Xiaoqing Zhang,Mei Liu
Bacterial infections and antibiotic abuse are a global threat to human health. In recent years, there has been a boom in research on antimicrobial agents with low toxicity and efficient nanomaterials. Boric acid-functionalized carbon dots (B-CDs) with negative surface charge were synthesized by the hydrothermal method. Covalent bonds were formed between the boric acid groups and the cis-diol groups of the polysaccharide in the bacterial cell wall, and numerous B-CDs were trapped on the bacterial surface. In the experiments of antibacterial activity, B-CDs presented strong bactericidal activity against Escherichia coli (E. coli) with a minimum bactericidal concentration of 12.5 μg/mL. The antibacterial mechanism suggested that B-CDs entered the cell interior by diffusion and posed significant damage to the double helix structure of E. coli DNA. Furthermore, B-CDs exhibited low toxicity. The results demonstrated that the novel antimicrobial B-CDs not only fought against E. coli infection and antibiotic misuse but also provided new ideas for safe and effective antimicrobial agents of carbon nanomaterials.
研究领域:
纳米技术
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材料科学
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微生物学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Moumita Maiti,Manas Sarkar,Soumen Maiti,Donghong Liu
This work explores noble metal coupled carbon-based nanohybrid materials specifically for their antibacterial and photo-disinfection capabilities from a broader perspective of health to clean. Using gold (Au) nanoparticles (NPs) on the surface of two different shaped zinc oxide-graphene (ZnO-rGO) nanohybrids such as flake and spherical, this experiment aims to manage a pathogen-free environment while filtering and recycling carcinogenic dye-containing wastewater. The shape-tailored ZnO-rGO-Au hybrid generate a substantial amount of reactive oxygen species ; ROSs: hydroxyl radical (•OH), superoxide (•O 2 - ), singlet oxygen, and ( 1 O 2 ) and focal electrostatic interactions on (gram-negative Escherichia coli and gram-positive Staphylococcus aureus ) bacterial cell membranes . Redox cycling and strong potential binding tendency rapture the structural organization of cells that is clearly reflected in growth kinetics, (3(4, 5-dimethylthiazol-2-yl)−2), 5-diphenyl tetrazolium bromide (MTT), inner permeable/ protein/ malondialdehyde assay, and microscopical images after the morphology dependent physical as well as the chemical effects of nanocomposites . The minimum bactericidal concentration (MBC) or minimum inhibitory concentration (MIC) studies show the Au/rGO-ZnO system to be the very potent antibacterial agent , and that only 0.18 mg/ml represents significant bactericidal activity while their toxicity towards mammalian cells is very low (>2 mg/ml). Furthermore, Au NPs alter the bandgap energy of Au/rGO-ZnO hybrids, causing the formation of ROSs at different pH levels or dosages of the catalyst, which results in excellent photocatalytic activity (96% degradation of Rhodamine B when using 0.75 mg catalyst). Based on a Pseudo-first-order kinetic model , a likely mechanistic pathway towards exceptional dye decomposition has also been identified.
研究领域:
微生物学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Anqi Dai,Wenjin Wang,Xingyu Heng,Wenjing Shu,Shaopu Lu,Yiming Xu,Dianliang Wang,Xiangqiang Pan,Na Li,Gaojian Chen,Jian Zhu
Bacterial drug resistance and biofilm adhesion present substantial challenges for both economic development and human health and safety. Consequently, the development of alternative antibacterial drugs has emerged as a crucial area of research. Main-chain cationic polymers exhibit notable advantages over side-chain cationic polymers in terms of their antibacterial properties, demonstrating efficacy comparable to that of antibiotics. This study presents the first synthesis of main-chain polyselenium salts and explores the impact of hydrophobic side chains, antianions, and hydrophobic structures within the polymer chain on antibacterial activity. These findings offer valuable insights into the development of antibacterial polymers. When optimized, the polyselenium salt exhibited remarkable antibacterial efficacy, with a minimum bactericidal concentration of 0.5 μg/mL while maintaining favorable biocompatibility before and after degradation. Furthermore, the polyselenium salt effectively eradicated the biofilms. The synthesized cationic polymer can undergo gradual degradation in PBS with lipase, reducing environmental contamination and minimizing adverse effects on the human body.
研究领域:
材料科学
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生物医学工程
·
药学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2012
·
IF 2.453
Jianying Huang,Hengjun Jiang,Miao Qiu,Xiaodong Geng,Ronghua Yang,Jianrong Li,Chaohua Zhang
Water-soluble quaternary chitin/chitosan derivatives, O -[(2-hydroxy-3-trimethylammonium)propyl chitin (OHT-chitin), N -[(2-hydroxy-3-trimethylammonium)propyl chitosan (NHT-chitosan), and N , N , N -trimethylchitosan (TMC), having identical molecular weight and same anion, were prepared, and their antibacterial activities against Escherichia coli and Staphylococcus aureus were evaluated. Their minimum inhibitory concentration (MIC) values varied from 0.04 mg/mL to 20.48 mg/mL, and the minimum bactericidal concentration (MBC) values varied from 0.16 mg/mL to 40.96 mg/mL against E. coli and S. aureus , respectively. Transmission electron microscopy (TEM) clearly showed that there was serious damage on the bacterial walls, whereas there was some dissimilarity between TMC-treated E. coli and S. aureus .
研究领域:
微生物学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 27
·275707
·
IF 3.874
Songfa Qiu,Fan Gao,Zhijun Liang,Ximing Zhong,Li Hao,Huayao Chen,Xinhua Zhou,Hongjun Zhou
Tea tree oil, a natural antibacterial compound, cannot be used effectively because of its volatile nature. In this work, a biocompatible carrier was prepared and loaded with tea tree essential oil. The carrier was prepared via the electrostatic or chemical action of aminated mesoporous silica and sodium rosin for achieving a low volatilization rate of tea tree essential oil. A synergistic antibacterial effect was observed between sodium rosin and tea tree essential oil. This method utilized the positive charge of the amino group and the condensation reaction with the carboxyl group to achieve physical and chemical interactions with sodium rosin. Fourier Transform Infrared, Brunauer–Emmet–Teller, Zeta potential, SEM, TEM, and TG were performed to characterize the structure and properties of the samples. Compared to the electrostatic effect, the chemically modified system exhibited a longer sustained release, and the sustained release curve followed the Korsmeyer–Peppas release model. Also, the antibacterial properties of the chemically modified system exhibited better minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) respectively, the MIC and MBC for E. coli were 0.3 mg ml−1 and 0.6 mg ml−1 respectively, for S. aureus were 0.15 mg ml−1 and 0.3 mg ml−1 respectively. More strikingly, the sample also demonstrated long-term antibacterial performance. Therefore, this work provides a new way for the delivery of volatile antibacterial drugs to achieve sustained-release and long-lasting antibacterial effects.
研究领域:
药学
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材料科学
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生物技术
·
化学
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产品关联
DOI
PubMed
高影响因子
MicrobiologyOpen
·
2020
·Vol. 10
·期 1
·e1148
·
IF 3.142
Xianghai Zeng,Pengfei She,Linying Zhou,Shijia Li,Zubair Hussain,Lihua Chen,Yong Wu
Graphical Penfluridol shows effective antimicrobial effects against Enterococcus faecalis in vitro and in vivo. The drug prevents biofilm formation and eliminates mature biofilms. The bacterium Enterococcus faecalis has increasingly attracted global attention as an important opportunistic pathogen due to its ability to form biofilms that are known to increase drug resistance. However, there are still no effective antibiofilm drugs in clinical settings. Here, by drug repurposing, we investigated the antibacterial activity of penfluridol (PF), an oral long-acting antipsychotic approved by the FDA, against E . faecalis type strain and its clinical isolates. It was found that PF inhibited the growth of E . faecalis planktonic cells with the MIC and MBC of 7.81 µg/ml and 15.63 ~ 62.50 µg/ml, respectively. Moreover, PF could significantly prevent the biofilm formation of E . faecalis at the concentration of 1 × MIC. Furthermore, PF significantly eradicated 24 h pre-formed biofilms of E . faecalis in a dose-dependent manner, with a concentration range of 1 × MIC to 8 × MIC. Here, through the checkerboard method with other tested conventional antibiotics, we also determined that gentamycin, penicillin G, and amikacin showed partial synergistic antibacterial effects with PF. Also, PF showed almost no hemolysis on human erythrocytes. In a mouse peritonitis model, a single dose of 20 mg/kg of PF treatment could significantly reduce the bacterial colonization in the liver (~5-fold reduction) and spleen (~3-fold reduction). In conclusion, these findings indicated that after structural optimization, PF has the potential as a new antibacterial agent against E . faecalis .
研究领域:
药理学
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微生物学
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传染病
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药物开发
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产品关联
DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2013
·Vol. 29
·期 6
·1214-1218
·
IF 0.735
Li Xian-liang,Zuo Wei-wen,Luo Meng,Shi Zuo-sen,Cui Zhan-chen,Zhu Song
Thiol-functionalized MCM-41 type mesoporous silica particles(MSPs) were prepared and loaded with silver chloride to act as antibacterial agents. The antibacterial activity of the silver chloride loaded MSPs(AgCl-MSPs) was evaluated by the minimum bactericidal concentration(MBC) against Candida albicans (ATCC 10231). The AgCl-MSPs with the highest antibacterial activity were then dispersed in hybrid coatings with different mass ratios to fabricate antibacterial coatings. The antibacterial activity of the coatings was tested against Candida albicans (ATCC 10231) and Streptococcus mutans (ATCC 25175). The resulting antibacterial coatings exhibited high antibacterial activity, good adhesion to the substrate and high hardness.
研究领域:
材料科学
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生物材料
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牙科
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）