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RSC Advances · 2016 ·Vol. 6 ·期 79 ·75359-75364 · IF 3.289

Single step incorporation of isatin to enaminone: a recyclable catalyst towards assembly of diverse four ring fused pyrrolo[2,3,4-kl]acridin-1-ones

Chunmei Li,Furen Zhang

A series of pyrrolo[2,3,4-kl]acridin-1-one derivatives were successfully synthesized from facile materials (enaminone and isatin) using a reusable solid acid as catalyst in water. A variety of structurally diverse enaminones and various isatins bearing different functional groups tolerated the reaction and gave the corresponding goal products with good to excellent yields. Advantages of this strategy include the mild conditions, operational simplicity, being convenient and environmentally benign, and the reusability of the heterogeneous catalyst. A mechanism was proposed to explain the formation of different substituted pyrrolo[2,3,4-kl]acridin-1-one derivatives.

研究领域: 有机化学 · 药物化学 · 绿色化学 · 杂环合成 · 催化化学

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Biomed Research International · 2017 ·Vol. 2017 ·期 1 ·2564363 · IF 2.476

Analysis of the Metabolites of Indole Degraded by an Isolated Acinetobacter pittii L1

Zuoyi Yang,Junhui Zhou,Yanbin Xu,Yaping Zhang,Haien Luo,KenLin Chang,Yujie Wang

Indole and its derivatives are typical nitrogen heterocyclic compounds and have been of immense concern since they are known for the risk of their toxic, recalcitrant, and carcinogenic properties for human and ecological environment. In this study, a Gram-negative bacterial strain of eliminating indole was isolated from a coking wastewater. The strain was confirmed as Acinetobacter pittii L1 based on the physiological and biochemical characterization and 16S ribosomal DNA (rDNA) gene sequence homology. 400 mg/L indole could be completely removed within 48 h by the strain on the optimum condition of 37°C, pH 7.4, and 150 rpm. The organic nitrogen was converted to NH 3 -N and then to and the organic carbon was partially transferred to CO 2 during the indole biodegradation. The metabolic pathways were proposed to explain the indole degradation based on the liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis of indigo, 4-(3-Hydroxy-1H-pyrrol-2-yl)-2-oxo-but-3-enoic acid, and isatin. The toxicity of the biodegradation products was evaluated using the Microtox test, which revealed that the metabolites were more toxic than indole. Our research holds promise for the potential application of Acinetobacter pittii L1 for NHCs degradation, production of indigoids, and soil remediation as well as treatment of indole containing wastewater.

研究领域: 环境微生物学 · 生物降解 · 分析化学 · 环境毒理学 · 废水生物处理 · 分子生物学

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Single step incorporation of isatin to enaminone: a recyclable catalyst towards assembly of diverse four ring fused pyrrolo[2,3,4-kl]acridin-1-ones

Analysis of the Metabolites of Indole Degraded by an Isolated Acinetobacter pittii L1