Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 6
·915-926
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IF 7.571
Liwei Zhang,Yajie Zhang,Fanshu Ma,Xingzhu Liu,Yangzhong Liu,Yi Cao,Renjun Pei
Hydrogel-based wound dressings with tissue adhesion abilities are widely used for wound closure. However, currently developed hydrogel adhesives are still poor at continuing to seal wounds while bleeding is ongoing. Herein, we demonstrate an antibacterial and hemostatic hydrogel adhesive with low-swelling properties and toughness for wound healing. The hydrogel was composed of Pluronic F127 diacrylate, quaternized chitosan diacrylate, silk fibroin, and tannic acid, and it was not only able to maintain good tissue adhesion abilities in a moist environment but it also showed guaranteed tissue adhesion and mechanical strength after absorbing water due to its low-swelling and toughness properties. Furthermore, in vitro and in vivo tests demonstrated that the hydrogel also had antibacterial, antioxidant, and hemostatic properties, which could promote tissue regeneration. All these findings demonstrate that this hydrogel with multifunctional properties is a promising material for clinical wound healing applications.
研究领域:
生物医学工程
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材料科学
·
组织工程
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Xiaoyu Rong,Xinhai He,Lu Jiang,Rui Yu,Weifang Xu,Caiyun Zhang,Huanhuan Liu
Exploring new dynamic bonds for multifunctional hydrogel in fabricating wound dressing materials has received great attention recently. This paper introduces a multifunctional hydrogel designed for wound healing using a novel dual-dynamic-bond cross-linking of Ag–Se coordination bonds and Se–Se diselenide bonds. These dynamic bonds give the hydrogel excellent mechanical and multistimulus self-healing capabilities. The redox sensitivity of the Se–Se bonds allows for adjustable adhesion capacity and easy removal of the hydrogel when exposed to stimuli like hydrogen peroxide (H2O2), addressing a common challenge in wound dressing. Moreover, the hydrogels also demonstrated antibacterial and hemostatic properties. Furthermore, the dual-dynamic cross-linked hydrogel dressings showed enhanced wound healing in mice with full-thickness skin wounds compared to the 3 M Tegaderm dressing. The hydrogel’s versatility, stemming from its robust structural characteristics, renders it appropriate for addressing acute wound care.
研究领域:
生物材料学
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医学工程
·
组织工程
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Meng Pan,Zonghao Tang,Jianbing Tu,Zhengchao Wang,Qinhui Chen,Rongdong Xiao,Haiqing Liu
Quick hemostats for non-lethal massive traumatic bleeding in battlefield and civilian accidents are important for reducing mortality and medical costs. Chitosan (CS) has been widely used as a clinic hemostat. To enhance its hemostatic efficiency, Zn 2 + in the form of zinc alginate (ZnAlg) was introduced to CS to make porous CS@ZnAlg microspheres with ZnAlg component on the surface. Such microspheres were prepared by successive steps of micro-emulsion, polyelectrolyte adhesion, and thermally induced phase separation. Their structure and hemostatic performance were analyzed by SEM, FT-IR, XPS and a series of in vitro hemostatic experiments including thromboelastography analysis. The composite microspheres had an outer and internal interconnected porous structure. Their size, surface area, and water absorption ratio were ca. 70 μm, 48 m 2 /g, and 1850%, respectively. Compared to the neat chitosan microspheres, the CS@ZnAlg microspheres showed shorter onset of clot formation, much faster in vitro and in vivo whole blood clotting, bigger clot, less blood loss, and shorter hemostatic time in the rat liver laceration and tail amputation models. The synergetic hemostatic effects from (1) the electrostatic attraction between chitosan component and red blood cells, (2) the activation of coagulation factor XII by Zn 2 + of zinc alginate component, and (3) physical blocking by microsphere matrix, contributed to the enhanced hemostatic performance of CS@ZnAlg microspheres.
研究领域:
生物医学工程
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材料科学
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血液学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Ying Liu,Xiao Ma,Qimeng Jiang,Guihua Yang
The hemorrhage in daily life was a great challenge for the life health. Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat. The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties. In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge. The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension. The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk. Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect. Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF). Moreover, CH/CS4 displayed superior wound healing ability and cytocompatibility. Therefore, the CH/CS4 has high potential application in medical hemostatic field.
研究领域:
生物医学工程
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Jiawen Chen,Shuning Chen,Wei Cheng,Jinhuo Lin,Shisheng Hou,Haiqing Liu,Qinhui Chen
Effective control of bleeding is critical to saving lives whether on the battle field or in civilian life. Microporous starch (MS) is a promising hemostat for its extensive sources, huge surface area and good biocompatibility. However, the hemostatic performance of MS is limited because of its complex preparation process and lack of effective component to activate coagulation factors . Herein, porous starch microspheres modified by calcium (Ca-PSM) with dense shell and honeycomb micro-porous core were prepared by electrostatic spray and supercritical CO 2 for the first time. The topological morphology of Ca-PSM changed with the increase of Tween-80 content within 0.5%. Ca-PSM possessed excellent water absorbability due to high specific surface area, and what's more, it showed good hemostatic performance because of the synergistic effects of physical adsorption and chemical activation mechanisms. The results of thrombelastograph (TEG) showed that the initial clotting time (R) and coagulation time (R + K) of Ca-PSM-1 were shortened by 47.1%, 53.3% than that of control group. The maximum blood clot strength (MA) of Ca-PSM-1 was also significantly raised. Furthermore, it was noteworthy that Ca-PSM could activate clotting cascade and induce erythrocyte adsorption. In summary, Ca-PSM as a hemostat will be a promising and alternative candidate for clinical application.
研究领域:
生物材料学
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医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Siqi Chen,Yanyan Zheng,Yan Fang,Yunxiang Weng,Haiqing Liu,Qinhui Chen
Hemostasis and subsequent anti-inflammatory measures are essential for wound healing in the human body following trauma or surgical procedures. Here, we try to use the dragging effect of a brush to prepare a Janus hydrogel with the least amount of bacteriostatic agent. The synthesized suspension of polyvinylbenzene-silica@quaternary ammonium salt (PDVB-SiO 2 @NR 4 + ) Janus particles (JNPs) was selected as ink and brush coated onto one side of a polyacrylic acid (PAA) hydrogel, resulting in Janus hydrogel (JNPs≌PAA). The anisotropic chemical composition, wetting properties, adhesion capabilities, and the obtained hemostatic performance of the Janus hydrogel were studied thoroughly. The hydrophilic PAA side promoted tissue adhesion, while the hydrophobic JNPs side exhibited antibacterial effects. The Janus hydrogel presented perfect hemostatic effect in vivo , owing to the procoagulant effect of the adhesive layer, negative charges, and blood-blocking properties of the hydrophobic layer. The presence of quaternary ammonium groups in the Janus hydrogel imparted strong antibacterial activity against E. coli and S. aureus . Furthermore, the Janus hydrogel showed a low hemolysis rate and high cell safety. This multifunctional hydrogel material holds great promise for wound treatment and expands the applications of hydrogel materials in the biomedical field.
研究领域:
生物材料学
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医学工程
·
药物开发
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Jiawen Chen,Kexin Chen,Qinglin Li,Guofa Dong,Jie Ai,Haiqing Liu,Qinhui Chen
Janus particles with obvious chemical compartition can perform their functions independently, so they have attracted much attention in biomedical materials. Herein, a mesoporous silica/silver Janus nanoparticle modified with cardanol (C-MSN@Ag) was designed and synthesized via redox and click chemical reactions and was further evaluated as a highly efficient hemostatic dressing. This Janus structure endowed C-MSN@Ag with both prominent hemostatic and antibacterial performance. The hemostatic time of C-MSN@Ag on rat liver laceration was up to 40% shorter than that of MSN and MSN@Ag because of adhesion of phenolic compounds on the tissue and the blocking effect of the hydrophobic alkyl chains from cardanol. Besides, C-MSN@Ag could promote coagulation by forming a three-dimensional network with fibrin more quickly than MSN and MSN@Ag. Additionally, due to the released silver ions and phenolic hydroxyl groups of cardanol, C-MSN@Ag exhibited a broad-spectrum antibacterial rate (∼99%) against both Escherichia coli and Staphylococcus aureus. C-MSN@Ag also possessed non-cytotoxicity. This work not only provides a way for the fabrication of silica-based Janus hemostatic agents by the atom-economical click reaction but also gives a direction for the application of the sustainable naturally occurring cardanol.
研究领域:
生物医学材料
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纳米医学
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药物化学
✓ 已验证
产品关联
DOI
PubMed
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Shumin Zhang,Lin Li,Xuehong Ren,Tung-Shi Huang
Bacterial cellulose (BC) is a natural polymer with remarkable superiority for fabricating biomaterials. In this study, a multiporous bacterial cellulose (MBC) film was modified with N-isopropylacrylamide (NIPAM), and the modified MBC film was imbued with antibacterial properties after chlorination. The dried chlorinated samples showed superb antibacterial efficacy and could inactivate 6.19 log of inoculated S. aureus and 6.29 log of E. coli within 1 min of contact. After releasing active chlorine for 12 h, 3.67 log of S. aureus and 3.97 log of E. coli were inactivated within 30 min of contact. The prepared films displayed high porous and layered structures with a resultant excellent water retention which can be applied as material for wound dressings. In addition, the chlorinated films showed hemostatic ability on wound bleeding and good biocompatibility. The prepared N-halamine functionalized MBC films might have great potential applications as wound dressings.
研究领域:
生物材料学
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医学工程
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Sciences-Basel
·
2018
·Vol. 8
·期 8
·1226
·
IF 1.689
Xinzhe Zhao,Jing Gao,Xingyou Hu,Huiwen Guo,Fujun Wang,Yansha Qiao,Lu Wang
As a promising agent for biomedical application, collagen has been used as a nanofiber to architecturally mimic its fibrillar structure in Extracellular Matrix (ECM); however, it has to be modified by techniques, such as crosslinking, to overcome its limitations in structural stability along with potential toxicity. Here, we prepared collagen/polyethylene oxide (PEO) nanofibrous membranes with varying crosslinking degrees and their properties, such as water stability, mechanical properties, blood clotting capacity and cytocompatibility, were studied systematically. By investigating the relationship between crosslinking degree and their properties, nanofibrous membranes with improved morphology retention, blood clotting capacity and cytocompatibility have been achieved. The result of circular dichroism measurement demonstrated that a triple helical fraction around 60.5% was retained. Moreover, the electrospun collagen/PEO at crosslinking degrees above 60.6% could maintain more than 72% of its original weight and its nanofibrous morphology under physiological conditions could be well preserved for up to 7 days. Furthermore, the crosslinked collagen/PEO membrane could provide a more friendly and suitable environment to promote cell proliferation, and about 70% of the clot can be formed in 5 min. With its superior performance in water stability, hemostasis and cytocompatibility, we anticipate that this nanofibrous membrane has great potential for wound dressing.Keywords:collagen;morphology retention;hemostasis;cytocompatibility;wound dressing
研究领域:
生物材料学
·
医学工程
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Jiawen Chen,Jie Ai,Shuning Chen,Zhiyan Xu,Jinhuo Lin,Haiqing Liu,Qinhui Chen
The powder hemostatic materials are increasingly appreciated because of their long storage time, wide storage temperature, portable property, especially their use both in vivo and epidermis. Mesoporous silica materials attracted more and more attention owing to their favorable biocompatibility and outstanding hemostatic performance, but their hemostatic process was too simple to meet the requirements. Herein, mesoporous silica nanoparticles modified by chitosan and hydrocaffeic acid (MSN@CS-HCA) were developed for rapid and safe hemorrhage control. By tissue adhesion, activating the coagulation cascade, aggregating red blood cells and platelets, MSN@CS-HCA with the porous network exhibited excellent hemostatic effects in both in vivo and in vitro coagulation tests. The hemostatic time of MSN@CS-HCA was 60.3% shorter than that of MSN in femoral artery trauma models of SD rats . Besides, MSN@CS-HCA with good biocompatibility and ability to promote wound healing, could form the network structure with fibrin in the blood, which enhanced the mechanical strength of the blood clot and acted as a physical barrier to prevent blood loss. In conclusion, MSN@CS-HCA will be a potential and prospective hemostatic dressing for the control of hemorrhage in more extensive clinical application future.
研究领域:
生物材料学
·
医学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Kaiyang Fang,Chenmeizi Wang,Yaqing Yang,Feng Tang,Fenglin Huang
Developing an effective hemostatic material that combines excellent biocompatibility with high blood absorption capacity remains a critical clinical challenge. In this study, ultralight three-dimensional (3D) silk fibroin (SF) scaffolds, composed of continuously interconnected nanofibers, are introduced as a novel hemostatic material. The distinctive fluffy nanofiber architecture endows the scaffolds with a remarkable porosity of 78.9 % and exceptional liquid absorption capacity. The integration of montmorillonite (MMT) further enhances the hemostatic properties of the scaffolds, while SF naturally promotes the intrinsic coagulation pathway. The scaffolds exhibit an impressive blood absorption capacity of 1687.7 %. In vitro evaluations indicate that the SF nanofiber scaffolds exhibit a blood clotting index rate of 24.6 %, a hemolysis ratio of less than 4 %, and outstanding biocompatibility. The blood coagulation time is significantly reduced from 449 s to 230 s. Additionally, the scaffolds show adhesion rates to erythrocytes and platelets of 52 % and 45.9 %, respectively. The nanofiber scaffolds aggregate and activate platelets extensively, accelerating the formation of platelet emboli, which collectively contribute to their superior hemostatic performance. Consequently, these nanofiber scaffolds hold substantial promise as absorbable hemostatic agents for achieving rapid hemostasis in clinical applications.
研究领域:
生物医学材料
·
组织工程
·
临床医学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Junqing Qian,Yan Chen,Haiyan Yang,Changyan Zhao,Xiaohua Zhao,Hui Guo
In order to develop starch hemostatic materials with excellent hemostatic properties, the preparation of crosslinked porous starch (SPS) with sodium trimetaphosphate (STMP) as cross-linking agent was studied in this paper. When the solid-liquid ratio of porous starch (PS) was 30%, the mass ratio of cross-linking agent to starch was 0.04–1, and the SPS was crosslinked at pH 10.0, 55 °C for 50–60 min, the water absorption ratio and swelling ratio of SPS reach up to 160.5% and 239.1%, respectively. The characterization by infrared spectra, scanning electron microscopy and X-Ray diffraction spectra confirmed that the structure of SPS is similar to that of PS. The degradation experiment in vitro indicated that the degradation effect of PS was better than that of SPS. The whole blood coagulation kinetics experiment showed that SPS could promote the formation of blood clot, and the adsorption experiment of red blood cells in vitro showed that SPS could adsorb red blood cells. The average hemostasis time of SPS in tail amputation 1 cm and liver laceration were 181.03 s and 179.30 s.
研究领域:
生物材料学
·
医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）