Nature Communications
·
2016
·Vol. 7
·期 1
·1-13
·
IF 11.329
Sun Yan,Guo Fang,Zuo Tongfei,Hua Jingjing,Diao Guowang
The locations and arrangements of carotenoids at the subcellular level are responsible for their designated functions, which reinforces the necessity of developing methods for constructing carotenoid-based suprastructures beyond the molecular level. Because carotenoids lack the binding sites necessary for controlled interactions, functional structures based on carotenoids are not easily obtained. Here, we show that carotene-based suprastructures were formed via the induction of pillararene through a phase-transfer-mediated host–guest interaction. More importantly, similar to the main component in natural photosynthesis, complexes could be synthesized after chlorophyll was introduced into the carotene-based suprastructure assembly process. Remarkably, compared with molecular carotene or chlorophyll, this synthesized suprastructure exhibits some photocatalytic activity when exposed to light, which can be exploited for photocatalytic reaction studies of energy capture and solar conversion in living organisms.
研究领域:
化学
·
光合作用研究
·
生物物理学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Chao-Yi Wang,Xin-Yue Lou,Zhi Cai,Ming-Zhe Zhang,Chengguo Jia,Jian-Chun Qin,Ying-Wei Yang
Synthetic fungicides have been widely used to protect crops from fungal diseases. However, excessive use of synthetic fungicides leads to the generation of fungicide resistance in fungal pathogens. Recently, smart cargo delivery systems have been introduced for the construction of a pesticide delivery nanoplatform, benefiting from their controlled release performance. Herein, a fungal pathogen microenvironment-responsive supramolecular fungicide nanoplatform has been designed and constructed, using quaternary ammonium salt (Q)-modified mesoporous silica nanoparticles (MSN-Q NPs) as nanocarriers loaded with berberine hydrochloride (BH) and carboxylatopillar[5]arene (CP[5]A) as nanogates to form BH-loaded CP[5]A@MSN-Q NPs for effective inhibition of Botrytis cinerea. CP[5]A as nanogates can endow the fungicide nanoplatform with pH stimuli-responsive release features for the control of fungicide release. The loaded BH, as a natural plant fungicide, provides an ecofriendly alternative to synthetic fungicides for controlling B. cinerea. Interestingly, we use oxalic acid (OA) secreted by B. cinerea as a trigger so that BH can be released from the fungicide nanoplatform on demand under pathogen microenvironments for controlling B. cinerea. The experimental results indicate that the fabricated fungicide nanoplatform could effectively inhibit the mycelial growth and spore germination, providing a new way for the management of B. cinerea in actual application.
研究领域:
农业科学
·
纳米技术
·
植物保护
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 90
·49153-49160
·
IF 3.708
Dan Liu,Nan Song,Ye-Chun Cheng,Dai-Xiong Chen,Qiong Jia,Ying-Wei Yang
Poly(glycidyl methacrylate-co-ethylene dimethacrylate) modified with a new supramolecular macrocycle, carboxylatopillar[5]arene, was successfully prepared inside a capillary. The functionalized polymer monolith material was characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and Fourier-transformed infrared spectra. The experimental results showed that this type of polymer possess a good network skeleton structure and excellent extraction properties for the enrichment of parabens by polymer monolith solid-phase microextraction coupled with high performance liquid chromatography. Compared with other pre-treatment methods, the simple operation and inexpensive instrumentation characteristics of the developed polymer monolith SPME method make it more suitable for the extraction of parabens in red wine samples with great potential for further broadening its applications in the enrichment of other real samples.
研究领域:
分析化学
·
环境科学
·
食品安全
·
材料科学
·
色谱学
✓ 已验证
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2014
·Vol. 20
·期 11
·2998-3004
·
IF 5.696
Yue Zhou,Li-Li Tan,Qing-Lan Li,Xi-Long Qiu,Ai-Di Qi,Yanchun Tao,Ying-Wei Yang
Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene- or pillarene-based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof-of-concept study is far from a real-life application, it provides a possible route to treat diseases related to the central nervous system. Graphical Supramolecular nanovalves : Mesoporous silica nanoparticles (MSNs) equipped with calixarene- or pillarene-based nanovalves were prepared and characterized (see scheme). Acetylcholine (ACh), a neurotransmitter, successfully triggered cargo release from the nanocontainers, which could be useful for Parkinson's disease (PD) treatment.
研究领域:
纳米医学
·
药物递送
·
超分子化学
·
神经生物学
·
生物材料
·
转化医学
✓ 已验证
DOI
高影响因子
Advanced Materials Interfaces
·
2021
·Vol. 8
·期 23
·2101627
·
IF 6.147
Jinjie Li,Jinhui Dong,He Wang,Xiaoyan Yang,Jianzhuang Chen,Jinlou Gu,Shaoliang Lin
The facile fabrication of superhydrophobic membrane with patterned and controllable wettability is crucial to the exploitation of precise control of water flow path. Here, an azobenzene-bridged bipedal pillararenes-crosslinked polypseudorotaxane is used to fabricate a superhydrophobic membrane via the combination of electrospraying and breath figure approaches. Regulation of the relative humidity during electrospraying process and the trans - cis isomerization of azobenzene provide the capability to control the water adhesion force of membrane. These rules are applied to engineer the wettability of membrane into various patterns via re-electrospraying or light irradiation with patterned photomask. These efforts demonstrate the potential of polypseudorotaxanes for applications in smart membrane with patterned wettability.
研究领域:
材料科学
·
化学
·
纳米技术
·
表面工程
·
高分子科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Qing-Lan Li,Yao Sun,Li Ren,Xin Wang,Chen Wang,Lin Li,Ying-Wei Yang,Xianghui Yu,Jihong Yu
A smart supramolecular nanosystem integrating targeting, chemotherapy, and photothermal therapy was constructed based on carboxylatopillar[5]arene (CP[5]A)-functionalized CuS nanoparticles (CuS@CP NPs). CuS@CP NPs with good monodispersibility and strong near-infrared absorption were synthesized in aqueous solution through a facile one-pot supramolecular capping method, followed by surface installation of a liver cancer-targeted galactose derivative through host–guest binding interaction. The resulting smart supramolecular nanosystem, namely, CuS@CPG, exhibited excellent photothermal ablation capability to HepG2 cells upon irradiation with laser at 808 nm. Chemotherapeutic drug, doxorubicin hydrochloride (DOX), was further loaded on CuS@CPG via electrostatic interactions between positively charged DOX and negatively charged CP[5]A to give CuS@CPG–DOX with a high drug-loading capacity up to 48.4%. The weakening of DOX–CP[5]A interactions in an acidic environment promoted the pH-responsive drug release from CuS@CPG–DOX. Significantly, this multifunctional supramolecular nanosystem showed a remarkably enhanced therapeutic effect through the combination of targeted chemotherapy and photothermal therapy upon in vitro cell study. Moreover, preliminary in vivo study demonstrated that CuS@CPG and CuS@CPG–DOX had good biocompatibility and excellent tumor inhibition effects upon near-infrared laser irradiation.
研究领域:
纳米医学
·
超分子化学
·
肿瘤学
·
药物递送
·
光热治疗
·
靶向治疗
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）