JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Li Yuan-Yuan,Yu Jia-Yan,Wang Tao,Wang Jing,Zhao Peng,Yang Xia,Wei Hong-Yuan,Chen Yue
Fab fragments obtained via enzymatic digestion of full-length antibodies or by gene recombination technology have smaller molecular weight and greater penetration ability. Those advantages make it uniquely suited to deliver radionuclides. In this study, we prepared a Fab fragment from the anti-EGFR antibody Cetuximab and labeled it with 177 Lu. The binding activity in vitro and biodistribution in vivo of [ 177 Lu]Lu-DOTA-Fab-Cetuximab were investigated. The [ 177 Lu]Lu-labeled Fab fragment showed improved tumor penetration and faster blood clearance compared to the full-length antibody.
研究领域:
医学
·
肿瘤学
·
核医学
✓ 已验证
产品关联
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2020
·
IF 4.966
Boxian Chen,Suping Yu,Xuan Zhao
The ability to reuse boron and minimize the volume of radioactive waste could be accomplished with modified reverse osmosis (RO) membranes. RO membranes were fabricated via polyethylenimine (PEI) grafting to separate silicon and radionuclides from boron-containing radioactive wastewater . The positively charged RO membrane promoted more efficient removal of nuclides and silicon while the rejection of boron declined from 55.88 % to 41.71 % after modification. Compared with virgin RO membrane, the SF B-Si , SF B-Cs , and SF B-Co of the modified RO membranes increased from 6.02, 5.16, and 12.62–29.52, 61.91, and 547.15, respectively. SF B-Si , SF B-Cs , and SF B-Co of the simulated RO system with modified RO membranes further increased to 156.96, 1068.12, and 83617.88, respectively. As a result, permeate water with 433.92 mg L −1 boron, 0.04 mg L −1 silicon, 1.62 μg · L −1 Cs(I), and 0.02 μg · L −1 Co(II) was obtained, which could satisfy radionuclide treatment requirements and allow for the reuse of boron. Overall, modified RO membranes would be able to reuse boron and minimize the volume of discharge of radioactive wastewater.
研究领域:
环境科学
·
材料科学
·
核能工程
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yanjun Zhang,Yu Yang,Satoshi Takizawa,Keisuke Kuroda,Zhiqian Jia,Peijuan Liu,Huangzhao Wei,Nigel J.D. Graham
The simultaneously efficient removal of radionuclides and heavy metals is an important and challenging topic for aquatic environmental protection. In this work, molybdenum disulfide (MoS 2 ) with heavy metal ion adsorption capacity and positively charged polyethyleneimine (PEI) were used to fabricate a novel layer-by-layer (LbL) self-assembly composite membrane by a simple alternating immersion method. The unique structure with positive charge ensures high removal for toxic metals (R Cs(I) = 99.83 %, R Sr(II) = 100 %, R Hg(II) = 99.2 %, R Pb(II) = 98.13 %, R As(III) = 98.5 %). The inherent low resistance channels in MoS 2 provided the optimized composite membrane an elevated water flux. Long-term experiments and membrane regeneration also demonstrated that the membrane possesses exceptional stability and reusability in removing low levels of radionuclides Cs(I) and Sr(II) from water. This study confirms the feasibility of the MoS 2 -PEI composite membrane for the treatment of contaminated waters containing radionuclides and heavy metals.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Materials
·
2024
·Vol. 17
·期 11
·2706
·
IF 3.1
Yingzhe Du,Lili Li,Yukun Yuan,Yufaning Yin,Genggeng Dai,Yaqing Ren,Shiying Li,Peng Lin
Throughout the nuclear power production process, the disposal of radioactive waste has consistently raised concerns about environmental safety. When the metal tanks used for waste disposal are corroded, radionuclides seep into the groundwater environment and eventually into the biosphere, causing significant damage to the environment. Hence, investigating the adsorption behavior of radionuclides on the corrosion products of metal tanks used for waste disposal is an essential component of safety and evaluation protocols at disposal sites. In order to understand the adsorption behavior of important radionuclides60Co,59Ni,90Sr,135Cs and129I on α-FeOOH, the influences of different pH values, contact time, temperature and ion concentration on the adsorption rate were studied. The adsorption mechanism was also discussed. It was revealed that the adsorption of key nuclides onto α-FeOOH is significantly influenced by both pH and temperature. This change in surface charge corresponds to alterations in the morphology of nuclide ions within the system, subsequently impacting the adsorption efficiency. Sodium ions (Na+) and chlorate ions (ClO3−) compete for coordination with nuclide ions, thereby exerting an additional influence on the adsorption process. The XPS analysis results demonstrate the formation of an internal coordination bond (Ni–O bond) between Ni2+and iron oxide, which is adsorbed onto α-FeOOH.
研究领域:
环境科学
·
核能工程
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Oncology
·
2022
·
IF 5.738
Zhang Xuemei,Yan Ziyu,Meng Zhaowei,Li Ning,Jia Qiang,Shen Yiming,Ji Yanhui
Objectives: Anaplastic thyroid cancer (ATC) cells cannot retain the radionuclide iodine 131 (131I) for treatment due to the inability to uptake iodine. This study investigated the feasibility of combining radionuclides with photothermal agents in the diagnosis and treatment of ATC.Methods: 131I was labeled on human serum albumin (HSA) by the standard chloramine T method. 131I-HSA and indocyanine green (ICG) were non-covalently bound by a simple stirring to obtain 131I-HSA-ICG nanoparticles. Characterizations were performed in vitro. The cytotoxicity and imaging ability were investigated by cell/in vivo experiments. The radio-photothermal therapy efficacy of the nanoparticles was evaluated at the cellular and in vivo levels.Results: The synthesized nanoparticles had a suitable size (25–45 nm) and objective biosafety. Under the irradiation of near-IR light, the photothermal conversion efficiency of the nanoparticles could reach 24.25%. In vivo fluorescence imaging and single-photon emission CT (SPECT)/CT imaging in small animals confirmed that I-HSA-ICG/131I-HSA-ICG nanoparticles could stay in tumor tissues for 4–6 days. Compared with other control groups, 131I-HSA-ICG nanoparticles had the most significant ablation effect on tumor cells under the irradiation of an 808-nm laser.Conclusions: In summary, 131I-HSA-ICG nanoparticles could successfully perform dual-modality imaging and treatment of ATC, which provides a new direction for the future treatment of iodine-refractory thyroid cancer.
研究领域:
肿瘤学
·
核医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
·
2022
·
IF 2.655
Maoyi Luo,Daqian Liu,Yao Yang,Xiongxin Dai,Yang Wu,keliang Shi
A simultaneous analytical method for sequential separation and determination of actinides and 90 Sr in large-size environmental samples has been developed. In this method, successive co-precipitation steps were firstly conducted to remove matrix elements, then sequential column separation method was applied for simultaneous separation and purification of actinides and 90 Sr/ 90 Y. By using vacuum box technology, the total analytical time was minimized and batch processing allowed analyzing 12 samples in four days. The activity of 90 Sr was obtained immediately by measuring its daughter radionuclide ( 90 Y) with triple-to-double coincidence ratio (TDCR) Cherenkov counting, while the concentrations of Pu isotopes and 241 Am could be measured by alpha spectrometry and mass spectrometric techniques. The overall recoveries of Pu, Am, Sr and Y were higher than 70% for the entire procedure, while the recovery ratios of Sr/Y were between 0.95 and 1.04 before chromatographic separation . The developed method was verified using 20 g and 50 g of environmental soil samples spiked with certified reference materials IAEA-384 or IAEA-385 and standard solution of 90 Sr/ 90 Y, and good agreement between the expected values and measured results has been achieved.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Zhenzhen Cui,Baoying Wang,Ruirui Li,Zihao Wang,Weicheng Fu,Junying Yan,Liang Wu,Yaoming Wang,Tongwen Xu
Rapid and highly effective enrichment of nuclides containing liquid effluent is crucial for online monitoring of radioactive trace elements from nuclear power plants (NPPs). In this study, auxiliary electrodialysis (AED) was proposed for high enrichment of trace ions in the liquid effluents of NPPs. The effects of the auxiliary ion type and concentration and the operating voltage on the AED concentration performance were investigated. When the volume ratio of the solution was 140: 1 with 0.03 mol/L HNO 3 as the auxiliary electrolyte, most of the nuclide ions were concentrated more than 50 times after the two-stage electrodialysis experiment. In the first-stage electrodialysis, the concentration of most ions, with the exception of the higher valence ions (Ru 3+ and Zr 4+ ), tends to increase with increasing operating voltage. The diluate stream volume could be minimized to 98.8% with a total energy consumption of 9.5 kWh/m 3 . By considering the impact of boron in the liquid effluents, more than 52 times concentrations could still be achieved by extending the running time of the first-stage ED (increasing the ion removal rate). The transmembrane fluxes of various cations decreased in the order of Cs + > Sr 2+ > Zn 2+ > Co 2+ ≈ Ni 2+ ≈ Mn 2+ > Fe 3+ > Cr 3+ > Ru 3+ > Zr 4+ , which is attributed to the experimental operating parameters and ionic properties. This research provided a viable technique for rapid and highly effective enrichment of nuclides containing liquid effluents for both radioactive element monitoring and wastewater volume reduction.
研究领域:
环境科学
·
核技术应用
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Kui Tang,Zeru Wang,Yawen Liu,Chenhui Yan,Yong Ge,Hao Zhang,Yanhao Song,Haoyuan Li,Xi Li,Miaomiao He,Lin Zhu,Tao Duan
The efficient removal of radionuclides from contaminated surfaces remains a persistent challenge in nuclear decontamination. In this study, we present a double-network composite hydrogel IA-PAAM/PAMPS (IA: iminodiacetic acid, PAAM: acrylamide, PAMPS: 2-Acrylamido-2 methylpropanesulfonic) as a highly effective approach for radionuclide removal. The hydrogel demonstrates excellent removal capabilities for both actinides (UO 2 2+ and Th 4+ ) and fission products (Sr 2+ and Cs + ). A large number of liquid adsorption and surface decontamination experiments have also confirmed that IA-PAAM/PAMPS has the universality of binding with various nuclides, and achieving a satisfactory decontamination rate of more than 90 % in 10 min. Then XPS and FT-IR analyses reveal that the hydrogel’s effectiveness stems from multiple mechanisms, including hydrogen bonding, electrostatic interactions, and complexation with sulfonic acid groups. Furthermore, the hydrogel exhibits high decontamination efficiency across various solid surfaces, indicating its potential for use in post-nuclear accident remediation.
研究领域:
环境科学
·
材料科学
·
放射化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Chuang Li,Zhan Li,Yu-Hsuan Chiao,Kecheng Guan,Xiaoliang Zhang,Tomohisa Yoshioka,Hideto Matsuyama
As the energy consumption surges in the past few decades, the utilization of reliable and cost-effective energy resources with minimum greenhouse gas emission is highly desirable, for which nuclear energy has gained intensive attention. The proper treatment of radioactive process water yet remains challenging, but is of vital importance due to its significant threats to environment and public health. In this work, a polydopamine/graphene oxide (PDA/GO) membrane was developed for radionuclide-contaminated water treatment. By the incorporation of PDA, the interlayer spacing of the GO membrane is regulated, as well as an improved anti-swelling property is achieved. At optimal preparation conditions, the PDA/GO has exhibited a high rejection of 99.9 % towards thorium ions with a satisfying water flux of 5.0 L·m −2 h −1 . Moreover, the influence of solution pH and thorium concentration on the membrane separation performance is studied. Results have indicated that the PDA/GO membrane presents a new promise for the treatment of radionuclide-contaminated water.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2020
·Vol. 37
·期 2
·1900421
·
IF 3.099
Yangyun Wang,Linlin Li,Xingpeng Shi,Liu Dong,Yihang Yang,Youjiu Zhang,Guolin Wu,Ran Zhu
Herein, an injectable photothermal hydrogel system containing a therapeutic radionuclide 188 Re is studied for combined radioisotope therapy and photothermal therapy (PTT) of cancer. A dopamine-conjugated poly(α,β-aspartic acid) copolymer (PDAEA) is used to trigger a sol–gel phase transition in mixture with Fe 3+ ions, rapidly forming a gel by simply mixing PDAEA and FeCl 3 phosphate buffer saline solutions. The injectable hydrogel exhibits strong near-infrared light absorbance and can efficiently convert light into a heating effect for local PTT treatment. The obtained hydrogel possesses a porous 3D microstructure, and can be utilized for radionuclide loading. After the Na 188 ReO 4 loading, the hydrogel is intratumorally injected into the tumor of mice bearing 4T1 murine breast cancer cells for studying the tumor retention and therapeutic efficiency. In vivo results show that Na 188 ReO 4 -loaded hydrogel exhibits significantly longer time in the tumor sites than that of free Na 188 ReO 4 . The tumor growth of mice treated with Na 188 ReO 4 -loaded hydrogel under near-infrared radiation is significantly inhibited compared with control groups. Therefore, the results show that the developed strategy using an injectable and biocompatible hydrogel may promote the applications of radioisotope therapy and photothermal therapy for cancer.
研究领域:
肿瘤学
·
生物材料学
·
放射医学
✓ 已验证
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2022
·Vol. 331
·期 5
·2159-2167
·
IF 1.754
Wang Litao,Cheng Jianfeng,Bao Chenyang,Wang Yanhui,Jiang Qiao,Pan Yuelong,Liu Yu,Hong Tao,Tuo Xianguo,Leng Yangchun
Groundwater is the most important factor contributing to the diffusion and migration of radionuclides in the repository. In this paper, the characteristic parameters of granite in a repository are obtained from static and dynamic experiments to simulate a three-dimensional geological model of the repository with the help of a groundwater modeling system (GMS). It was shown that the longest distances of 137 Cs and 60 Co migrations for 500 a were 146.66 m and 145.04 m, respectively. This work could be of great significance to ensure the long-term safe operation of this type of waste repository.
研究领域:
环境科学
·
放射生物学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2015
·
IF 2.605
Long Fan,Xiaoyan Shu,Xirui Lu,Yi Xie,Yi Ding,Tao Duan,Bingrong Dang,Yanlin Wu
The present work explores the potential of Gd 2 Zr 2 O 7 pyrochlore based materials for incorporation of trialkyl phosphine oxides (TRPO) waste which is a mixture of multi-nuclides with multi-valence. A series of (Gd,A) 2 (Zr,B) 2 O 7 ceramics were synthesized to investigate the influence of multi-nuclides incorporation on phase structure and aqueous stability of Gd 2 Zr 2 O 7 . XRD and BSE results show that all the ceramics exhibit a single pyrochlore structure. Raman spectroscopy reveals that the degree of structural order for (Gd,A) 2 (Zr,B) 2 O 7 solid solutions increases with enhanced TRPO waste content. In addition, aqueous stability testing was carried out using the MCC-1 static leach test method. The results demonstrate that the normalized release rates of the elements in TRPO waste are kept in a low value below 10 −4 g m −2 d −1 . La shows the highest normalized release rate of all the involved elements, while Zr exhibits the best chemical stability.
研究领域:
材料科学
·
核化学与放射化学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）