Frontiers in Materials
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2023
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IF 3.2
Ti Gang,Fan Yi,Tang Jian,Niu Chenguang,Xiong Xiaoyan
The morphology of dispersed particles has been proven to have a significant impact on performance of electrorheological (ER) materials, while there is a lack of relevant research on its impact on the properties of electrorheological elastomers (EREs). In this study, the TiO2 particles with spherical, short rod, and long rod shape were fabricated with sol-gel method, and the EREs were prepared with these three kinds of particles as dispersion phase. Particle characterization results show that the rod-shape TiO2 particles with larger average size exhibit a combination of anatase and brookite phase. The viscoelastic properties of three types of EREs under varying strain amplitude and shear frequency were tested. The results indicate that the long rod-shape TiO2 particles filled EREs shows higher storage modulus G′ and higher relative ER effect within the electric field from 0 to 3 kV/mm. The observations indicate the use of rod-shape TiO2 particles in the form of brookite phase may help enhance the ER properties of elastomers. The investigation contributes to the designing, preparation, and application of anisotropic ERE.
研究领域:
材料科学
·
物理学
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DOI
高影响因子
OPTICS EXPRESS
·
2024
·Vol. 32
·期 2
·1465-1477
·
IF 3.2
Xu Chen,Mingyuan Liu,Chunming Zhou,Chunming Zhou,Hang Chen,Tianyuan Zhou,Tianyuan Zhou,Yanbin Li,Yanbin Li,Shenghui Lin,Cong Wei,Cen Shao,Cen Shao,Guannan Chen,Guannan Chen,Jian Kang,Jian Kang,Pengde Han,Wieslaw Strek,Hao Chen,Hao Chen,Le Zhang,Le Zhang,Le Zhang,Le Zhang
High power and high brightness laser lighting puts forward new requirements for phosphor converters such as high luminous efficiency, high thermal conductivity and high saturation threshold due to the severe thermal effect. The structure design of phosphor converters is proposed as what we believe to be a novel strategy for less heat production and more heat conduction. In this work, the rod-shaped YAG:Ce phosphor ceramics (PCs) and disc-shaped YAG:Ce PCs as control group were fabricated by the gel casting and vacuum sintering, to comparatively study the luminescence performance for LD lighting, on the premise that the total number of transverse Ce3+ ions and the volume of samples from two comparison groups were same. All rod YAG:Ce PCs with low Ce3+ concentration exhibited the high luminous efficiency and better thermal stability than YAG:Ce discs with high Ce3+ concentration. Under the laser power density of 47.8 W/mm2, the luminous saturation was never observed in all rod-shaped YAG:Ce PCs. The high luminous efficacy of 245∼274 lm/W, CRI of 56.3∼59.5 and CCT of 4509∼4478 K were achieved. More importantly, due to the extremely low Ce3+ doping concentration (0.01 at%), rod-shaped ceramics based LDs devices showed the excellent thermal performance and their surface temperatures were even below 30.5 °C surprisingly under the laser power density of 20.3 W·mm-2 (2 W). These results indicate that the rod shape of phosphor converter is a promising structure engineering for high power laser lighting.
研究领域:
材料科学
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光学工程
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DOI
PubMed
高影响因子
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
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2018
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IF 3.566
Jiuling Wang,Yiwei Yang,Miaorong Yu,Guoqing Hu,Yong Gan,Huajian Gao,Xinghua Shi
It is known that rod-like nanoparticles (NPs) can achieve higher diffusivity than their spherical counterparts in biological porous media such as mucus and tumor interstitial matrix, but the underlying mechanisms still remain elusive. Here, we present a joint experimental and theoretical study to show that the aspect ratio (AR) of NPs and their adhesive interactions with the host medium play key roles in such anomalous diffusion behaviors of nanorods. In an adhesive polymer solution/gel (e.g., mucus), hopping diffusion enables nanorods to achieve higher diffusivity than spherical NPs with diameters equal to the minor axis of the rods, and there exists an optimal AR that leads to maximum diffusivity. In contrast, the diffusivity of nanorods decreases monotonically with increasing AR in a non-adhesive polymer solution/gel (e.g., hydroxyethyl cellulose, HEC). Our theoretical model, which captures all the experimental observations, generalizes the so-called obstruction-scaling model by incorporating the effects of the NPs/matrix interaction via the mean first passage time (MFPT) theory. This work reveals the physical origin of the anomalous diffusion behaviors of rod-like NPs in biological gels and may provide guidelines for a range of applications that involve NPs diffusion in complex porous media.
研究领域:
生物物理学
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材料科学
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医学工程
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DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2019
·Vol. 76
·期 4
·1363-1370
·
IF 3.255
Chengfeng Lei,Shili Yang,Wenxiao Lei,Innocent Nyamwasa,Jia Hu,Xiulian Sun
BACKGROUND Baculoviruses provide long-lasting control of crop pests and are harmless to humans and non-target animals, making them attractive bioinsecticides. Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has a wide-host range and is one such commercial bioinsecticide, but its low infectivity to older larvae and less-sensitive species precludes its large-scale application. We sought to improve the infectivity of AcMNPV. RESULTS Two enhancing factors, the truncated enhancin from Agrotis segetum granulovirus and GP37 from Cydia pomonella granulovirus, were expressed in fusion with the N-terminal and middle domain of the polyhedrin envelope protein of AcMNPV. Western blotting and immunoelectron microscopy analysis indicated that the enhancing factors were expressed on the occlusion bodies of the resulting AcMNPV variants. Bioassays showed that the median lethal doses of the recombinant viruses were 3.9-fold to 7.4-fold lower than those of the wild-type virus against the second and fourth instar of Spodoptera exigua larvae. The yields of occlusion bodies from the two recombinants in S. exigua larvae were comparable with those of the wild-type virus both in vitro and in vivo . Further bioassays showed that the AcMNPV variants fusing the enhancing factors were incapable of infecting the second instar larvae of S. litura , Helicoverpa armigera , and Pyrausta nubilalis , which were not sensitive to the wild-type AcMNPV. CONCLUSION These genetically modified AcMNPV variants exhibited an enhanced infectivity and may offer better baculovirus control of crop pests. © 2019 Society of Chemical Industry
研究领域:
病毒学
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昆虫学
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生物技术
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DOI
PubMed
高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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2022
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IF 4.117
Tan Qin,Yu Wang,Jing Nie,Lushan Yu,Su Zeng
Background Sodium taurocholate co -transportering polypeptide (NTCP, SLC10A1 ) is a vital bile acid transporter and the functional receptor of hepatitis B and D virus. The oligomerization of NTCP is important for the structural study of its interaction with HBV preS1 peptide. Methods Recombinant NTCPs were expressed in Sf9 host cell using baculoviruses. Function of recombinant NTCP was verified by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method. A quantitative fluorescence resonance energy transfer (FRET) method was established to analyze the interaction between NTCP wild type (WT) and mutants. Co-immunoprecipitation (Co-IP) was used to test the interaction between NTCP variants. Results Sub-cellular location of recombinant NTCPs varies with the modification of NTCP. Bands of monomer, dimer and oligomers were shown in gel analysis of NTCP. Significant FRET was observed between cyan florescence protein (CFP) tagged NTCP and yellow florescence protein (YFP) tagged NTCP. FRET efficiency between CFP- and YFP-NTCP S267F mutants was lower than WT. Co-IP results showed that S267F interacts with WT NTCP when co-expressed in cell. Conclusion Dimer is the predominant form of NTCP expressed in Sf9 when solubilized with detergent. FRET and Co-IP analysis support that NTCP forms oligomers in Sf9 cell. General significance Our results showed that NTCP formed oligomers in Sf9 cell. Meanwhile the FRET analysis of NTCP variants further elucidated the molecular mechanism of NTCP oligomerization.
研究领域:
病毒学
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分子生物学
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细胞生物学
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DOI
PubMed
高影响因子
Chemical Science
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2018
·Vol. 10
·期 5
·1351-1359
·
IF 9.063
Zhongju Ye,Hua Liu,Fuyan Wang,Xin Wang,Lin Wei,Lehui Xiao
It has been demonstrated that rod-shaped particles can achieve a high translocation efficiency for gene and drug delivery in biological samples. Previous theoretical calculations also confirmed that rod-shaped particles display higher diffusivity than their spherical counterparts in biological porous media. Understanding the diffusion dynamics of biological and non-biological rod-shaped particles in biological solutions as well as close to the lipid membrane is therefore fundamentally significant for the rational design of efficient cargos. With dark-field optical microscopy, the translational and three-dimensional (3D) orientational diffusion dynamics of individual rod-shaped particles (i.e., E. coli and upconversion microrods, UCMRs) in phosphate buffered saline (PBS) and on the lipid membrane are tracked at the single-particle level. In the buffer solution, faster rotation of E. coli in the z direction was observed even though its dynamics in the x–y plane is comparable with that of UCMRs. Interestingly, on the lipid membrane, distinct from the confined motion of UCMRs, anomalous rocking diffusion was observed, which might facilitate the subsequent survey of stronger association sites on the two-dimensional (2D) surface. These results would afford deep insight into the better understanding of the translocation mechanism by using rod-shaped particles as a delivery cargo in biological samples.
研究领域:
生物物理学
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药物递送
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2019
·
IF 5.667
Yanqian Wu,Yi Xiao,Yushu Huang,Yanyun Xu,Donglei You,Wei Lu,Jiahui Yu
A biodegradable brush-type copolymer PHF-g-(PCL-PEG) based on a cleavable polyacetal backbone and biodegradable side chain modified with polyethylene glycol (PEG) was synthesized in this paper. This particular structure was directional to facilitate the formation of spherical or rod-shaped micelles. Flow cytometry showed that rod-shaped micelles displayed enhanced cellular uptake compared to spherical micelles. Rod-shaped micelles were selected to investigate their drug delivery abilities in detail. In vitro experiments verified the pH-triggered drug release of DOX-loaded micelles, and the release rate of doxorubicin (DOX) was 77% at pH 5.0 and 26% at pH 7.4. In drug-release kinetic analysis, a double-exponential model achieved the best fit. The copolymer appeared to be almost nontoxic, while the DOX-loaded micelles showed equivalent cytotoxicity compared to DOX at high concentration. The endocytosis of DOX-loaded micelles was two times that of DOX. Our findings suggest that the pH-sensitive brush type copolymer could be a possible carrier in drug delivery.
研究领域:
生物材料学
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药物递送系统
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高分子化学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 16
·8732-8741
·
IF 6.895
Hang Ping,Lokendra Poudel,Hao Xie,Weijian Fang,Zhaoyong Zou,Pengcheng Zhai,Wolfgang Wagermaier,Peter Fratzl,Weimin Wang,Hao Wang,Padraic O'Reilly,Wai-Yim Ching,Zhengyi Fu
Mesoporous silica particles of controlled size and shape are potentially beneficial for many applications, but their usage may be limited by the complex procedure of fabrication. Biotemplating provides a facile approach to synthesize materials with desired shapes. Herein, a bioinspired design principle is adopted through displaying silaffin-derived 5R5 proteins on the surface of Escherichia coli by genetic manipulations. The genetically modified Escherichia coli provides a three-dimensional template to regulate the synthesis of rod-shaped silica. The silicification is initiated on the cell surface under the functionality of 5R5 proteins and subsequentially the inner space is gradually filled. Density functional theory simulation reveals the interfacial interactions between silica precursors and R5 peptides at the atomic scale. There is a large conformation change of this protein during biosilicification. Electrostatic interactions contribute to the high affinity between positively charged residues (Lys4, Arg16, Arg17) and negatively charged tetraethyl orthosilicate. Hydrogen bonds develop between Arg16 (O⋯H), Arg17 (O⋯H and N⋯H), Leu19 (O⋯H) residues and the forming silica agglomerates. In addition, the resulting rod-shaped silica copy of the bacteria can transform into mesoporous SiOx nanorods composed of carbon-coated nanoparticles after carbonization, which is shown to allow superior lithium storage performance.
研究领域:
材料科学
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生物化学
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Si-Han Zhou,Rui-Dong Wang,Tian-Tian Wu,Shi-Hui Deng,Ji-Chao Guo,Shu-Min Zhou,Xuan Zhou,Jiajia Du,Qi-Hua Zhao,Xiaoxia Ren,Ming-jin Xie
As many of the disadvantages of traditional single therapy can be avoided with combination therapy, combination therapy has become a new treatment method. Herein, a long rod-shaped gallium composite multifunctional material (CP–Au-PEG-FA@BSA@IR780) based on chemotherapy therapy (CT), photothermal therapy (PTT) and photodynamic therapy (PDT) is constructed to increase reactive oxygen species (ROS) levels and Au NP release. CP-Au-PEG-FA@BSA@IR780 has fluorescence localization characteristics and can combine with CT-DNA to cause cancer cell apoptosis. The in vitro cytotoxicity experiments showed the excellent biocompatibility and great therapeutic efficacy of the designed nanoplatform compared to those of the IR780 group, which had weak red fluorescence. The in vivo experiments also showed that the designed micro/nano platform can effectively eliminate HCT116 tumors by allowing the temperature of the tumor site to exceed 55 °C (thermal ablation) under light irradiation . The main mechanism of chemotherapy indicated that the presence of Fe 2+ /Fe 3+ can disrupt the rod-shaped structure of the original material and increase the content of Ga 3+ . Overall, CP-Au-PEG-FA@BSA@IR780 is a promising cancer therapy strategy that combines CT, PTT, and PDT and provides new insights into the synthesis method of enhancing composite materials with photothermal properties.
研究领域:
肿瘤学
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纳米医学
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生物材料学
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产品关联
DOI
高影响因子
Laser & Photonics Reviews
·
2024
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IF 9.8
Haixia Cui,Yurou Yan,Zhe Feng,Yongkang Zhu,Yuhui Feng,Shujuan Liu,Qiang Zhao
Copper-based organic–inorganic hybrid halides (OIHHs) have garnered significant interest in X-ray imaging due to their flexible structural adjustability, efficient light emission, strong X-ray absorption, etc. Herein, four copper-based OIHH crystals composed of the same organic ligands (isopropyl triphenylphosphonium cations, IPP + ) and inorganic parts (Cu 2 I 4 2− ) are synthesized by varying the ratios of raw materials and types of reaction solvents. Although these crystals share identical structures, they exhibit different luminescent behaviors (blue, green, white, and yellow) attributed to vacancy defects originating from CuI. Notably, the novel copper-based OIHH (CP2) with green emission shows the best luminescence efficiency (99.54%) and excellent scintillation performance (50675 photons MeV −1 ). The traditional technology of scintillation screens mixing scintillator powders and polymers often results in light scattering due to powder aggregation and inhomogeneity. To address this challenge, the dispersant polyvinyl pyrrolidone is introduced to prepare uniform rod-like microcrystals of CP2. The scintillation screen based on CP2 microcrystals achieves a high spatial resolution of 16–18 lp mm −1 , surpassing the resolution of most copper-based OIHH scintillators. Furthermore, it is imaging capabilities are validated using a commercial X-ray flat panel detector, demonstrating imaging performance comparable to that of commercial scintillators.
研究领域:
材料科学
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医学影像学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
·
IF 4.831
Xieyin Li,Yuqian Zhang,Mian Wei,Manman Wang,Jing Wang,Guifu Zuo
A rod-like melem with high fluorescence quantum yield of 71.3 % was prepared in this work to enhance the chemiluminescence (CL) intensity of Na 2 SO 3 -Ce (Ⅳ) system. The results showed that the CL intensity of Na 2 SO 3 -Ce (Ⅳ) system could be increased by 350 times based on chemiluminescence resonance energy transfer (CRET) mechanism. Furthermore, a CL sensor based on Na 2 SO 3 -Ce (Ⅳ)-melem system was designed to detect reduced glutathione (G-SH). It was indicated that the CL sensor exhibited excellent G-SH detection performance with a detection limit of 0.065 nM and a linear range from 0.32 to 650 μM. This study applied melem for CL detection and provided a new way for the detection of G-SH.
研究领域:
分析化学
·
生物医学
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DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Fei Li,Dong Wang,Qiongzhen Liu,Bo Wang,Weibing Zhong,Mufang Li,Ke Liu,Zhentan Lu,Haiqing Jiang,Qinghua Zhao,Chuanxi Xiong
This study attempts to prompt the formation of microorganism films on flexible textile-based anodes and enhances the performance of living microorganisms by introducing magnetic properties to the anodes. A magnetic and electrically conductive anode for a microbial fuel cell is designed and fabricated by encapsulating uniformly dispersed SrFe 12 O 19 nanoparticles into the poly(vinyl alcohol- co -ethylene) (PVA- co -PE) nanofibers and forming a three-dimensional (3D) polypyrrole (PPy) network on the surface of flexible composite nanofiber based fabric. A dual-chamber MFC equipped with the magnetized anode shows a maximum power density of 3317 mW m −2 , which is significantly larger than that of the non-magnetized anode (2471 mW m −2 ). This study demonstrates that the hard-magnetic anode providing an inherent magnetic field can greatly promote bio-electrochemical reaction rates of E. coli , and decrease the anode charge transfer resistance in a MFC system.
研究领域:
生物技术
·
材料科学
·
环境工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）