Cell Reports
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2025
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IF 6.9
Zhao Cui,Jiameng Li,Caifeng Li,Shiwen Deng,Wei Liu,Tong Lei,Junxian Cao,Ziyi Wang,Xiaoxu Wang,Shuhua Ma,Yinhua Zhu,Hongjun Yang,Peng Chen
α-ketoglutaric acid (AKG), a tricarboxylic acid cycle metabolite central to aerobic metabolism and longevity, retains unresolved anti-aging protein targets. Here, we demonstrate that reduced isocitrate dehydrogenase 1 (IDH1) expression during senescence lowers AKG production, accelerating the aging of mesenchymal stem cells (MSCs). Exogenous AKG or IDH1 overexpression restores AKG levels, enabling 2-oxoglutarate and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1)-catalyzed hydroxylation of ribosomal protein S23 (RPS23) at proline 62. Mechanistically, AKG stabilizes the OGFOD1-RPS23 complex, enhancing translation accuracy to limit misfolded protein accumulation while sustaining synthesis rates, thereby balancing proteostasis. The natural flavonoid scutellarin (Scu), identified as an IDH1 agonist, elevates AKG to delay MSC senescence. In aged mice, Scu improves cognitive function, reduces osteoporosis and skin aging, and suppresses senescence-associated secretory phenotype. Our findings identify the AKG-IDH1-RPS23 axis as a regulator of stem cell senescence and we propose metabolic reprogramming strategies for anti-aging therapies.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2023
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IF 4.2
Shuai Sun,Wenxun Sun,Ruiyu Zhang,Yifei Ding,Linghui Meng,Yongping Bai
The reinforcement of thermoplastic polyester is very valuable in the fabrication of advanced films, specialty fibers, and engineering plastics. However, mainstream reinforcement strategies of inorganic filling are currently facing great drawbacks of thermoplasticity, transparency, and toughness loss. Here, we developed a one-pot achieving bulk-reinforced poly(ethylene terephthalate-co-trimethyl citrate) with exceptional mechanical properties, including a synergistically high tensile strength of 59.0 MPa and an elongation of 280%. In this way, the facile obtained copolyester is transparent and multiprocessable as well. The entire polymerization process is monitored and analyzed in detail. As a result, the mechanical enhancement is attributed to the enhanced entangling structures. This study provides an industrially achievable method for the inherent strengthening of polyester materials.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2024
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IF 3.8
Yuanji Gao,Yijun Liu,Xingyu Li,Kaineng Huang
Herein, ambient electric arc ionization mass spectrometry was used to examine 16 plasticizers in various wrap films, demonstrating high sensitivity (detection limit: <0.2 ng/mg) and precision (intra-/inter-day precision: <12 %). The ease of operation helps in the identification of wrap film and plasticizer analysis. In addition, the introduction of a cold arc plasma treatment presents a practical and innovative method for effectively eliminating plasticizers. This innovative strategy has implications for both environmental protection and food safety.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Yu Ding,Huan Li,Junhong Jia,Shikun Ouyang,Wei Jiang,Lingrui Chen,Yajun Zhao,Zejun Zhang,Yuanzhu Mi
The separation of oily wastewater is a significant issue in the petroleum industry. In current work, a highly efficient demulsifier (TCDA) was synthesized through a one-step low-temperature method for the purpose of demulsifying O/W emulsions. The structure was characterized using FT-IR and 1 H NMR spectra. The oil–water separation ability was evaluated through light transmittance (T%) and oil removal rate (η%) of separated water. The results showed that T% of 88.6 % and η% of 99.8 % could be obtained with the dosage of 30 mg/L at ambient temperature. In addition, TCDA demonstrated good acid and salt resistance. The relative solubility number (RSN), three-phase contact angle, dynamic interfacial tension, zeta potential and optical micrograph were characterized to explore possible demulsification mechanism. It was found that TCDA effectively reduced interfacial tension and penetrated the interfacial membrane, thereby facilitating the separation of O/W emulsion. Overall, these results indicate that the TCDA demulsifier shows promise for using in the demulsification of oily wastewater.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Liwei Shen,Guosheng Ai,Hanguang Liu,Lianggen Zhu,Lu Lai,Xuemin Yan,Weichu Yu,Yuanzhu Mi
A significant amount of water-in-oil (W/O) emulsion is generated during petroleum extraction. However, the current commercial demulsifiers are expensive to produce and requires high demulsification temperatures, leading to increased energy and economic consumption. To enhance the efficiency of demulsifiers and reduce the cost of demulsifying W/O emulsions, we have successfully developed a novel demulsifier named TCED through a straightforward two-step process. This demulsifier features trimethyl citrate as the hydrophilic core grafted with three hydrophobic chains. Its structure was characterized using EA, FT-IR and 1 H NMR spectroscopy , and the demulsification performance was comprehensively evaluated. At a low demulsification temperature of 40 °C, TCED demonstrated a remarkable demulsification efficiency (DE) of 99.06% and 98.74% in emulsions containing water contents of 70% (E70) and 50% (E50), respectively. Especially, a DE of 100% could be obtained in both E70 and E50 emulsions at a concentration of 600 mg/L. Moreover, TCED displayed a high DE even at high salinity levels of 50,000 mg/L and across a wide pH range of 2–10. Additionally, the phase interface was consistently clear after demulsification. To investigate the demulsification mechanism of TCED, various adsorption kinetics experiments were conducted, including measurements of interfacial tension (IFT), surface tension (SFT), interfacial competitive adsorption, and stability of interfacial film. The results obtained from the experiments indicated that TCED possessed remarkable diffusion and replacement capabilities within the emulsions. As a result, it effectively disrupted the original interfacial active substances, such as asphaltenes aggregates found in crude oil. TCED exhibits a high DE at low concentration and temperature. This characteristic highlights its significant potential for low-temperature demulsification applications in the petroleum industry.
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