CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2020
·
IF 3.35
Bo-Zhi Chen,Xiaohui Ju,Ning Liu,Chang-Hui Chu,Jin-Peng Lu,Chen Wang,Shi-Peng Sun
Few studies have reported on the detail of the mass production process of nanofiltration (NF) membranes and modules due to technical confidentiality. This work presents a procedure of fabrication of NF membranes and modules on the pilot scale. Thin film composite (TFC) NF flat-sheet membranes of 300 mm width were continuously fabricated via custom-designed equipment. The fabrication parameters and their effects on NF performance were systematically investigated. The optimized conditions parameters were achieved for excellent NF modules’ performance. The modules show over 75 L m −2 h −1 flux at 6 bar and over 95% MgSO 4 rejection. This study may provide insightful guidelines for the scale-up of NF membranes for water treatment and other applications.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Materials Futures
·
2024
·Vol. 3
·期 2
·025001
·
IF 12
Junfeng Xiao,Mengxing Zhang,Fei Zhai,Hongrui Wei,Sen Liu,Peng Wang,Zhiyang Liu,Zhongying Ji,Xiaolong Wang
Three-dimensional (3D) printing allows for the creation of complex, layered structures with precise micro and macro architectures that are not achievable through traditional methods. By designing 3D structures with geometric precision, it is possible to achieve selective regulation of mechanical properties, enabling efficient dissipation of mechanical energy. In this study, a series of modular samples inspired by the Bouligand structure were designed and produced using a direct ink writing system, along with a classical printable polydimethylsiloxane ink. By altering the angles of filaments in adjacent layers (from 30° to 90°) and the filament spacing during printing (from 0.8 mm to 2.4 mm), the mechanical properties of these modular samples can be adjusted. Compression mechanical testing revealed that the 3D printed modular Bouligand structures exhibit stress-strain responses that enable multiple adjustments of the elastic modulus from 0.06 MPa to over 0.8 MPa. The mechanical properties were adjusted more than 10 times in printed samples prepared using uniform materials. The gradient control mechanism of mechanical properties during this process was analyzed using finite element analysis. Finally, 3D printed customized modular Bouligand structures can be assembled to create an array with Bouligand structures displaying various orientations and interlayer details tailored to specific requirements. By decomposing the original Bouligand structure and then assembling the modular samples into a specialized array, this research aims to provide parameters for achieving gradient energy absorption structures through modular 3D printing.
研究领域:
材料科学
·
力学工程
✓ 已验证
产品关联
DOI
高影响因子
Nano Today
·
2024
·
IF 13.2
Huayang Zhang,Shangzhen Xie,Guangyi Tian,Yihang Zhang,Zhiguang Guo
With global water scarcity a growing problem, fog harvesting technology has emerged as an effective solution. Industrial development and population growth have exacerbated the need for efficient, dismantlable, and assembled fog harvesting devices, as well as the requirement to optimize the droplet capture-transport relationship. In this study, a novel modular bionic 3D tree-like structure for fog harvesting system (3D-TSFHS) was developed to achieve rapid droplet transport by means of Nepenthes-inspired superslip leaves (SSLs). In addition, aluminum (Al) cones with superhydrophilic and superhydrophobic (SHL-SHB) patterns were prepared to enhance the droplet capture efficiency by drawing on the special wettability and structural features of various plants and animals such as cactus, spider silk, desert beetles, lizards and camphor leaves. This artificial design significantly enhances the overall capture and transport relationship. The resulting embedded superslip leaves Al cone fog harvesting (E-SLAC-FH) dramatically improves the fog harvesting efficiency and exhibits excellent durability. Assembling this fog harvesting into a 3D-TSFHS achieves a high fog harvesting efficiency of 0.462 g∙cm −2 ∙min −1 . The system's modular design and its exceptional durability ensure its potential for a wide range of applications in a variety of real-world scenarios.
研究领域:
材料科学
·
仿生学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Ziyue Gao,Minghao Li,Haoxu Yu,Shuai Huang,Faze Chen
Spontaneous liquid transport is increasingly being applied in various fields such as microfluidics, fuel cells, phase change heat transfer, water harvesting, etc. However, long-distance spontaneous liquid transport with path-customizable motion trajectories is still challenging. Drawing multi-inspirations from the wedge-shaped structures of iris petals, the continuous structures of bamboo joints, and the microgroove structures of Nepenthes mouth edge, we fabricate a modular, pump-free biomimetic liquid transport platform by 3D printing and surface modification. The platform is composed of sequential wedge notches, and a crescent-shaped groove is designed at the joint of every two connected wedge structures. The platform is characterized by path-customizable liquid transport trajectories and can be used to achieve long-distance liquid transport without the need of external energy fields, and the multi-level nested structures along the depth significantly facilitates the liquid transport. Experimental study and theoretical force analysis show that the crescent-shaped grooves enable the liquid to overcome joint barriers by converting potential energy accumulated at joints into kinetic energy, achieving a maximum velocity of 18 mm/s. Taking advantage of the flexibility of 3D printing and long-distance transport capability, the modular structure of the platform enables customization of the transport distance and trajectory. By assembling 14 bamboo-like wedge-shaped units in series, we realized a transport distance up to 350 mm, which could be further increased by connecting more units. Furthermore, we develop various modular and multifunctional liquid transport platforms for anti-gravity transport, liquid diversion, and customized transport trajectories, which demonstrate that our design strategy could be an available solution for path-customizable liquids transport in fields like bio-sensing, fuel cells, etc.
研究领域:
微流控技术
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
LAB ON A CHIP
·
2016
·Vol. 16
·期 24
·4718-4724
·
IF 5.586
Tianbao Li,Lei Zhao,Wenming Liu,Juan Xu,Jinyi Wang
A novel, facile, and flexible approach for the easy assembly of microfluidic droplet devices using commercially available components is presented. Three different types of devices have been designed and tested, and the experimental results indicated that the devices offer a promising platform for the controllable generation of highly monodisperse droplets with sizes in the micrometer to millimeter diameter ranges. The advantages of the devices include their low cost, portability, reusability, high accuracy, and reliability. Most importantly, the simple and reversible combination of the different components allows the flexible design of versatile devices for fabricating multiple droplets with diverse structures. Therefore, the devices constitute a powerful microplatform that can be used for scientific and industrial applications.
研究领域:
生物工程
·
化学工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
iScience
·
2021
·
IF 5.458
Qingbin Zeng,Qianni Guo,Yaping Yuan,Baolong Wang,Meiju Sui,Xin Lou,Louis-S. Bouchard,Xin Zhou
Magnetic resonance imaging (MRI) provides structural and functional information, but it did not probe chemistry. Chemical information could help improve specificity of detection. Herein, we introduce a general method based on a modular design to construct a molecular building block Xe probe to help image intracellular biothiols (glutathione (GSH), cysteine (Cys) and homocysteine (Hcy)), the abnormal content of which is related to various diseases. This molecular building block possesses a high signal-to-noise ratio and no background signal effects. Its detection threshold was 100 pM, which enabled detection of intracellular biothiols in live cells. The construction strategy can be easily extended to the detection of any other biomolecule or biomarker. This modular design strategy promotes efficiency of development of low-cost multifunctional probes that can be combined with other readout parameters, such as optical readouts, to complement 129 Xe MRI to usher in new capabilities for molecular imaging.
研究领域:
生物化学
·
医学影像
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hongkai Wang,Yinzheng Niu,Hui Liu,Ye Zhu
Nucleic acid detection is crucial for early disease diagnosis and related clinical applications. Exploring nucleic acid amplification-free yet highly sensitive detection strategies is of significance for the development of accurate and user-friendly point-of-care testing devices. Herein, a modularized universal electrochemical sensing strategy was proposed based on the synergistic effect of CRISPR/Cas12 system and nanoporous materials. The trans -cleavage activity of Cas12a, which was activated by HPV-16 target, was utilized to cut the gatekeepers of mesoporous silica nanoparticle nanocontainers. The released methylene blue was entrapped by a mercaptobenzoic acid functionalized nanoporous gold (NPG) sensing platform. By virtue of the excellent electrocatalytic ability of NPG, ultrasensitive detection of HPV-16 was achieved over a broad linear range of 7 orders of magnitude with a detection limit as low as 0.41 fM. Moreover, determination of HPV-18 was easily achieved by only altering crRNA, revealing the remarkable universality of this strategy and its superiority of modularized design. The practical applicability of the proposed sensing strategy was verified in terms of specificity, stability, and complex biological sample analysis, demonstrating its promising prospects in the development of reliable, universal, robust, and user-friendly point-of-care diagnostic devices.
研究领域:
生物技术
·
医学诊断
·
纳米科学
✓ 已验证
产品关联
DOI
高影响因子
Science Advances
·
2023
·Vol. 9
·期 50
·
IF 13.6
Lin Su,Dongdong Jin,Yuqiong Wang,Qinglong Wang,Chengfeng Pan,Shuai Jiang,Haojin Yang,Zhengxin Yang,Xin Wang,Neng Xia,Kai Fung Chan,Philip Wai Yan Chiu,Joseph Jao-Yiu Sung,Li Zhang
The magnetic microrobots promise benefits in minimally invasive cell-based therapy. However, they generally suffer from an inevitable compromise between their magnetic responsiveness and biomedical functions. Herein, we report a modularized microrobot consisting of magnetic actuation (MA) and cell scaffold (CS) modules. The MA module with strong magnetism and pH-responsive deformability and the CS module with cell loading-release capabilities were fabricated by three-dimensional printing technique. Subsequently, assembly of modules was performed by designing a shaft-hole structure and customizing their relative dimensions, which enabled magnetic navigation in complex environments, while not deteriorating the cellular functionalities. On-demand disassembly at targeted lesion was then realized to facilitate CS module delivery and retrieval of the MA module. Furthermore, the feasibility of proposed system was validated in an in vivo rabbit bile duct. Therefore, this work presents a modular design–based strategy that enables uncompromised fabrication of multifunctional microrobots and stimulates their development for future cell-based therapy.
研究领域:
生物医学工程
·
微创治疗
·
细胞疗法
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Sciences-Basel
·
2025
·Vol. 15
·期 7
·3721
·
IF 2.5
Guangbing Liu,Da Ke,Hasnain Moavia,Chen Ling,Yanhong Zhang,Yu Shen
This study presents the development and evaluation of an innovative modular ecological transition zone system for riparian restoration. Through systematic optimization, we developed a C25-grade ecological concrete module (100 mm × 100 mm × 100 mm) with a specialized cavity design (φ61 mm × H60 mm) that achieves optimal balance between structural integrity (20–30 MPa compressive strength) and environmental functionality (>15% porosity, >1 × 10−4cm s−1permeability). The module incorporates precisely calibrated proportions of cement (378 kg m−3), reinforcing agent (12 kg m−3), aggregate (1650 kg m−3), and water (137 L m−3), creating a robust platform for environmental remediation. The system was evaluated at two scales: module-scale experiments in 25 L containers (833:1 mL g−1ratio) and kinetic studies (10:1 mL g−1ratio), revealing a sophisticated three-phase removal process. The initial rapid surface adsorption phase (0–4 h) achieved removal rates of 0.28–0.42 mg g−1h−1, followed by pore diffusion (4–24 h) and chemical fixation phases, with removal patterns effectively modeled using a modified pseudo-second-order equation. The system demonstrated exceptional heavy metal removal capabilities across varying concentration ranges, achieving removal efficiencies of 95.6% for Pb2+ions, 92.3% for Cd2+ions, 84.2% for Cr3+ions, 89.7% for Cu2+ions, and 84.8% for Zn2+ions under optimal conditions. Performance remained robust across two orders of magnitude in concentration ranges, with removal efficiencies maintaining above 80% at both experimental scales. The modular design’s cost-effectiveness is demonstrated through material costs of USD 45–60 m−3, with operational costs 40–60% lower than conventional systems. This research provides a practical, cost-effective solution for riparian zone restoration, combining structural durability with efficient pollutant removal capabilities while maintaining consistent performance across varying environmental conditions.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2025
·
IF 4.7
Wen-Kai Liu,Xiu-Xin Ren,Lian Xu,Juan Lin
Hydroxytyrosol, a naturally occurring chemical with antioxidant and antiviral properties, is widely employed in the nutrition, pharmaceutical, and cosmetic industries. In the present study, a modularized cascade composed of Modules 1 and 2 was designed and implemented to convert l -tyrosine to hydroxytyrosol. Module 1 was a four-enzymatic cascade for converting l -tyrosine to tyrosol. Engineering Module 1 by fine-tuning the expression of the desired enzymes resulted in a robust whole-cell catalyst, BL21 (M1-13), which converted l -tyrosine to tyrosol at high substrate loading. Module 2 involved a 4-hydroxyphenylacetate 3-monooxygenase (HpaBC)-catalyzed reaction to hydroxylate tyrosol to form hydroxytyrosol. The rational design of the HpaB subunit led to a positive variant, HpaB-Mu (T292S/R474A), which was subsequently applied to Module 2 for tyrosol hydroxylation, yielding a robust whole-cell catalyst, BL21 (M2-05). The two designed modules were merged for one-pot conversion of l -tyrosine to hydroxytyrosol by adjusting the ratio and total amount of whole-cell catalyst loading, capable of converting 40 mM of l -tyrosine to 35.8 mM of hydroxytyrosol with a high space–time yield (1.38 g/L/h). The current study proved that engineering HpaB at the substrate tunnel was a feasible way to boost its activity and proposed an effective method for synthesizing hydroxytyrosol from low-cost substrates, which has great economic potential.
研究领域:
生物化学
·
合成生物学
·
酶工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
iScience
·
2022
·
IF 6.107
Zhexin Huang,Cunyue Wei,Lina Dong,Anyang Wang,Hongyi Yao,Zhongwei Guo,Shengli Mi
Owing to the innate good biocompatibility, tissue-like softness and other unique properties, hydrogels are of particular interest as promising compliant materials for biomimetic soft actuators. However, the actuation diversity of hydrogel actuators is always restricted by their structure design and fabrication methods. Herein, origami structures were introduced to the design of fluid-driven hydrogel actuators to achieve diverse actuation movements, and a facile fabrication strategy based on removable templates and inside-out diffusion-induced in situ hydrogel crosslinking was adopted. As a result, three types of modular cuboid actuator units (CAUs) achieved linear motion, bending, and twisting. Moreover, combinations of multiple CAUs achieved different actuation modes, including actuation decoupling, superposition, and reprogramming. The diverse actuation functionality would enable new possibilities in application fields for hydrogel soft actuators. Several simple application demos, such as grippers for grasping tasks and a multi-way circuit switch, demonstrated their potential for further applications.
研究领域:
生物材料学
·
仿生工程
·
智能材料
✓ 已验证
DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Qiongdi Zhang,Yuxuan Hao,Tonghua Zeng,Weiliang Shu,Pan Xue,Yang Li,Chi Huang,Liwei Ouyang,Xuming Zou,Zhen Zhao,Jiahong Wang,Xue-Feng Yu,Wenhua Zhou
Graphene field-effect transistors (GFETs) are widely used in biosensing due to their excellent properties in biomolecular signal amplification, exhibiting great potential for high-sensitivity and point-of-care testing in clinical diagnosis. However, difficulties in complicated fabrication steps are the main limitations for the further studies and applications of GFETs. In this study, a modular fabrication technique is introduced to construct microfluidic GFET biosensors within 3 independent steps. The low-melting metal electrodes and intricate flow channels are incorporated to maintain the structural integrity of graphene and facilitate subsequent sensing operations. The as-fabricated GFET biosensor demonstrates excellent long-term stability, and performs effectively in various ion environments. It also exhibits high sensitivity and selectivity for detecting single-stranded nucleic acids at a 10 f m concentration. Furthermore, when combined with the CRISPR/Cas12a system, it facilitates amplification-free and rapid detection of nucleic acids at a concentration of 1 f m . Thus, it is believed that this modular-fabricated microfluidic GFET may shed light on further development of FET-based biosensors in various applications.
研究领域:
生物传感器
·
临床诊断
·
材料科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）