JOURNAL OF MOLECULAR LIQUIDS
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2016
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IF 2.74
Junzhi Li,Junqiang Wang,Wei Zhao,Xiaoliang Li
Isobaric vapor-liquid equilibrium (VLE) data for the four systems n -heptane + 2-methylthiophene, 2,2,4-trimethylpentane + 2-methylthiophene, n -nonane + 2-methylthiophene, n -decane + 2-methylthiophene were measured at 90.00 kPa with a modified Rose-Williams still. Gas chromatography equipped with a flame ionization detector was used to analyze composition of the samples from the vapor-liquid equilibrium systems. All the VLE measurements passed the thermodynamic consistent test using the Herington method and the Van Ness test. The azeotropic behavior was found in the 2,2,4-trimethylpentane + 2-methylthiophene system. The experimental data were correlated by the Wilson and NRTL activity coefficient models and also compared with the original UNIFAC predictive model. The corresponding parameters for the three models were obtained. The results exhibited that the measured data got agree well with the calculated values using the Wilson, NRTL and original UNIFAC models.
研究领域:
化学工程
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物理化学
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ACS Nano
·
2025
·
IF 16
Yutian Lei,Yakun Shi,Ping Li,Jing Li,Wenqing Zhang,Si-Yang Liu,Yuzhi Xu,Zhaofan Luo,Xing Han,Yanfei Zhang,Jianhe Guo,Zong Dai
The reliable application of surface-enhanced Raman scattering (SERS) in bioanalysis is critically constrained by inherent trade-offs among sensitivity, chemical stability, and signal homogeneity of conventional substrate materials. Although silver–gold core–shell nanocubes (Ag@Au NCs) stand out for their high SERS activity and improved stability, preparing complete and uniform Ag@Au NCs remains challenging due to galvanic replacement-induced Ag core etching. To address this problem, this work reveals three distinct growth modes during Au shell deposition and proposes a size-determined growth rule to guide well-preserved Ag@Au NCs synthesis. We identified that larger Ag nanocubes (Ag NCs) with fewer unpassivated {111} facets preferentially form well-preserved Ag@Au NCs through layer epitaxial growth─an exclusive mode enabling intact ultrathin Au shells without Ag core etching. The resulting Ag@Au NCs exhibit exceptional batch-to-batch consistency and retain the high SERS activity of pristine Ag NCs, while achieving prolonged chemical stability (>180 days). Benefiting from their uniform morphology, these NCs can be assembled into highly ordered two-dimensional substrates with superior signal reproducibility (RSD = 4.96%) and plasmon activity (Raman enhancement factor >107). By integrating this substrate with a tetrahedral DNA-based detection method, a portable SERS biosensor cartridge was developed for multiplexed miRNA profiling in human plasma. Leveraging the superior performance, this platform demonstrates compelling potential for reliable cervical cancer diagnosis and staging. The modular cartridge design also makes it a versatile platform for diverse biomedical applications.
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Science Advances
·
2026
·Vol. 12
·期 8
·
IF 13.9
Weijian Sun,Kaicheng Yang,Yifan Zhao,Liping Sun,Qingchi Xu,Jian Weng,Jun Xu
Traditional petroleum distillation faces high energy demands, necessitating innovative alternatives like membrane separation. This study presents a breakthrough in dual-range and precise pore size modulation of metal-organic frameworks (MOFs) through a ligand functionalization strategy. By tailoring steric configurations and spatial orientations of light-responsive azobenzene groups, we achieved broad-range pore tuning (0.41 to 0.68 nanometers) via functional group length variation, coupled with subnanometer precision through reversible trans-to-cis photoisomerization. Four representative branched alkanes were selected to validate the MOF’s high selectivity. Results showed its capacity to generate a constant carbon-atom-count–dependent permeation gradient, realizing a four-step sequential separation that increased C 6 H 14 purity from 25 to 92.2%. This synergistic approach uniquely combines large-scale pore adjustment with dynamic fine-tuning, decoupling separation efficiency from energy-intensive processes. The membranes’ structural stability and reversible light responsiveness further highlight their potential for sustainable hydrocarbon processing. By integrating molecular design with stimuli-responsive control, this work advances MOF-based membranes as a transformative solution for energy-efficient petroleum fractionation and precise molecular sieving.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Shen Yan,Eric Brendle,Mengyuan Li,Shengyu Zhang,Xiao Dong Chen,Winston Duo Wu
Spray drying and spray freeze drying induce distinct particle structure. • IGC is highly effective in resolving molecular-level surface characteristics. • IGC-ID reveals surface leucine enrichment and elevated dispersive energy. • IGC-FC quantifies hydrophilic site reduction and maps polar surface areas. • Surface energetics serve as a quantitative predictor for wetting and release. The unpredictable wettability of pharmaceutical microparticles, often stemming from complex phase transitions during processing, frequently eludes conventional unidimensional assessments of surface hydrophilicity. In this study, mannitol-leucine microparticles were fabricated via spray drying and spray freeze drying. Their structural properties—including morphology, particle size, and polymorphism—were systematically correlated with surface energetics (dispersive energy, acid–base characteristics, and hydrophilic site distribution) as delineated by inverse gas chromatography (IGC). Increasing leucine content induced pronounced surface wrinkling, sustained crystalline stability, and resulted in larger particle sizes in spray-dried samples. Conversely, spray-freeze-dried particles maintained a relatively uniform morphology but exhibited unstable δ-mannitol polymorphs with enhanced dispersibility. IGC analysis uncovered that leucine enrichment elevated dispersive surface energy, attenuated surface basicity, and diminished the hydrophilic surface area, with these effects being more pronounced in the spray-dried samples. Crucially, both the absolute hydrophilic surface area and the fractional distribution of hydrophilic domains were identified as key determinants modulating particle wettability and release behavior. This study highlights the capacity of IGC to resolve multiparametric surface energetics, thereby advancing the mechanistic understanding of pharmaceutical particle wettability through non-invasive, high-precision characterization. Download: Download high-res image (129KB) Download: Download full-size image
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GREEN CHEMISTRY
·
2025
·Vol. 27
·期 26
·7908-7917
·
IF 9.2
Shuying Tian,Jing Dai,Zhengjian Li,Qiqi Wu,Guangxu Chen
Against global resource scarcity and environmental crises, recycling large quantities of discarded polyolefin waste presents an urgent challenge for humanity. However, the thermal degradation of polyolefins, which typically requires high temperatures to cleave the carbon–carbon (C–C) bonds, has been hindered by energy limitations. We present a simple approach that uses inexpensive AlCl3 and dichloromethane to convert polystyrene into aromatics at 40 °C within 3 hours, achieving a polystyrene conversion of over 70 wt%. The Lewis acid catalysts interact with benzene under acidic conditions, promoting the elimination of the C–C backbone to generate carbocations, which subsequently undergo β-scission. The dissolution of polystyrene in dichloromethane increases the reaction interface, thereby enhancing the reaction rate. This study provides a cost-effective approach for the high-value utilization of aromatic rings in polystyrene.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2025
·
IF 3.8
Ma Shaojie,Zhu Yuchen,Li Wenbo,Chen Boxin,Zhao Bin,Feng Fei
Due to the high conformal films, atomic layer deposition (ALD) alumina has been used as a uniform stationary phase or support layer of stationary phase for micro gas chromatographic column. However, the severe tailing of chromatographic peaks appears when ALD alumina is used as the stationary phase. Recently, an H-diffusion model was proposed to explain the H accumulation phenomenon of ALD alumina films. Compared with the normal-resistance silicon substrates, the ALD alumina films based on low-resistance silicon substrates have fewer H impurities, which may further improve the tailing of chromatographic peaks and the theoretical number of plates. In this paper, a micro gas chromatographic column based on the low-resistance silicon (LR-μGCC) substrate (resistivity, 0.001–0.005 Ω·cm) using alumina deposited by atomic layer deposition as the stationary phase is reported. Compared with normal-resistance silicon substrates (resistivity, 1–10 Ω·cm), the micro gas chromatographic columns (μGCC) prepared on low-resistance silicon substrates have a higher separation performance. The test results showed that the LR-μGCC increased the theoretical plate number of alkane mixtures (n-hexane, n-octane, n-nonane, and n-decane) by 20.9%, 74.8%, 139.4%, and 55.4%, respectively, and reduced the tailing factor by 13.0%, 41.8%, 48.6%, and 49.1%, respectively. Graphical
研究领域:
分析化学
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材料科学
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BIOCHEMICAL ENGINEERING JOURNAL
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2025
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IF 3.8
Min Zhang,Yongfu Ruan,Yi Hu,Yiying Huo,Meng Wang,Zhiwei Zhu,Yunming Fang
Artemisinin, a vital antimalarial agent, is traditionally extracted from Artemisia annua L. by plant-based extraction. The microbial biosynthesis of the artemisinin precursor, amorpha-4,11-diene (AD), followed by its chemical conversion into artemisinin provides a sustainable solution to meet the demand for artemisinin while overcoming the limitations of plant-based extraction. Kluyveromyces marxianus is a promising host for microbial cell factories owing to its robust thermotolerance, rapid growth kinetics, and ability to utilize a wide range of carbon sources. Herein, genetic modification tools for K. marxianus , including transformation methods and expression vectors, were identified and optimized, while the sesquiterpene biosynthetic capacity of K. marxianus was preliminarily evaluated. To enhance the precursor metabolite supply, eight key genes from the endogenous mevalonate pathway were overexpressed within the K. marxianus genome. A dual co-expression strategy, involving both extrachromosomal and chromosomally integrated expression of amorpha-4,11-diene synthase ( ADS ) was employed, followed by high-temperature fermentation to optimize production. Finally, an engineered K. marxianus strain was developed for the first time, capable of stable, efficient, and cost-effective production of AD, with a titer of 66.78 mg/L, a 113-fold increase compared with the wild-type strain. This engineered strain serves as a robust chassis and a valuable reference for the production and study of other terpenoids, laying the groundwork for further exploration of K. marxianus characteristics and the biosynthesis of AD.
研究领域:
微生物学
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生物技术
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药理学
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Small
·
2025
·
IF 12.1
Zhuolin Wu,Yutong Xiong,Yongfeng Yang,Qingdao Zeng,Jinjin Li
Graphite used as an oil lubricant additive demonstrates superior friction-reducing capability, but the optimal oil molecular structure for achieving the best lubrication state remains debated. In this study, the synergistic lubrication between alkane molecules with different chain lengths and graphite is investigated and compared using atomic force microscopy (AFM), scanning tunneling microscopy (STM), and molecular dynamics (MD) simulations. Superlubricity occurred in the hexadecane environment with an extremely low friction coefficient of 0.001, representing a reduction of over 80% compared to the dodecane (µ = 0.006) and nonane (µ = 0.009) environments. The observed structural superlubricity arises from the ordered alignment of long-chain alkane molecules along the zigzag direction of the graphite surface, which promotes the formation of stable confined molecular layers. Furthermore, their boundary slip on the graphite surface with low energy barriers contributes to the realization of ultralow friction. This observation elucidates the critical role of alkane chain length in modulating the synergistic lubrication mechanism of graphite nanoflakes, providing fundamental guidance for designing high-performance lubrication systems.
研究领域:
摩擦学
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材料科学
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纳米技术
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化学物理
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Huan Sun,Shen Yan,Chaojie Wu,Jingye Ma,Kangwei Lu,Xi Cheng,Wenqi Yan,Shengyu Zhang,Xiao Dong Chen,Winston Duo Wu
Active pharmaceutical ingredient (API) embedded dry powder for inhalation (AeDPI) shows higher drug loading and delivery dose for directly treating various lung infections. Inspired by the dandelion, we propose a novel kind of AeDPI microparticle structure fabricated by spray freeze drying technology, which would potentially enhance the alveoli deposition efficiency. When inhaling, such microparticles are expected to be easily broken-up into fragments containing API that acts as ‘seed’ and could be delivered to alveoli aided by the low density ‘pappus’ composed of excipient. Herein, itraconazole (ITZ), a first-line drug for treating pulmonary aspergillosis, was selected as model API. TPGS, an amphiphilic surfactant, was used to achieve stable primary ITZ nanocrystal (INc) suspensions for spray freeze drying. A series of microparticles were prepared, and the dandelion-like structure was successfully achieved. The effects of feed liquid compositions and freezing parameters on the microparticle size, morphology, surface energy, crystal properties and in vitro aerosol performance were systematically investigated. The optimal sample (SF (-50) D-INc 7 Leu 3 -2) in one-way experiment showed the highest fine particle fraction of ~ 68.96% and extra fine particle fraction of ~ 36.87%, equivalently ~ 4.60 mg and ~ 2.46 mg could reach the lung and alveoli, respectively, when inhaling 10 mg dry powders. The response surface methodology (RSM) analysis provided the optimized design space for fabricating microparticles with higher deep lung deposition performance. This study demonstrates the advantages of AeDPI microparticle with dandelion-like structure on promoting the delivery efficiency of high-dose drug to the deep lung.
研究领域:
药学
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生物医学工程
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材料科学
·
呼吸医学
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ANALYST
·
2024
·Vol. 149
·期 5
·1579-1585
·
IF 3.6
Boxin Chen,Yuchen Zhu,Shaojie Ma,Bin Zhao,Fei Feng
A semi-packed gas chromatographic column has the advantages of high specific surface area and low column pressure. We report that the stagnation regions formed in the adjacent posts along the channel of the semi-packed columns can decrease the area and height of chromatographic peaks, which makes it difficult to detect low-concentration mixed gases. A semi-packed column with staggered elliptic cylindrical post arrays (SC-S) made using a micro-electro-mechanical system technique is presented, and the separation performance of SC-S is compared with that of a semi-packed column with aligned elliptic cylindrical post arrays (SC-A). The simulation results show that the width of stagnation regions in SC-S is 86.89% smaller than that in SC-A. The experimental results indicate that the area and height of chromatographic peaks increased as stagnation regions reduced. In the separation of the alkane mixture from C8 through C10 with 10 ppm concentration, the chromatographic peak of decane was hardly identified in SC-A while the chromatographic peak in SC-S was still clearly visible. The chromatographic peak heights of octane and nonane were increased by 65.06% and 130.00%, respectively, in SC-S. The peak areas of octane and nonane were increased by 120.45% and 168.18%, respectively.
研究领域:
分析化学
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微机电系统技术
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Lijun Cheng,Yang Yun,Jimei Chi,Zhiyu Tan,Daixi Xie,Sisi Chen,Yanlin Song,Meng Su
Perovskite quantum dots (PQDs) are promising materials for photonic and optoelectronic devices, relying on efficient and reliable patterning methods. However, the complex patterning process and poor stability of PQDs restrict their practical applications. Here, a patterning-induced encapsulation strategy (PIE-PQDs) is demonstrated for directly patterning PQDs into a thin polystyrene (PS) film. The prepared PQDs@PS composite film displays excellent air stability (30d, 92%), UV resistance (30d, 85%), and water resistance (30d,88%). Notably, even in harsh environments such as acid/alkali/alcohol aqueous solution, the composite film still preserves high luminescence. A binary solvent engineering strategy is induced to precisely control the distribution of PQDs inside the polymer film, resulting in morphologically controllable PQDs@PS microstructures for optical information encryption. Patterned PQDs@PS composite film can be compatible with diverse substrates including silicon, glass, paper, and plastic with the feature of optical information encryption. This method shows a universal in situ protection approach for patterning and integrating PQDs on flexible substrates, offering significant potential for display, optical data storage, information encryption, and anti-counterfeiting.
研究领域:
材料科学
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光学工程
·
纳米技术
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高影响因子
Catalysis Science & Technology
·
2024
·
IF 4.4
Lijin Gan,Zekun Liu,Lei Feng,Yi Duan,Guangyuan Xu,Si Chen,Huan Yan
Adipic aldehyde, a precursor for polymers, has significant industrial applications, where the hydroformylation of 1,3-butadiene is a promising route to fabricate adipic aldehyde. However, the heterogeneous hydroformylation of 1,3-butadiene has been rarely reported. In this work, we reported ligand-modified Rh-supported single-atom catalysts and investigated them for efficient hydroformylation of 1,3-butadiene. Among the selected phosphine ligand candidates, the L11 ligand (NiXantphos) coordinated Rh atoms could achieve the highest selectivity to adipic aldehyde. Furthermore, in situ CO DRIFTS indicated that active species similar to homogeneous catalysts were formed on the surface of the ligand modified and supported Rh catalyst during the reaction, demonstrating the similar hydroformylation mechanism and origins of the various products.
研究领域:
催化化学
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工业化学
·
材料科学
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高影响因子
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