ACS Nano
·
2024
·
IF 15.8
Yutao Ma,Zhihua Li,Yucheng Luo,Yao Chen,Le Ma,Xiaoya Liu,Jingyu Xiao,Man Huang,Yingnan Li,Hongliang Jiang,Meijuan Wang,Xiaoqian Wang,Jiangtao Li,Jian Kong,Peng Shi,Hanry Yu,Xingyu Jiang,Qiongyu Guo
Transarterial chemoembolization (TACE), the mainstay treatment of unresectable primary liver cancer that primarily employs nondegradable drug-loaded embolic agents to achieve synergistic vascular embolization and locoregional chemotherapy effects, suffers from an inferior drug burst behavior lacking long-term drug release controllability that severely limits the TACE efficacy. Here we developed gelatin-based drug-eluting microembolics grafted with nanosized poly(acrylic acid) serving as a biodegradable ion-exchange platform that leverages a counterion condensation effect to achieve high-efficiency electrostatic drug loading with electropositive drugs such as doxorubicin (i.e., drug loading capacity >34 mg/mL, encapsulation efficiency >98%, and loading time <10 min) and an enzymatic surface-erosion degradation pattern (∼2 months) to offer sustained locoregional pharmacokinetics with long-lasting deep-tumor retention capability for TACE treatment. The microembolics demonstrated facile microcatheter deliverability in a healthy porcine liver embolization model, superior tumor-killing capacity in a rabbit VX2 liver cancer embolization model, and stabilized extravascular drug penetration depth (>3 mm for 3 months) in a rabbit ear embolization model. Importantly, the microembolics finally exhibited vessel remodeling-induced permanent embolization with minimal inflammation responses after complete degradation. Such a biodegradable ion-exchange drug carrier provides an effective and versatile strategy for enhancing long-term therapeutic responses of various local chemotherapy treatments.
研究领域:
药学
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生物医学工程
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肿瘤学
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材料科学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 45
·7511-7520
·
IF 4.776
Dedai Lu,Yunfei Li,Xiangya Wang,Ting’e Li,Yongyong Zhang,Hongyun Guo,Shaobo Sun,Xiaoqi Wang,Yongdong Zhang,Ziqiang Lei
A series of hyperbranched, thermo-responsive and mussel-inspired polypeptides were synthesized and used for surgical adhesion, hemostasis and interventional embolization. These polypeptides showed excellent tissue-adhesive properties according to adhesive strength tests on porcine skin and bone in vitro, where the maximum lap-shear adhesion strength on porcine skin was 114.5 kPa and the maximum tensile adhesion strength on bone was 786 kPa. In vivo animal experiments indicated that these polypeptides exhibit superior hemostatic properties and healing effects in skin incisions and osteotomy gap; the skin incision healing and osteotomy gap remodeling were completed in all rats after 14 and 60 days, respectively. In vivo evaluation of the embolization ability of these polypeptides was performed on rabbit kidney models, resulting in successful occlusion of renal arteries, which led to gross ischemic changes in the embolized kidneys up to 16 days. A trial embolization procedure on H22 tumor-bearing rat models also confirmed the gelability of these polypeptides in tumor arteries, which might cause damage to embolized tumors. Therefore, these polypeptides are expected to be good candidates as surgical tissue adhesives, antibleeding materials, and effective embolic materials.
研究领域:
生物医学工程
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材料科学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Pengfei Cai,Lei Cao,Yangfan Ding,Yu Han,Xiao Yu,Jie Cui,Hongsheng Wang,Jinglei Wu,Mohamed EL-Newehy,Meera Moydeen Abdulhameed,Xiumei Mo,Shoubao Wang,Binbin Sun
Transcatheter arterial embolization (TAE) is an effective treatment for hemangiomas or highly vascular tumors. However, conventional embolic agents have limitations such as off-target embolization, regurgitation, and embolic migration, which can affect the efficacy and safety of embolic therapy. The study designed a highly elastic modified embolic scaffold constructed with Polycaprolactone/Gelatin (PCL/GEL) nanofibers to achieve precise in situ embolization in vivo. The embolic scaffolds can be extruded to a small size for smooth intervention in the vessel and rapidly regain their volume when reaching the target area. The results of the in vitro study indicate that the embolic scaffolds modified with lysine and PEI exhibit good biocompatibility and functionality. Furthermore, the in vivo rabbit ear embolization test demonstrated that the modified embolic scaffolds fit closely to the vessels and induced a significant amount of neo tissue deposition in the embolized area. The embolization process using the modified embolic scaffolds is safe and stable and results in more desirable embolization outcomes compared to commercial gelatin embolic agents. In conclusion, the modified highly elastic embolic scaffolds designed in this study offer a novel method for in situ embolization that has potential for clinical application in TAE.
研究领域:
生物医学工程
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介入治疗
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材料科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Guobao Chen,Runan Wei,Xiang Huang,Fuping Wang,Zhongmin Chen
Transcatheter arterial chemoembolization (TACE) is well known as an effective treatment for hepatocellular carcinoma (HCC). In the present study, a novel embolic agent of sodium alginate (SA)-modified silk fibroin (SF) microspheres was successfully prepared by emulsifying cross-linking method. The SA-modified SF microspheres were evaluated for the ability of embolization by investigating the morphology, particle size, swelling ratio, degradation, cytotoxicity, blood compatibility, and in vivo embolization. The results found that SA-modified SF microspheres had smooth surfaces and good sphericity. Swelling ratio of the microspheres can meet the requirements of arterial embolic agent and have pH and temperature sensitivity. Furthermore, hemolytic and anticoagulant studies have proved that the microspheres have good blood compatibility. Cytotoxicity tests indicated that the microspheres could promote the proliferation of fibroblasts and HUVEC. In vivo embolization evaluation of microspheres revealed that the arteries could be embolized by SA-modified SF microspheres in 3 weeks. The ability of drug loading and releasing of microspheres was proved by the controlled release profile of Adriamycin hydrochloride. The findings indicated that the SA-modified SF microspheres can be used as a potentially biodegradable arterial embolic agent for liver cancer therapy.
研究领域:
生物医学工程
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药学
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癌症研究
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·Vol. 12
·期 32
·2301559
·
IF 10
Guorong Jia,Tao Wang,Rou Li,Xiao Li,Gaofeng Sun,Wei Chen,Ye Peng,Chao Cheng,Jijin Yang,Changjing Zuo
In interventional treatment, materials are administered into the blood supply artery and directly delivered to tumors, offering proper scenarios for nanomedicine potential clinical applications. Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are effective treatment methods for hepatocellular carcinoma (HCC), but postoperative residual tumor may result in intrahepatic recurrence and distant metastasis. The combination therapy of TACE and TARE based on multifunctional nanoparticles (NPs) is expected to overcome the drug resistance in hypoxic tumors and improve the therapeutic effect. Herein, BaGdF 5 NPs are synthesized and then coated with polydopamine (PDA), conjugated with the chemotherapeutic drug cis-diamminedichloride platinum (CDDP), radio-labeled with therapeutic radionuclide 131 I, yielding 131 I-BaGdF 5 @PDA-CDDP NPs. The in vitro anti-cancer effects of 131 I-BaGdF 5 @PDA-CDDP NPs are confirmed using CCK-8 and γ-H2AX assays in Huh7 cells. Mixed with Lipiodol, 131 I-BaGdF 5 @PDA-CDDP NPs are injected into the hepatic artery via a microcatheter to realize the TACE and TARE combination therapy in a rabbit VX2 liver tumor model. The results indicate that glucose metabolism is clearly decreased based on 18 F-FDG PET imaging and the apoptosis of tumor cells is increased. Furthermore, 131 I and BaGdF 5 NPs can be used for SPECT imaging and CT/MR imaging respectively, facilitating real-time monitoring of the in vivo biodistribution of 131 I-BaGdF 5 @PDA-CDDP NPs.
研究领域:
医学影像学
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肿瘤学
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介入放射学
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产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2021
·
IF 5.571
Xiaotian Zhao,Wanqiu Huang,Xufeng Li,Runxing Lin,Qiuxia Li,Jingmiao Wu,Zongjun Yu,Yanfang Zhou,Hong Huang,Mingguang Yu,Yugang Huang,Guodong Ye
Vascular embolization is a well-known therapeutic treatment against hepatocellular carcinoma . However, existing embolic agents require complex synthesis, toxic organic solvents and sometimes produce only low yields. In this study, a novel photopolymerization technique, which addresses these issues, was used to prepare embolic microspheres successfully from the sucrose multi-allyl ether monomer in one step. Compared to the preparation of such microspheres always involved in multiple steps or complicated conditions, we obtained the microspheres used photoclick method in a soft template with simple, economic and feasible procedure. This work focuses on the synthesis of new materials by conducting a photopolymerzation in the presence of the sucrose monomer and the photoinitiator . Then, the embolic microspheres obtained were characterized by morphology assay, degradation, and swelling test. Cell experiments showed that the microspheres had good biocompatibility . Rabbit embolizations showed that the microspheres had long-term embolic effects. It is manifested that one-step preparation of photoclick method hold great potential and competitiveness of being used in preparation embolic microspheres in clinic.
研究领域:
医学材料学
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肿瘤治疗学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yue Yu,Yang Liu,Chao Wang,Chang Chen,Qingsong Ye,Zhewei Zhang,Lifeng Luo,Chengjun Song,Chenxuan Zhao,Zhiwen Zou,Yitao Ding,Jinhui Wu
Tumor embolization therapy often involves complex procedures and poses challenges for physicians, especially with radiological imaging guidance. Inspired by physiological processes of misfolded protein aggregation and thrombus formation, we developed a protein-based embolic agent using ethiodized oil and human serum albumin for targeted tumor embolization. By occupying the hydrophobic cavity of albumin and disrupting its refolding process, these ethiodized oil bound human serum albumin nanoparticles (Oil@HSA NPs) achieve spontaneous aggregation and size growth at high concentrations, a unique advantage over conventional phospholipid nanoparticles. When combined with bacterium-induced coagulation in tumor vessels, Oil@HSA NPs selectively accumulate at tumor sites, blocking blood flow and significantly inhibiting tumor growth. This study introduces a practical and innovative approach to tumor embolization, offering a streamlined and effective alternative for vascular targeting in cancer therapy.
研究领域:
医学
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肿瘤学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2022
·Vol. 80
·期 3
·2697-2711
·
IF 2.843
Yin Peinan,Wei Chengxiong,Jin Xin,Yu Xiaogang,Wu Chengwei,Zhang Wei
Trans-catheter arterial embolization, as a minimally invasive therapy strategy, has become a choice for treating liver cancer. Development of embolic agents integrated with therapy and imagining functions is desired. Herein, magnetic polyvinyl alcohol (PVA) microspheres as embolic agents are prepared by emulsification method. The diameter of the magnetic PVA microspheres ranges from 10 to 110 μm, and the required size can be obtained by sieving. The temperature of magnetic PVA microspheres suspension could stabilize at 49 °C under the applied magnetic field, which indicates the microspheres have self-regulating temperature hyperthermia characteristic due to the application of magnetic nanoparticles with low Curie point. In addition, magnetic PVA microspheres possess obvious contrast effects on CT and T2-weighted imaging due to the existence of magnetic nanoparticles. Cytotoxicity assay indicates the survival rate of cells cultured with leach liquor of 30 mg/mL PVA/MNPs microspheres is 97.4%, which shows the magnetic microspheres have good cell biocompatibility. The developed magnetic microspheres have the potential to realize embolization, self-regulating temperature hyperthermia, and CT/MR imaging simultaneously in interventional therapy.
研究领域:
医学成像
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癌症治疗
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生物医学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Man Huang,Zijian Chen,Yutao Ma,Yingnan Li,Zhihua Li,Runyuan Wang,Yiqi Zhang,Qiongyu Guo
Transarterial embolization (TAE) is a widely used interventional procedure for treating various diseased vascular conditions, including tumors and arteriovenous malformations. The success of the TAE relies heavily on the effectiveness and stability of embolic agents used to occlude target vessels. While considerable attention has been given to the material and size of embolic particles, the role of the particulate shape in endovascular stability has been less explored. This study investigates how the geometric properties of embolic particles influence their behavior within the vascular system, particularly regarding their retention, distribution, and overall stability after deployment. We demonstrate that particle shape significantly affects the dynamics of embolic agents, with capsule-shaped particles exhibiting enhanced adherence to vessel walls, reducing the likelihood of migration and improving the long-term occlusion stability. In contrast, spherical particles are more prone to dislodgement, leading to suboptimal embolization and potential complications. These findings underscore the critical importance of particulate shape in optimizing the endovascular stability of TAE, suggesting that tailored embolic agents with specific morphological properties could improve clinical outcomes by enhancing the treatment’s durability and efficacy.
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产品关联
DOI
PubMed
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2020
·
IF 2.169
Xiaolin Fang,Aizong Shen
Transcatheter arterial chemoembolization (TACE) is the preferred treatment for patients with advanced hepatocellular carcinoma (HCC), but it lacks safe and effective embolic agents. 5-Fluorouracil (5-FU) is a broad-spectrum anticancer drug, but its clinical application is limited due to drug resistance and toxic side effects. Therefore, in this study, we developed a new liquid embolic agent with 5-FU as the model drug. We found that this liquid embolic agent possesses good gelling properties and embolic effects. An in vitro drug release model of the agent conformed to the Weibull model. Cumulative release of the drug over 7 d was ∼90%, consisting of an initial burst followed by sustained release. Cytotoxicity testing showed that each liquid embolic composition is cytocompatible and only mildly cytotoxic. Pharmacokinetic experiments showed that the formulation significantly prolongs the t1/2 of 5-FU (approximately five times that of 5-FU solution) and 5-FU residence time in the body (approximately three times that of 5-FU solution). These results indicate that the liquid embolic agent has embolic capacity and could be used as a potential therapeutic method for TACE.
研究领域:
医学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Jing-jing Rong,Ming Liang,Feng-qi Xuan,Jing-yang Sun,Li-jun Zhao,Hui-zhen Zheng,Xiao-xiang Tian,Dan Liu,Quan-yu Zhang,Cheng-fei Peng,Fei Li,Xiao-zeng Wang,Ya-ling Han,Wei-ting Yu
Transcatheter arterial embolization (TAE) is the best non-laparotomy choice for solid visceral organs rupture and bleeding nowadays. In our previous study, a new biodegradable macromolecule material thrombin-loaded alginate-calcium microsphere (TACM) was prepared and its characteristics were investigated preliminarily. In this study, we further investigated the biocompatibility of TACMs, as well as physical characteristic, application method and effect of TACMs with thrombus (embolic agent). The in vivo results attested that TACMs were non-irritating and non-genotoxic with desired biocompatibility, although brought about a slight and temporary inflammation. Application research showed that the function of thrombin was inhibited by common contrast agents, and it was impracticable to add contrast agents in TACMs with thrombus for tracing under X-rays in TAE. Then, a novel delivery method was developed. In addition, stress resistance test indicated that the TACMs with thrombus was significantly stronger than single autologous thrombus, the optimized ratio of TACMs to whole blood was 2:3 for forming mixed thrombus. Finally, large animal experiment revealed that the novel embolic agent – TACMs mixed thrombus was effective and safe in treating hemorrhage of solid abdominal viscera by TAE.
研究领域:
医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2014
·
IF 3.785
Ling-Ran Du,Xiao-Jing Lu,Hai-Tao Guan,Yong-Jie Yang,Meng-Jie Gu,Zhuo-Zhao Zheng,Tian-Shi Lv,Zi-Guang Yan,Li Song,Ying-Hua Zou,Nai-Qi Fu,Xian-Rong Qi,Tian-Yuan Fan
New type of liquid embolic agents based on a liquid crystalline material of glyceryl monooleate (GMO) was developed and evaluated in this study. Ternary phase diagram of GMO , water and ethanol was constructed and three isotropic liquids (ILs, GMO:ethanol:water = 49:21:30, 60:20:20 and 72:18:10 (w/w/w)) were selected as potential liquid embolic agents, which could spontaneously form viscous gel cast when contacting with water or physiological fluid. The ILs exhibited excellent microcatheter deliverability due to low viscosity, and were proved to successfully block the saline flow when performed in a device to simulate embolization in vitro . The ILs also showed good cytocompatibility on L929 mouse fibroblast cell line. The embolization of ILs to rabbit kidneys was performed successfully under monitoring of digital subtraction angiography (DSA), and embolic degree was affected by the initial formulation composition and used volume. At 5th week after embolization, DSA and computed tomography (CT) confirmed the renal arteries embolized with IL did not recanalize in follow-up period, and an obvious atrophy of the embolized kidney was observed. Therefore, the GMO-based liquid embolic agents showed feasible and effective to embolize, and potential use in clinical interventional embolization therapy.
研究领域:
生物材料学
·
介入放射学
·
药剂学
·
血管内治疗
·
转化医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）