Frontiers of Materials Science
·
2023
·Vol. 17
·期 4
·1-11
·
IF 2.7
Zhang Hao,Luo Siyuan,Yang Weili,Luo Qisheng,Kannan Perumal Ramesh,Li Yao,Kong Xiangdong
Uncontrolled hemorrhage resulting from traumas causes severe health risks. There is an urgent need for expeditious hemostatic materials to treat bleeding incidents. Here, we developed a natural protein-based hemostatic sponge extracted from nonmulberry cocoons that exhibited rapid coagulation and effective absorption. We first built a degumming and dissolution system suitable for the Dictyoploca japonica cocoons to obtain regenerated silk fibroin (DSF). The DSF was then combined with carboxymethyl chitosan (CMCS) by glutaraldehyde (GA) crosslinking to ensure the structural stability of sponges. The resulting DSF–CMCS–GA exhibited remarkable hemostatic properties, displaying the highest absorption rate. It also demonstrated comparable efficacy to commercial hemostatic sponges. The blood-clotting index and hemolysis test showed that the prepared sponge possessed hemostatic activity and good hemocompatibility. Compared with mulberry silk fibroin hemostatic sponges (SF–CMCS–GA), DSF–CMCS–GA showed slightly better effects, making them a potential alternative to mulberry silk. In conclusion, our study introduces the use of Dictyoploca japonica silk fibroin for hemostasis, highlighting the exploitation of wild silkworm resources and providing an excellent silk fibroin-based hemostatic sealant for acute accident wounds and biomedical applications involving massive hemorrhage.
研究领域:
生物材料学
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医学工程
·
创伤治疗
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 16
·1-14
·
IF 2.8
Wu Di,Weng Ling,Zhang Xiaorui,Guan Lizhu,Wu Zijian
In recent years, wearable devices have developed rapidly. With its excellent performance, flexible piezoresistive sensors are widely used in human health monitoring, motion monitoring, artificial intelligence and wearable electronic devices. In this paper, a wearable flexible multilayer piezoresistive sensor based on mulberry silk fabric is designed. During the preparation of the flexible piezoresistive sensor, polydopamine (PDA), silver nanoparticles (AgNPs), MXene and polypyrrole (PPy) were coated on the surface of the mulberry silk fabric layer-by-layer, and then five layers of conductive fabric were stacked together, using 3M tape, PDMS resin and flexible wire for encapsulating. A wearable flexible multilayer piezoresistive sensor based on mulberry silk fabric is obtained. After testing, several substances have been successfully loaded onto the surface of mulberry silk fabric, and the effect of coating fabric is ideal. Furthermore the sensor shows excellent performance such as sensitivity of 2.0510 under low strain, sensitivity of 1.1171 under high strain and cycle stability of 1000 times, which is superior to the previously reported sensor based on fabric, and has broad application prospects.
研究领域:
材料科学
·
生物医学工程
·
可穿戴设备
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产品关联
DOI
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Na Li,Yuanyuan Qian,Tong Guan,Yi Luo,Jianzhong Qin,Shijun Lu,Feng Zhang
An ideal bone tissue engineering scaffold is expected to possess anisotropic architectures to facilitate cell adhesion and migration and thereby to induce bone tissue regeneration. However, it is still challenging to create a scaffold with the desired nanostructure and anisotropic microstructure that can promote bone repair. Herein, we developed a facile strategy to create a pure nonmulberry Tussah silk fibroin (TSF) nanofiber scaffold with a radially ordered microstructure by physical shearing and directional ice crystallization. Physical shearing disassembles natural silk into nanofibers with diameters ranging from 50 to 500 nm. TSF nanofibers in aqueous solution are intertwined into a 3D porous scaffold with radially aligned channels via radial ice templating. The width of the radiating structure in the scaffold increased with distance from the center, and the TSF nanofiber concentration decreased. These scaffolds supported cell adhesion, migration and proliferation in vitro and accelerated bone regeneration in vivo . The biomimetic structures and tunable radial structures support the potential application of radial TSF nanofiber scaffolds in bone tissue engineering.
研究领域:
生物材料学
·
组织工程学
·
再生医学
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DOI
高影响因子
Coatings
·
2018
·Vol. 8
·期 2
·68
·
IF 2.35
Jia Li,Boxiang Wang,Jie Lin,Dehong Cheng,Yanhua Lu
Multifunctional mulberry silk fabrics with excellent temperature- and pH-sensitivity, antibacterial properties and permeability are successfully prepared by surface modification with PNIPAAm/chitosan/poly(ethylene oxide) nanofibers. The nanofibers deposited on the surface of mulberry silk fabric are produced by the electrospinning technique. The surface properties of mulberry silk fabrics were changed by coating process and glutaraldehyde vapor cross-linking technology. The PNIPAAm/chitosan/PEO nanofibers have good apparent morphology and uniform fiber diameter. The contact angle of modified mulberry silk obviously increases with the increasing temperature. The bacterial reduction rates of modification of mulberry silk againstE. coliandS. aureusall reach above 80%. Permeability test results show that it can largely improve the poor permeability of coated fabric by intelligent nanofiber modification technology. The air permeability of temperature- and pH-sensitivity mulberry silk fabric modified with PNIPAAm/chitosan/PEO nanofibers, which has reached about 5.1 × 102L/m2/s, is higher than that of the silk fabric coated with PNIPAAm/chitosan/PEO solution that reached 1.5 × 102L/m2/s. The nanofibers coated with mulberry silk fabrics show outstanding temperature- and pH-sensitivity, antibacterial properties and permeability, and may be a potential application in medical care, intelligent materials and textiles.Keywords:chitosan;poly(N-isopropyl acrylamide);mulberry silk;electrospinning;antibacterial activity;thermosensitive behavior
研究领域:
材料科学
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纺织工程
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）