SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Cheng-lu Zhang,Chang Liu,Shi-ru Nie,Xiang-ling Li,Yi-ming Wang,Yang Zhang,Jing-hao Guo,Yue-dong Sun
On the basis of classical Schiff base reaction, two novel and efficient fluorescent probes ( DQNS , DQNS1 ) were designed and synthesized by introducing Schiff base structure into dis-quinolinone unit for structural modification, which can be used to detect Al 3+ and ClO − . Because the power supply capacity of H is weaker than that of methoxy, DQNS shows better optical performance: a large Stokes Shift (132 nm), identify Al 3+ and ClO − with high sensitivity and selectivity, low detection limit (29.8 nM and 25 nM) and fast response time (10 min and 10 s). Through the working curve and NMR titration experiment, the recognition mechanism of Al 3+ and ClO − (PET and ICT) probes are confirmed. Meanwhile, it is speculated that the probe has continuity for the detection of Al 3+ and ClO − . Furthermore, DQNS detection of Al 3+ and ClO − was applied to real water samples and living cell imaging.
研究领域:
化学
·
生物学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Qiwen Jiang,Yi jing,Yeyan Ni,Ruoshi Gao,Pingyan Zhou
Chitin, a functional carbohydrate derived from waste products of seafood industry, contains abundant nitrogen, which makes it become a very suitable carbon precursor for the synthesis of carbon quantum dots (CQDs). Demonstrated in this work was synthesizing CQDs using this N-enriched primary feed-stock. The as-prepared N-doped carbon quantum dot( N-CQDs ) showed both photoluminescence exposed to UV radiation and a good potentiality in fluorescent sensor for detecting of ClO − . Significantly, the detection limit of ClO − was 1.47 μM and its linear range was 0–50 μM (R 2 = 0.9922). In addition, the structures and properties of the N-CQDs were further investigated. As indicated in the results, the N-CQDs exhibited a spheroidal morphology with an average diameter of 4.21 nm. Its quantum yield was 25.8%. Moreover, the N content of this N-CQDs increased to 9.89%, consisting of multiple functional groups such as N , C N and N H.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Shu Wang,Shun-Hua Wu,Wen-Le Fang,Xiao-Feng Guo,Hong Wang
A facile and straightforward strategy was used to prepare carbon dots (CDs) using catechol as carbon source in one-pot hydrothermal method . The synthesis method is simple without any doping and modification and the prepared CDs do not require any post-processing. Characterizations of the obtained CDs indicated that they had high crystallinity and higher quantum yield (QY, 32%) than most non-functionalized and non-doped CDs. Noticeably, the fluorescence of CDs could be quenched with hypochlorite (ClO − ) by oxidation of the residual pyrocatechol groups on the surface to o -benzoquinone exhibiting high sensitivity and selectivity for ClO − . The assay covered a linear range from 0.1 to 10 μM with a low detection limit of 30 nM. The results showed that the CDs provided a promising potential tool for the detection of ClO − in real water samples.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2022
·Vol. 33
·期 2
·575-586
·
IF 2.525
Zhou Boxin,Han Yunlong,Liu Jingyu,Cheng Kai,Dong Mingdong,Tang Xu
Hypochlorite is an important biological reactive oxygen species, which plays a pivotal role in various life activities. Excessive presence in the human body or excessive intake in life causes a series of diseases. To monitor the hypochlorite level in living cells, organisms and environment water samples, we herein designed and synthesized three organic small molecule fluorescent probes with different recognition sites based on nitrile biphenyl. Through performance comparison, it was found that probe A-HM exhibited the best detection performance for hypochlorite with a low detection limit of 2.47 × 10 –6 M. The introduction of hypochlorite will induce probe fluorescence A-HM to turn on, and the fluorescence colour will change from colourless to green. The application of A-HM in biological systems has been demonstrated by the imaging monitoring of hypochlorite in MCF-7, L929 cells and zebrafish. Furthermore, A-HM was also used for the accurate determination of the hypochlorite level in real water samples with high sensitivity and good recoveries.
研究领域:
分析化学
·
生物化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2019
·
IF 3.261
Yong Tang,Yuanyuan Li,Lei Liu,Haocheng Ni,Juan Han,Lei Wang,Yanli Mao,Liang Ni,Yun Wang
A simple colorimetric and fluorescent probe bearing coumarin and p-toluenesulfonyl hydrazide moieties was developed, which was capable of displaying excellent selectivity for hypochlorite. The distinct absorption spectral shift (49 nm) was induced by ClO − -triggered oxidative hydrolysis of C N double bonds in aqueous solution, which was accompanied by the optical variation from yellow to colorless. Besides, this probe solution underwent a dramatic intensification (162-fold) of the fluorescence signaling at 444 nm via the addition of ClO − (3 equiv.) within a short time. More importantly, the results achieved by fluorescence spectra revealed an excellent linear relation of probe 1 for ClO − with excellent sensitivity (9.1 nM). Further, the good recoveries and cellular experiments verified the prospective functions of this probe in real water environment and SW 480 cells.
研究领域:
生物化学
·
分析化学
·
医学检测
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Yuanyuan Li,Lei Liu,Yong Tang,Yun Wang,Juan Han,Liang Ni
In this study, a new fluorescence probe HMAQ based on quinazoline and diaminomaleonitrile was constructed for sensing ClO − and Al 3+ . A fluorescence blue-shift with 102 nm together with a color change from golden-yellow to colorless was found by hypochlorite-induced hydrolysis of –CH=N- group to release the initial fluorophore. Besides, Al 3+ could cause a 72-nm blue-shifted emission spectra and a color change from golden-yellow to brown. As expected, HMAQ exhibited a satisfactory selectivity and sensitivity to ClO − /Al 3+ with a quick response. Most notably, the reversibility of the [HMAQ+Al 3+ ] complex could be used to detect ClO − and Al 3+ simultaneously without mutual interferences. The detection limits of HMAQ for ClO − and Al 3+ were turned out to be 10.2 nM and 1.56 nM, respectively. The high-performance results of real-time detections demonstrated the enormous potential of HMAQ in real-water samples and living cells.
研究领域:
分析化学
·
生物医学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2016
·Vol. 183
·期 7
·2221-2227
·
IF 4.831
Lin Yanping,Yao Bixia,Huang Tingting,Zhang Shichao,Cao Xiaotong,Weng Wen
The authors report that nitrogen-doped carbon dots (N-CDs) represent a viable fluorescent probe for the determination of dissolved free chlorine. The N-CDs can be fairly easily prepared by a solvothermal method using citric acid, tartaric acid and ethanediamine as the precursors, display excitation/emission maxima of 360/460 nm, and have a quantum yield of 42.2 %. Free chlorine and ClO − quench fluorescence, and this was exploited to design a method for fluorometric determination of chlorine and hypochlorite. The probe has a short response time (< 1 min), excellent selectivity, high sensitivity, and a linear response range that extends from 0.1 to 27 μM. The limit of detection is as low as 29.7 nM. The method was applied to the determination of chlorine dissolved in tap water.
Fluorescent nitrogen-doped carbon dots (N-CQDs) displaying excitation/emission maxima of 360/460 nm were fabricated by a one-pot solvothermal method. The photoluminescence (PL) of the N-CQDs is quenched by free chlorine and ClO − , and this was exploited to design a method for fluorometric determination of chlorine and hypochlorite.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2020
·
IF 4.613
Aiqing Feng,Peilian Liu,Qiqi Liang,Xinyi Zhang,Liping Huang,Yongmei Jia,Mubiao Xie,Qing Yan,Chengpeng Li,Sheng Wang
In this work, we have developed a new carbazole-based fluorescent probe ( E )-1-methyl-4-(2-(5-(9-phenyl-9 H -carbazol-3-yl) thiophen-2-yl)vinyl)pyridin-1-ium ( PCTP ) for ratiometric and colormetric ClO − sensing. PCTP displayed red emission due to the intramolecular charge transfer (ICT) effect of phenylcarbazol moiety, while this effect can be rapidly weakened and led to the significant fluorescence change (from red to green) in the presence of ClO − . PCTP is more highly selective and sensitive towards ClO − detection than other various biological related species. The detection limit (LOD) was calculated to be 10.8 nM. More importantly, PCTP has been successfully applied in ClO − imaging in living cells and zebrafishes.
研究领域:
生物化学
·
分析化学
·
细胞生物学
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2020
·
IF 4.613
Fanyong Yan,Xiaodong Sun,Yingxia Jiang,Ruijie Wang,Yuyang Zhang,Yali Cui
The microenvironment in biological systems is associated with pathological of organisms. In this work, HBTC, a red-emitting probe with abilities of responding to OCl − and environmental viscosity was designed and synthesized to preliminary apply in cell imaging . HBTC showed weak fluorescence in the dissolved state due to intramolecular rotation, and it showed about 620 nm red light emission when molecules are restricted. Through red-to-turquoise ratiometric fluorescence signal, HBTC showed the capacity to selective detecte OCl − , and the LOD was calculated to be 0.141 μM in OCl − concentration range of 2–20 μM. Finally, HBTC was used for preliminary cell fluorescence imaging. It is expected that HBTC will be used to study the diseases related between OCl − concentration and viscosity in cells.
研究领域:
生物化学
·
医学影像
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 107
·105795-105800
·
IF 3.289
Lanfang Pang,Yanmei Zhou,Wenli Gao,Haohan Song,Xiao Wang,Yong Wang
The 7-hydroxy-4-methylcoumarin as an “off–on” fluorescent probe exhibited excellent selectivity and sensitivity towards hypochlorite over other reactive oxygen species and relevant ions. Upon treatment with hypochlorite, the fluorescence intensity of the probe gradually increased 86-fold. A good linear increase of the fluorescence intensity could be observed with increasing hypochlorite concentration over a wide linear range of 0–150 μM, and a detection limit as low as 67 nM was obtained. Moreover, the probe could also be successfully applied for the detection of hypochlorite in tap water and living cells, which provided great potential for the quantitative detection of hypochlorite in water samples and cancer cells.
研究领域:
分析化学
·
生物化学
·
医学检测
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 29
·5854-5861
·
IF 4.543
Bao-xing Shen,Ying Qian,Zheng-qing Qi,Chang-gui Lu,Qi Sun,Xiang Xia,Yi-ping Cui
Hypochlorite serves as a significant antimicrobial agent in the human immune system, and its detection is of great importance. Herein, a novel near-infrared BODIPY-based ClO− fluorescent probe (NCS-BOD-OCH3) was designed and synthesized. The emission bands of NCS-BOD-OCH3 concentrated at 595 nm and 665 nm. Since the electron withdrawing group 1,3,4-oxadiazole was formed after the desulfurization reaction, the fluorescence intensity of NCS-BOD-OCH3 decreased significantly in THF/H2O (v/v, 1 : 1, buffered with 10 mM PBS pH = 7.4), which is visible to the naked eye with an obvious color change. NCS-BOD-OCH3 can realize the two-photon up-converted fluorescence emission. The low detection limit was calculated from the titration results, with the figure for NCS-BOD-OCH3/ClO− being 1.15 × 10−6 M. The result of living cell imaging experiment demonstrated that NCS-BOD-OCH3 can successfully detect ClO− in living cells and can serve as a NIR mitochondrial imaging agent. It is an excellent platform for developing NIR ClO− fluorescent probes.
研究领域:
生物化学
·
医学影像学
·
化学生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Xiaoyuan Sun,Jianhua Wang,Zhuobin Shang,Hui Wang,Yu Wang,Shaomin Shuang
In this research, a new triphenylamine-thiophene-based fluorescent probe, denoted as TTD, was constructed for simultaneous detection of viscosity and hypochlorite (ClO − ) with dual-response signals. The hindrance of intramolecular bond rotation within TTD in a high-viscosity environment turns on the probe’s emission at 600 nm, resulting in strong red fluorescence. Simultaneously, the oxidation of the imine moiety to the aldehyde product, induced by ClO − , leads to substantial emission enhancement at 460 nm, generating vivid blue fluorescence. As a result, TTD can be employed for the dual-color visualization of changes in viscosity and ClO − levels, demonstrating good selectivity. TTD has been applied to image the elevated level of viscosity induced by nystatin, rotenone or erastin as well as exogenously introduced ClO − in living cells. Importantly, from two independent emission channels, TTD is capable of monitoring both ClO − and viscosity fluctuations within live cells during the inflammatory response triggered by lipopolysaccharide (LPS).
研究领域:
生物化学
·
细胞生物学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）