iScience
·
2025
·Vol. 28
·期 11
·
IF 4.1
Yiyang Gao,Qihao Jiang,Jing Chen,Yanming Liu
Through molecular design, this study developed a conformal self-healing organogel (CSHO) via molecular design. Utilizing acryloylmorpholine (ACMO) and hydroxyethyl acrylamide (HEAA) as monomers, tributyl citrate (TBC) as the solvent, and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) as an electrolyte salt, the organogel was polymerized by UV curing. A dual supramolecular network of hydrogen and lithium bonds provided excellent mechanical strength without chemical crosslinkers, while also enabling self-healing. TBC enhanced flexibility and established continuous ion channels, boosting ionic conductivity. The CSHO exhibited excellent conformability to complex surfaces, replicating fine textures, and was recyclable through a water-based process. Mechanical sensing tests showed that the CSHO could respond sensitively and in real time to pressing and stretching. This work presents a strategy for multifunctional ionic conductors, advancing flexible sensors and wearable devices.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2025
·
IF 3.5
Huifang Li,Shuo Wang,Wenbin Fan,Dahuan Liu
Solvent extraction has emerged as a highly promising method for lithium extraction . In this study, a sustainable extraction system was developed using 2-ethylhexyl phosphate mono 2-ethylhexyl ester (P507) and tri-butyl phosphate (TBP). By precisely controlling the coordination mode of Fe 3+ with TBP and P507 during the stripping process, a green extraction process was achieved. The research comprehensively investigated the effects of various factors, such as the type of diluent, saponification ratio, volume ratio of TBP, molar ratio of Fe/Li, and extraction phase ratio. Through systematic experiments, the optimal parameters were identified, and the coordination mechanism between the organic compounds and metal ions was elucidated. This work not only provides a promising approach for lithium recovery from salt lake brines but also establishes a solid theoretical foundation for the industrial application of the TBP-P507 extraction system, thereby holding great potential for promoting the development of the lithium extraction industry.
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iScience
·
2025
·Vol. 28
·期 7
·112867
·
IF 4.1
Yiyang Gao,Qihao Jiang,Yanming Liu
This study introduces a UV-curing resin leveraging the Christiansen effect to achieve dynamic color modulation in phase-separated elastomers (PSE) through solvent composition and temperature control. By matching refractive indices between solvent (dimethyl phthalate/tributyl citrate) and polymer phases, PSE selectively transmits-specific wavelengths, enabling continuous color shifts from red to purple. The elastomers exhibit robust mechanical properties (>600% elongation, >300 kPa modulus) and function across a broad temperature range (−25°C–130°C). Compatible with 3D printing, the resin enables real-time solvent adjustments during fabrication, supporting spatially continuous color transitions without parameter modifications. This approach advances applications in adaptive optical devices, temperature-responsive displays, and multi-material 3D printing, offering a dye-free strategy for structural coloration in smart materials. Chemistry; Materials science; Physics
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Environment & Health
·
2025
·
IF 6.3
Haosong Chen,Yixian Cheng,Yao Zhou,Rui Fu,Jianguang Jia,Shuyuan Zhang,Junjie Chen,Haikun Cao,Peng Zhang,Qilong Geng,Jinghua Gu,Bo Chen,Wenxiu Han,Maoming Xiong,Ting Li,Guodong Cao
Tributyl citrate (TBC), a widely used substitute for phthalate plasticizers, has shown increasing environmental accumulation, raising concerns about its potential human health risks. However, its toxicological effects, particularly regarding gastrointestinal disease progression, remain largely unexplored. In this study, animal experiments first demonstrated that TBC aggravates colonic inflammation in a mouse model of microplastic-induced colitis. Computational toxicology analysis further predicted TBC to possess potential carcinogenic properties, suggesting its role in promoting colitis-associated carcinogenesis. Using integrated bioinformatics approaches, we combined network toxicology, molecular docking, and molecular dynamics simulations to identify the putative toxicological targets and molecular pathways involved in TBC-induced inflammation-to-cancer transition. A total of 299 TBC-related targets were identified from multilevel databases, and 13 core targets were highlighted through STRING and Cytoscape analyses, including AKT2, MAPK1, MAPK3, HSP90AA1, PIK3CD, BCL2, PIK3R1, PIK3CB, ESR1, CASP3, KRAS, and ERBB2. GO and KEGG enrichment analyses indicated that TBC may drive carcinogenic progression via pathways associated with oxidative stress and inflammatory responses. Molecular docking and dynamics simulations validated the stable interactions between TBC and key targets. To further confirm TBC’s role in colitis-associated tumorigenesis, we employed an AOM/DSS-induced colorectal cancer mouse model and found that TBC significantly exacerbated both intestinal inflammation and tumor formation. Transcriptomic analysis further validated the enrichment of ROS-mediated chemical carcinogenesis pathways and revealed that intestinal barrier disruption may also be a critical contributor to TBC-mediated cancer progression. Collectively, this study provides a theoretical basis for understanding the molecular mechanisms by which TBC aggravates inflammation-associated colorectal cancer, and offers a framework for risk assessment and regulatory strategies addressing plasticizer exposure in digestive health.
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Advanced Fiber Materials
·
2023
·Vol. 5
·期 2
·632-649
·
IF 16.1
Wang Lu,Ma Jingyi,Guo Tao,Zhang Fenghua,Dong Aimeng,Zhang Shiqi,Liu Yanju,Yuan Huiping,Leng Jinsong
Micro- and nano-fibers of shape memory polymers (SMP) offer multiple advantages like high specific surface area, porosity, and intelligence, and are suitable for biomedical applications. In this study, biodegradable poly (p-dioxanone) (PPDO) materials were incorporated to improve the brittleness of shape memory polylactic acid (PLA), and plasticizers were used to reduce the transition temperature of SMP composites such that their transitions could be induced close to body temperature. Furthermore, an electrostatic spinning technology was applied to prepare SMP fibers with wrinkled structures and regulate their microstructures and morphologies such that the intelligent transition of wrinkled and smooth morphologies can be achieved on the fiber surface. The application of this controllable-morphology fiber membrane in intelligent controlled drug release and scar inhibition after Ahmed Glaucoma Valve (AGV) implantation was also studied. The drug release from the stretched and deformed drug-loaded fiber membranes was faster than those from membranes with the original shape. This membrane with micro- and nano-fibers had good anti-scarring effects that improved after drug loading. The achievement of intelligent controlled drug release and the evident anti-scarring effects of the membrane broaden the application of SMP fibers in the biomedical field. Graphical Abstract
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MATERIALS & DESIGN
·
2023
·
IF 8.4
Wei Cao
Plasticizers are common additives used to enhance the flexibility and workability of polymer materials. Recent findings suggest a great potential for typical plasticizers being used as rejuvenators to recycle oxidized paving asphalts. This study investigated the rejuvenating effectiveness of two plasticizers via rheological evaluation and explored the underlying mechanism by analytical characterizations and molecular dynamics (MD) simulations. A conventional plasticizer dibutyl phthalate (DBP) and an environmentally friendly tributyl citrate (TBC) were selected given the discrepancies in their molecular structures. Both plasticizers were effective in restoring the rheological performance of the aged asphalt; TBC was relatively more efficient which was attributed to its higher molecular polarity and the formation of hydrogen bonds with the oxidized asphalt molecules. Analyses based on the gel permeation chromatography and differential scanning calorimetry suggested the capability of the plasticizers in dissociating the oxidized asphalt molecules and improving the molecular mobility. The improved molecular mobility was considered responsible for the reversing effect of the plasticizers, as compared to aging, in terms of widening the relaxation spectrum and broadening the glass transition region. The plasticizers’ dissociating effect was confirmed and visualized in the simulations by inspecting their impacts on the spatial arrangement and distribution of the asphaltenes.
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Drug Delivery and Translational Research
·
2022
·Vol. 13
·期 1
·9-17
·
IF 5.671
Yuan Hao,Zhang Zhengyu,Hu Liandong
In this study, a new gastro-floating sustained-release capsule (GFC) with levodopa (LD) and benserazide hydrochloride (BH) was successfully developed. GFCs were prepared by filling the LD and BH granules into hard capsules and coated with cellulose acetate (CA) solution as a controlled-release layer. The effects of formulation factors on the release of GFCs were conducted. The AUC 0~24 (µg h/mL) of LD were 69.31 ± 3.61 (μg h/mL) and 28.87 ± 2.58 (μg h/mL) and the C max were 7.84 ± 0.34 (μg/mL) and 9.21 ± 1.04 (μg/mL) in the GFCs and commercial tablets respectively. The relative bioavailability of LD was 267.55 ± 34.54%. Compared with commercial tablets, the pharmacokinetic study indicated that the developed GFCs provided a better sustained-release effect and higher bioavailability than commercial tablets. Graphical abstract
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Yitian Qin,Guodong Kang,Yiming Cao
Highly permeable reverse osmosis (RO) membranes are desirable for alleviating the energy burden and ensuring future water sustainability. Herein, the effectiveness of green plasticizer-assisted interfacial polymerization (GPAIP) for preparing polyamide thin-film composite (TFC) RO membranes with significantly enhanced water permeability was demonstrated. The presence of green citrate plasticizers, namely tributyl citrate (TBC) or acetyl tributyl citrate (ATBC), led to the formation of new hydrogen bonds and inhibited the formation of the initial interchain amide-amide bonding, thus markedly reducing chain rigidity as demonstrated by the decreased elasticity modulus. More flexible polyamide chains resulted in the creation of more ultrafast water channels during filtration. Furthermore, TBC-modified membranes exhibited more elastic polyamide layers and higher water flux than that of ATBC-modified membranes on account of the presence of both hydrogen bond acceptors (O H) and hydrogen bond donors (C=O) in TBC molecules. Specifically, water flux of 0.6 wt% TBC-modified and 0.6 wt% ATBC-modified membranes was 83.6 L m −2 h −1 and 49.7 L m −2 h −1 respectively, more than 5 times and 3 times that of the pristine membrane. The excellent performance of TFC RO membranes fabricated via GPAIP together with the facile membrane manufacturing process offered the possibility of breaking the predicament in desalination field, which could eventually help ease the current freshwater crisis.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Zechun Ren,Xinyuan Zhou,Kejiao Ding,Tong Ji,Hao Sun,Xiang Chi,Yunzhao Wei,Min Xu,Liping Cai,Changlei Xia
In this study, we report the development of a sustainable polymer system with 50 wt% lignin content, suitable for additive manufacturing and high value-added utilization of lignin. The plasticized polylactic acid (PLA) was incorporated with lignin to develop the bendable and malleable green composites with excellent 3D printing adaptability. The biocomposites exhibit increases of 765.54 % and 125.27 % in both elongation and toughness, respectively. The plasticizer enhances the dispersion of lignin and the molecular mobility of the PLA chains. The good dispersion of lignin particles within the structure and the reduction of chemical cross-linking promote the local relaxation of the polymer chains. The good local relaxation of the polymer chains and the high flexibility allow to obtain a better integration between the printed layers with good printability. This research demonstrates the promising potential of this composite system for sustainable manufacturing and provides insights into novel material design for high-value applications of lignin.
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Advanced Science
·
2023
·Vol. 10
·期 33
·2304106
·
IF 15.1
Sen Li,Jiantao Huang,Meilan Wang,Ka Deng,Chenhui Guo,Bin Li,Yu Cheng,Hongyan Sun,Hong Ye,Tingrui Pan,Yu Chang
The conformal integration of the electronic skin on the non-developable surface is in great demand for the comprehensive tactile sensing of robotics and prosthetics. However, the current techniques still encounter obstacles in achieving conformal integration of film-like electronic skin on non-developable surfaces with substantial curvatures for contact pressure detection and tactile mapping. In this paper, by utilizing the 3D printing technology to prepare the 3D electrode array in the structural component following its surface curvature, and covering it with a molded functional shell to form the pressure sensitive iontronic interface, a device is proposed to achieve high-sensitive pressure detection and high-fidelity tactile mapping on a complicated non-developable surface, called structural electronic skin (SES). The SES is prepared in a 3D printed fingertip with 46 tactile sensing units distributed on its curved surface, achieving the integration of both structural and tactile functions in a single component. By integrating the smart fingertip into a dexterous hand, a series of demonstrations are presented to show the dead-zone free pressure detection and tactile mapping with high sensitivity, for instance, 2D pulse wave monitoring and robotic injection in a medical robot, object recognition and compliant control in a smart prosthesis.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 34
·期 2
·676-690
·
IF 3.348
Qing-Wen Liu,Yu-Lin Hong,Chang Wang,Yun Liu,Cheng-Mei Liu
Preparing a polylactide (PLA)/plasticizer system has been regarded as an effective solution to improve the ductility of brittle PLA. In this reach, a novel type of alkyl phosphine oxides consisting of three aliphatic ester substituents was prepared from PH 3 tail gas, and its potential to be employed as a PLA plasticizer was studied. Differential scanning calorimeter tests confirmed that the newly-prepared plasticizer decreased the T g of PLA (28 wt% plasticizer) from 52°C (neat PLA) to 11°C, and increased the elongation at break from 11% (neat PLA) to 271% (plasticized PLA). X-ray diffraction results showed that the crystallization degree of PLA (28 wt% plasticizer) increased from 0.12% of neat PLA to 14.04%, while Young's modulus of PLA remained as high as 121.3 MPa, which was much higher than that of the PLA/citrate ester systems with same plasticizer content. These novel phosphorus-containing plasticizers exhibited excellent thermal stability and a weight-loss of the system no more than 2.5% at 180°C; therefore, no unpleasant volatiles were released during processing. In contrast, the weight loss of the PLA/citrate system was as high as 10.8% at 180°C, forming heavy fog with an unpleasant smell during thermal mixing. Scanning electron microscopy was employed to observe the microstructure of the PLA/plasticizer systems, which indicated that the carboxylic butyl ester-containing phosphine oxides was compatible with PLA matrix.
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Polymers
·
2023
·Vol. 15
·期 7
·1755
·
IF 5
Junyuan Zhang,Zilong Peng,Mengjie Wang,Yinan Li,Jinyin Wu,Yifan Jiang,Chaolong Liu,Guqiang Li,Lin Xu,Hongbo Lan
The fabrication of various 3D tissue engineering tubular scaffolds with fibrous structures, to assist the human body in rapidly repairing a variety of ailments, is receiving more and more attention. Due to the inefficiency of the majority of fibrous preparation techniques, the question of how to rapidly produce the requisite three-dimensional tubular microfiber scaffold structures has become an urgent problem. In this study, an efficient polymer fiber preparation method was developed, using a high-speed airflow drive. Melt blending of polycaprolactone (PCL), polylactic acid (PLA), and tributyl citrate (TBC), was used for the printing material, to achieve the efficient preparation of tubular microfiber scaffolds with different structures. The scaffold diameter was as small as 2 mm, the wall thickness was up to 100 μm, and the fiber injection efficiency reached 15.48 g/h. By utilizing simulations to optimize the printing parameters and by adjusting the printing settings, it was possible to achieve a controlled fiber diameter in the range of 3 μm to 15 μm. In addition, plasma treatment was applied to the microfibers’ surface, to increase their wettability, and the efficiency of the hydrophilic modification was demonstrated. Furthermore, the mechanical property test demonstrated that the fibers have a tensile strength of 1.36 ± 0.16 MPa and a tensile strain of 30.8 ± 3.5%. The radial compressive strain of the tubular scaffold could reach 60% of the original scaffold’s diameter. Finally, the in vitro degradation of the fibers at various pH values was tested. The results showed that, under alkaline conditions, the surface of the fibers would be severely crushed and the rate of deterioration would increase.Keywords:airflow-field-driven;3D printing;microfiber scaffold;polycaprolactone (PCL);polylactic acid (PLA)
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