DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
·
2021
·
IF 3.636
Yu-Chen Pu,Rui Wang,Hui-Hui Liu,Sheng-Ping Lu,Fan-Xi Tang,You-Ming Hou
Recent works have generally indicated that insects exhibit two immune response strategies: external and internal immune defense. However, the immune-related trade-offs and physiological regulatory mechanisms in red palm weevil , a major invasive pest , remain unclear. Based on postinfection survivorship experiments, we initially measured baseline constitutive external immunity (antibacterial activity of external secretions) and internal immunity (phenoloxidase and antibacterial activity of hemolymph) in uninfected individuals. Then, we challenged the individual immune system and examined subsequent investment in immune function. Our data showed that multiple factors (instar, age, sex, mating status, immune treatment) interacted to affect immune components and infection outcomes, but the magnitude and nature of the impact varied in each case. Although immune senescence is a common phenomenon in which immune function decreases with age, different components of the immune system changed differentially. Notably, mating activity may impose an immunity-related cost, with some evidence of sexual dimorphism and age-associated differences. Finally, parameters related to life-history traits usually decreased temporarily because of increased immunity, suggesting that the ultimate consequences of immune function fitness may be physiologically traded off with other fitness aspects, including growth, development, mating, reproduction, and longevity. These results reveal the complex factors that impact immunity as well as the physiological regulation of individual immunity, which may determine the evolution and outcome of immune senescence and trade-offs.
研究领域:
昆虫学
·
免疫学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Yicheng Zhang,Weiming Yu,Renjie Li,Yanchao Xu,Liguo Shen,Hongjun Lin,Bao-Qiang Liao,Guosheng Wu
The permeability-selectivity trade-off remains the major drawback limiting application of membrane technology. This study provided a new strategy to break through this trade-off. A novel conductive membrane prepared by electroless Ni plating of the polyvinylidene fluoride (PVDF) membrane was used for dyeing wastewater treatment by applying an electric field. Series analyses demonstrated success of immobilizing a Ni/NiO layer on the pristine PVDF membrane. The conductive membrane possessed improved hydrophilicity indicated by the water contact angle decrease from 75.5° to 45.0°. Moreover, the conductive PVDF membrane integrating electric field voltage of 20 V simultaneously possessed high selectivity (97.93% rejection) and extremely high permeability (202.51 ± 9.63 L m −2 h −1 at 0.1 MPa) for filtration of Congo red (CR) solution, significantly breaking through the permeability-selectivity trade-off. The filtration performance was quite stable even after 6 filtration cycles, indicating the feasibility of the conductive membrane for long-term treatment of CR wastewater. In addition, the conductive membrane showed high antifouling ability to methylene blue (MB), rhodamine B (RB), CR and microorganisms. The conductive membranes, together with the new strategy, offered in-depth insights into membrane fabrication.
研究领域:
环境科学
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材料科学
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污水处理
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DOI
高影响因子
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2012
·Vol. 97
·期 8
·3355-3362
·
IF 3.425
Guo Fei,Xu Haoming,Xu Hongna,Yu Hongwei
Despite directed evolution being a practical and efficient method of improving the properties of enzymes, a trade-off between the targeted property and other essential properties often exists which hinders the efficiency of directed evolution. In our previous work, mutant CVH of an esterase from Rhodobacter sphaeroides with high enantioselectivity was obtained by directed evolution, unfortunately its activity cannot catch another mutant YH. To compensate the trade-off of mutant CVH, site-directed saturation mutagenesis was conducted on four residues, three (Asn62, Met121, and Leu145) were hot spots determined from directed evolution, and one (Tyr27) was introduced to make up the large distance between a mutation (Asn62) and the substrate. A new mutant (HMVY) with high enantioselectivity and comparable activity to YH was obtained. According to the kinetic analysis and molecular dynamics simulations, it was understood that the high enantioselectivity and poor activity of mutant CVH was caused by different decrement of efficiency constants to two isomers, ( R )-, ( S )-methyl mandelate, and the high enantioselectivity and activity of mutant HWVY was caused by improved activity towards the preferred substrate (( S )-methyl mandelate), which provided the interpretation of the trade-off compensation. This work could provide a way to compensate the trade-off of enantioselectivity and activity in the process of enzyme evolution.
研究领域:
生物化学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2021
·
IF 8.742
Zhe Yang,Longting Li,Chi Jiang,Na Zhao,Shenghao Zhang,Yaoli Guo,Yi Chen,Shuangmei Xue,Chenhao Ji,Shuzhen Zhao,Ralph Rolly Gonzales,Hideto Matsuyama,Jianzhong Xia,Q. Jason Niu
Membrane fouling as well as the “trade-off effect” between water permeability and selectivity are the grand challenges for nanofiltration (NF) membranes. In this study, a macrocyclic molecule, Noria, was embedded in the polyamide layer to fabricate a thin film nanocomposite (TFN) membrane with high performances of separation and antifouling. Noria was first synthesized and dissolved in a piperazine (PIP) aqueous solution. Then the TFN membrane (i.e., PIP-Noria-TMC membrane, TMC is the abbreviation of 1,3,5-benzenetricarbonyl trichloride) was prepared by interfacial polymerization using PIP-Noria mixture as aqueous phase. The optimal PIP-Noria-TMC membrane reached 147.6 L m -2 h -1 MPa -1 of water permeability, which was almost twice that of the pristine NF membrane (i.e., PIP-TMC membrane). Meanwhile, the PIP-Noria-TMC membrane exhibited comparable Na 2 SO 4 rejection (∼98%) to the PIP-TMC membrane and outstanding mono/divalent salt selectivity. Besides, static adsorption tests using E.coli and bovine serum albumin (BSA) as the model foulants revealed that the surface of PIP-Noria-TMC membranes with high hydrophilicity and electronegative charge could effectively resist foulant attachment, which was also exhibited in the dynamic BSA filtration tests. Therefore, this work provided a practicable pathway to simultaneously overcome the permeability-selectivity trade-off and membrane fouling problems for the NF process.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
DESALINATION
·
2023
·
IF 9.9
Jia-Hao Liu,Fei Xie,Han-Zhuo Ding,Jia-Wei Mo,Xiao-Gang Jin,Xiao-Hua Ma,Zhen-Liang Xu
The permeance-selectivity trade-off has been a long-standing problem in membrane separation process, which has limited the application potential of many membrane separation techniques. Here we introduce chitosan (CS) nanofibers interlayer to optimize the substrate to improve the separation performance of thin-film composite (TFC) membrane fabricated by electrospray-assisted interfacial polymerization (EIP). A series of characterizations were conducted and the results showed that the introduction of CS nanofibers prevented polyamide from invading the substrate's pores, and increased the content of interfacial amine monomer to promote interfacial polymerization (IP) reaction. At the same time, the enhanced confinement effect formed a rougher selection layer, providing more water transport paths and enhancing the hydrophilicity of the membrane. Compared with the control TFC membrane with polyethersulfone (PES) substrate, the TFC/CS/PES membrane with CS/PES composite substrate showed excellent separation performance, achieving 4.5 times increase in permeance while maintaining a high MgCl 2 rejection. Our work provides a new strategy for optimizing the substrate and improving the properties of the membranes.
研究领域:
材料科学
·
膜分离技术
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Shengjun Du,Minglong Guo,Guangxing Yang,Qiao Zhang,Zhiting Liu,Feng Peng
The highly-efficient separation of CH 4 /N 2 mixture on carbon materials is significantly hindered by the inherent trade-off that exists between CH 4 adsorption capacity and CH 4 /N 2 separation selectivity. Herein, we have constructed a type of novel carbon materials (PGC- x ) with well-controlled ultramicropores ranging from 0.48 to 0.57 nm for CH 4 /N 2 separation. The Zn-based salt template was in-situ confined into the polymer framework during the co-assembly of phloroglucinol and glyoxylic acid. The subsequent evaporation of Zn at high temperature gives rise to the adjustable ultramicropore structure, effectively devoid of mesopores and macropores. Benefiting from the optimal pore size of 0.50 nm, PGC-1 demonstrated high CH 4 uptake of up to 1.50 mmol/g. Meanwhile, the CH 4 /N 2 (15/85 and 85/15, v/v) separation selectivity of PGC-1 at 298 K and 1.0 bar reached 5.8 and 6.0, respectively. Dynamic breakthrough experiments proved that PGC-1 could be used as efficient adsorbent for capturing low or high concentration of CH 4 from N 2 . This work offers a promising design principle for optimizing porous structure of carbon materials, with the aim of minimizing the selectivity-capacity trade-off that often arises in the separation of diverse gas pairs.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Haike Li,Zhiyun Kong,Huan Zhang,Xiaolei Wang,Xin Wei,Ruichao Yang,Xueyi Zhang
Organic solvent nanofiltration (OSN) membranes are suitable for separating drugs from solvents, especially heat-sensitive drugs. However, the trade-off effect between permeance and rejection limits the effective utilization of OSN membranes. In this study, a gel OSN membrane with high permeability-selectivity was prepared by bridging sodium alginate (SA) with HKUST-1 and then cross-linking with Ca 2+ ions. The interspersed distribution of HKUST-1 among the flexible polymer chains results in three-dimensional pores of the gel membrane, which enriches the solvent transport channels. Meanwhile, SA is cross-linked by Cu 2+ from HKUST-1 and Ca 2+ , which densifies the pore structure and enhances the solute rejection of the gel membrane. When the concentrations of HKUST-1, SA, and Ca 2+ are 2.5 wt%, the gel membrane (HKUST-1 2.5% -CaSA) has strong hydrophilicity (11.1°), a small pore size (0.59 nm), and a relatively high porosity (56.89 %). The ethanol permeance of the HKUST-1 2.5% -CaSA gel membrane reaches 43.8 L·m −2 ·h −1 ·bar −1 , with a tracycline (TC) rejection as high as 97 %. Moreover, the HKUST-1 2.5% -CaSA gel membrane is capable of achieving high rejection of TC in other organic solvents (acetone, ethyl acetate, and isopropanol). Even after being immersed in non-polar (n-hexane) and polar solvents (N,N-dimethylformamide, isopropanol, ethanol) for a period of 20 days, the separation performance of the gel OSN membrane remains consistent, confirming the excellent solvent resistance and potential in drug separation and solvent recovery.
研究领域:
材料科学
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制药工程
·
分离技术
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Baoying Wang,Ruirui Li,Zhenzhen Cui,Zihao Wang,Weicheng Fu,Junying Yan,Chenxiao Jiang,Liang Wu,Tongwen Xu,Yaoming Wang
Efficient separation of magnesium and lithium is essential for the extraction of lithium resources from salt-lake brines. However, the current membrane separation technologies are challenged by the membrane permeability-selectivity trade-off. Herein, we demonstrated a facile and practical approach to fabricate crown ether-functionalized polymeric membranes with excellent Li + /Mg 2+ separation performance by incorporating 12-crown-4 rings into the cellulose triacetate polymer network. The tightly and regularly arranged polymer chains anchored the crown ether rings firmly in the membrane structure, thereby facilitating the formation of stable and highly selective cation transport channels inside the membrane. As a result, the prepared membrane achieved an ultrahigh Li + /Mg 2+ separation factor of ∼872 and Li + flux of 22.6 μmol m −2 s −1 , which was much superior to that of commercial CIMS and reported membrane separation technologies. The good long-term stability of the fabricated membrane is promising for achieving efficient magnesium-lithium separation in large-scale industrial applications.
研究领域:
材料科学
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环境工程
·
化学工程
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产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2025
·
IF 21.1
Menglu Zhang,Yueping Bao,Li-an Hou,Xiaoqiang An,Yiran Chai,Chuyang Y. Tang,Yiqun Fan,Yu Yang
This study presents a novel Co 3 O 4 /g-C 3 N 4 functionalized ceramic membrane (Co-CN-M) for emerging contaminants removal by integrating visible-light photocatalysis and peroxymonosulfate oxidation. The membrane was fabricated via in-situ growth of ZIF-67 on g-C 3 N 4 -modified substrates followed by calcination. The Co-CN-M overcomes the conventional trade-off between reactivity and permeability, simultaneously achieving outstanding degradation efficiency ( k = 0.24 min −1 for bisphenol A) and ultrahigh water flux (724 L·m −2 ·h −1 ·bar −1 ). This exceptional performance stems from: (1) the p-n heterojunction at g-C 3 N 4 /Co 3 O 4 interface that enhances charge transfer and Co 2+ /Co 3+ cycling, promoting h + /O 2 ·− -dominated degradation; and (2) a unique honeycomb morphology that facilitates mass transfer via enhanced surface properties and internal nanochannels. Application viability was also demonstrated by excellent antifouling and self-cleaning properties (>70 % flux recovery) and stable long-term (96 h) operation in surface water with minimal cobalt leaching (<0.007 mg·L −1 ). This work offers valuable insights into metal-organic framework (MOF)-based functional membrane fabrication for effective water purification.
研究领域:
环境科学
·
材料科学
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Xiaokang Chen,Le Su,Yi Tan,Jian Yuan,Yujin Mou,Wei-Qiao Deng,Hao Wu
Platinum (Pt) electrocatalysts face a trade-off between catalytic activity and durability in the hydrogen evolution reaction (HER). Designing Pt with a predominantly exposed (1 1 1) facet while improving its intrinsic activity remains a challenging endeavor. In this study, we synthesize high-entropy alloy (HEA) catalysts containing PtPdAuCuCo, featuring tunable (1 1 1)/(1 1 1) twin boundaries (TBs) achieved by entropy modulation. The incorporation of TBs creates favorable convex sites that facilitates overpotentially deposited hydrogen, leading to fast HER kinetics. Density functional theory (DFT) calculations indicate that the presence of TBs strengthens the H adsorption due to enhanced electron transfer from the metal to the adsorbate, an effect not observed in TB-free HEAs with even greater Pt contents. Moreover, the HEA with TBs shows an upshifted d band center and increased bonding state occupancy compared to its TB-free counterpart. Consequently, it exhibits exceptional HER performance, achieving outstanding stability for 15 days without degradation and ultralow overpotentials of 51 and 72 mV at 10 and 100 mA cm −2 , respectively, outperforming TB-free HEAs. The mass activity reaches 3.05 A mg −1 Pt at 100 mV, exceeding that for TB-free HEA by 23.5 folds. Our findings highlight the potential of TB-engineering to optimize the activity-durability trade-off in Pt electrocatalysts.
研究领域:
材料科学
·
电化学
·
催化科学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Haoliang Xiao,Ning Zhang,Jiaxiang Li,Min Zhong,Pengchao Xie,Songlin Wang,Jun Ma
Radical-based cleaning technology is regarded as an efficient solution for fouled membranes. Nevertheless, limited studies have investigated the inevitable residual fouling and its effects on membrane filtration under prolonged use of these methods. To explore, the peroxymonosulfate/hydroxylamine/ferrous (PMS/NH 2 OH/Fe(II)) system, known for generating abundant radicals, was employed in this study. With the help of hydroxyl radical (HO · ), PMS/NH 2 OH/Fe(II) effectively restored the flux of membranes fouled by humic acid (HA), bovine serum albumin (BSA), and sodium alginate (SA) in dead-end filtration to 96 %, 97 %, and 103 % of their original values, respectively. Over cyclic radical cleanings, the membrane flux increased to 181 %∼219 % of the original flux. However, the retention performance remained nearly unchanged, suggesting a breakthrough in the selectivity-permeability trade-off. Comprehensive characterization of the membranes indicated that the maintenance of retention performance relied on the reduced porosity due to residual fouling, while the increased flux was attributed to the carboxylation modification of residual fouling. Supported by this mechanism, PMS/NH 2 OH/Fe(II) maintained satisfactory cleaning efficiency during practical cleaning of East Lake-fouled membranes. Overall, this study uncovers how repeated radical-based cleaning affects membrane performance, offering foundational insights for the application of this technology.
研究领域:
环境工程
·
材料科学
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产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Xiong Jinqi,Mao Shanjun,Luo Qian,Ning Honghui,Lu Bing,Liu Yanling,Wang Yong
As a crucial industrial process for the production of bulk and fine chemicals, semi-hydrogenation of alkynes faces the trade-off between activity and selectivity due to undesirable over-hydrogenation. By breaking the energy linear scaling relationships, we report an efficient additive-free WO 3 -based single-atom Pd catalytic system with a vertical size effect of hydrogen spillover. Hydrogen spillover induced hydrophilic polar layer (HPL) with limited thickness on WO 3 -based support exhibits unconventional size effect to Pd site, in which over-hydrogenation is greatly suppressed on Pd 1 site due to the polar repulsive interaction between HPL and nonpolar C=C bonds, whereas this is invalid for Pd nanoparticles with higher altitudes. By further enhancing the HPL through Mo doping, activated Pd 1 /MoWO 3 achieves recorded performance of 98.4% selectivity and 10200 h −1 activity for semi-hydrogenation of 2-methyl-3-butyn-2-ol, 26-fold increase in activity of Lindlar catalyst. This observed vertical size effect of hydrogen spillover offers broad potential in catalytic performance regulation.
研究领域:
催化化学
·
材料科学
·
工业化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）