Triboelectric nanogenerator (TENG) has shown great potential in real-time monitoring of individual physiological state. Conductive metal nanofibers maintain good stability and mechanical strain as electrodes. Herein, a simple and safe strategy was provided to prepare electrospun gelatin membranes with in-situ coated silver layer for flexible TENG devices. Electrospun gelatin membranes were prepared by a one-pot method of dopamine-grafted gelatinmodification and physical modification through blending with polyvinyl alcohol (PVA). The silver coated electrospun membrane was constructed using the reductive immobilization of silver by dopamine. The content of silver and the output signal of the TENG can be further controlled using bio-crosslinked gelatin membranes. The electrospun gelatin membranes with immobilized silver layers did not show significantly cytotoxic to fibroblasts. The tensile strength of the membranes crosslinked reached 4 MPa, which was more flexible than the membranes uncrosslinked. The membranes showed significant inhibition against Staphylococcus aureus ( S. aureus ) and Pseudomonas aeruginosa ( P. aeruginosa ). The triboelectric output performance of the membrane can be controlled by adjusting the crosslinking method, which providing an effective strategy for implementing TENG in the monitoring of the wound healing process.
Xuan Qin,Haoliang Shi,Zhen Wen,Binbin Chu,Hongyang Li,Houyu Wang,Yao He,Xuhui Sun
Electrotherapy is of great interest in the field of tissue repair as an effective, well-tolerated, and noninvasive treatment. Triboelectric nanogenerator (TENG) has shown advantages in promoting wound healing due to its peak output characteristic and low Joule heating effect. However, it is limited in infected wound healing due to poor antimicrobial capacity. Here, a wearable triboelectric stimulator (WTS) is developed that consists of a flexible TENG (F-TENG) and a triboelectric-responsive drug delivery hydrogel (TR-DDH) for healing of bacterium-infected wounds. F-TENG can generate pulsed current to wounds by converting mechanical energy from body movements. Polypyrrole is prone to reduction and volume contraction under electrical stimulation, resulting in desorption of curcumin nanoparticles (CUR NPs) from the polypyrrole in TR-DDH. Therefore, the highly efficient and controllable release of CUR NPs can be achieved by triboelectric stimulation. According to the in vitro and in vivo experiments, WTS has the greatest antimicrobial effect and the fastest promotion of infected wound healing compared to treatment with electrical stimulation or curcumin. Finally, the safety assessment demonstrates that the WTS has excellent tissue safety for chronic wound healing. Synergistic therapy with WTS provides an efficient strategy for chronic wound healing and smart-responsive drug delivery systems.
危险品化学品经营许可证（带存储）